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Home/Compounds/CAS 147127-20-6
Formula C9H14N5O4PMW 287.21Research-use catalog entryCOA/SDS by request

Tenofovir

CAS Number: 147127-20-6

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Loading RDKit molecule structure...
InChIKey: SGOIRFVFHAKUTI-ZCFIWIBFSA-NC9H14N5O4P | MW 287.21

Chemical Absolute Identifiers

CAS Number

147127-20-6

PubChem CID

464205

Molecular Formula

C9H14N5O4P

Molecular Weight

287.21 g/mol

Exact Mass

287.078341

InChIKey

SGOIRFVFHAKUTI-ZCFIWIBFSA-N

IUPAC Name

[(2R)-1-(6-aminopurin-9-yl)propan-2-yl]oxymethylphosphonic acid

SMILES String

C[C@H](CN1C=NC2=C(N=CN=C21)N)OCP(=O)(O)O

Physical Properties

Melting Point

276–28 °C

pKa

3.8

Properties are provided as catalog reference data and may be confirmed through supplier documentation when required.

Catalog Facts

Structural features

Tenofovir (CAS 147127-20-6) is listed in the Advanced Chemicals portfolio, with molecular formula C9H14N5O4P and molecular weight 287. 21 g/mol.

Sourcing context

Catalog reference for RFQ preparation, supplier confirmation, and research chemical sourcing review.

Research use context

Intended for research building-block and synthetic chemistry workflows; structure-derived tags include nitrogen-containing heterocycle.

Documentation needs

COA/SDS status, availability, lead time, pack size, and shipment documentation can be confirmed during quotation.

Applications & Classification

Heterocyclic Building BlocksSynthetic ChemistryResearch intermediateCustom synthesis building blockResearch chemical sourcingCustom synthesis and catalog availability reviewCOA, SDS, pricing, and fulfillment workflow
Biological target reference

ChEMBL reports experimental activity evidence for: Human immunodeficiency virus type 1 reverse transcriptase (Human immunodeficiency virus 1) — 13 assays; 5-hydroxytryptamine receptor 1A (Homo sapiens) — 2 assays; 5-hydroxytryptamine receptor 2A (Homo sapiens) — 2 assays; 5-hydroxytryptamine receptor 2B (Homo sapiens) — 2 assays; Adenylate kinase 2, mitochondrial (Homo sapiens) — 2 assays. These records describe research assays and do not establish therapeutic efficacy or clinical use.

Human immunodeficiency virus type 1 reverse transcriptase

Human immunodeficiency virus 1 · SINGLE PROTEIN · 13 qualifying assays · 5 documents · best pChEMBL 6.42

Experimental evidence source: ChEMBL

5-hydroxytryptamine receptor 1A

Homo sapiens · SINGLE PROTEIN · 2 qualifying assays · 1 documents

Experimental evidence source: ChEMBL

5-hydroxytryptamine receptor 2A

Homo sapiens · SINGLE PROTEIN · 2 qualifying assays · 1 documents

Experimental evidence source: ChEMBL

5-hydroxytryptamine receptor 2B

Homo sapiens · SINGLE PROTEIN · 2 qualifying assays · 1 documents

Experimental evidence source: ChEMBL

Adenylate kinase 2, mitochondrial

Homo sapiens · SINGLE PROTEIN · 2 qualifying assays · 1 documents

Experimental evidence source: ChEMBL

Safety & Handling

Safety and handling reference content is available through documentation requests.

For supplier-issued SDS, request documentation before handling, storage, shipment, or procurement decisions.

Preliminary Safety Reference

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Safety Reference / SDS Request

Names & Synonyms / External Identifiers

Chemical Name

Tenofovir

Names & Synonyms

PMPA(R)-9-(2-Phosphonomethoxypropyl)adenine(R)-PMPAtenofovir (anhydrous)Tenofovir anhydrous
Show all synonyms
anhydrous tenofovirtenofovir (anh.)({[(2R)-1-(6-amino-9H-purin-9-yl)propan-2-yl]oxy}methyl)phosphonic acid(R)-9-(Phosphonomethoxypropyl)adenine(R)-9-(2-Phosphonylmethoxypropyl)adeninePMP-A(((1R)-2-(6-Amino-9H-purin-9-yl)-1-methylethoxy)methyl)phosphonic acidPhosphonic acid, (((1R)-2-(6-amino-9H-purin-9-yl)-1-methylethoxy)methyl)-tenofovirum((2R)-1-(6-aminopurin-9-yl)propan-2-yl)oxymethylphosphonic acid((((2R)-1-(6-amino-9H-purin-9-yl)propan-2-yl)oxy)methyl)phosphonic acid{[(1R)-2-(6-amino-9H-purin-9-yl)-1-methylethoxy]methyl}phosphonic acidPhosphonic acid, [[(1R)-2-(6-amino-9H-purin-9-yl)-1-methylethoxy]methyl]-Disoproxil, Tenofovir
External Identifiers
EC NUMBER: 604-571-2DSSTOX SUBSTANCE ID: DTXSID9040132CHEMBL ID: CHEMBL3989702CHEMBL ID: CHEMBL483CHEBI ID: CHEBI:63625UNII: W4HFE001U5DRUGBANK ID: DB14126HMDB ID: HMDB0014445KEGG ID: C17407METABOLOMICS WORKBENCH ID: 42689NCI THESAURUS CODE: C170540NCI THESAURUS CODE: C29490PHARMGKB ID: PA10204RXCUI: 1546017WIKIDATA ID: Q155954
Experimental Spectrum References
ATR-IR Spectra — Forensic Spectral ResearchRaman Spectra — Forensic Spectral Research
Literature & Patent References
DOI 10.1016/j.ejmech.2023.116020Membrane-permeable tenofovir-di- and monophosphate analogues.DOI 10.1016/j.ejmech.2024.116614Lipid-conjugated nucleoside monophosphate and monophosphonate prodrugs: A versatile drug delivery paradigm.DOI 10.1016/j.ejmech.2024.116948Sensitive quantification of fibroblast activation protein and high-throughput screening for inhibition by FDA-approved compounds.DOI 10.1021/acsmedchemlett.4c00037Discovery of Hepatitis B Virus Surface Antigen Suppressor GS-8873.PMID 38086193Membrane-permeable tenofovir-di- and monophosphate analogues.PMID 38628802Discovery of Hepatitis B Virus Surface Antigen Suppressor GS-8873.PMID 38925014Lipid-conjugated nucleoside monophosphate and monophosphonate prodrugs: A versatile drug delivery paradigm.PMID 39437576Sensitive quantification of fibroblast activation protein and high-throughput screening for inhibition by FDA-approved compounds.

Documentation & Compliance Facts

Compliance Facts

Shipment review: Required

Documentation available by request

Certificate of Analysis (COA): By request

Supplier Safety Data Sheet (SDS): By request

Purity and pack size confirmation: By request

Availability and lead time review: Confirmed by RFQ

Shipment documentation review: By request

For supplier-issued documentation by request, use the RFQ actions on this page.Review preliminary safety reference

What happens after RFQ

  1. 1We review the CAS identity, quantity, and documentation request.
  2. 2We check sourcing options, supplier availability, COA/SDS, purity, pack size, and lead time.
  3. 3We review destination and shipment documentation needs when applicable.
  4. 4We follow up with a quotation or clarification request.

Text Reference Cues

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Non-public related references

(S)-PmpaCAS 147127-19-3
9-(2-Hydroxypropyl)adenine, (R)-CAS 14047-28-0
Ethyl adenine-9-acetateCAS 25477-96-7
5'-Adenylic acid, monohydrateCAS 18422-05-4
Adenosine 5'-monophosphate disodiumCAS 4578-31-8

Non-public references are shown as text only and do not imply equivalence, availability, or shared use.

Catalog navigation

Related Catalog Entries

Other public CAS pages in this catalog. These links support navigation across additional intermediates and do not imply equivalence, availability, or shared use.

CAS 147127-19-3(S)-PmpaCAS 14047-28-09-(2-Hydroxypropyl)adenine, (R)-CAS 25477-96-7Ethyl adenine-9-acetateCAS 30516-87-1ZidovudineCAS 134678-17-4LamivudineCAS 59277-89-32-amino-9-(2-hydroxyethoxymethyl)-3H-purin-6-oneCAS 124832-26-4ValacyclovirCAS 1002310-00-0Tert-butyl 1-(2-chloro-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)ethylcarbamateCAS 1005174-17-3(E)-3-(2-Propyl-6-(trifluoromethyl)pyridin-3-yl)acrylic acidCAS 1018125-49-92-(3-Cyclopropyl-6-ethyl-4-(trifluoromethyl)-1H-pyrazolo[3,4-b]pyridin-1-yl)acetic acid

RFQ questions for CAS 147127-20-6

What are the key identifiers for Tenofovir (CAS 147127-20-6)?

Tenofovir is identified by CAS 147127-20-6, with molecular formula C9H14N5O4P, molecular weight 287.21, InChIKey SGOIRFVFHAKUTI-ZCFIWIBFSA-N.

Does CAS 147127-20-6 have reported biological target evidence?

ChEMBL contains qualifying experimental assay evidence associated with Human immunodeficiency virus type 1 reverse transcriptase, 5-hydroxytryptamine receptor 1A, 5-hydroxytryptamine receptor 2A, 5-hydroxytryptamine receptor 2B, Adenylate kinase 2, mitochondrial. These records do not establish therapeutic efficacy or clinical use.

Can I request a COA for CAS 147127-20-6?

Yes. Submit an RFQ and specify COA requirements. Lot-specific COA depends on supplier confirmation.

Can I request supplier SDS for Tenofovir?

Yes. Supplier SDS can be requested through the RFQ workflow before handling, storage, shipment, or procurement decisions.

Is CAS 147127-20-6 available for quotation?

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