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- 1 g
- Purity
- 99%
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CAS Number: 162401-32-3
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CAS Number
162401-32-3
PubChem CID
449193
Molecular Formula
C17H14Cl2F2N2O3
Molecular Weight
403.2 g/mol
Exact Mass
402.034954
InChIKey
MNDBXUUTURYVHR-UHFFFAOYSA-N
IUPAC Name
3-(cyclopropylmethoxy)-N-(3,5-dichloro-4-pyridinyl)-4-(difluoromethoxy)benzamide
SMILES String
C1CC1COC2=C(C=CC(=C2)C(=O)NC3=C(C=NC=C3Cl)Cl)OC(F)F
pKa
8.74
Properties are provided as catalog reference data and may be confirmed through supplier documentation when required.
Structural features
Roflumilast (CAS 162401-32-3) is listed in the Pharmaceutical Intermediates portfolio, with molecular formula C17H14Cl2F2N2O3 and molecular weight 403. 20 g/mol.
Sourcing context
Catalog reference for RFQ preparation, supplier confirmation, and research chemical sourcing review.
Research use context
Intended for research-stage medicinal chemistry and intermediate synthesis workflows; structure-derived tags include nitrogen-containing heterocycle.
Documentation needs
COA/SDS status, availability, lead time, pack size, and shipment documentation can be confirmed during quotation.
ChEMBL reports experimental activity evidence for: 3',5'-cyclic-AMP phosphodiesterase 4D (Homo sapiens) — 26 assays; 3',5'-cyclic-AMP phosphodiesterase 4B (Homo sapiens) — 34 assays; 3',5'-cyclic-AMP phosphodiesterase 4A (Homo sapiens) — 4 assays; 3',5'-cyclic-AMP phosphodiesterase 4C (Homo sapiens) — 2 assays; Histone-lysine N-methyltransferase SETD7 (Homo sapiens) — 3 assays. These records describe research assays and do not establish therapeutic efficacy or clinical use.
3',5'-cyclic-AMP phosphodiesterase 4D
Homo sapiens · SINGLE PROTEIN · 26 qualifying assays · 26 documents · best pChEMBL 9.89
Experimental evidence source: ChEMBL
3',5'-cyclic-AMP phosphodiesterase 4B
Homo sapiens · SINGLE PROTEIN · 34 qualifying assays · 30 documents · best pChEMBL 9.82
Experimental evidence source: ChEMBL
3',5'-cyclic-AMP phosphodiesterase 4A
Homo sapiens · SINGLE PROTEIN · 4 qualifying assays · 4 documents · best pChEMBL 9.68
Experimental evidence source: ChEMBL
3',5'-cyclic-AMP phosphodiesterase 4C
Homo sapiens · SINGLE PROTEIN · 2 qualifying assays · 2 documents · best pChEMBL 8.77
Experimental evidence source: ChEMBL
Histone-lysine N-methyltransferase SETD7
Homo sapiens · SINGLE PROTEIN · 3 qualifying assays · 1 documents
Experimental evidence source: ChEMBL
Safety and handling reference content is available through documentation requests.
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Preliminary Safety Reference
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Safety Reference / SDS RequestCatalog navigation
Other public CAS pages in this catalog. These links support navigation across additional intermediates and do not imply equivalence, availability, or shared use.
Roflumilast is identified by CAS 162401-32-3, with molecular formula C17H14Cl2F2N2O3, molecular weight 403.2, InChIKey MNDBXUUTURYVHR-UHFFFAOYSA-N.
ChEMBL contains qualifying experimental assay evidence associated with 3',5'-cyclic-AMP phosphodiesterase 4D, 3',5'-cyclic-AMP phosphodiesterase 4B, 3',5'-cyclic-AMP phosphodiesterase 4A, 3',5'-cyclic-AMP phosphodiesterase 4C, Histone-lysine N-methyltransferase SETD7. These records do not establish therapeutic efficacy or clinical use.
Yes. Submit an RFQ and specify COA requirements. Lot-specific COA depends on supplier confirmation.
Yes. Supplier SDS can be requested through the RFQ workflow before handling, storage, shipment, or procurement decisions.
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