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Home/Compounds/CAS 2259-96-3
Formula C14H16ClN3O4S2MW 389.9Research-use catalog entryCOA/SDS by request

Cyclothiazide

CAS Number: 2259-96-3

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Loading RDKit molecule structure...
InChIKey: BOCUKUHCLICSIY-UHFFFAOYSA-NC14H16ClN3O4S2 | MW 389.9

Chemical Absolute Identifiers

CAS Number

2259-96-3

PubChem CID

2910

Molecular Formula

C14H16ClN3O4S2

Molecular Weight

389.9 g/mol

Exact Mass

389.027076

InChIKey

BOCUKUHCLICSIY-UHFFFAOYSA-N

IUPAC Name

3-(2-bicyclo[2.2.1]hept-5-enyl)-6-chloro-1,1-dioxo-3,4-dihydro-2H-1lambda6,2,4-benzothiadiazine-7-sulfonamide

SMILES String

NS(=O)(=O)c1cc2c(cc1Cl)NC(C1CC3C=CC1C3)NS2(=O)=O

Physical Properties

Melting Point

234.0 °C

Water Solubility

0.279 g/L

pKa

10.7

Properties are provided as catalog reference data and may be confirmed through supplier documentation when required.

Catalog Facts

Structural features

Cyclothiazide (CAS 2259-96-3) is listed in the Advanced Chemicals portfolio, with molecular formula C14H16ClN3O4S2 and molecular weight 389. 90 g/mol.

Sourcing context

Catalog reference for RFQ preparation, supplier confirmation, and research chemical sourcing review.

Research use context

Intended for research building-block and synthetic chemistry workflows; structure-derived tags include nitrogen-containing heterocycle.

Documentation needs

COA/SDS status, availability, lead time, pack size, and shipment documentation can be confirmed during quotation.

Applications & Classification

Organic Building BlocksSynthetic ChemistryResearch intermediateCustom synthesis building blockResearch chemical sourcingCustom synthesis and catalog availability reviewCOA, SDS, pricing, and fulfillment workflow
Biological target reference

ChEMBL reports experimental activity evidence for: Glutamate receptor 1 (Homo sapiens) — 4 assays; Glutamate receptor 2 (Homo sapiens) — 3 assays; Glutamate receptor 4 (Homo sapiens) — 2 assays; Prelamin-A/C (Homo sapiens) — 2 assays; Muscarinic acetylcholine receptor M1 (Homo sapiens) — 2 assays. These records describe research assays and do not establish therapeutic efficacy or clinical use.

Glutamate receptor 1

Homo sapiens · SINGLE PROTEIN · 4 qualifying assays · 1 documents · best pChEMBL 6

Experimental evidence source: ChEMBL

Glutamate receptor 2

Homo sapiens · SINGLE PROTEIN · 3 qualifying assays · 2 documents · best pChEMBL 5.65

Experimental evidence source: ChEMBL

Glutamate receptor 4

Homo sapiens · SINGLE PROTEIN · 2 qualifying assays · 2 documents · best pChEMBL 5.42

Experimental evidence source: ChEMBL

Prelamin-A/C

Homo sapiens · SINGLE PROTEIN · 2 qualifying assays · 1 documents · best pChEMBL 5.2

Experimental evidence source: ChEMBL

Muscarinic acetylcholine receptor M1

Homo sapiens · SINGLE PROTEIN · 2 qualifying assays · 1 documents · best pChEMBL 4.75

Experimental evidence source: ChEMBL

Safety & Handling

Safety and handling reference content is available through documentation requests.

For supplier-issued SDS, request documentation before handling, storage, shipment, or procurement decisions.

Preliminary Safety Reference

For supplier-issued SDS or COA, submit a documentation request.

Safety Reference / SDS Request

Names & Synonyms / External Identifiers

Chemical Name

Cyclothiazide

Names & Synonyms

AnhydronAquirelFluidilRenazideValmiran
Show all synonyms
DoburilCiclotiazidaCiclotiazideCyclothiazidumMDi 193Lilly 35,4836-Chloro-3,4-dihydro-3-(5-norbornen-2-yl)-2H-1,2,4-benzothiadiazine-7-sulfonamide 1,1-dioxide6-Chloro-3,4-dihydro-3-(2-norbornen-5-yl)-2H-1,2,4-benzothiadiazine-7-sulfonamide 1,1-dioxide6-Chloro-3,4-dihydro-3-(2-norbornen-5-yl)-7-sulfamoyl-1,2,4-benzothiadiazine 1,1-dioxide6-Chloro-3-(2-norbornen-5-yl)-7-sulfamyl-3,4-dihydro-1,2,4-benzothiadiazine 1,1-dioxide2H-1,2,4-Benzothiadiazine-7-sulfonamide, 6-chloro-3,4-dihydro-3-(5-norbornen-2-yl)-, 1,1-dioxide2H-1,2,4-Benzothiadiazine-7-sulfonamide, 3-bicyclo(2.2.1)hept-5-en-2-yl-6-chloro-3,4-dihydro-, 1,1-dioxide2H-1,2,4-Benzothiadiazine-7-sulfonamide, 3-bicyclo[2.2.1]hept-5-en-2-yl-6-chloro-3,4-dihydro-, 1,1-dioxide6-Chloro-3,4-dihydro-3-(norbornen-2-yl)-2H-1,2,4-benzothiadiazine-7-sulfonamide 1,1-dioxide3-{bicyclo[2.2.1]hept-5-en-2-yl}-6-chloro-1,1-dioxo-3,4-dihydro-2H-1$l^{6},2,4-benzothiadiazine-7-sulfonamide
External Identifiers
EC NUMBER: 218-859-7DSSTOX SUBSTANCE ID: DTXSID3022871CHEMBL ID: CHEMBL61593CHEBI ID: CHEBI:31448UNII: P71U09G5BWDRUGBANK ID: DB00606HMDB ID: HMDB0014744KEGG ID: C12685KEGG ID: D01256METABOLOMICS WORKBENCH ID: 42935NCI THESAURUS CODE: C65358PHARMGKB ID: PA449168WIKIDATA ID: Q5199066
Experimental Spectrum References
ATR-IR Spectra — Forensic Spectral ResearchFTIR Spectra — Forensic Spectral Research
Literature & Patent References
DOI 10.1038/s41467-023-40064-9A preclinical secondary pharmacology resource illuminates target-adverse drug reaction associations of marketed drugs.PMID 37468498A preclinical secondary pharmacology resource illuminates target-adverse drug reaction associations of marketed drugs.DOI 10.6019/CHEMBL4651402Screening of ~5500 FDA-approved drugs and clinical candidates for anti-SARS-CoV-2 activityDOI 10.6019/CHEMBL4808148HDAC6 screening dataset using tau-based substrate in an enzymatic assay yields selective inhibitors and activatorsDOI 10.21203/rs.3.rs-23951/v1Identification of inhibitors of SARS-CoV-2 in-vitro cellular toxicity in human (Caco-2) cells using a large scale drug repurposing collectionDOI 10.6019/CHEMBL4495564Identification of inhibitors of SARS-Cov2 M-Pro enzymatic activity using a small molecule repurposing screenDOI 10.6019/CHEMBL4495565Cytopathic SARS-Cov2 screening on VERO-E6 cells in a large repurposing effortDOI 10.1039/C9MD00262FBivalent AMPA receptor positive allosteric modulators of the bis(pyrimidine) series.

Documentation & Compliance Facts

Compliance Facts

Shipment review: Required

Documentation available by request

Certificate of Analysis (COA): By request

Supplier Safety Data Sheet (SDS): By request

Purity and pack size confirmation: By request

Availability and lead time review: Confirmed by RFQ

Shipment documentation review: By request

For supplier-issued documentation by request, use the RFQ actions on this page.Review preliminary safety reference

What happens after RFQ

  1. 1We review the CAS identity, quantity, and documentation request.
  2. 2We check sourcing options, supplier availability, COA/SDS, purity, pack size, and lead time.
  3. 3We review destination and shipment documentation needs when applicable.
  4. 4We follow up with a quotation or clarification request.

Text Reference Cues

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Non-public related references

CyclopenthiazideCAS 742-20-1

Non-public references are shown as text only and do not imply equivalence, availability, or shared use.

Catalog navigation

Related Catalog Entries

Other public CAS pages in this catalog. These links support navigation across additional intermediates and do not imply equivalence, availability, or shared use.

CAS 742-20-1CyclopenthiazideCAS 3056-17-5StavudineCAS 56-86-0L-Glutamic AcidCAS 21829-25-4NifedipineCAS 100643-71-8DesloratadineCAS 1002310-00-0Tert-butyl 1-(2-chloro-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)ethylcarbamateCAS 1005174-17-3(E)-3-(2-Propyl-6-(trifluoromethyl)pyridin-3-yl)acrylic acidCAS 1018125-49-92-(3-Cyclopropyl-6-ethyl-4-(trifluoromethyl)-1H-pyrazolo[3,4-b]pyridin-1-yl)acetic acidCAS 1018128-07-8Isopropyl 4-chloro-2-methylquinoline-6-carboxylateCAS 1018142-22-76-cyclopropyl-1-(2,2-difluoroethyl)-3-methyl-1H-pyrazolo[3,4-b]pyridine-4-carboxylic acid

RFQ questions for CAS 2259-96-3

What are the key identifiers for Cyclothiazide (CAS 2259-96-3)?

Cyclothiazide is identified by CAS 2259-96-3, with molecular formula C14H16ClN3O4S2, molecular weight 389.9, InChIKey BOCUKUHCLICSIY-UHFFFAOYSA-N.

Does CAS 2259-96-3 have reported biological target evidence?

ChEMBL contains qualifying experimental assay evidence associated with Glutamate receptor 1, Glutamate receptor 2, Glutamate receptor 4, Prelamin-A/C, Muscarinic acetylcholine receptor M1. These records do not establish therapeutic efficacy or clinical use.

Can I request a COA for CAS 2259-96-3?

Yes. Submit an RFQ and specify COA requirements. Lot-specific COA depends on supplier confirmation.

Can I request supplier SDS for Cyclothiazide?

Yes. Supplier SDS can be requested through the RFQ workflow before handling, storage, shipment, or procurement decisions.

Is CAS 2259-96-3 available for quotation?

Availability, pack size, lead time, and pricing are confirmed through RFQ.

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