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Home/Compounds/CAS 22204-53-1
Formula C14H14O3MW 230.26Research-use catalog entryCOA/SDS by request

Naproxen

CAS Number: 22204-53-1

Sourcing & RFQ

Submit an RFQ to review pricing, availability, lead time, pack size, purity, COA, and supplier SDS for this catalog entry.

Available options

Available Options

Package
1 kg
Purity
98%
Price
USD 330
Availability
Shipping review required
Delivery
Shipping review required

Price observed Jul 22, 2026

Package
100 g
Purity
98%
Price
USD 70
Availability
Shipping review required
Delivery
Shipping review required

Price observed Jul 22, 2026

Package
25 g
Purity
98%
Price
USD 50
Availability
Shipping review required
Delivery
Shipping review required

Price observed Jul 22, 2026

Shipping review is required before pricing or stock can be confirmed publicly. Shipping, duties, and documentation fees are confirmed before order acceptance.

Loading RDKit molecule structure...
InChIKey: CMWTZPSULFXXJA-VIFPVBQESA-NC14H14O3 | MW 230.26

Chemical Absolute Identifiers

CAS Number

22204-53-1

PubChem CID

156391

Molecular Formula

C14H14O3

Molecular Weight

230.26 g/mol

Exact Mass

230.094294

InChIKey

CMWTZPSULFXXJA-VIFPVBQESA-N

IUPAC Name

(2S)-2-(6-methoxynaphthalen-2-yl)propanoic acid

SMILES String

C[C@@H](C1=CC2=C(C=C1)C=C(C=C2)OC)C(=O)O

Physical Properties

pKa

4.15–4.18

Properties are provided as catalog reference data and may be confirmed through supplier documentation when required.

Catalog Facts

Structural features

Naproxen (CAS 22204-53-1) is listed in the Pharmaceutical Intermediates portfolio, with molecular formula C14H14O3 and molecular weight 230. 26 g/mol.

Sourcing context

Catalog reference for RFQ preparation, supplier confirmation, and research chemical sourcing review.

Research use context

Intended for research-stage medicinal chemistry and intermediate synthesis workflows.

Documentation needs

COA/SDS status, availability, lead time, pack size, and shipment documentation can be confirmed during quotation.

Applications & Classification

Pharmaceutical Intermediate ResearchResearch intermediateCustom synthesis building blockPharmaceutical intermediate researchResearch chemical sourcingCustom synthesis and catalog availability reviewCOA, SDS, pricing, and fulfillment workflow
Biological target reference

ChEMBL reports experimental activity evidence for: Prostaglandin G/H synthase 1 (Ovis aries) — 14 assays; Prostaglandin G/H synthase 1 (Homo sapiens) — 10 assays; Aldo-keto reductase family 1 member C3 (Homo sapiens) — 4 assays; Thyrotropin receptor (Homo sapiens) — 2 assays; Prostaglandin G/H synthase 2 (Homo sapiens) — 20 assays. These records describe research assays and do not establish therapeutic efficacy or clinical use.

Prostaglandin G/H synthase 1

Ovis aries · SINGLE PROTEIN · 14 qualifying assays · 14 documents · best pChEMBL 7.21

Experimental evidence source: ChEMBL

Prostaglandin G/H synthase 1

Homo sapiens · SINGLE PROTEIN · 10 qualifying assays · 9 documents · best pChEMBL 7.18

Experimental evidence source: ChEMBL

Aldo-keto reductase family 1 member C3

Homo sapiens · SINGLE PROTEIN · 4 qualifying assays · 4 documents · best pChEMBL 6.75

Experimental evidence source: ChEMBL

Thyrotropin receptor

Homo sapiens · SINGLE PROTEIN · 2 qualifying assays · 1 documents · best pChEMBL 6.1

Experimental evidence source: ChEMBL

Prostaglandin G/H synthase 2

Homo sapiens · SINGLE PROTEIN · 20 qualifying assays · 19 documents · best pChEMBL 6.05

Experimental evidence source: ChEMBL

Safety & Handling

Handling & Storage

  • Keep container tightly closed and dry.
  • Store in a well-ventilated place.

PPE

Respiratory protection if needed

First Aid

  • Do not give anything to an unconscious person.
  • Rinse mouth with water.

Stability / Reactivity

  • Reactivity and stability.
Show additional safety reference fields

Fire Fighting

  • If necessary, wear a self-contained breathing apparatus for firefighting operations.

Accidental Release

  • Do not generate dust when collecting and disposing.
  • Sweep and shovel up.

For supplier-issued SDS, request documentation before handling, storage, shipment, or procurement decisions.

Preliminary Safety Reference

For supplier-issued SDS or COA, submit a documentation request.

Safety Reference / SDS Request

Names & Synonyms / External Identifiers

Chemical Name

Naproxen

Names & Synonyms

(S)-NaproxenNaprosyn(+)-NaproxenEquiproxenNaproxene
Show all synonyms
d-Naproxen(S)-(+)-NaproxenNaixanEc-Naprosyn(+)-(S)-Naproxen(S)-(+)-2-(6-Methoxy-2-naphthyl)propionic acidLaraflexNaprosyneNaproxenoNycoprenCalosenReuxenBonylNaxenAxer
External Identifiers
EC NUMBER: 244-838-7DSSTOX SUBSTANCE ID: DTXSID4040686CHEMBL ID: CHEMBL154CHEBI ID: CHEBI:7476UNII: 57Y76R9ATQDRUGBANK ID: DB00788HMDB ID: HMDB0001923KEGG ID: C01517KEGG ID: D00118METABOLOMICS WORKBENCH ID: 37931NCI THESAURUS CODE: C680PHARMGKB ID: PA450595RXCUI: 7258WIKIDATA ID: Q1215575
Experimental Spectrum References
13C NMR Spectra1D NMR Spectra1H NMR Spectra — Sigma-Aldrich Co. LLC.ATR-IR Spectra — Forensic Spectral ResearchRaman Spectra — Forensic Spectral Research
Literature & Patent References
DOI 10.1021/acs.jmedchem.4c02496One-Pot Synthesis of Novel Tetrasubstituted α-Aminophosphonates Derived from α-Methylphosphoserine and <i>In Vivo</i> Evaluation as Anti-Inflammatory Agents.PMID 39963027One-Pot Synthesis of Novel Tetrasubstituted α-Aminophosphonates Derived from α-Methylphosphoserine and <i>In Vivo</i> Evaluation as Anti-Inflammatory Agents.DOI 10.1016/j.ejmech.2024.116396Privileged small molecules against neglected tropical diseases: A perspective from structure activity relationships.DOI 10.1016/j.ejmech.2024.116699Acid-sensitive prodrugs; a promising approach for site-specific and targeted drug release.DOI 10.1016/j.isci.2024.108907Identification and evaluation of small-molecule inhibitors against the dNTPase SAMHD1 via a comprehensive screening funnelDOI 10.1021/acs.jmedchem.4c00823Carbon Monoxide as a Potential Therapeutic Agent: A Molecular Analysis of Its Safety Profiles.DOI 10.1021/acs.jmedchem.4c01254A Highly Atom-Efficient Prodrug Approach to Generate Synergy between H<sub>2</sub>S and Nonsteroidal Anti-inflammatory Drugs and Improve Safety.DOI 10.5281/zenodo.13943903Linking interpersonal differences in gut microbiota composition and drug biotransformation activity

Documentation & Compliance Facts

Compliance Facts

Shipment review: Required

Documentation available by request

Certificate of Analysis (COA): By request

Supplier Safety Data Sheet (SDS): By request

Purity and pack size confirmation: By request

Availability and lead time review: Confirmed by RFQ

Shipment documentation review: By request

For supplier-issued documentation by request, use the RFQ actions on this page.Review preliminary safety reference

What happens after RFQ

  1. 1We review the CAS identity, quantity, and documentation request.
  2. 2We check sourcing options, supplier availability, COA/SDS, purity, pack size, and lead time.
  3. 3We review destination and shipment documentation needs when applicable.
  4. 4We follow up with a quotation or clarification request.

Text Reference Cues

Show non-linked catalog cues

Non-public related references

Methyl 3-(4-methoxyphenyl)propiolateCAS 7515-17-5
methyl 2-(5-methoxy-2-methyl-1H-indol-3-yl)acetateCAS 7588-36-5
N-Methoxy-6,N-dimethyl-nicotinamideCAS 221615-71-0
tert-butyl N-(6-chloropyridin-2-yl)carbamateCAS 159603-71-1

Non-public references are shown as text only and do not imply equivalence, availability, or shared use.

Catalog navigation

Related Catalog Entries

Other public CAS pages in this catalog. These links support navigation across additional intermediates and do not imply equivalence, availability, or shared use.

CAS 181695-72-7ValdecoxibCAS 134678-17-4LamivudineCAS 21829-25-4NifedipineCAS 169590-42-5CelecoxibCAS 122-11-2SulfadimethoxineCAS 1002310-00-0Tert-butyl 1-(2-chloro-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)ethylcarbamateCAS 1005174-17-3(E)-3-(2-Propyl-6-(trifluoromethyl)pyridin-3-yl)acrylic acidCAS 1018125-49-92-(3-Cyclopropyl-6-ethyl-4-(trifluoromethyl)-1H-pyrazolo[3,4-b]pyridin-1-yl)acetic acidCAS 1018128-07-8Isopropyl 4-chloro-2-methylquinoline-6-carboxylateCAS 1018142-22-76-cyclopropyl-1-(2,2-difluoroethyl)-3-methyl-1H-pyrazolo[3,4-b]pyridine-4-carboxylic acid

RFQ questions for CAS 22204-53-1

What are the key identifiers for Naproxen (CAS 22204-53-1)?

Naproxen is identified by CAS 22204-53-1, with molecular formula C14H14O3, molecular weight 230.26, InChIKey CMWTZPSULFXXJA-VIFPVBQESA-N.

Does CAS 22204-53-1 have reported biological target evidence?

ChEMBL contains qualifying experimental assay evidence associated with Prostaglandin G/H synthase 1, Prostaglandin G/H synthase 1, Aldo-keto reductase family 1 member C3, Thyrotropin receptor, Prostaglandin G/H synthase 2. These records do not establish therapeutic efficacy or clinical use.

Can I request a COA for CAS 22204-53-1?

Yes. Submit an RFQ and specify COA requirements. Lot-specific COA depends on supplier confirmation.

Can I request supplier SDS for Naproxen?

Yes. Supplier SDS can be requested through the RFQ workflow before handling, storage, shipment, or procurement decisions.

Is CAS 22204-53-1 available for quotation?

Availability, pack size, lead time, and pricing are confirmed through RFQ.

Can MolGraph support bulk sourcing or custom synthesis review?

Submit the CAS number, quantity, purity requirement, and destination country for sourcing review.