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Home/Compounds/CAS 1397-89-3
Formula C47H73NO17MW 924.1Research-use catalog entryCOA/SDS by request

Amphotericin B

CAS Number: 1397-89-3

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Loading RDKit molecule structure...
InChIKey: APKFDSVGJQXUKY-INPOYWNPSA-NC47H73NO17 | MW 924.1

Chemical Absolute Identifiers

CAS Number

1397-89-3

PubChem CID

5280965

Molecular Formula

C47H73NO17

Molecular Weight

924.1 g/mol

Exact Mass

923.48785

InChIKey

APKFDSVGJQXUKY-INPOYWNPSA-N

IUPAC Name

(1R,3S,5R,6R,9R,11R,15S,16R,17R,18S,19E,21E,23E,25E,27E,29E,31E,33R,35S,36R,37S)-33-[(2R,3S,4S,5S,6R)-4-amino-3,5-dihydroxy-6-methyloxan-2-yl]oxy-1,3,5,6,9,11,17,37-octahydroxy-15,16,18-trimethyl-13-oxo-14,39-dioxabicyclo[33.3.1]nonatriaconta-19,21,23,25,27,29,31-heptaene-36-carboxylic acid

SMILES String

C[C@@H]1[C@H](O)[C@@H](C)/C=C/C=C/C=C/C=C/C=C/C=C/C=C/[C@H](O[C@@H]2O[C@H](C)[C@@H](O)[C@H](N)[C@@H]2O)C[C@@H]2O[C@](O)(C[C@@H](O)C[C@@H](O)[C@H](O)CC[C@@H](O)C[C@@H](O)CC(=O)O[C@H]1C)C[C@H](O)[C@H]2C(=O)O

Physical Properties

Appearance

Amphotericin b is a bright yellow powder. (NTP, 1992)

Melting Point

17.0 °C

Properties are provided as catalog reference data and may be confirmed through supplier documentation when required.

Catalog Facts

Structural features

Amphotericin B (CAS 1397-89-3) is listed in the Pharmaceutical Intermediates portfolio, with molecular formula C47H73NO17 and molecular weight 924. 10 g/mol.

Sourcing context

Catalog reference for RFQ preparation, supplier confirmation, and research chemical sourcing review.

Research use context

Intended for research-stage medicinal chemistry and intermediate synthesis workflows; structure-derived tags include nitrogen-containing heterocycle.

Documentation needs

COA/SDS status, availability, lead time, pack size, and shipment documentation can be confirmed during quotation.

Applications & Classification

Pharmaceutical Intermediate ResearchResearch intermediateCustom synthesis building blockPharmaceutical intermediate researchResearch chemical sourcingCustom synthesis and catalog availability reviewCOA, SDS, pricing, and fulfillment workflow
Biological target reference

ChEMBL reports experimental activity evidence for: 3-hydroxyacyl-CoA dehydrogenase type-2 (Homo sapiens) — 2 assays; Tyrosyl-DNA phosphodiesterase 1 (Homo sapiens) — 2 assays; Vitamin D3 receptor (Homo sapiens) — 2 assays. These records describe research assays and do not establish therapeutic efficacy or clinical use.

3-hydroxyacyl-CoA dehydrogenase type-2

Homo sapiens · SINGLE PROTEIN · 2 qualifying assays · 1 documents · best pChEMBL 4.5

Experimental evidence source: ChEMBL

Tyrosyl-DNA phosphodiesterase 1

Homo sapiens · SINGLE PROTEIN · 2 qualifying assays · 1 documents

Experimental evidence source: ChEMBL

Vitamin D3 receptor

Homo sapiens · SINGLE PROTEIN · 2 qualifying assays · 1 documents

Experimental evidence source: ChEMBL

Safety & Handling

Safety and handling reference content is available through documentation requests.

For supplier-issued SDS, request documentation before handling, storage, shipment, or procurement decisions.

Preliminary Safety Reference

For supplier-issued SDS or COA, submit a documentation request.

Safety Reference / SDS Request

Names & Synonyms / External Identifiers

Chemical Name

Amphotericin B

Names & Synonyms

Amphotericine BAmfotericina BHalizonAmpho-MoronalAmphotericinum B
Show all synonyms
FungizoneAmphocinAmphotecFungilinAmphozoneAmphotericinBAMPH-BAmphotocerinAmbilAmphotericin B liposomeMysteclin-FAmphotericin b, liposomeNS 718ABELCET, LIPOSOMAL AMPHOTERICIN BFungisone
External Identifiers
EC NUMBER: 215-742-2DSSTOX SUBSTANCE ID: DTXSID9022601CHEMBL ID: CHEMBL267345CHEBI ID: CHEBI:2682UNII: 7XU7A7DROEDRUGBANK ID: DB00681HMDB ID: HMDB0014819KEGG ID: C06573KEGG ID: D00203METABOLOMICS WORKBENCH ID: 21324NCI THESAURUS CODE: C238PHARMGKB ID: PA448415RXCUI: 732
Experimental Spectrum References
13C NMR SpectraUV Spectra
Literature & Patent References
DOI 10.1016/j.bmc.2014.11.028Clofazimine analogs with antileishmanial and antiplasmodial activity.DOI 10.1016/j.bmc.2014.11.038New synthetic sulfone derivatives inhibit growth, adhesion and the leucine arylamidase APE2 gene expression of Candida albicans in vitro.DOI 10.1016/j.bmcl.2014.11.056Ionic liquid catalyzed synthesis of 2-(indole-3-yl)-thiochroman-4-ones and their novel antifungal activities.DOI 10.1016/j.ejmech.2014.10.026Antimycobacterial activity of natural products and synthetic agents: pyrrolodiquinolines and vermelhotin as anti-tubercular leads against clinical multidrug resistant isolates of Mycobacterium tuberculosis.DOI 10.1016/j.ejmech.2014.10.040Design, synthesis and anti-leishmanial activity of novel symmetrical bispyridinium cyclophanes.PMID 25462220Antimycobacterial activity of natural products and synthetic agents: pyrrolodiquinolines and vermelhotin as anti-tubercular leads against clinical multidrug resistant isolates of Mycobacterium tuberculosis.PMID 25462252Design, synthesis and anti-leishmanial activity of novel symmetrical bispyridinium cyclophanes.PMID 25497962Clofazimine analogs with antileishmanial and antiplasmodial activity.

Documentation & Compliance Facts

Compliance Facts

Shipment review: Required

Documentation available by request

Certificate of Analysis (COA): By request

Supplier Safety Data Sheet (SDS): By request

Purity and pack size confirmation: By request

Availability and lead time review: Confirmed by RFQ

Shipment documentation review: By request

For supplier-issued documentation by request, use the RFQ actions on this page.Review preliminary safety reference

What happens after RFQ

  1. 1We review the CAS identity, quantity, and documentation request.
  2. 2We check sourcing options, supplier availability, COA/SDS, purity, pack size, and lead time.
  3. 3We review destination and shipment documentation needs when applicable.
  4. 4We follow up with a quotation or clarification request.

Text Reference Cues

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Non-public related references

NatamycinCAS 7681-93-8

Non-public references are shown as text only and do not imply equivalence, availability, or shared use.

Catalog navigation

Related Catalog Entries

Other public CAS pages in this catalog. These links support navigation across additional intermediates and do not imply equivalence, availability, or shared use.

CAS 7681-93-8NatamycinCAS 118-75-2ChloranilCAS 21829-25-4NifedipineCAS 91-53-2EthoxyquinCAS 118-10-5(S)-Quinolin-4-yl((1S,2R,4S,5R)-5-vinylquinuclidin-2-yl)methanol , CinchonineCAS 13292-46-1RifampicinCAS 1002310-00-0Tert-butyl 1-(2-chloro-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)ethylcarbamateCAS 1005174-17-3(E)-3-(2-Propyl-6-(trifluoromethyl)pyridin-3-yl)acrylic acidCAS 1018125-49-92-(3-Cyclopropyl-6-ethyl-4-(trifluoromethyl)-1H-pyrazolo[3,4-b]pyridin-1-yl)acetic acidCAS 1018128-07-8Isopropyl 4-chloro-2-methylquinoline-6-carboxylate

RFQ questions for CAS 1397-89-3

What are the key identifiers for Amphotericin B (CAS 1397-89-3)?

Amphotericin B is identified by CAS 1397-89-3, with molecular formula C47H73NO17, molecular weight 924.1, InChIKey APKFDSVGJQXUKY-INPOYWNPSA-N.

Does CAS 1397-89-3 have reported biological target evidence?

ChEMBL contains qualifying experimental assay evidence associated with 3-hydroxyacyl-CoA dehydrogenase type-2, Tyrosyl-DNA phosphodiesterase 1, Vitamin D3 receptor. These records do not establish therapeutic efficacy or clinical use.

Can I request a COA for CAS 1397-89-3?

Yes. Submit an RFQ and specify COA requirements. Lot-specific COA depends on supplier confirmation.

Can I request supplier SDS for Amphotericin B?

Yes. Supplier SDS can be requested through the RFQ workflow before handling, storage, shipment, or procurement decisions.

Is CAS 1397-89-3 available for quotation?

Availability, pack size, lead time, and pricing are confirmed through RFQ.

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