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CAS Number: 1351636-18-4
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CAS Number
1351636-18-4
PubChem CID
54755438
Molecular Formula
C25H22N6O3
Molecular Weight
454.5 g/mol
Exact Mass
454.175339
InChIKey
SEJLPXCPMNSRAM-GOSISDBHSA-N
IUPAC Name
6-amino-9-[(3R)-1-but-2-ynoylpyrrolidin-3-yl]-7-(4-phenoxyphenyl)purin-8-one
SMILES String
CC#CC(=O)N1CC[C@@H](n2c(=O)n(-c3ccc(Oc4ccccc4)cc3)c3c(N)ncnc32)C1
No physical property values available.
Properties are provided as catalog reference data and may be confirmed through supplier documentation when required.
Structural features
Tirabrutinib (CAS 1351636-18-4) is listed in the Advanced Chemicals portfolio, with molecular formula C25H22N6O3 and molecular weight 454. 50 g/mol.
Sourcing context
Catalog reference for RFQ preparation, supplier confirmation, and research chemical sourcing review.
Research use context
Intended for research building-block and synthetic chemistry workflows; structure-derived tags include nitrogen-containing heterocycle.
Documentation needs
COA/SDS status, availability, lead time, pack size, and shipment documentation can be confirmed during quotation.
ChEMBL reports experimental activity evidence for: Cytoplasmic tyrosine-protein kinase BMX (Homo sapiens) — 4 assays; Tyrosine-protein kinase BTK (Homo sapiens) — 14 assays; Tyrosine-protein kinase Tec (Homo sapiens) — 4 assays; Tyrosine-protein kinase TXK (Homo sapiens) — 2 assays; Receptor tyrosine-protein kinase erbB-2 (Homo sapiens) — 3 assays. These records describe research assays and do not establish therapeutic efficacy or clinical use.
Cytoplasmic tyrosine-protein kinase BMX
Homo sapiens · SINGLE PROTEIN · 4 qualifying assays · 4 documents · best pChEMBL 8.37
Experimental evidence source: ChEMBL
Tyrosine-protein kinase BTK
Homo sapiens · SINGLE PROTEIN · 14 qualifying assays · 7 documents · best pChEMBL 8.28
Experimental evidence source: ChEMBL
Tyrosine-protein kinase Tec
Homo sapiens · SINGLE PROTEIN · 4 qualifying assays · 4 documents · best pChEMBL 8.21
Experimental evidence source: ChEMBL
Tyrosine-protein kinase TXK
Homo sapiens · SINGLE PROTEIN · 2 qualifying assays · 2 documents · best pChEMBL 6.94
Experimental evidence source: ChEMBL
Receptor tyrosine-protein kinase erbB-2
Homo sapiens · SINGLE PROTEIN · 3 qualifying assays · 3 documents · best pChEMBL 6.21
Experimental evidence source: ChEMBL
Safety and handling reference content is available through documentation requests.
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Preliminary Safety Reference
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Safety Reference / SDS RequestCatalog navigation
Other public CAS pages in this catalog. These links support navigation across additional intermediates and do not imply equivalence, availability, or shared use.
Tirabrutinib is identified by CAS 1351636-18-4, with molecular formula C25H22N6O3, molecular weight 454.5, InChIKey SEJLPXCPMNSRAM-GOSISDBHSA-N.
ChEMBL contains qualifying experimental assay evidence associated with Cytoplasmic tyrosine-protein kinase BMX, Tyrosine-protein kinase BTK, Tyrosine-protein kinase Tec, Tyrosine-protein kinase TXK, Receptor tyrosine-protein kinase erbB-2. These records do not establish therapeutic efficacy or clinical use.
Yes. Submit an RFQ and specify COA requirements. Lot-specific COA depends on supplier confirmation.
Yes. Supplier SDS can be requested through the RFQ workflow before handling, storage, shipment, or procurement decisions.
Availability, pack size, lead time, and pricing are confirmed through RFQ.
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