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Home/Compounds/CAS 23110-15-8
Formula C26H34O7MW 458.5Research-use catalog entryCOA/SDS by request

Fumagillin

CAS Number: 23110-15-8

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Loading RDKit molecule structure...
InChIKey: NGGMYCMLYOUNGM-CSDLUJIJSA-NC26H34O7 | MW 458.5

Chemical Absolute Identifiers

CAS Number

23110-15-8

PubChem CID

6917655

Molecular Formula

C26H34O7

Molecular Weight

458.5 g/mol

Exact Mass

458.230453

InChIKey

NGGMYCMLYOUNGM-CSDLUJIJSA-N

IUPAC Name

(2E,4E,6E,8E)-10-[[(3R,4S,5S,6R)-5-methoxy-4-[(2R,3R)-2-methyl-3-(3-methylbut-2-enyl)oxiran-2-yl]-1-oxaspiro[2.5]octan-6-yl]oxy]-10-oxodeca-2,4,6,8-tetraenoic acid

SMILES String

CO[C@@H]1[C@H](OC(=O)/C=C/C=C/C=C/C=C/C(=O)O)CC[C@]2(CO2)[C@H]1[C@@]1(C)O[C@@H]1CC=C(C)C

Physical Properties

No physical property values available.

Properties are provided as catalog reference data and may be confirmed through supplier documentation when required.

Catalog Facts

Structural features

Fumagillin (CAS 23110-15-8) is listed in the Advanced Chemicals portfolio, with molecular formula C26H34O7 and molecular weight 458. 50 g/mol.

Sourcing context

Catalog reference for RFQ preparation, supplier confirmation, and research chemical sourcing review.

Research use context

Intended for research building-block and synthetic chemistry workflows.

Documentation needs

COA/SDS status, availability, lead time, pack size, and shipment documentation can be confirmed during quotation.

Applications & Classification

Heterocyclic Building BlocksSynthetic ChemistryResearch intermediateCustom synthesis building blockResearch chemical sourcingCustom synthesis and catalog availability reviewCOA, SDS, pricing, and fulfillment workflow
Biological target reference

ChEMBL reports experimental activity evidence for: Methionine aminopeptidase 2 (Homo sapiens) — 4 assays; Nuclear factor erythroid 2-related factor 2 (Homo sapiens) — 2 assays; Protein deacetylase HDAC6 (Homo sapiens) — 2 assays; Tyrosyl-DNA phosphodiesterase 1 (Homo sapiens) — 2 assays. These records describe research assays and do not establish therapeutic efficacy or clinical use.

Methionine aminopeptidase 2

Homo sapiens · SINGLE PROTEIN · 4 qualifying assays · 4 documents · best pChEMBL 9.2

Experimental evidence source: ChEMBL

Nuclear factor erythroid 2-related factor 2

Homo sapiens · SINGLE PROTEIN · 2 qualifying assays · 1 documents

Experimental evidence source: ChEMBL

Protein deacetylase HDAC6

Homo sapiens · SINGLE PROTEIN · 2 qualifying assays · 1 documents

Experimental evidence source: ChEMBL

Tyrosyl-DNA phosphodiesterase 1

Homo sapiens · SINGLE PROTEIN · 2 qualifying assays · 1 documents

Experimental evidence source: ChEMBL

Safety & Handling

Safety and handling reference content is available through documentation requests.

For supplier-issued SDS, request documentation before handling, storage, shipment, or procurement decisions.

Preliminary Safety Reference

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Safety Reference / SDS Request

Names & Synonyms / External Identifiers

Chemical Name

Fumagillin

Names & Synonyms

FugillinFumidilAmebacilinFumagilinaFumagilline
Show all synonyms
FumagillinumFumagillina2,4,6,8-Decatetraenedioic acid, 4-(1,2-epoxy-1,5-dimethyl-4-hexenyl)-5-methoxy-1-oxaspiro(2,5)oct-6-yl ester(2E,4E,6E,8E)-10-({(3R,4S,5S,6R)-5-methoxy-4-[(2R,3R)-2-methyl-3-(3-methylbut-2-en-1-yl)oxiran-2-yl]-1-oxaspiro[2.5]oct-6-yl}oxy)-10-oxodeca-2,4,6,8-tetraenoic acid2,4,6,8-DECATETRAENEDIOIC ACID, MONO((3R,4S,5S,6R)-5-METHOXY-4-((2R,3R)-2-METHYL-3-(3-METHYL-2-BUTENYL)OXIRANYL)-1-OXASPIRO(2.5)OCT-6-YL) ESTER, (2E,4E,6E,8E)-Fumidil-B(2E,4E,6E,8E)-10-(((3R,4S,5S,6R)-5-methoxy-4-((2R,3R)-2-methyl-3-(3-methylbut-2-en-1-yl)oxiran-2-yl)-1-oxaspiro(2.5)oct-6-yl)oxy)-10-oxodeca-2,4,6,8-tetraenoic acid(2E,4E,6E,8E)-10-(((3R,4S,5S,6R)-5-methoxy-4-((2R,3R)-2-methyl-3-(3-methylbut-2-enyl)oxiran-2-yl)-1-oxaspiro(2.5)octan-6-yl)oxy)-10-oxodeca-2,4,6,8-tetraenoic acid(-)-FumagillinAmebacillinFugilin(2E,4E,6E,8E)-10-(((3R,4S,5S,6R)-5-methoxy-4-((2R,3R)-2-methyl-3-(3-methylbut-2-en-1-yl)oxiran-2-yl)-1-oxaspiro[2.5]octan-6-yl)oxy)-10-oxodeca-2,4,6,8-tetraenoic acidFumagillin DCHFlisint
External Identifiers
EC NUMBER: 245-433-8DSSTOX SUBSTANCE ID: DTXSID7040736CHEMBL ID: CHEMBL32838CHEBI ID: CHEBI:48635UNII: 7OW73204U1DRUGBANK ID: DB02640METABOLOMICS WORKBENCH ID: 28238NCI THESAURUS CODE: C75963WIKIDATA ID: Q120199
Literature & Patent References
DOI 10.6019/CHEMBL4808148HDAC6 screening dataset using tau-based substrate in an enzymatic assay yields selective inhibitors and activatorsDOI 10.1021/acs.jnatprod.9b01190NF-κB Inhibitory and Antibacterial Helvolic and Fumagillin Derivatives from Aspergillus terreus.PMID 32163285NF-κB Inhibitory and Antibacterial Helvolic and Fumagillin Derivatives from Aspergillus terreus.DOI 10.1016/j.ejmech.2013.10.033Design, synthesis and evaluation of a cellular stable and detectable biotinylated fumagillin probe and investigation of cell permeability of fumagillin and its analogs to endothelial and cancer cells.PMID 24211639Design, synthesis and evaluation of a cellular stable and detectable biotinylated fumagillin probe and investigation of cell permeability of fumagillin and its analogs to endothelial and cancer cells.DOI 10.1016/j.bmc.2012.09.040Exploration of natural compounds as sources of new bifunctional scaffolds targeting cholinesterases and beta amyloid aggregation: the case of chelerythrine.PMID 23062825Exploration of natural compounds as sources of new bifunctional scaffolds targeting cholinesterases and beta amyloid aggregation: the case of chelerythrine.DOI 10.1016/j.ejmech.2011.01.026Identification, structural properties and chelating capacity of miltipolone as a broad-spectrum inhibitor to cancer cells.

Documentation & Compliance Facts

Compliance Facts

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Text Reference Cues

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Non-public references are shown as text only and do not imply equivalence, availability, or shared use.

Catalog navigation

Related Catalog Entries

Other public CAS pages in this catalog. These links support navigation across additional intermediates and do not imply equivalence, availability, or shared use.

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RFQ questions for CAS 23110-15-8

What are the key identifiers for Fumagillin (CAS 23110-15-8)?

Fumagillin is identified by CAS 23110-15-8, with molecular formula C26H34O7, molecular weight 458.5, InChIKey NGGMYCMLYOUNGM-CSDLUJIJSA-N.

Does CAS 23110-15-8 have reported biological target evidence?

ChEMBL contains qualifying experimental assay evidence associated with Methionine aminopeptidase 2, Nuclear factor erythroid 2-related factor 2, Protein deacetylase HDAC6, Tyrosyl-DNA phosphodiesterase 1. These records do not establish therapeutic efficacy or clinical use.

Can I request a COA for CAS 23110-15-8?

Yes. Submit an RFQ and specify COA requirements. Lot-specific COA depends on supplier confirmation.

Can I request supplier SDS for Fumagillin?

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Is CAS 23110-15-8 available for quotation?

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