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Home/Compounds/CAS 2135-17-3
Formula C22H28F2O5MW 410.5Research-use catalog entryCOA/SDS by request

Flumethasone

CAS Number: 2135-17-3

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Loading RDKit molecule structure...
InChIKey: WXURHACBFYSXBI-GQKYHHCASA-NC22H28F2O5 | MW 410.5

Chemical Absolute Identifiers

CAS Number

2135-17-3

PubChem CID

16490

Molecular Formula

C22H28F2O5

Molecular Weight

410.5 g/mol

Exact Mass

410.19048

InChIKey

WXURHACBFYSXBI-GQKYHHCASA-N

IUPAC Name

(6S,8S,9R,10S,11S,13S,14S,16R,17R)-6,9-difluoro-11,17-dihydroxy-17-(2-hydroxyacetyl)-10,13,16-trimethyl-6,7,8,11,12,14,15,16-octahydrocyclopenta[a]phenanthren-3-one

SMILES String

C[C@@H]1C[C@H]2[C@@H]3C[C@@H](C4=CC(=O)C=C[C@@]4([C@]3([C@H](C[C@@]2([C@]1(C(=O)CO)O)C)O)F)C)F

Physical Properties

Melting Point

219.0 °C

Water Solubility

0.392 mg/L

Properties are provided as catalog reference data and may be confirmed through supplier documentation when required.

Catalog Facts

Structural features

Flumethasone (CAS 2135-17-3) is listed in the Pharmaceutical Intermediates portfolio, with molecular formula C22H28F2O5 and molecular weight 410. 50 g/mol.

Sourcing context

Catalog reference for RFQ preparation, supplier confirmation, and research chemical sourcing review.

Research use context

Intended for research-stage medicinal chemistry and intermediate synthesis workflows.

Documentation needs

COA/SDS status, availability, lead time, pack size, and shipment documentation can be confirmed during quotation.

Applications & Classification

Pharmaceutical Intermediate ResearchResearch intermediateCustom synthesis building blockPharmaceutical intermediate researchResearch chemical sourcingCustom synthesis and catalog availability reviewCOA, SDS, pricing, and fulfillment workflow
Biological target reference

ChEMBL reports experimental activity evidence for: Hypoxia-inducible factor 1-alpha (Homo sapiens) — 2 assays; Alpha-1A adrenergic receptor (Homo sapiens) — 2 assays; Muscarinic acetylcholine receptor M1 (Homo sapiens) — 2 assays; Prostaglandin G/H synthase 1 (Homo sapiens) — 2 assays; Thromboxane A2 receptor (Homo sapiens) — 2 assays. These records describe research assays and do not establish therapeutic efficacy or clinical use.

Hypoxia-inducible factor 1-alpha

Homo sapiens · SINGLE PROTEIN · 2 qualifying assays · 1 documents · best pChEMBL 8.3

Experimental evidence source: ChEMBL

Alpha-1A adrenergic receptor

Homo sapiens · SINGLE PROTEIN · 2 qualifying assays · 1 documents

Experimental evidence source: ChEMBL

Muscarinic acetylcholine receptor M1

Homo sapiens · SINGLE PROTEIN · 2 qualifying assays · 1 documents

Experimental evidence source: ChEMBL

Prostaglandin G/H synthase 1

Homo sapiens · SINGLE PROTEIN · 2 qualifying assays · 1 documents

Experimental evidence source: ChEMBL

Thromboxane A2 receptor

Homo sapiens · SINGLE PROTEIN · 2 qualifying assays · 1 documents

Experimental evidence source: ChEMBL

Safety & Handling

Handling & Storage

  • Keep container tightly closed and dry.
  • Store in a well-ventilated place.

PPE

Respiratory protection if needed

First Aid

  • Do not give anything to an unconscious person.
  • Rinse mouth with water.

Stability / Reactivity

  • Reactivity.
  • Carbon monoxide, carbon dioxide, hydrogen fluoride.

Disposal

  • Dispose of the remaining and non-recyclable solution to a licensed company.
  • Contact a professional agency with a waste disposal license to handle this substance.
Show additional safety reference fields

Fire Fighting

  • If necessary, wear a self-contained breathing apparatus for firefighting.

Accidental Release

  • Do not generate dust when collecting and disposing.
  • Sweep and shovel up.

For supplier-issued SDS, request documentation before handling, storage, shipment, or procurement decisions.

Preliminary Safety Reference

For supplier-issued SDS or COA, submit a documentation request.

Safety Reference / SDS Request

Names & Synonyms / External Identifiers

Chemical Name

Flumethasone

Names & Synonyms

FlumetasoneFlucortFlumetasonaFlumetasonum6alpha,9-Difluoro-11beta,17,21-trihydroxy-16alpha-methylpregna-1,4-diene-3,20-dione
Show all synonyms
U-10,974Pregna-1,4-diene-3,20-dione, 6,9-difluoro-11,17,21-trihydroxy-16-methyl-, (6alpha,11beta,16alpha)-FluorodexamethasoneBimasoneFlucort TabletsAnaprime Suspensionflumethasoni pivalasFlucorticinFlumethasonAnaprimeMethagonFluvetAniprimeCortexilarRS 2177
External Identifiers
EC NUMBER: 218-370-9DSSTOX SUBSTANCE ID: DTXSID2045365CHEMBL ID: CHEMBL1201392CHEBI ID: CHEBI:34764UNII: LR3CD8SX89DRUGBANK ID: DB00663KEGG ID: C14479KEGG ID: D04208METABOLOMICS WORKBENCH ID: 55028NCI THESAURUS CODE: C65717WIKIDATA ID: Q4383636
Experimental Spectrum References
13C NMR SpectraATR-IR Spectra — Forensic Spectral ResearchFTIR Spectra — Forensic Spectral ResearchRaman Spectra — Forensic Spectral Research
Literature & Patent References
DOI 10.1016/j.isci.2024.108907Identification and evaluation of small-molecule inhibitors against the dNTPase SAMHD1 via a comprehensive screening funnelPMID 38318365Identification and evaluation of small-molecule inhibitors against the dNTPase SAMHD1 via a comprehensive screening funnelDOI 10.1038/s41467-023-40064-9A preclinical secondary pharmacology resource illuminates target-adverse drug reaction associations of marketed drugs.PMID 37468498A preclinical secondary pharmacology resource illuminates target-adverse drug reaction associations of marketed drugs.DOI 10.6019/CHEMBL4651402Screening of ~5500 FDA-approved drugs and clinical candidates for anti-SARS-CoV-2 activityDOI 10.6019/CHEMBL4808148HDAC6 screening dataset using tau-based substrate in an enzymatic assay yields selective inhibitors and activatorsDOI 10.1101/2020.04.03.023846In vitro screening of a FDA approved chemical library reveals potential inhibitors of SARS-CoV-2 replicationDOI 10.21203/rs.3.rs-23951/v1Identification of inhibitors of SARS-CoV-2 in-vitro cellular toxicity in human (Caco-2) cells using a large scale drug repurposing collection

Documentation & Compliance Facts

Compliance Facts

Shipment review: Required

Documentation available by request

Certificate of Analysis (COA): By request

Supplier Safety Data Sheet (SDS): By request

Purity and pack size confirmation: By request

Availability and lead time review: Confirmed by RFQ

Shipment documentation review: By request

For supplier-issued documentation by request, use the RFQ actions on this page.Review preliminary safety reference

What happens after RFQ

  1. 1We review the CAS identity, quantity, and documentation request.
  2. 2We check sourcing options, supplier availability, COA/SDS, purity, pack size, and lead time.
  3. 3We review destination and shipment documentation needs when applicable.
  4. 4We follow up with a quotation or clarification request.

Text Reference Cues

Show non-linked catalog cues

Non-public related references

16alpha-HydroxyprednisoloneCAS 13951-70-7
DesonideCAS 638-94-8
Desisobutyryl-ciclesonideCAS 161115-59-9
21-Hydroxypregna-1,4,9(11),16-tetraene-3,20-dione 21-acetateCAS 37413-91-5

Non-public references are shown as text only and do not imply equivalence, availability, or shared use.

Catalog navigation

Related Catalog Entries

Other public CAS pages in this catalog. These links support navigation across additional intermediates and do not imply equivalence, availability, or shared use.

CAS 13951-70-716alpha-HydroxyprednisoloneCAS 131-53-32,2'-Dihydroxy-4-methoxybenzophenoneCAS 21829-25-4NifedipineCAS 302-79-4Retinoic AcidCAS 128-13-2Ursodeoxycholic AcidCAS 1002310-00-0Tert-butyl 1-(2-chloro-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)ethylcarbamateCAS 1005174-17-3(E)-3-(2-Propyl-6-(trifluoromethyl)pyridin-3-yl)acrylic acidCAS 1018125-49-92-(3-Cyclopropyl-6-ethyl-4-(trifluoromethyl)-1H-pyrazolo[3,4-b]pyridin-1-yl)acetic acidCAS 1018128-07-8Isopropyl 4-chloro-2-methylquinoline-6-carboxylateCAS 1018142-22-76-cyclopropyl-1-(2,2-difluoroethyl)-3-methyl-1H-pyrazolo[3,4-b]pyridine-4-carboxylic acid

RFQ questions for CAS 2135-17-3

What are the key identifiers for Flumethasone (CAS 2135-17-3)?

Flumethasone is identified by CAS 2135-17-3, with molecular formula C22H28F2O5, molecular weight 410.5, InChIKey WXURHACBFYSXBI-GQKYHHCASA-N.

Does CAS 2135-17-3 have reported biological target evidence?

ChEMBL contains qualifying experimental assay evidence associated with Hypoxia-inducible factor 1-alpha, Alpha-1A adrenergic receptor, Muscarinic acetylcholine receptor M1, Prostaglandin G/H synthase 1, Thromboxane A2 receptor. These records do not establish therapeutic efficacy or clinical use.

Can I request a COA for CAS 2135-17-3?

Yes. Submit an RFQ and specify COA requirements. Lot-specific COA depends on supplier confirmation.

Can I request supplier SDS for Flumethasone?

Yes. Supplier SDS can be requested through the RFQ workflow before handling, storage, shipment, or procurement decisions.

Is CAS 2135-17-3 available for quotation?

Availability, pack size, lead time, and pricing are confirmed through RFQ.

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