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Home/Compounds/CAS 220904-99-4
Formula C15H8Br2ClNO2MW 429.49Research-use catalog entryCOA/SDS by request

5-Chloro-3-(3,5-dibromo-4-hydroxybenzylidene)indolin-2-one

CAS Number: 220904-99-4

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Loading RDKit molecule structure...
InChIKey: MPIHOJMBMIMKAJ-KMKOMSMNSA-NC15H8Br2ClNO2 | MW 429.49

Chemical Absolute Identifiers

CAS Number

220904-99-4

PubChem CID

25014542

Molecular Formula

C15H8Br2ClNO2

Molecular Weight

429.49 g/mol

Exact Mass

428.85898

InChIKey

MPIHOJMBMIMKAJ-KMKOMSMNSA-N

IUPAC Name

(3Z)-5-chloro-3-[(3,5-dibromo-4-hydroxyphenyl)methylidene]-1H-indol-2-one

SMILES String

O=C1Nc2ccc(Cl)cc2/C1=C/c1cc(Br)c(O)c(Br)c1

Physical Properties

No physical property values available.

Properties are provided as catalog reference data and may be confirmed through supplier documentation when required.

Catalog Facts

Structural features

5-Chloro-3-(3,5-dibromo-4-hydroxybenzylidene)indolin-2-one (CAS 220904-99-4) is listed in the Advanced Chemicals portfolio, with molecular formula C15H8Br2ClNO2 and molecular weight 429. 49 g/mol.

Sourcing context

Catalog reference for RFQ preparation, supplier confirmation, and research chemical sourcing review.

Research use context

Intended for research building-block and synthetic chemistry workflows; structure-derived tags include nitrogen-containing heterocycle.

Documentation needs

COA/SDS status, availability, lead time, pack size, and shipment documentation can be confirmed during quotation.

Applications & Classification

Organic Building BlocksSynthetic ChemistryResearch intermediateCustom synthesis building blockResearch chemical sourcingCustom synthesis and catalog availability reviewCOA, SDS, pricing, and fulfillment workflow
Biological target reference

ChEMBL reports experimental activity evidence for: Leucine-rich repeat serine/threonine-protein kinase 2 (Homo sapiens) — 4 assays; Glycogen synthase kinase-3 beta (Homo sapiens) — 2 assays. These records describe research assays and do not establish therapeutic efficacy or clinical use.

Leucine-rich repeat serine/threonine-protein kinase 2

Homo sapiens · SINGLE PROTEIN · 4 qualifying assays · 1 documents · best pChEMBL 8

Experimental evidence source: ChEMBL

Glycogen synthase kinase-3 beta

Homo sapiens · SINGLE PROTEIN · 2 qualifying assays · 1 documents

Experimental evidence source: ChEMBL

Safety & Handling

Safety and handling reference content is available through documentation requests.

For supplier-issued SDS, request documentation before handling, storage, shipment, or procurement decisions.

Preliminary Safety Reference

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Safety Reference / SDS Request

Names & Synonyms / External Identifiers

Chemical Name

5-Chloro-3-(3,5-dibromo-4-hydroxybenzylidene)indolin-2-one

Names & Synonyms

Raf inhibitor 2C15H8Br2ClNO2(3Z)-5-chloro-3-[(3,5-dibromo-4-hydroxy-phenyl)methylene]indolin-2-one
External Identifiers
CHEMBL ID: CHEMBL2206014
Literature & Patent References
DOI 10.1016/j.bmcl.2014.08.049Indolinone based LRRK2 kinase inhibitors with a key hydrogen bond.PMID 25219901Indolinone based LRRK2 kinase inhibitors with a key hydrogen bond.DOI 10.1016/j.bmcl.2012.10.016Modification of a promiscuous inhibitor shifts the inhibition from γ-secretase to FLT-3.PMID 23107479Modification of a promiscuous inhibitor shifts the inhibition from γ-secretase to FLT-3.

Documentation & Compliance Facts

Compliance Facts

Shipment review: Required

Documentation available by request

Certificate of Analysis (COA): By request

Supplier Safety Data Sheet (SDS): By request

Purity and pack size confirmation: By request

Availability and lead time review: Confirmed by RFQ

Shipment documentation review: By request

For supplier-issued documentation by request, use the RFQ actions on this page.Review preliminary safety reference

What happens after RFQ

  1. 1We review the CAS identity, quantity, and documentation request.
  2. 2We check sourcing options, supplier availability, COA/SDS, purity, pack size, and lead time.
  3. 3We review destination and shipment documentation needs when applicable.
  4. 4We follow up with a quotation or clarification request.

Text Reference Cues

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Non-public related references

LC3-mHTT-IN-AN1CAS 486443-73-6
3-(3,4-Dichlorobenzylidene)indolin-2-oneCAS 114727-43-4
3-Benzylideneindolin-2-oneCAS 3359-49-7
3-(4-Fluorobenzylidene)indolin-2-oneCAS 3476-86-6
2-(2,2-Dibromovinyl)-4-chloro-1-fluorobenzeneCAS 1881272-50-9

Non-public references are shown as text only and do not imply equivalence, availability, or shared use.

Catalog navigation

Related Catalog Entries

Other public CAS pages in this catalog. These links support navigation across additional intermediates and do not imply equivalence, availability, or shared use.

CAS 486443-73-6LC3-mHTT-IN-AN1CAS 114727-43-43-(3,4-Dichlorobenzylidene)indolin-2-oneCAS 3359-49-73-Benzylideneindolin-2-oneCAS 120685-11-2MidostaurinCAS 319460-85-0AxitinibCAS 443913-73-3VandetanibCAS 62996-74-1StaurosporineCAS 1002310-00-0Tert-butyl 1-(2-chloro-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)ethylcarbamateCAS 1005174-17-3(E)-3-(2-Propyl-6-(trifluoromethyl)pyridin-3-yl)acrylic acidCAS 1018125-49-92-(3-Cyclopropyl-6-ethyl-4-(trifluoromethyl)-1H-pyrazolo[3,4-b]pyridin-1-yl)acetic acid

RFQ questions for CAS 220904-99-4

What are the key identifiers for 5-Chloro-3-(3,5-dibromo-4-hydroxybenzylidene)indolin-2-one (CAS 220904-99-4)?

5-Chloro-3-(3,5-dibromo-4-hydroxybenzylidene)indolin-2-one is identified by CAS 220904-99-4, with molecular formula C15H8Br2ClNO2, molecular weight 429.49, InChIKey MPIHOJMBMIMKAJ-KMKOMSMNSA-N.

Does CAS 220904-99-4 have reported biological target evidence?

ChEMBL contains qualifying experimental assay evidence associated with Leucine-rich repeat serine/threonine-protein kinase 2, Glycogen synthase kinase-3 beta. These records do not establish therapeutic efficacy or clinical use.

Can I request a COA for CAS 220904-99-4?

Yes. Submit an RFQ and specify COA requirements. Lot-specific COA depends on supplier confirmation.

Can I request supplier SDS for 5-Chloro-3-(3,5-dibromo-4-hydroxybenzylidene)indolin-2-one?

Yes. Supplier SDS can be requested through the RFQ workflow before handling, storage, shipment, or procurement decisions.

Is CAS 220904-99-4 available for quotation?

Availability, pack size, lead time, and pricing are confirmed through RFQ.

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