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Home/Compounds/CAS 1589527-65-0
Formula C28H25F3N6OMW 518.5Research-use catalog entryCOA/SDS by request

Kira6

CAS Number: 1589527-65-0

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Purity
97%
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25 mg
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Loading RDKit molecule structure...
InChIKey: NOHQEAFAESMMDX-UHFFFAOYSA-NC28H25F3N6O | MW 518.5

Chemical Absolute Identifiers

CAS Number

1589527-65-0

PubChem CID

73425700

Molecular Formula

C28H25F3N6O

Molecular Weight

518.5 g/mol

Exact Mass

518.204194

InChIKey

NOHQEAFAESMMDX-UHFFFAOYSA-N

IUPAC Name

1-[4-(8-amino-3-tert-butylimidazo[1,5-a]pyrazin-1-yl)naphthalen-1-yl]-3-[3-(trifluoromethyl)phenyl]urea

SMILES String

CC(C)(C)c1nc(-c2ccc(NC(=O)Nc3cccc(C(F)(F)F)c3)c3ccccc23)c2c(N)nccn12

Physical Properties

No physical property values available.

Properties are provided as catalog reference data and may be confirmed through supplier documentation when required.

Catalog Facts

Structural features

Kira6 (CAS 1589527-65-0) is listed in the Advanced Chemicals portfolio, with molecular formula C28H25F3N6O and molecular weight 518. 50 g/mol.

Sourcing context

Catalog reference for RFQ preparation, supplier confirmation, and research chemical sourcing review.

Research use context

Intended for research building-block and synthetic chemistry workflows; structure-derived tags include nitrogen-containing heterocycle.

Documentation needs

COA/SDS status, availability, lead time, pack size, and shipment documentation can be confirmed during quotation.

Applications & Classification

Organic Building BlocksSynthetic ChemistryResearch intermediateCustom synthesis building blockResearch chemical sourcingCustom synthesis and catalog availability reviewCOA, SDS, pricing, and fulfillment workflow
Biological target reference

ChEMBL reports experimental activity evidence for: Serine/threonine-protein kinase/endoribonuclease IRE1 (Homo sapiens) — 3 assays. These records describe research assays and do not establish therapeutic efficacy or clinical use.

Serine/threonine-protein kinase/endoribonuclease IRE1

Homo sapiens · SINGLE PROTEIN · 3 qualifying assays · 1 documents · best pChEMBL 7.44

Experimental evidence source: ChEMBL

Safety & Handling

Safety and handling reference content is available through documentation requests.

For supplier-issued SDS, request documentation before handling, storage, shipment, or procurement decisions.

Preliminary Safety Reference

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Safety Reference / SDS Request

Names & Synonyms / External Identifiers

Chemical Name

Kira6

Names & Synonyms

1-(4-(8-amino-3-tert-butylimidazo(1,5-a)pyrazin-1-yl)naphthalen-1-yl)-3-(3-(trifluoromethyl)phenyl)urea1-(4-(8-Amino-3-tert-butylimidazo[1,5-a]pyrazin-1-yl)naphthalen-1-yl)-3-(3-(trifluoromethyl)phenyl)urea1-(4-(8-amino-3-(tert-butyl)imidazo[1,5-a]pyrazin-1-yl)naphthalen-1-yl)-3-(3-(trifluoromethyl)phenyl)ureaN-[4-[8-Amino-3-(1,1-dimethylethyl)imidazo[1,5-a]pyrazin-1-yl]-1-naphthalenyl]-N'-[3-(trifluoromethyl)phenyl]ureaUrea, N-[4-[8-amino-3-(1,1-dimethylethyl)imidazo[1,5-a]pyrazin-1-yl]-1-naphthalenyl]-N'-[3-(trifluoromethyl)phenyl]-
Show all synonyms
KIRA6?s86581-[4-(8-amino-3-tert-butyl-imidazo[1,5-a]pyrazin-1-yl)-1-naphthyl]-3-[3-(trifluoromethyl)phenyl]urea3-(4-{8-amino-3-tert-butyl-1H,7H-imidazo[1,5-a]pyrazin-1-ylidene}-1,4-dihydronaphthalen-1-ylidene)-1-[3-(trifluoromethyl)phenyl]urea3-tert-Butyl-1-(4-(3-(3-(trifluoromethyl)phenyl)ureido)-1-naphthyl)-2,3a,6-triaza-7-indenamine
External Identifiers
EC NUMBER: 856-651-3DSSTOX SUBSTANCE ID: DTXSID901377716CHEMBL ID: CHEMBL5532629
Literature & Patent References
DOI 10.1021/acs.jmedchem.3c02425Discovery of Potent, Selective, and Orally Available IRE1α Inhibitors Demonstrating Comparable PD Modulation to IRE1 Knockdown in a Multiple Myeloma Model.PMID 38748820Discovery of Potent, Selective, and Orally Available IRE1α Inhibitors Demonstrating Comparable PD Modulation to IRE1 Knockdown in a Multiple Myeloma Model.DOI 10.1021/acschembio.5b00940DOI 10.1021/acschembio.5b00940PMID 27227314PMID 27227314

Documentation & Compliance Facts

Compliance Facts

Shipment review: Required

Documentation available by request

Certificate of Analysis (COA): By request

Supplier Safety Data Sheet (SDS): By request

Purity and pack size confirmation: By request

Availability and lead time review: Confirmed by RFQ

Shipment documentation review: By request

For supplier-issued documentation by request, use the RFQ actions on this page.Review preliminary safety reference

What happens after RFQ

  1. 1We review the CAS identity, quantity, and documentation request.
  2. 2We check sourcing options, supplier availability, COA/SDS, purity, pack size, and lead time.
  3. 3We review destination and shipment documentation needs when applicable.
  4. 4We follow up with a quotation or clarification request.

Text Reference Cues

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Non-public related references

N-Phenyl-N'-2-pyridinylureaCAS 2327-17-5
1-NaphthylureaCAS 6950-84-1
2(2'-Hydroxy-5'-(phenyl)ureylenphenyl) benzothiazoleCAS 202190-80-5
NelotanserinCAS 839713-36-9
1-(3-Fluorophenyl)-3-(3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)ureaCAS 874302-03-1

Non-public references are shown as text only and do not imply equivalence, availability, or shared use.

Catalog navigation

Related Catalog Entries

Other public CAS pages in this catalog. These links support navigation across additional intermediates and do not imply equivalence, availability, or shared use.

CAS 1002310-00-0Tert-butyl 1-(2-chloro-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)ethylcarbamateCAS 1005174-17-3(E)-3-(2-Propyl-6-(trifluoromethyl)pyridin-3-yl)acrylic acidCAS 1018125-49-92-(3-Cyclopropyl-6-ethyl-4-(trifluoromethyl)-1H-pyrazolo[3,4-b]pyridin-1-yl)acetic acidCAS 1018128-07-8Isopropyl 4-chloro-2-methylquinoline-6-carboxylateCAS 1018142-22-76-cyclopropyl-1-(2,2-difluoroethyl)-3-methyl-1H-pyrazolo[3,4-b]pyridine-4-carboxylic acidCAS 1018144-00-72-(3-Cyclopropyl-6-isopropyl-4-(trifluoromethyl)-1H-pyrazolo[3,4-b]pyridin-1-yl)acetic acid

RFQ questions for CAS 1589527-65-0

What are the key identifiers for Kira6 (CAS 1589527-65-0)?

Kira6 is identified by CAS 1589527-65-0, with molecular formula C28H25F3N6O, molecular weight 518.5, InChIKey NOHQEAFAESMMDX-UHFFFAOYSA-N.

Does CAS 1589527-65-0 have reported biological target evidence?

ChEMBL contains qualifying experimental assay evidence associated with Serine/threonine-protein kinase/endoribonuclease IRE1. These records do not establish therapeutic efficacy or clinical use.

Can I request a COA for CAS 1589527-65-0?

Yes. Submit an RFQ and specify COA requirements. Lot-specific COA depends on supplier confirmation.

Can I request supplier SDS for Kira6?

Yes. Supplier SDS can be requested through the RFQ workflow before handling, storage, shipment, or procurement decisions.

Is CAS 1589527-65-0 available for quotation?

Availability, pack size, lead time, and pricing are confirmed through RFQ.

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