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Home/Compounds/CAS 145918-75-8
Formula C8H11N3O4MW 213.19Research-use catalog entryCOA/SDS by request

Troxacitabine

CAS Number: 145918-75-8

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Loading RDKit molecule structure...
InChIKey: RXRGZNYSEHTMHC-BQBZGAKWSA-NC8H11N3O4 | MW 213.19

Chemical Absolute Identifiers

CAS Number

145918-75-8

PubChem CID

454194

Molecular Formula

C8H11N3O4

Molecular Weight

213.19 g/mol

Exact Mass

213.074956

InChIKey

RXRGZNYSEHTMHC-BQBZGAKWSA-N

IUPAC Name

4-amino-1-[(2S,4S)-2-(hydroxymethyl)-1,3-dioxolan-4-yl]pyrimidin-2-one

SMILES String

C1[C@H](O[C@H](O1)CO)N2C=CC(=NC2=O)N

Physical Properties

No physical property values available.

Properties are provided as catalog reference data and may be confirmed through supplier documentation when required.

Catalog Facts

Structural features

Troxacitabine (CAS 145918-75-8) is listed in the Advanced Chemicals portfolio, with molecular formula C8H11N3O4 and molecular weight 213. 19 g/mol.

Sourcing context

Catalog reference for RFQ preparation, supplier confirmation, and research chemical sourcing review.

Research use context

Intended for research building-block and synthetic chemistry workflows; structure-derived tags include nitrogen-containing heterocycle.

Documentation needs

COA/SDS status, availability, lead time, pack size, and shipment documentation can be confirmed during quotation.

Applications & Classification

Heterocyclic Building BlocksSynthetic ChemistryResearch intermediateCustom synthesis building blockResearch chemical sourcingCustom synthesis and catalog availability reviewCOA, SDS, pricing, and fulfillment workflow
Biological target reference

ChEMBL reports experimental activity evidence for: Tyrosyl-DNA phosphodiesterase 1 (Homo sapiens) — 2 assays. These records describe research assays and do not establish therapeutic efficacy or clinical use.

Tyrosyl-DNA phosphodiesterase 1

Homo sapiens · SINGLE PROTEIN · 2 qualifying assays · 1 documents

Experimental evidence source: ChEMBL

Safety & Handling

Safety and handling reference content is available through documentation requests.

For supplier-issued SDS, request documentation before handling, storage, shipment, or procurement decisions.

Preliminary Safety Reference

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Safety Reference / SDS Request

Names & Synonyms / External Identifiers

Chemical Name

Troxacitabine

Names & Synonyms

TroxatylL-Oddc(-)-ODDCTroxacitabina2(1H)-Pyrimidinone, 4-amino-1-[(2S,4S)-2-(hydroxymethyl)-1,3-dioxolan-4-yl]-
Show all synonyms
(2S-cis)-4-Amino-1-(2-(hydroxymethyl)-1,3-dioxolan-4-yl)-2(1H)-pyrimidinoneHmd-cytosine2(1H)-Pyrimidinone, 4-amino-1-((2S,4S)-2-(hydroxymethyl)-1,3-dioxolan-4-yl)-beta-L-Dioxolane-cytidine1-(2-(Hydroxymethyl)-1,3-dioxolan-4-yl)cytosinetroxacitabinum2S(-)-cis-HMD-cytosine2R(-)-trans-HMD-cytosine4-amino-1-((2S,4S)-2-(hydroxymethyl)-1,3-dioxolan-4-yl)-1,2-dihydropyrimidin-2-one4-amino-1-((2S,4S)-2-(hydroxymethyl)-1,3-dioxolan-4-yl)pyrimidin-2(1H)-onecis-Dioxolane-C(-)-1-((2S,4S)-2-(Hydroxymethyl)-1,3-dioxolan-4-yl)cytosine4-Amino-1-[(2s,4s)-2-(Hydroxymethyl)-1,3-Dioxolan-4-Yl]pyrimidin-2(1h)-One
External Identifiers
CHEMBL ID: CHEMBL359164CHEBI ID: CHEBI:134886UNII: 60KQZ0388YDRUGBANK ID: DB04961KEGG ID: D06255METABOLOMICS WORKBENCH ID: 149356NCI THESAURUS CODE: C1438WIKIDATA ID: Q7846702Bch-4556
Literature & Patent References
DOI 10.1021/acs.jmedchem.1c00790Geminal Diheteroatomic Motifs: Some Applications of Acetals, Ketals, and Their Sulfur and Nitrogen Homologues in Medicinal Chemistry and Drug Design.PMID 34213340Geminal Diheteroatomic Motifs: Some Applications of Acetals, Ketals, and Their Sulfur and Nitrogen Homologues in Medicinal Chemistry and Drug Design.DOI 10.1124/dmd.108.020479Trend analysis of a database of intravenous pharmacokinetic parameters in humans for 670 drug compounds.PMID 18426954Trend analysis of a database of intravenous pharmacokinetic parameters in humans for 670 drug compounds.DOI 10.1021/jm0612923In vitro optimization of non-small cell lung cancer activity with troxacitabine, L-1,3-dioxolane-cytidine, prodrugs.PMID 17419604In vitro optimization of non-small cell lung cancer activity with troxacitabine, L-1,3-dioxolane-cytidine, prodrugs.DOI 10.1016/0960-894X(95)00343-RDioxolane cytosine nucleosides as anti-hepatitis B agentsDOI 10.1021/jm00057a001L-beta-(2S,4S)- and L-alpha-(2S,4R)-dioxolanyl nucleosides as potential anti-HIV agents: asymmetric synthesis and structure-activity relationships.

Documentation & Compliance Facts

Compliance Facts

Shipment review: Required

Documentation available by request

Certificate of Analysis (COA): By request

Supplier Safety Data Sheet (SDS): By request

Purity and pack size confirmation: By request

Availability and lead time review: Confirmed by RFQ

Shipment documentation review: By request

For supplier-issued documentation by request, use the RFQ actions on this page.Review preliminary safety reference

What happens after RFQ

  1. 1We review the CAS identity, quantity, and documentation request.
  2. 2We check sourcing options, supplier availability, COA/SDS, purity, pack size, and lead time.
  3. 3We review destination and shipment documentation needs when applicable.
  4. 4We follow up with a quotation or clarification request.

Text Reference Cues

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Non-public related references

Glycerol carbonateCAS 931-40-8
2',3'-O-(1-Methylethylidene)inosineCAS 2140-11-6
((3aR,4R,6R,6aR)-6-(6-amino-2-chloro-9H-purin-9-yl)-2,2-dimethyltetrahydrofuro[3,4-d][1,3]dioxol-4-yl)methanolCAS 24639-06-3

Non-public references are shown as text only and do not imply equivalence, availability, or shared use.

Catalog navigation

Related Catalog Entries

Other public CAS pages in this catalog. These links support navigation across additional intermediates and do not imply equivalence, availability, or shared use.

CAS 1002310-00-0Tert-butyl 1-(2-chloro-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)ethylcarbamateCAS 1005174-17-3(E)-3-(2-Propyl-6-(trifluoromethyl)pyridin-3-yl)acrylic acidCAS 1018125-49-92-(3-Cyclopropyl-6-ethyl-4-(trifluoromethyl)-1H-pyrazolo[3,4-b]pyridin-1-yl)acetic acidCAS 1018128-07-8Isopropyl 4-chloro-2-methylquinoline-6-carboxylateCAS 1018142-22-76-cyclopropyl-1-(2,2-difluoroethyl)-3-methyl-1H-pyrazolo[3,4-b]pyridine-4-carboxylic acidCAS 1018144-00-72-(3-Cyclopropyl-6-isopropyl-4-(trifluoromethyl)-1H-pyrazolo[3,4-b]pyridin-1-yl)acetic acid

RFQ questions for CAS 145918-75-8

What are the key identifiers for Troxacitabine (CAS 145918-75-8)?

Troxacitabine is identified by CAS 145918-75-8, with molecular formula C8H11N3O4, molecular weight 213.19, InChIKey RXRGZNYSEHTMHC-BQBZGAKWSA-N.

Does CAS 145918-75-8 have reported biological target evidence?

ChEMBL contains qualifying experimental assay evidence associated with Tyrosyl-DNA phosphodiesterase 1. These records do not establish therapeutic efficacy or clinical use.

Can I request a COA for CAS 145918-75-8?

Yes. Submit an RFQ and specify COA requirements. Lot-specific COA depends on supplier confirmation.

Can I request supplier SDS for Troxacitabine?

Yes. Supplier SDS can be requested through the RFQ workflow before handling, storage, shipment, or procurement decisions.

Is CAS 145918-75-8 available for quotation?

Availability, pack size, lead time, and pricing are confirmed through RFQ.

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