MolGraph
CompoundsDocumentationComplianceAbout
MolGraph

Research chemical sourcing and molecular building block RFQ workflows.

MolGraph is operated by Tessorix Inc.

support@molgraph.com

Products are intended for laboratory research use only and are not for human or veterinary use.

Compounds

  • Compound catalog
  • CAS Search

Company

  • About
  • Contact

Documentation

  • Quality Documentation
  • SDS Disclaimer

Compliance

  • Compliance

Legal

  • Terms
  • Privacy

Copyright © 2026 MolGraph. All Rights Reserved.

Home/Compounds/CAS 321-64-2
Formula C13H14N2MW 198.26Research-use catalog entryCOA/SDS by request

Tacrine

CAS Number: 321-64-2

Sourcing & RFQ

Submit an RFQ to review pricing, availability, lead time, pack size, purity, COA, and supplier SDS for this catalog entry.

Available options

Available Options

Package
1 g
Purity
98%
Price
Request review
Availability
Shipping review required
Delivery
Shipping review required
Package
100 g
Purity
98%
Price
Request review
Availability
Shipping review required
Delivery
Shipping review required
Package
25 g
Purity
98%
Price
Request review
Availability
Shipping review required
Delivery
Shipping review required
Package
5 g
Purity
98%
Price
Request review
Availability
Shipping review required
Delivery
Shipping review required

Shipping review is required before pricing or stock can be confirmed publicly. Shipping, duties, and documentation fees are confirmed before order acceptance.

Loading RDKit molecule structure...
InChIKey: YLJREFDVOIBQDA-UHFFFAOYSA-NC13H14N2 | MW 198.26

Chemical Absolute Identifiers

CAS Number

321-64-2

PubChem CID

1935

Molecular Formula

C13H14N2

Molecular Weight

198.26 g/mol

Exact Mass

198.115698

InChIKey

YLJREFDVOIBQDA-UHFFFAOYSA-N

IUPAC Name

1,2,3,4-tetrahydroacridin-9-amine

SMILES String

Nc1c2c(nc3ccccc13)CCCC2

Physical Properties

Melting Point

183.5 °C

pKa

9.8–9.95

Properties are provided as catalog reference data and may be confirmed through supplier documentation when required.

Catalog Facts

Structural features

Tacrine (CAS 321-64-2) is listed in the Advanced Chemicals portfolio, with molecular formula C13H14N2 and molecular weight 198. 26 g/mol.

Sourcing context

Catalog reference for RFQ preparation, supplier confirmation, and research chemical sourcing review.

Research use context

Intended for research building-block and synthetic chemistry workflows; structure-derived tags include nitrogen-containing heterocycle.

Documentation needs

COA/SDS status, availability, lead time, pack size, and shipment documentation can be confirmed during quotation.

Applications & Classification

Heterocyclic Building BlocksSynthetic ChemistryResearch intermediateCustom synthesis building blockResearch chemical sourcingCustom synthesis and catalog availability reviewCOA, SDS, pricing, and fulfillment workflow
Biological target reference

ChEMBL reports experimental activity evidence for: Cholinesterase (Homo sapiens) — 146 assays; Cholinesterase (Equus caballus) — 160 assays; Acetylcholinesterase (Electrophorus electricus) — 198 assays; Acetylcholinesterase (Homo sapiens) — 218 assays; Butyrylcholinesterase (Equus caballus) — 13 assays. These records describe research assays and do not establish therapeutic efficacy or clinical use.

Cholinesterase

Homo sapiens · SINGLE PROTEIN · 146 qualifying assays · 141 documents · best pChEMBL 10.57

Experimental evidence source: ChEMBL

Cholinesterase

Equus caballus · SINGLE PROTEIN · 160 qualifying assays · 149 documents · best pChEMBL 8.92

Experimental evidence source: ChEMBL

Acetylcholinesterase

Electrophorus electricus · SINGLE PROTEIN · 198 qualifying assays · 174 documents · best pChEMBL 8.73

Experimental evidence source: ChEMBL

Acetylcholinesterase

Homo sapiens · SINGLE PROTEIN · 218 qualifying assays · 191 documents · best pChEMBL 8.5

Experimental evidence source: ChEMBL

Butyrylcholinesterase

Equus caballus · SINGLE PROTEIN · 13 qualifying assays · 13 documents · best pChEMBL 8.29

Experimental evidence source: ChEMBL

Safety & Handling

Safety and handling reference content is available through documentation requests.

For supplier-issued SDS, request documentation before handling, storage, shipment, or procurement decisions.

Preliminary Safety Reference

For supplier-issued SDS or COA, submit a documentation request.

Safety Reference / SDS Request

Names & Synonyms / External Identifiers

Chemical Name

Tacrine

Names & Synonyms

Tetrahydroaminacrine1,2,3,4-TETRAHYDRO-9-ACRIDINAMINETetrahydroaminoacridineTetrahydroaminocrinTetrahydroaminocrine
Show all synonyms
9-amino-1,2,3,4-tetrahydroacridineTacrinaTacrinalTacrinum9-Acridinamine, 1,2,3,4-tetrahydro-1,2,3,4-Tetrahydro-9-aminoacridine5-Amino-6,7,8,9-tetrahydroacridine1,2,3,4-TetrahydroaminoacridineCognexCS 12602Tacrine (INN)Acridine, 1,2,3,4-tetrahydro-9-amino-tacrine.HClAcridine, 9-amino-1,2,3,4-tetrahydro-
External Identifiers
EC NUMBER: 206-291-2EC NUMBER: 693-573-7DSSTOX SUBSTANCE ID: DTXSID1037272CHEMBL ID: CHEMBL1337960CHEMBL ID: CHEMBL95CHEBI ID: CHEBI:45980UNII: 4VX7YNB537DRUGBANK ID: DB00382HMDB ID: HMDB0014526KEGG ID: C01453KEGG ID: D08555METABOLOMICS WORKBENCH ID: 42749NCI THESAURUS CODE: C61961PHARMGKB ID: PA451576WIKIDATA ID: Q421076
Experimental Spectrum References
1H NMR SpectraFTIR SpectraUV-VIS Spectra
Literature & Patent References
DOI 10.1016/j.ejmech.2024.117030Discovery of novel thiosemicarbazone-acridine targeting butyrylcholinesterase with antioxidant, metal complexing and neuroprotector abilities as potential treatment of Alzheimer's disease: In vitro, in vivo, and in silico studies.DOI 10.1016/j.ejmech.2024.117201Discovery of novel bicyclic and tricyclic cyclohepta[b]thiophene derivatives as multipotent AChE and BChE inhibitors, in-Vivo and in-Vitro assays, ADMET and molecular docking simulation.DOI 10.1016/j.ejmech.2025.117326Synthesis and biological evaluation of natural cleistanolate, its enantiomer and analogues.DOI 10.1016/j.ejmech.2025.117531Discovery of ultra short β-peptoids with selective activity against drug-resistant Mycobacterium tuberculosis.DOI 10.1016/j.ejmech.2025.117678Novel tacrine-based multi-target directed Ligands: Enhancing cholinesterase inhibition, NMDA receptor antagonism, and CNS bioavailability for Alzheimer's disease treatment.DOI 10.1039/D4MD00804ANovel multipotent conjugate bearing tacrine and donepezil motifs with dual cholinergic inhibition and neuroprotective properties targeting Alzheimer's disease.PMID 39531933Discovery of novel thiosemicarbazone-acridine targeting butyrylcholinesterase with antioxidant, metal complexing and neuroprotector abilities as potential treatment of Alzheimer's disease: In vitro, in vivo, and in silico studies.PMID 39731791Discovery of novel bicyclic and tricyclic cyclohepta[b]thiophene derivatives as multipotent AChE and BChE inhibitors, in-Vivo and in-Vitro assays, ADMET and molecular docking simulation.

Documentation & Compliance Facts

Compliance Facts

Shipment review: Required

Documentation available by request

Certificate of Analysis (COA): By request

Supplier Safety Data Sheet (SDS): By request

Purity and pack size confirmation: By request

Availability and lead time review: Confirmed by RFQ

Shipment documentation review: By request

For supplier-issued documentation by request, use the RFQ actions on this page.Review preliminary safety reference

What happens after RFQ

  1. 1We review the CAS identity, quantity, and documentation request.
  2. 2We check sourcing options, supplier availability, COA/SDS, purity, pack size, and lead time.
  3. 3We review destination and shipment documentation needs when applicable.
  4. 4We follow up with a quotation or clarification request.

Text Reference Cues

Show non-linked catalog cues

Non-public related references

1,2,3,4-Tetrahydro-9-acridinamine hydrochloride hydrate (1:?:?)CAS 7149-50-0
9-Chloro-1,2,3,4-tetrahydroacridineCAS 5396-30-5
1,2,3,4-tetrahydroacridin-9-ylazanium chlorideCAS 1684-40-8
VelnacrineCAS 124027-47-0
9-AminoacridineCAS 90-45-9

Non-public references are shown as text only and do not imply equivalence, availability, or shared use.

Catalog navigation

Related Catalog Entries

Other public CAS pages in this catalog. These links support navigation across additional intermediates and do not imply equivalence, availability, or shared use.

CAS 7149-50-01,2,3,4-Tetrahydro-9-acridinamine hydrochloride hydrate (1:?:?)CAS 5396-30-59-Chloro-1,2,3,4-tetrahydroacridineCAS 1684-40-81,2,3,4-tetrahydroacridin-9-ylazanium chlorideCAS 124027-47-0VelnacrineCAS 90-45-99-AminoacridineCAS 21829-25-4NifedipineCAS 23593-75-1ClotrimazoleCAS 520-36-5ApigeninCAS 169590-42-5CelecoxibCAS 1002310-00-0Tert-butyl 1-(2-chloro-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)ethylcarbamate

RFQ questions for CAS 321-64-2

What are the key identifiers for Tacrine (CAS 321-64-2)?

Tacrine is identified by CAS 321-64-2, with molecular formula C13H14N2, molecular weight 198.26, InChIKey YLJREFDVOIBQDA-UHFFFAOYSA-N.

Does CAS 321-64-2 have reported biological target evidence?

ChEMBL contains qualifying experimental assay evidence associated with Cholinesterase, Cholinesterase, Acetylcholinesterase, Acetylcholinesterase, Butyrylcholinesterase. These records do not establish therapeutic efficacy or clinical use.

Can I request a COA for CAS 321-64-2?

Yes. Submit an RFQ and specify COA requirements. Lot-specific COA depends on supplier confirmation.

Can I request supplier SDS for Tacrine?

Yes. Supplier SDS can be requested through the RFQ workflow before handling, storage, shipment, or procurement decisions.

Is CAS 321-64-2 available for quotation?

Availability, pack size, lead time, and pricing are confirmed through RFQ.

Can MolGraph support bulk sourcing or custom synthesis review?

Submit the CAS number, quantity, purity requirement, and destination country for sourcing review.