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Home/Compounds/CAS 238750-77-1
Formula C21H30N2O6MW 406.5Research-use catalog entryCOA/SDS by request

Tosedostat

CAS Number: 238750-77-1

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Loading RDKit molecule structure...
InChIKey: FWFGIHPGRQZWIW-SQNIBIBYSA-NC21H30N2O6 | MW 406.5

Chemical Absolute Identifiers

CAS Number

238750-77-1

PubChem CID

15547703

Molecular Formula

C21H30N2O6

Molecular Weight

406.5 g/mol

Exact Mass

406.210387

InChIKey

FWFGIHPGRQZWIW-SQNIBIBYSA-N

IUPAC Name

cyclopentyl (2S)-2-[[(2R)-2-[(1S)-1-hydroxy-2-(hydroxyamino)-2-oxoethyl]-4-methylpentanoyl]amino]-2-phenylacetate

SMILES String

CC(C)C[C@@H](C(=O)N[C@H](C(=O)OC1CCCC1)c1ccccc1)[C@H](O)C(=O)NO

Physical Properties

No physical property values available.

Properties are provided as catalog reference data and may be confirmed through supplier documentation when required.

Catalog Facts

Structural features

Tosedostat (CAS 238750-77-1) is listed in the Advanced Chemicals portfolio, with molecular formula C21H30N2O6 and molecular weight 406. 50 g/mol.

Sourcing context

Catalog reference for RFQ preparation, supplier confirmation, and research chemical sourcing review.

Research use context

Intended for research building-block and synthetic chemistry workflows; structure-derived tags include nitrogen-containing heterocycle.

Documentation needs

COA/SDS status, availability, lead time, pack size, and shipment documentation can be confirmed during quotation.

Applications & Classification

Organic Building BlocksSynthetic ChemistryResearch intermediateCustom synthesis building blockResearch chemical sourcingCustom synthesis and catalog availability reviewCOA, SDS, pricing, and fulfillment workflow
Biological target reference

ChEMBL reports experimental activity evidence for: Aminopeptidase N (Homo sapiens) — 6 assays; Puromycin-sensitive aminopeptidase (Homo sapiens) — 2 assays; Protein deacetylase HDAC6 (Homo sapiens) — 2 assays. These records describe research assays and do not establish therapeutic efficacy or clinical use.

Aminopeptidase N

Homo sapiens · SINGLE PROTEIN · 6 qualifying assays · 4 documents · best pChEMBL 7.52

Experimental evidence source: ChEMBL

Puromycin-sensitive aminopeptidase

Homo sapiens · SINGLE PROTEIN · 2 qualifying assays · 2 documents · best pChEMBL 6.58

Experimental evidence source: ChEMBL

Protein deacetylase HDAC6

Homo sapiens · SINGLE PROTEIN · 2 qualifying assays · 1 documents

Experimental evidence source: ChEMBL

Safety & Handling

Safety and handling reference content is available through documentation requests.

For supplier-issued SDS, request documentation before handling, storage, shipment, or procurement decisions.

Preliminary Safety Reference

For supplier-issued SDS or COA, submit a documentation request.

Safety Reference / SDS Request

Names & Synonyms / External Identifiers

Chemical Name

Tosedostat

Names & Synonyms

CHR 2797Benzeneacetic acid, alpha-(((2R)-2-((1S)-1-hydroxy-2-(hydroxyamino)-2-oxoethyl)-4-methyl-1-oxopentyl)amino)-, cyclopentyl ester, (alphaS)-tosedostatumAminopeptidase inhibitor CHR-27972-(2-(Hydroxy(hydroxycarbamoyl)methyl)-4-methylpentanoylamino)-2-phenylethanoic acid cyclopentyl ester
Show all synonyms
CYCLOPENTYL (2S)-2-((2R)-2-((1S)-1-HYDROXY-2-(HYDROXYAMINO)-2-OXOETHYL)-4-METHYLPENTANAMIDO)-2-PHENYLACETATEcyclopentyl (2S)-2-((2R,3S)-3-hydroxy-3-(hydroxycarbamoyl)-2-(2-methylpropyl)propanamido)-2-phenylacetateTosedostat (CHR2797)cyclopentyl (S)-2-((R)-2-((S)-1-hydroxy-2-(hydroxyamino)-2-oxoethyl)-4-methylpentanamido)-2-phenylacetateTosedostat [INN]Tosedostat [USAN:INN]Tosedostat (USAN/INN)TOSEDOSTAT [USAN]Tosedostat (CHR2797)?TOSEDOSTAT [WHO-DD](S)-cyclopentyl 2-((R)-2-((S)-1-hydroxy-2-(hydroxyamino)-2-oxoethyl)-4-methylpentanamido)-2-phenylacetatecyclopentyl (2S)-2-[[(2R)-2-[(1S)-1-hydroxy-2-(hydroxyamino)-2-oxo-ethyl]-4-methyl-pentanoyl]amino]-2-phenyl-acetateBENZENEACETIC ACID, .ALPHA.-(((2R)-2-((1S)-1-HYDROXY-2-(HYDROXYAMINO)-2-OXOETHYL)-4- METHYL-1-OXOPENTY)LAMINO)-, CYCLOPENTYL ESTER, (.ALPHA.S)-Cyclopentyl (2S)-{(2R)-2-[(1S)-1-hydroxy-2-(hydroxyamino)-2-oxoethyl]-4-methylpentanamido}(phenyl)acetate
External Identifiers
DSSTOX SUBSTANCE ID: DTXSID60178577CHEMBL ID: CHEMBL2103847CHEBI ID: CHEBI:95044UNII: KZK563J2UWDRUGBANK ID: DB11781KEGG ID: D10026METABOLOMICS WORKBENCH ID: 152879NCI THESAURUS CODE: C70650WIKIDATA ID: Q27166812
Literature & Patent References
DOI 10.1016/j.ejmech.2024.116604Modulation of endogenous opioid signaling by inhibitors of puromycin-sensitive aminopeptidase.DOI 10.1021/acs.jmedchem.4c00840ERAP Inhibitors in Autoimmunity and Immuno-Oncology: Medicinal Chemistry Insights.PMID 38917665Modulation of endogenous opioid signaling by inhibitors of puromycin-sensitive aminopeptidase.PMID 39011823ERAP Inhibitors in Autoimmunity and Immuno-Oncology: Medicinal Chemistry Insights.DOI 10.6019/CHEMBL4808148HDAC6 screening dataset using tau-based substrate in an enzymatic assay yields selective inhibitors and activatorsDOI 10.21203/rs.3.rs-23951/v1Identification of inhibitors of SARS-CoV-2 in-vitro cellular toxicity in human (Caco-2) cells using a large scale drug repurposing collectionDOI 10.6019/CHEMBL4495564Identification of inhibitors of SARS-Cov2 M-Pro enzymatic activity using a small molecule repurposing screenDOI 10.6019/CHEMBL4495565Cytopathic SARS-Cov2 screening on VERO-E6 cells in a large repurposing effort

Documentation & Compliance Facts

Compliance Facts

Shipment review: Required

Documentation available by request

Certificate of Analysis (COA): By request

Supplier Safety Data Sheet (SDS): By request

Purity and pack size confirmation: By request

Availability and lead time review: Confirmed by RFQ

Shipment documentation review: By request

For supplier-issued documentation by request, use the RFQ actions on this page.Review preliminary safety reference

What happens after RFQ

  1. 1We review the CAS identity, quantity, and documentation request.
  2. 2We check sourcing options, supplier availability, COA/SDS, purity, pack size, and lead time.
  3. 3We review destination and shipment documentation needs when applicable.
  4. 4We follow up with a quotation or clarification request.

Text Reference Cues

Show non-linked catalog cues

Non-public related references

Benzyl hydroxycarbamateCAS 3426-71-9
Arp-100CAS 704888-90-4
GI254023XCAS 260264-93-5
Benzohydroxamic acidCAS 495-18-1
Ethyl 4-(hydroxyamino)benzoateCAS 24171-85-5

Non-public references are shown as text only and do not imply equivalence, availability, or shared use.

Catalog navigation

Related Catalog Entries

Other public CAS pages in this catalog. These links support navigation across additional intermediates and do not imply equivalence, availability, or shared use.

CAS 13434-13-4ActinoninCAS 154039-60-8MarimastatCAS 100-88-9CyclamateCAS 1002310-00-0Tert-butyl 1-(2-chloro-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)ethylcarbamateCAS 1005174-17-3(E)-3-(2-Propyl-6-(trifluoromethyl)pyridin-3-yl)acrylic acidCAS 1018125-49-92-(3-Cyclopropyl-6-ethyl-4-(trifluoromethyl)-1H-pyrazolo[3,4-b]pyridin-1-yl)acetic acidCAS 1018128-07-8Isopropyl 4-chloro-2-methylquinoline-6-carboxylateCAS 1018142-22-76-cyclopropyl-1-(2,2-difluoroethyl)-3-methyl-1H-pyrazolo[3,4-b]pyridine-4-carboxylic acidCAS 1018144-00-72-(3-Cyclopropyl-6-isopropyl-4-(trifluoromethyl)-1H-pyrazolo[3,4-b]pyridin-1-yl)acetic acid

RFQ questions for CAS 238750-77-1

What are the key identifiers for Tosedostat (CAS 238750-77-1)?

Tosedostat is identified by CAS 238750-77-1, with molecular formula C21H30N2O6, molecular weight 406.5, InChIKey FWFGIHPGRQZWIW-SQNIBIBYSA-N.

Does CAS 238750-77-1 have reported biological target evidence?

ChEMBL contains qualifying experimental assay evidence associated with Aminopeptidase N, Puromycin-sensitive aminopeptidase, Protein deacetylase HDAC6. These records do not establish therapeutic efficacy or clinical use.

Can I request a COA for CAS 238750-77-1?

Yes. Submit an RFQ and specify COA requirements. Lot-specific COA depends on supplier confirmation.

Can I request supplier SDS for Tosedostat?

Yes. Supplier SDS can be requested through the RFQ workflow before handling, storage, shipment, or procurement decisions.

Is CAS 238750-77-1 available for quotation?

Availability, pack size, lead time, and pricing are confirmed through RFQ.

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