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Home/Compounds/CAS 25316-40-9
Formula C27H30ClNO11MW 580Research-use catalog entryCOA/SDS by request

Doxorubicin Hydrochloride

CAS Number: 25316-40-9

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Loading RDKit molecule structure...
InChIKey: MWWSFMDVAYGXBV-RUELKSSGSA-NC27H30ClNO11 | MW 580

Chemical Absolute Identifiers

CAS Number

25316-40-9

PubChem CID

443939

Molecular Formula

C27H30ClNO11

Molecular Weight

580 g/mol

Exact Mass

579.150739

InChIKey

MWWSFMDVAYGXBV-RUELKSSGSA-N

IUPAC Name

(7S,9S)-7-[(2R,4S,5S,6S)-4-amino-5-hydroxy-6-methyloxan-2-yl]oxy-6,9,11-trihydroxy-9-(2-hydroxyacetyl)-4-methoxy-8,10-dihydro-7H-tetracene-5,12-dione;hydrochloride

SMILES String

C[C@H]1[C@H]([C@H](C[C@@H](O1)O[C@H]2C[C@@](CC3=C2C(=C4C(=C3O)C(=O)C5=C(C4=O)C(=CC=C5)OC)O)(C(=O)CO)O)N)O.Cl

Physical Properties

Water Solubility

1.99e+3 mol/L

Properties are provided as catalog reference data and may be confirmed through supplier documentation when required.

Catalog Facts

Structural features

Doxorubicin Hydrochloride (CAS 25316-40-9) is listed in the Pharmaceutical Intermediates portfolio, with molecular formula C27H30ClNO11 and molecular weight 580. 00 g/mol.

Sourcing context

Catalog reference for RFQ preparation, supplier confirmation, and research chemical sourcing review.

Research use context

Intended for research-stage medicinal chemistry and intermediate synthesis workflows; structure-derived tags include nitrogen-containing heterocycle.

Documentation needs

COA/SDS status, availability, lead time, pack size, and shipment documentation can be confirmed during quotation.

Applications & Classification

Pharmaceutical Intermediate ResearchResearch intermediateCustom synthesis building blockPharmaceutical intermediate researchResearch chemical sourcingCustom synthesis and catalog availability reviewCOA, SDS, pricing, and fulfillment workflow
Biological target reference

ChEMBL reports experimental activity evidence for: Thyroid hormone receptor beta (Homo sapiens) — 4 assays; Nuclear receptor ROR-gamma (Mus musculus) — 2 assays; Microtubule-associated protein tau (Homo sapiens) — 2 assays; Signal transducer and activator of transcription 6 (Homo sapiens) — 2 assays; Hypoxia-inducible factor 1-alpha (Homo sapiens) — 3 assays. These records describe research assays and do not establish therapeutic efficacy or clinical use.

Thyroid hormone receptor beta

Homo sapiens · SINGLE PROTEIN · 4 qualifying assays · 1 documents · best pChEMBL 5.55

Experimental evidence source: ChEMBL

Nuclear receptor ROR-gamma

Mus musculus · SINGLE PROTEIN · 2 qualifying assays · 1 documents · best pChEMBL 5.55

Experimental evidence source: ChEMBL

Microtubule-associated protein tau

Homo sapiens · SINGLE PROTEIN · 2 qualifying assays · 1 documents · best pChEMBL 5.5

Experimental evidence source: ChEMBL

Signal transducer and activator of transcription 6

Homo sapiens · SINGLE PROTEIN · 2 qualifying assays · 1 documents · best pChEMBL 5.4

Experimental evidence source: ChEMBL

Hypoxia-inducible factor 1-alpha

Homo sapiens · SINGLE PROTEIN · 3 qualifying assays · 1 documents · best pChEMBL 5.3

Experimental evidence source: ChEMBL

Safety & Handling

Safety and handling reference content is available through documentation requests.

For supplier-issued SDS, request documentation before handling, storage, shipment, or procurement decisions.

Preliminary Safety Reference

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Safety Reference / SDS Request

Names & Synonyms / External Identifiers

Chemical Name

Doxorubicin Hydrochloride

Names & Synonyms

Doxorubicin HClADRIAMYCIN HYDROCHLORIDEAdriacinAdriamycin PFSAdriamycin RDF
Show all synonyms
ADRIAMYCIN, HYDROCHLORIDEAdriablastina csdoxorubicin.HClhydroxydaunomycin hydrochlorideDoxorubicini hydrochloridumDoxorubicin citric acid saltLiposomal doxorubicin hydrochlorideDOXORUBICIN HYDROCHLORIDE LIPOSOME5,12-Naphthacenedione, 10-((3-amino-2,3,6-trideoxy-alpha-L-lyxo-hexopyranosyl)oxy)-7,8,9,10-tetrahydro-6,8,11-trihydroxy-8-(hydroxyacetyl)-1-methoxy-, hydrochloride, (8S,10S)-FI 106adriamycineFarmiblastinaAdrimedacDoxolemDoxorubin
External Identifiers
EC NUMBER: 246-818-3DSSTOX SUBSTANCE ID: DTXSID3030636CHEMBL ID: CHEMBL359744CHEBI ID: CHEBI:31522UNII: 82F2G7BL4EKEGG ID: D01275NCI THESAURUS CODE: C1326RXCUI: 142433
Literature & Patent References
DOI 10.1016/j.bmc.2025.118094Discovery of 3-indolylbenzoquinone derivatives with therapeutic potential for breast cancer.DOI 10.1016/j.bmc.2025.118143Design, synthesis and biological evaluation of novel hydroxamic acid-derived histone deacetylase inhibitors bearing a 2-oxoindoline scaffold as potential antitumor agents.DOI 10.1016/j.bmcl.2025.130096Applications of innovative synthetic strategies in anticancer drug discovery: The driving force of new chemical reactions.DOI 10.1016/j.ejmech.2025.117519Design, synthesis and biological evaluation of Golgi-targeting anion transporters as inducers of Golgiphagy and apoptosis in cancer cells.DOI 10.1021/acs.jnatprod.4c01374Screening, Discovery, and Optimization of the Natural Antitubercular Chlorflavonin from a Marine-Derived Fungal Library.DOI 10.1021/acs.jnatprod.4c01433(±)-Feionemycin A and Chromonemycins A-D, Rearranged Aromatic Polyketides Uncovered by Type II Polyketide Gene Cluster Expression.DOI 10.1021/acs.jnatprod.5c00141Sealgamide: An Antitrypanosomal Lipopeptide Isolated from a Marine <i>Okeania</i> sp. Cyanobacterium.DOI 10.1021/acs.jnatprod.5c00144Total Synthesis of (-)- and (+)-Talaroenamine B and Diphenylene Derivatives.

Documentation & Compliance Facts

Compliance Facts

Shipment review: Required

Documentation available by request

Certificate of Analysis (COA): By request

Supplier Safety Data Sheet (SDS): By request

Purity and pack size confirmation: By request

Availability and lead time review: Confirmed by RFQ

Shipment documentation review: By request

For supplier-issued documentation by request, use the RFQ actions on this page.Review preliminary safety reference

What happens after RFQ

  1. 1We review the CAS identity, quantity, and documentation request.
  2. 2We check sourcing options, supplier availability, COA/SDS, purity, pack size, and lead time.
  3. 3We review destination and shipment documentation needs when applicable.
  4. 4We follow up with a quotation or clarification request.

Text Reference Cues

Additional text reference cues are not available for this catalog entry.

Non-public references are shown as text only and do not imply equivalence, availability, or shared use.

Catalog navigation

Related Catalog Entries

Other public CAS pages in this catalog. These links support navigation across additional intermediates and do not imply equivalence, availability, or shared use.

CAS 520-36-5ApigeninCAS 50-65-7NiclosamideCAS 97-18-7BithionolCAS 10083-24-6PiceatannolCAS 118-10-5(S)-Quinolin-4-yl((1S,2R,4S,5R)-5-vinylquinuclidin-2-yl)methanol , CinchonineCAS 1002310-00-0Tert-butyl 1-(2-chloro-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)ethylcarbamateCAS 1005174-17-3(E)-3-(2-Propyl-6-(trifluoromethyl)pyridin-3-yl)acrylic acidCAS 1018125-49-92-(3-Cyclopropyl-6-ethyl-4-(trifluoromethyl)-1H-pyrazolo[3,4-b]pyridin-1-yl)acetic acidCAS 1018128-07-8Isopropyl 4-chloro-2-methylquinoline-6-carboxylateCAS 1018142-22-76-cyclopropyl-1-(2,2-difluoroethyl)-3-methyl-1H-pyrazolo[3,4-b]pyridine-4-carboxylic acid

RFQ questions for CAS 25316-40-9

What are the key identifiers for Doxorubicin Hydrochloride (CAS 25316-40-9)?

Doxorubicin Hydrochloride is identified by CAS 25316-40-9, with molecular formula C27H30ClNO11, molecular weight 580, InChIKey MWWSFMDVAYGXBV-RUELKSSGSA-N.

Does CAS 25316-40-9 have reported biological target evidence?

ChEMBL contains qualifying experimental assay evidence associated with Thyroid hormone receptor beta, Nuclear receptor ROR-gamma, Microtubule-associated protein tau, Signal transducer and activator of transcription 6, Hypoxia-inducible factor 1-alpha. These records do not establish therapeutic efficacy or clinical use.

Can I request a COA for CAS 25316-40-9?

Yes. Submit an RFQ and specify COA requirements. Lot-specific COA depends on supplier confirmation.

Can I request supplier SDS for Doxorubicin Hydrochloride?

Yes. Supplier SDS can be requested through the RFQ workflow before handling, storage, shipment, or procurement decisions.

Is CAS 25316-40-9 available for quotation?

Availability, pack size, lead time, and pricing are confirmed through RFQ.

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