MolGraph
CompoundsDocumentationComplianceAbout
MolGraph

Research chemical sourcing and molecular building block RFQ workflows.

MolGraph is operated by Tessorix Inc.

support@molgraph.com

Products are intended for laboratory research use only and are not for human or veterinary use.

Compounds

  • Compound catalog
  • CAS Search

Company

  • About
  • Contact

Documentation

  • Quality Documentation
  • SDS Disclaimer

Compliance

  • Compliance

Legal

  • Terms
  • Privacy

Copyright © 2026 MolGraph. All Rights Reserved.

Home/Compounds/CAS 157-03-9
Formula C6H9N3O3MW 171.15Research-use catalog entryCOA/SDS by request

6-diazo-5-oxo-L-norleucine

CAS Number: 157-03-9

Sourcing & RFQ

Submit an RFQ to review pricing, availability, lead time, pack size, purity, COA, and supplier SDS for this catalog entry.

Available options

Available Options

Package
1 mg
Purity
97%
Price
Request review
Availability
Shipping review required
Delivery
Shipping review required
Package
10 mg
Purity
97%
Price
Request review
Availability
Shipping review required
Delivery
Shipping review required
Package
25 mg
Purity
97%
Price
Request review
Availability
Shipping review required
Delivery
Shipping review required
Package
5 mg
Purity
97%
Price
Request review
Availability
Shipping review required
Delivery
Shipping review required
Package
50 mg
Purity
97%
Price
Request review
Availability
Shipping review required
Delivery
Shipping review required

Shipping review is required before pricing or stock can be confirmed publicly. Shipping, duties, and documentation fees are confirmed before order acceptance.

Loading RDKit molecule structure...
InChIKey: YCWQAMGASJSUIP-YFKPBYRVSA-NC6H9N3O3 | MW 171.15

Chemical Absolute Identifiers

CAS Number

157-03-9

PubChem CID

9087

Molecular Formula

C6H9N3O3

Molecular Weight

171.15 g/mol

Exact Mass

171.064391

InChIKey

YCWQAMGASJSUIP-YFKPBYRVSA-N

IUPAC Name

(2S)-2-amino-6-diazo-5-oxohexanoic acid

SMILES String

C(CC(=O)C=[N+]=[N-])[C@@H](C(=O)O)N

Physical Properties

No physical property values available.

Properties are provided as catalog reference data and may be confirmed through supplier documentation when required.

Catalog Facts

Structural features

6-diazo-5-oxo-L-norleucine (CAS 157-03-9) is listed in the Advanced Chemicals portfolio, with molecular formula C6H9N3O3 and molecular weight 171. 15 g/mol.

Sourcing context

Catalog reference for RFQ preparation, supplier confirmation, and research chemical sourcing review.

Research use context

Intended for research building-block and synthetic chemistry workflows.

Documentation needs

COA/SDS status, availability, lead time, pack size, and shipment documentation can be confirmed during quotation.

Applications & Classification

Organic Building BlocksSynthetic ChemistryResearch intermediateCustom synthesis building blockResearch chemical sourcingCustom synthesis and catalog availability reviewCOA, SDS, pricing, and fulfillment workflow
Biological target reference

ChEMBL reports experimental activity evidence for: Glutaminase kidney isoform, mitochondrial (Mus musculus) — 2 assays. These records describe research assays and do not establish therapeutic efficacy or clinical use.

Glutaminase kidney isoform, mitochondrial

Mus musculus · SINGLE PROTEIN · 2 qualifying assays · 1 documents

Experimental evidence source: ChEMBL

Safety & Handling

Handling & Storage

  • Keep container tightly closed and dry.
  • Store in a well-ventilated place.

PPE

Respiratory protection if needed

First Aid

  • Do not give anything to an unconscious person.
  • Rinse mouth with water.

Stability / Reactivity

  • Reactivity and reaction.
  • Carbon monoxide, carbon dioxide, nitrogen oxides.

Disposal

  • Waste product: Dispose of remaining and non-recyclable solutions to a licensed company.
  • Contact a professional agency with a waste disposal license to handle this substance.
Show additional safety reference fields

Fire Fighting

  • If necessary, wear a self-contained breathing apparatus for firefighting.

Accidental Release

  • Do not generate dust when collecting and disposing.
  • Sweep and shovel up.

For supplier-issued SDS, request documentation before handling, storage, shipment, or procurement decisions.

Preliminary Safety Reference

For supplier-issued SDS or COA, submit a documentation request.

Safety Reference / SDS Request

Names & Synonyms / External Identifiers

Chemical Name

6-diazo-5-oxo-L-norleucine

Names & Synonyms

diazooxonorleucineL-DON6 Diazo 5 oxo L norleucineNorleucine, 6-diazo-5-oxo-6-Diazo-5-oxo-L-nor-Leucine
Show all synonyms
L-Norleucine, 6-diazo-5-oxo-DON (pharmaceutical)(2S)-2-amino-6-diazo-5-oxo-hexanoic acid(S)-2-Amino-6-diazo-5-oxocaproic acidH-6-Diazo-5-oxo-Nle-OHL-6-Diazo-5-oxonorleucineL-Norleucine,6-diazo-5-oxo-Norleucine, 6-diazo-5-oxo, L-(S)-2-amino-6-diazo-5-oxohexanoic acidNCIMech_000302NCIStruc1_000220NCIStruc2_000175(L)-DON4-04-00-03278 (Beilstein Handbook Reference)
External Identifiers
EC NUMBER: 621-136-2DSSTOX SUBSTANCE ID: DTXSID501028846CHEMBL ID: CHEMBL4303391CHEMBL ID: CHEMBL97485CHEBI ID: CHEBI:138889UNII: 03J0H273KZDRUGBANK ID: DB17537KEGG ID: C22429NCI THESAURUS CODE: C427
Literature & Patent References
DOI 10.1016/j.bmcl.2023.129266Design, synthesis, structure-activity relationship studies, and evaluation of novel GLS1 inhibitors.PMID 37011768Design, synthesis, structure-activity relationship studies, and evaluation of novel GLS1 inhibitors.DOI 10.6019/CHEMBL4651402Screening of ~5500 FDA-approved drugs and clinical candidates for anti-SARS-CoV-2 activityDOI 10.1021/acs.jmedchem.8b02009Tumor-Targeted Delivery of 6-Diazo-5-oxo-l-norleucine (DON) Using Substituted Acetylated Lysine Prodrugs.PMID 30892035Tumor-Targeted Delivery of 6-Diazo-5-oxo-l-norleucine (DON) Using Substituted Acetylated Lysine Prodrugs.DOI 10.1021/acs.jmedchem.7b00966N-(Pivaloyloxy)alkoxy-carbonyl Prodrugs of the Glutamine Antagonist 6-Diazo-5-oxo-l-norleucine (DON) as a Potential Treatment for HIV Associated Neurocognitive Disorders.PMID 28759224N-(Pivaloyloxy)alkoxy-carbonyl Prodrugs of the Glutamine Antagonist 6-Diazo-5-oxo-l-norleucine (DON) as a Potential Treatment for HIV Associated Neurocognitive Disorders.DOI 10.1021/acs.jmedchem.6b01069Discovery of 6-Diazo-5-oxo-l-norleucine (DON) Prodrugs with Enhanced CSF Delivery in Monkeys: A Potential Treatment for Glioblastoma.

Documentation & Compliance Facts

Compliance Facts

Shipment review: Required

Documentation available by request

Certificate of Analysis (COA): By request

Supplier Safety Data Sheet (SDS): By request

Purity and pack size confirmation: By request

Availability and lead time review: Confirmed by RFQ

Shipment documentation review: By request

For supplier-issued documentation by request, use the RFQ actions on this page.Review preliminary safety reference

What happens after RFQ

  1. 1We review the CAS identity, quantity, and documentation request.
  2. 2We check sourcing options, supplier availability, COA/SDS, purity, pack size, and lead time.
  3. 3We review destination and shipment documentation needs when applicable.
  4. 4We follow up with a quotation or clarification request.

Text Reference Cues

Show non-linked catalog cues

Non-public related references

AzaserineCAS 115-02-6
ethyl (2S)-2-(((2S)-2-amino-4-methylpentanoyl)amino)-6-diazo-5-oxohexanoateCAS 1998725-11-3
N-Benzyloxycarbonyl-leucyl-valyl-glycine diazomethaneCAS 119670-30-3

Non-public references are shown as text only and do not imply equivalence, availability, or shared use.

Catalog navigation

Related Catalog Entries

Other public CAS pages in this catalog. These links support navigation across additional intermediates and do not imply equivalence, availability, or shared use.

CAS 115-02-6AzaserineCAS 1998725-11-3ethyl (2S)-2-(((2S)-2-amino-4-methylpentanoyl)amino)-6-diazo-5-oxohexanoateCAS 1002310-00-0Tert-butyl 1-(2-chloro-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)ethylcarbamateCAS 1005174-17-3(E)-3-(2-Propyl-6-(trifluoromethyl)pyridin-3-yl)acrylic acidCAS 1018125-49-92-(3-Cyclopropyl-6-ethyl-4-(trifluoromethyl)-1H-pyrazolo[3,4-b]pyridin-1-yl)acetic acidCAS 1018128-07-8Isopropyl 4-chloro-2-methylquinoline-6-carboxylateCAS 1018142-22-76-cyclopropyl-1-(2,2-difluoroethyl)-3-methyl-1H-pyrazolo[3,4-b]pyridine-4-carboxylic acidCAS 1018144-00-72-(3-Cyclopropyl-6-isopropyl-4-(trifluoromethyl)-1H-pyrazolo[3,4-b]pyridin-1-yl)acetic acid

RFQ questions for CAS 157-03-9

What are the key identifiers for 6-diazo-5-oxo-L-norleucine (CAS 157-03-9)?

6-diazo-5-oxo-L-norleucine is identified by CAS 157-03-9, with molecular formula C6H9N3O3, molecular weight 171.15, InChIKey YCWQAMGASJSUIP-YFKPBYRVSA-N.

Does CAS 157-03-9 have reported biological target evidence?

ChEMBL contains qualifying experimental assay evidence associated with Glutaminase kidney isoform, mitochondrial. These records do not establish therapeutic efficacy or clinical use.

Can I request a COA for CAS 157-03-9?

Yes. Submit an RFQ and specify COA requirements. Lot-specific COA depends on supplier confirmation.

Can I request supplier SDS for 6-diazo-5-oxo-L-norleucine?

Yes. Supplier SDS can be requested through the RFQ workflow before handling, storage, shipment, or procurement decisions.

Is CAS 157-03-9 available for quotation?

Availability, pack size, lead time, and pricing are confirmed through RFQ.

Can MolGraph support bulk sourcing or custom synthesis review?

Submit the CAS number, quantity, purity requirement, and destination country for sourcing review.