tert-butyl N-(1,1,1-trifluoropent-4-yn-2-yl)carbamate

tert-butyl N-(1,1,1-trifluoropent-4-yn-2-yl)carbamate, with CAS 2703780-46-3, is a sophisticated organic intermediate characterized by three distinct functional groups: a tert-butyl carbamate (Boc) protecting group, a highly electron-withdrawing trifluoromethyl group, and a terminal alkyne. This unique combination makes it a valuable reagent for advanced synthetic chemistry. The Boc group offers facile protection and deprotection of the amine, while the trifluoromethyl group can impart specific electronic and steric properties to molecules, often enhancing metabolic stability or lipophilicity in drug discovery. The terminal alkyne is a reactive handle for various transformations, including 'click chemistry' reactions (e.g., copper-catalyzed azide-alkyne cycloaddition) and other alkyne-based couplings, allowing for diverse molecular elaborations. This compound is intended for Research Use Only (RUO).

• Handle tert-butyl N-(1,1,1-trifluoropent-4-yn-2-yl)carbamate with appropriate personal protective equipment, including gloves, eye protection, and a lab coat. Work in a well-ventilated area or fume hood to avoid inhalation of dust or vapors. Prevent skin and eye contact. Store in a cool, dry place, away from incompatible materials. Dispose of waste in accordance with local regulations for chemical waste.