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Home/Compounds/CAS 1360457-46-0
Formula C12H16BNO5SMW 297.14Research-use catalog entryCOA/SDS by request

Vaborbactam

CAS Number: 1360457-46-0

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Available Options

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1 mg
Purity
98%
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5 mg
Purity
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Loading RDKit molecule structure...
InChIKey: IOOWNWLVCOUUEX-WPRPVWTQSA-NC12H16BNO5S | MW 297.14

Chemical Absolute Identifiers

CAS Number

1360457-46-0

PubChem CID

56649692

Molecular Formula

C12H16BNO5S

Molecular Weight

297.14 g/mol

Exact Mass

297.084224

InChIKey

IOOWNWLVCOUUEX-WPRPVWTQSA-N

IUPAC Name

2-[(3R,6S)-2-hydroxy-3-[(2-thiophen-2-ylacetyl)amino]oxaborinan-6-yl]acetic acid

SMILES String

O=C(O)C[C@@H]1CC[C@H](NC(=O)Cc2cccs2)B(O)O1

Physical Properties

No physical property values available.

Properties are provided as catalog reference data and may be confirmed through supplier documentation when required.

Catalog Facts

Structural features

Vaborbactam (CAS 1360457-46-0) is listed in the Advanced Chemicals portfolio, with molecular formula C12H16BNO5S and molecular weight 297. 14 g/mol.

Sourcing context

Catalog reference for RFQ preparation, supplier confirmation, and research chemical sourcing review.

Research use context

Intended for research building-block and synthetic chemistry workflows; structure-derived tags include nitrogen-containing heterocycle, boronic-acid-related structure.

Documentation needs

COA/SDS status, availability, lead time, pack size, and shipment documentation can be confirmed during quotation.

Applications & Classification

Boronic Acids and EstersSynthetic ChemistryResearch intermediateCustom synthesis building blockResearch chemical sourcingCustom synthesis and catalog availability reviewCOA, SDS, pricing, and fulfillment workflow
Biological target reference

ChEMBL reports experimental activity evidence for: Class A carbapenemase KPC-2 (Escherichia coli) — 5 assays; Beta lactamase TEM-1 (Klebsiella pneumoniae) — 20 assays; Beta-lactamase (Klebsiella pneumoniae) — 9 assays; Beta-lactamase SHV-1 (Klebsiella pneumoniae) — 8 assays; Carbapenem-hydrolyzing beta-lactamase KPC (Klebsiella oxytoca) — 8 assays. These records describe research assays and do not establish therapeutic efficacy or clinical use.

Class A carbapenemase KPC-2

Escherichia coli · SINGLE PROTEIN · 5 qualifying assays · 2 documents · best pChEMBL 7.25

Experimental evidence source: ChEMBL

Beta lactamase TEM-1

Klebsiella pneumoniae · SINGLE PROTEIN · 20 qualifying assays · 1 documents

Experimental evidence source: ChEMBL

Beta-lactamase

Klebsiella pneumoniae · SINGLE PROTEIN · 9 qualifying assays · 1 documents

Experimental evidence source: ChEMBL

Beta-lactamase SHV-1

Klebsiella pneumoniae · SINGLE PROTEIN · 8 qualifying assays · 1 documents

Experimental evidence source: ChEMBL

Carbapenem-hydrolyzing beta-lactamase KPC

Klebsiella oxytoca · SINGLE PROTEIN · 8 qualifying assays · 1 documents

Experimental evidence source: ChEMBL

Safety & Handling

Safety and handling reference content is available through documentation requests.

For supplier-issued SDS, request documentation before handling, storage, shipment, or procurement decisions.

Preliminary Safety Reference

For supplier-issued SDS or COA, submit a documentation request.

Safety Reference / SDS Request

Names & Synonyms / External Identifiers

Chemical Name

Vaborbactam

Names & Synonyms

2-((3R,6S)-2-hydroxy-3-(2-(thiophen-2-yl)acetamido)-1,2-oxaborinan-6-yl)acetic acidVABOMERE COMPONENT VABORBACTAM1,2-Oxaborinane-6-acetic acid, 2-hydroxy-3-((2-(2-thienyl)acetyl)amino)-, (3R,6S)-CARBAVANCE COMPONENT VABORBACTAM(3R,6S)-2-Hydroxy-3-[[2-(2-thienyl)acetyl]amino]-1,2-oxaborinane-6-acetic acid
Show all synonyms
2-[(3R,6S)-2-hydroxy-3-[2-(thiophen-2-yl)acetamido]-1,2-oxaborinan-6-yl]acetic acidvaborbactamum(3R,6S)-2-Hydroxy-3-((2-(2-thienyl)acetyl)amino)-1,2-oxaborinane-6-acetic acid2-((3R,6S)-2-hydroxy-3-((2-thiophen-2-ylacetyl)amino)oxaborinan-6-yl)acetic acidVaborbactam [INN]RPX 7009Vaborbactam?VABORBACTAM [MI]Vaborbactam. RPX7009Vaborbactam (USAN/INN)Vaborbactam [USAN:INN]VABORBACTAM [USAN]VABORBACTAM [WHO-DD]VABORBACTAM [ORANGE BOOK]
External Identifiers
EC NUMBER: 807-463-5DSSTOX SUBSTANCE ID: DTXSID901027690CHEMBL ID: CHEMBL3317857UNII: 1C75676F8VDRUGBANK ID: DB12107KEGG ID: D10998METABOLOMICS WORKBENCH ID: 153155NCI THESAURUS CODE: C152810RXCUI: 1945213WIKIDATA ID: Q27252228
Literature & Patent References
DOI 10.1016/j.bmc.2022.116722Broad-spectrum cyclic boronate β-lactamase inhibitors featuring an intramolecular prodrug for oral bioavailability.DOI 10.1021/acs.jmedchem.2c00523Discovery of a Novel Oral Proteasome Inhibitor to Block NLRP3 Inflammasome Activation with Anti-inflammation Activity.PMID 35358864Broad-spectrum cyclic boronate β-lactamase inhibitors featuring an intramolecular prodrug for oral bioavailability.PMID 36063115Discovery of a Novel Oral Proteasome Inhibitor to Block NLRP3 Inflammasome Activation with Anti-inflammation Activity.DOI 10.1021/acs.jmedchem.1c00717High-Throughput Crystallography Reveals Boron-Containing Inhibitors of a Penicillin-Binding Protein with Di- and Tricovalent Binding Modes.PMID 34337941High-Throughput Crystallography Reveals Boron-Containing Inhibitors of a Penicillin-Binding Protein with Di- and Tricovalent Binding Modes.DOI 10.1021/acs.jmedchem.9b01518Discovery of Taniborbactam (VNRX-5133): A Broad-Spectrum Serine- and Metallo-β-lactamase Inhibitor for Carbapenem-Resistant Bacterial Infections.DOI 10.1021/acs.jmedchem.9b01976Discovery of Cyclic Boronic Acid QPX7728, an Ultrabroad-Spectrum Inhibitor of Serine and Metallo-β-lactamases.

Documentation & Compliance Facts

Compliance Facts

Shipment review: Required

Documentation available by request

Certificate of Analysis (COA): By request

Supplier Safety Data Sheet (SDS): By request

Purity and pack size confirmation: By request

Availability and lead time review: Confirmed by RFQ

Shipment documentation review: By request

For supplier-issued documentation by request, use the RFQ actions on this page.Review preliminary safety reference

What happens after RFQ

  1. 1We review the CAS identity, quantity, and documentation request.
  2. 2We check sourcing options, supplier availability, COA/SDS, purity, pack size, and lead time.
  3. 3We review destination and shipment documentation needs when applicable.
  4. 4We follow up with a quotation or clarification request.

Text Reference Cues

Show non-linked catalog cues

Non-public related references

2-(1-Hydroxy-1,3-dihydro-2,1-benzoxaborol-3-yl)acetic acidCAS 19203-45-3
2-(1-Hydroxy-1,3-dihydrobenzo[c][1,2]oxaborol-7-yl)acetic acidCAS 1268335-32-5
3-(1-Hydroxy-1,3-dihydro-2,1-benzoxaborol-7-yl)propanoic acidCAS 1268335-33-6
1-Hydroxy-1,3-dihydro-2,1-benzoxaborole-7-carboxylic AcidCAS 1268335-28-9
1-Hydroxy-1,3-dihydrobenzo[c][1,2]oxaborole-4-carboxylic acidCAS 2346531-04-0

Non-public references are shown as text only and do not imply equivalence, availability, or shared use.

Catalog navigation

Related Catalog Entries

Other public CAS pages in this catalog. These links support navigation across additional intermediates and do not imply equivalence, availability, or shared use.

CAS 61477-96-1PiperacillinCAS 209467-52-7CeftobiproleCAS 89786-04-9TazobactamCAS 1002310-00-0Tert-butyl 1-(2-chloro-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)ethylcarbamateCAS 1005174-17-3(E)-3-(2-Propyl-6-(trifluoromethyl)pyridin-3-yl)acrylic acidCAS 1018125-49-92-(3-Cyclopropyl-6-ethyl-4-(trifluoromethyl)-1H-pyrazolo[3,4-b]pyridin-1-yl)acetic acidCAS 1018128-07-8Isopropyl 4-chloro-2-methylquinoline-6-carboxylateCAS 1018142-22-76-cyclopropyl-1-(2,2-difluoroethyl)-3-methyl-1H-pyrazolo[3,4-b]pyridine-4-carboxylic acidCAS 1018144-00-72-(3-Cyclopropyl-6-isopropyl-4-(trifluoromethyl)-1H-pyrazolo[3,4-b]pyridin-1-yl)acetic acid

RFQ questions for CAS 1360457-46-0

What are the key identifiers for Vaborbactam (CAS 1360457-46-0)?

Vaborbactam is identified by CAS 1360457-46-0, with molecular formula C12H16BNO5S, molecular weight 297.14, InChIKey IOOWNWLVCOUUEX-WPRPVWTQSA-N.

Does CAS 1360457-46-0 have reported biological target evidence?

ChEMBL contains qualifying experimental assay evidence associated with Class A carbapenemase KPC-2, Beta lactamase TEM-1, Beta-lactamase, Beta-lactamase SHV-1, Carbapenem-hydrolyzing beta-lactamase KPC. These records do not establish therapeutic efficacy or clinical use.

Can I request a COA for CAS 1360457-46-0?

Yes. Submit an RFQ and specify COA requirements. Lot-specific COA depends on supplier confirmation.

Can I request supplier SDS for Vaborbactam?

Yes. Supplier SDS can be requested through the RFQ workflow before handling, storage, shipment, or procurement decisions.

Is CAS 1360457-46-0 available for quotation?

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