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Home/Compounds/CAS 154052-92-3
Formula C10H7NO3SMW 221.23Research-use catalog entryCOA/SDS by request

(5Z)-5-[(4-hydroxyphenyl)methylidene]-1,3-thiazolidine-2,4-dione

CAS Number: 154052-92-3

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Purity
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Loading RDKit molecule structure...
InChIKey: ARHIHDVVUHVQCP-YVMONPNESA-NC10H7NO3S | MW 221.23

Chemical Absolute Identifiers

CAS Number

154052-92-3

PubChem CID

1276529

Molecular Formula

C10H7NO3S

Molecular Weight

221.23 g/mol

Exact Mass

221.014664

InChIKey

ARHIHDVVUHVQCP-YVMONPNESA-N

SMILES String

O=C1NC(=O)/C(=C/c2ccc(O)cc2)S1

Physical Properties

No physical property values available.

Properties are provided as catalog reference data and may be confirmed through supplier documentation when required.

Catalog Facts

Structural features

(5Z)-5-[(4-hydroxyphenyl)methylidene]-1,3-thiazolidine-2,4-dione (CAS 154052-92-3) is listed in the Advanced Chemicals portfolio, with molecular formula C10H7NO3S and molecular weight 221. 23 g/mol.

Sourcing context

Catalog reference for RFQ preparation, supplier confirmation, and research chemical sourcing review.

Research use context

Intended for research building-block and synthetic chemistry workflows; structure-derived tags include nitrogen-containing heterocycle.

Documentation needs

COA/SDS status, availability, lead time, pack size, and shipment documentation can be confirmed during quotation.

Applications & Classification

Heterocyclic Building BlocksSynthetic ChemistryResearch intermediateCustom synthesis building blockResearch chemical sourcingCustom synthesis and catalog availability reviewCOA, SDS, pricing, and fulfillment workflow
Biological target reference

ChEMBL reports experimental activity evidence for: Aldo-keto reductase family 1 member B1 (Homo sapiens) — 2 assays; Glycogen synthase kinase-3 beta (Homo sapiens) — 2 assays; Tyrosinase (Agaricus bisporus) — 4 assays; Tyrosyl-DNA phosphodiesterase 1 (Homo sapiens) — 2 assays; ATPase family AAA domain-containing protein 5 (Homo sapiens) — 2 assays. These records describe research assays and do not establish therapeutic efficacy or clinical use.

Aldo-keto reductase family 1 member B1

Homo sapiens · SINGLE PROTEIN · 2 qualifying assays · 2 documents · best pChEMBL 7.7

Experimental evidence source: ChEMBL

Glycogen synthase kinase-3 beta

Homo sapiens · SINGLE PROTEIN · 2 qualifying assays · 1 documents · best pChEMBL 5.05

Experimental evidence source: ChEMBL

Tyrosinase

Agaricus bisporus · SINGLE PROTEIN · 4 qualifying assays · 1 documents · best pChEMBL 4.87

Experimental evidence source: ChEMBL

Tyrosyl-DNA phosphodiesterase 1

Homo sapiens · SINGLE PROTEIN · 2 qualifying assays · 1 documents · best pChEMBL 4.6

Experimental evidence source: ChEMBL

ATPase family AAA domain-containing protein 5

Homo sapiens · SINGLE PROTEIN · 2 qualifying assays · 1 documents

Experimental evidence source: ChEMBL

Safety & Handling

Safety and handling reference content is available through documentation requests.

For supplier-issued SDS, request documentation before handling, storage, shipment, or procurement decisions.

Preliminary Safety Reference

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Safety Reference / SDS Request

Names & Synonyms / External Identifiers

Chemical Name

(5Z)-5-[(4-hydroxyphenyl)methylidene]-1,3-thiazolidine-2,4-dione

Names & Synonyms

(Z)-5-(4-Hydroxybenzylidene)thiazolidine-2,4-dione5-(4-hydroxybenzylidene)thiazolidine-2,4-dione2,4-Thiazolidinedione, 5-[(4-hydroxyphenyl)methylene]-, (5Z)-(5E)-5-(4-hydroxybenzylidene)-1,3-thiazolidine-2,4-dionecid_1276529
Show all synonyms
REGID_for_CID_12765295-(4-Hydroxybenzylidene)thiazolidine-24-dioneAG-205/048490115-(4-hydroxybenzylidene)-1,3-thiazolidine-2,4-dione(5Z)-5-(4-hydroxybenzylidene)thiazolidine-2,4-quinone(5Z)-5-[(4-hydroxyphenyl)methylene]thiazolidine-2,4-dione(5Z)-5-[(4-hydroxyphenyl)methylidene]thiazolidine-2,4-dione
External Identifiers
DSSTOX SUBSTANCE ID: DTXSID001357179CHEMBL ID: CHEMBL87706
Literature & Patent References
DOI 10.1021/acs.jmedchem.8b00610Tau-Centric Multitarget Approach for Alzheimer's Disease: Development of First-in-Class Dual Glycogen Synthase Kinase 3β and Tau-Aggregation Inhibitors.PMID 30078314Tau-Centric Multitarget Approach for Alzheimer's Disease: Development of First-in-Class Dual Glycogen Synthase Kinase 3β and Tau-Aggregation Inhibitors.DOI 10.1016/j.ejmech.2012.01.019Design and synthesis of 5-(substituted benzylidene)thiazolidine-2,4-dione derivatives as novel tyrosinase inhibitors.DOI 10.1021/jm201243pPrivileged scaffolds or promiscuous binders: a comparative study on rhodanines and related heterocycles in medicinal chemistry.PMID 22077389Privileged scaffolds or promiscuous binders: a comparative study on rhodanines and related heterocycles in medicinal chemistry.PMID 22301213Design and synthesis of 5-(substituted benzylidene)thiazolidine-2,4-dione derivatives as novel tyrosinase inhibitors.DOI 10.1016/j.bmcl.2010.11.041In vitro evaluation of 5-arylidene-2-thioxo-4-thiazolidinones active as aldose reductase inhibitors.PMID 21129963In vitro evaluation of 5-arylidene-2-thioxo-4-thiazolidinones active as aldose reductase inhibitors.

Documentation & Compliance Facts

Compliance Facts

Shipment review: Required

Documentation available by request

Certificate of Analysis (COA): By request

Supplier Safety Data Sheet (SDS): By request

Purity and pack size confirmation: By request

Availability and lead time review: Confirmed by RFQ

Shipment documentation review: By request

For supplier-issued documentation by request, use the RFQ actions on this page.Review preliminary safety reference

What happens after RFQ

  1. 1We review the CAS identity, quantity, and documentation request.
  2. 2We check sourcing options, supplier availability, COA/SDS, purity, pack size, and lead time.
  3. 3We review destination and shipment documentation needs when applicable.
  4. 4We follow up with a quotation or clarification request.

Text Reference Cues

Show non-linked catalog cues

Non-public related references

(5Z)-5-((4-hydroxyphenyl)methylidene)-2-sulfanylidene-1,3-thiazolidin-4-oneCAS 81154-14-5
MirinCAS 299953-00-7
(5Z)-5-((4-hydroxyphenyl)methylidene)-2-sulfanylidene-1,3-thiazolidin-4-oneCAS 6339-79-3
4-[(2,4-dioxo-1,3-thiazolidin-5-ylidene)methyl]benzoic AcidCAS 199167-79-8
5-(4-Methoxybenzylidene)thiazolidine-2,4-dioneCAS 6320-51-0

Non-public references are shown as text only and do not imply equivalence, availability, or shared use.

Catalog navigation

Related Catalog Entries

Other public CAS pages in this catalog. These links support navigation across additional intermediates and do not imply equivalence, availability, or shared use.

CAS 81154-14-5(5Z)-5-((4-hydroxyphenyl)methylidene)-2-sulfanylidene-1,3-thiazolidin-4-oneCAS 299953-00-7MirinCAS 6339-79-3(5Z)-5-((4-hydroxyphenyl)methylidene)-2-sulfanylidene-1,3-thiazolidin-4-oneCAS 199167-79-84-[(2,4-dioxo-1,3-thiazolidin-5-ylidene)methyl]benzoic AcidCAS 6320-51-05-(4-Methoxybenzylidene)thiazolidine-2,4-dioneCAS 520-36-5ApigeninCAS 487-49-0OnonetinCAS 65646-68-6FenretinideCAS 327036-89-5Tdzd-8CAS 1002310-00-0Tert-butyl 1-(2-chloro-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)ethylcarbamate

RFQ questions for CAS 154052-92-3

What are the key identifiers for (5Z)-5-[(4-hydroxyphenyl)methylidene]-1,3-thiazolidine-2,4-dione (CAS 154052-92-3)?

(5Z)-5-[(4-hydroxyphenyl)methylidene]-1,3-thiazolidine-2,4-dione is identified by CAS 154052-92-3, with molecular formula C10H7NO3S, molecular weight 221.23, InChIKey ARHIHDVVUHVQCP-YVMONPNESA-N.

Does CAS 154052-92-3 have reported biological target evidence?

ChEMBL contains qualifying experimental assay evidence associated with Aldo-keto reductase family 1 member B1, Glycogen synthase kinase-3 beta, Tyrosinase, Tyrosyl-DNA phosphodiesterase 1, ATPase family AAA domain-containing protein 5. These records do not establish therapeutic efficacy or clinical use.

Can I request a COA for CAS 154052-92-3?

Yes. Submit an RFQ and specify COA requirements. Lot-specific COA depends on supplier confirmation.

Can I request supplier SDS for (5Z)-5-[(4-hydroxyphenyl)methylidene]-1,3-thiazolidine-2,4-dione?

Yes. Supplier SDS can be requested through the RFQ workflow before handling, storage, shipment, or procurement decisions.

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