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Home/Compounds/CAS 274901-16-5
Formula C17H25N3O2MW 303.4Research-use catalog entryCOA/SDS by request

Vildagliptin

CAS Number: 274901-16-5

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Loading RDKit molecule structure...
InChIKey: SYOKIDBDQMKNDQ-XWTIBIIYSA-NC17H25N3O2 | MW 303.4

Chemical Absolute Identifiers

CAS Number

274901-16-5

PubChem CID

6918537

Molecular Formula

C17H25N3O2

Molecular Weight

303.4 g/mol

Exact Mass

303.194677

InChIKey

SYOKIDBDQMKNDQ-XWTIBIIYSA-N

IUPAC Name

(2S)-1-[2-[(3-hydroxy-1-adamantyl)amino]acetyl]pyrrolidine-2-carbonitrile

SMILES String

N#C[C@@H]1CCCN1C(=O)CNC12CC3CC(CC(O)(C3)C1)C2

Physical Properties

Water Solubility

1.75 g/L

Properties are provided as catalog reference data and may be confirmed through supplier documentation when required.

Catalog Facts

Structural features

Vildagliptin (CAS 274901-16-5) is listed in the Pharmaceutical Intermediates portfolio, with molecular formula C17H25N3O2 and molecular weight 303. 40 g/mol.

Sourcing context

Catalog reference for RFQ preparation, supplier confirmation, and research chemical sourcing review.

Research use context

Intended for research-stage medicinal chemistry and intermediate synthesis workflows; structure-derived tags include nitrogen-containing heterocycle.

Documentation needs

COA/SDS status, availability, lead time, pack size, and shipment documentation can be confirmed during quotation.

Applications & Classification

Pharmaceutical Intermediate ResearchResearch intermediateCustom synthesis building blockPharmaceutical intermediate researchResearch chemical sourcingCustom synthesis and catalog availability reviewCOA, SDS, pricing, and fulfillment workflow
Biological target reference

ChEMBL reports experimental activity evidence for: Dipeptidyl peptidase 9 (Homo sapiens) — 17 assays; Dipeptidyl peptidase 4 (Homo sapiens) — 66 assays; Dipeptidyl peptidase 8 (Homo sapiens) — 23 assays; Dipeptidyl peptidase IV (Porphyromonas gingivalis) — 3 assays; Dipeptidyl peptidase 4 (Mus musculus) — 2 assays. These records describe research assays and do not establish therapeutic efficacy or clinical use.

Dipeptidyl peptidase 9

Homo sapiens · SINGLE PROTEIN · 17 qualifying assays · 16 documents · best pChEMBL 9.92

Experimental evidence source: ChEMBL

Dipeptidyl peptidase 4

Homo sapiens · SINGLE PROTEIN · 66 qualifying assays · 36 documents · best pChEMBL 9.24

Experimental evidence source: ChEMBL

Dipeptidyl peptidase 8

Homo sapiens · SINGLE PROTEIN · 23 qualifying assays · 22 documents · best pChEMBL 8.73

Experimental evidence source: ChEMBL

Dipeptidyl peptidase IV

Porphyromonas gingivalis · SINGLE PROTEIN · 3 qualifying assays · 1 documents · best pChEMBL 7.77

Experimental evidence source: ChEMBL

Dipeptidyl peptidase 4

Mus musculus · SINGLE PROTEIN · 2 qualifying assays · 2 documents · best pChEMBL 7.58

Experimental evidence source: ChEMBL

Safety & Handling

Safety and handling reference content is available through documentation requests.

For supplier-issued SDS, request documentation before handling, storage, shipment, or procurement decisions.

Preliminary Safety Reference

For supplier-issued SDS or COA, submit a documentation request.

Safety Reference / SDS Request

Names & Synonyms / External Identifiers

Chemical Name

Vildagliptin

Names & Synonyms

GalvusEquaVitagliptinNVP-LAF 237vildagliptine
Show all synonyms
Vildagliptina(2S)-(((3-hydroxyadamantan-1-yl)amino)acetyl)pyrrolidine-2-carbonitrilevildagliptinumNVP LAF237(2S)-{((3-Hydroxyadamantan-1-yl)amino)acetyl}pyrrolidine-2-carbonitrile(2S)-1-(2-((3-hydroxy-1-adamantyl)amino)acetyl)pyrrolidine-2-carbonitrileXiliarxJalraVildagliptin (LAF-237)LAF 2372-Pyrrolidinecarbonitrile, 1-[2-[(3-hydroxytricyclo[3.3.1.13,7]dec-1-yl)amino]acetyl]-, (2S)-(2S)-1-{2-[(3-hydroxyadamantan-1-yl)amino]acetyl}pyrrolidine-2-carbonitrile2-Pyrrolidinecarbonitrile, 1-(((3-hydroxytricyclo(3.3.1.13,7)dec-1-yl)amino)acetyl)-, (2S)-Galvus (TN)
External Identifiers
EC NUMBER: 630-410-0CHEMBL ID: CHEMBL142703CHEBI ID: CHEBI:135285UNII: I6B4B2U96PDRUGBANK ID: DB04876HMDB ID: HMDB0015596KEGG ID: D07080METABOLOMICS WORKBENCH ID: 43636NCI THESAURUS CODE: C66653PHARMGKB ID: PA165958346WIKIDATA ID: Q421042
Literature & Patent References
DOI 10.1021/acs.jmedchem.5c00056Substrate Specificity of the Organic Cation Transporters MATE1 and MATE2K and Functional Overlap with OCT1 and OCT2.PMID 40512599Substrate Specificity of the Organic Cation Transporters MATE1 and MATE2K and Functional Overlap with OCT1 and OCT2.DOI 10.1016/j.ejmech.2024.116464Synthesis and clinical application of representative small-molecule dipeptidyl Peptidase-4 (DPP-4) inhibitors for the treatment of type 2 diabetes mellitus (T2DM).DOI 10.1016/j.ejmech.2024.116948Sensitive quantification of fibroblast activation protein and high-throughput screening for inhibition by FDA-approved compounds.PMID 38704940Synthesis and clinical application of representative small-molecule dipeptidyl Peptidase-4 (DPP-4) inhibitors for the treatment of type 2 diabetes mellitus (T2DM).PMID 39437576Sensitive quantification of fibroblast activation protein and high-throughput screening for inhibition by FDA-approved compounds.DOI 10.1021/acs.jmedchem.3c00412Development of Long-Acting Dipeptidyl Peptidase-4 Inhibitors: Structural Evolution and Long-Acting Determinants.DOI 10.1021/acs.jmedchem.3c00609Highly Selective Inhibitors of Dipeptidyl Peptidase 9 (DPP9) Derived from the Clinically Used DPP4-Inhibitor Vildagliptin.

Documentation & Compliance Facts

Compliance Facts

Shipment review: Required

Documentation available by request

Certificate of Analysis (COA): By request

Supplier Safety Data Sheet (SDS): By request

Purity and pack size confirmation: By request

Availability and lead time review: Confirmed by RFQ

Shipment documentation review: By request

For supplier-issued documentation by request, use the RFQ actions on this page.Review preliminary safety reference

What happens after RFQ

  1. 1We review the CAS identity, quantity, and documentation request.
  2. 2We check sourcing options, supplier availability, COA/SDS, purity, pack size, and lead time.
  3. 3We review destination and shipment documentation needs when applicable.
  4. 4We follow up with a quotation or clarification request.

Text Reference Cues

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Non-public related references

2-((3-Hydroxyadamantan-1-yl)amino)acetic acidCAS 1032564-18-3
(2S)-1-(2-chloroacetyl)pyrrolidine-2-carbonitrileCAS 207557-35-5
3-Amino-1-adamantanolCAS 702-82-9
1-(2-Chloroacetyl)pyrrolidine-2-carboxylic acidCAS 23500-10-9
(S)-1-(2-Chloroacetyl)pyrrolidine-2-carboxamideCAS 214398-99-9

Non-public references are shown as text only and do not imply equivalence, availability, or shared use.

Catalog navigation

Related Catalog Entries

Other public CAS pages in this catalog. These links support navigation across additional intermediates and do not imply equivalence, availability, or shared use.

CAS 1032564-18-32-((3-Hydroxyadamantan-1-yl)amino)acetic acidCAS 207557-35-5(2S)-1-(2-chloroacetyl)pyrrolidine-2-carbonitrileCAS 100643-71-8DesloratadineCAS 138112-76-2AgomelatineCAS 181695-72-7ValdecoxibCAS 668270-12-0LinagliptinCAS 138402-11-6IrbesartanCAS 1002310-00-0Tert-butyl 1-(2-chloro-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)ethylcarbamateCAS 1005174-17-3(E)-3-(2-Propyl-6-(trifluoromethyl)pyridin-3-yl)acrylic acidCAS 1018125-49-92-(3-Cyclopropyl-6-ethyl-4-(trifluoromethyl)-1H-pyrazolo[3,4-b]pyridin-1-yl)acetic acid

RFQ questions for CAS 274901-16-5

What are the key identifiers for Vildagliptin (CAS 274901-16-5)?

Vildagliptin is identified by CAS 274901-16-5, with molecular formula C17H25N3O2, molecular weight 303.4, InChIKey SYOKIDBDQMKNDQ-XWTIBIIYSA-N.

Does CAS 274901-16-5 have reported biological target evidence?

ChEMBL contains qualifying experimental assay evidence associated with Dipeptidyl peptidase 9, Dipeptidyl peptidase 4, Dipeptidyl peptidase 8, Dipeptidyl peptidase IV, Dipeptidyl peptidase 4. These records do not establish therapeutic efficacy or clinical use.

Can I request a COA for CAS 274901-16-5?

Yes. Submit an RFQ and specify COA requirements. Lot-specific COA depends on supplier confirmation.

Can I request supplier SDS for Vildagliptin?

Yes. Supplier SDS can be requested through the RFQ workflow before handling, storage, shipment, or procurement decisions.

Is CAS 274901-16-5 available for quotation?

Availability, pack size, lead time, and pricing are confirmed through RFQ.

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