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Home/Compounds/CAS 327036-89-5
Formula C10H10N2O2SMW 222.27Research-use catalog entryCOA/SDS by request

Tdzd-8

CAS Number: 327036-89-5

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Loading RDKit molecule structure...
InChIKey: JDSJDASOXWCHPN-UHFFFAOYSA-NC10H10N2O2S | MW 222.27

Chemical Absolute Identifiers

CAS Number

327036-89-5

PubChem CID

4124851

Molecular Formula

C10H10N2O2S

Molecular Weight

222.27 g/mol

Exact Mass

222.046299

InChIKey

JDSJDASOXWCHPN-UHFFFAOYSA-N

IUPAC Name

4-benzyl-2-methyl-1,2,4-thiadiazolidine-3,5-dione

SMILES String

Cn1sc(=O)n(Cc2ccccc2)c1=O

Physical Properties

No physical property values available.

Properties are provided as catalog reference data and may be confirmed through supplier documentation when required.

Catalog Facts

Structural features

Tdzd-8 (CAS 327036-89-5) is listed in the Inhibitors and Agonists portfolio, with molecular formula C10H10N2O2S and molecular weight 222. 27 g/mol.

Sourcing context

Catalog reference for RFQ preparation, supplier confirmation, and research chemical sourcing review.

Research use context

Intended for biochemical and pharmacology research workflows; structure-derived tags include nitrogen-containing heterocycle.

Documentation needs

COA/SDS status, availability, lead time, pack size, and shipment documentation can be confirmed during quotation.

Applications & Classification

Bioactivity ScreeningResearch intermediateCustom synthesis building blockResearch chemical sourcingCustom synthesis and catalog availability reviewCOA, SDS, pricing, and fulfillment workflow
Biological target reference

ChEMBL reports experimental activity evidence for: Replicase polyprotein 1ab (Severe acute respiratory syndrome coronavirus 2) — 5 assays; Glycogen synthase kinase-3 beta (Homo sapiens) — 22 assays; Nuclear receptor ROR-gamma (Mus musculus) — 2 assays; Insulin receptor (Homo sapiens) — 5 assays; Tyrosine-protein kinase Lck (Homo sapiens) — 5 assays. These records describe research assays and do not establish therapeutic efficacy or clinical use.

Replicase polyprotein 1ab

Severe acute respiratory syndrome coronavirus 2 · SINGLE PROTEIN · 5 qualifying assays · 4 documents · best pChEMBL 6.85

Experimental evidence source: ChEMBL

Glycogen synthase kinase-3 beta

Homo sapiens · SINGLE PROTEIN · 22 qualifying assays · 14 documents · best pChEMBL 6.16

Experimental evidence source: ChEMBL

Nuclear receptor ROR-gamma

Mus musculus · SINGLE PROTEIN · 2 qualifying assays · 1 documents · best pChEMBL 5.5

Experimental evidence source: ChEMBL

Insulin receptor

Homo sapiens · SINGLE PROTEIN · 5 qualifying assays · 2 documents

Experimental evidence source: ChEMBL

Tyrosine-protein kinase Lck

Homo sapiens · SINGLE PROTEIN · 5 qualifying assays · 2 documents

Experimental evidence source: ChEMBL

Safety & Handling

Safety and handling reference content is available through documentation requests.

For supplier-issued SDS, request documentation before handling, storage, shipment, or procurement decisions.

Preliminary Safety Reference

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Safety Reference / SDS Request

Names & Synonyms / External Identifiers

Chemical Name

Tdzd-8

Names & Synonyms

GSK-3beta Inhibitor ITDZD 81,2,4-Thiadiazolidine-3,5-dione, 2-methyl-4-(phenylmethyl)-NP 011392-methyl-4-(phenylmethyl)-1,2,4-thiadiazolidine-3,5-dione
Show all synonyms
GSK-3b Inhibitor ITDZD8TDZD-8?4-Benzyl-2-methyl-[1,2,4]thiadiazolidine-3,5-dioneTDZD 8 - Bio-X trade markThiadiazolidinone (TDZD) deriv. 8s2926TDZD-8 (NP-01139)SDCCGSBI-0086752.P003TDZD-8, >=98% (HPLC), needlesB44364-?Benzyl-?2-?methyl-?1,?2,?4-?thiadiazolidine-?3,?5-?dioneU3W
External Identifiers
EC NUMBER: 636-505-3DSSTOX SUBSTANCE ID: DTXSID30399590CHEMBL ID: CHEMBL284861CHEBI ID: CHEBI:147411HMDB ID: HMDB0258758WIKIDATA ID: Q27077898thiadiazolidinone-8
Experimental Spectrum References
13C NMR Spectra
Literature & Patent References
DOI 10.1021/acs.jmedchem.5c00377Structure-Based Discovery Targeting GSK-3α Reveals Potent Nanomolar Selective 4-Phenyl-1&lt;i&gt;H&lt;/i&gt;-benzofuro[3,2-&lt;i&gt;b&lt;/i&gt;]pyrazolo[4,3-&lt;i&gt;e&lt;/i&gt;]pyridine Inhibitor with Promising Glioblastoma and CNS-Active Potential in Cellular Models.PMID 40198746Structure-Based Discovery Targeting GSK-3α Reveals Potent Nanomolar Selective 4-Phenyl-1&lt;i&gt;H&lt;/i&gt;-benzofuro[3,2-&lt;i&gt;b&lt;/i&gt;]pyrazolo[4,3-&lt;i&gt;e&lt;/i&gt;]pyridine Inhibitor with Promising Glioblastoma and CNS-Active Potential in Cellular Models.DOI 10.1016/j.ejmech.2023.115491The research progress of SARS-CoV-2 main protease inhibitors from 2020 to 2022.DOI 10.1016/j.ejmech.2023.115718Small molecule inhibitors of NLRP3 inflammasome and GSK-3β in the management of traumatic brain injury: A review.PMID 37244162The research progress of SARS-CoV-2 main protease inhibitors from 2020 to 2022.PMID 37573828Small molecule inhibitors of NLRP3 inflammasome and GSK-3β in the management of traumatic brain injury: A review.DOI 10.1016/j.ejmech.2022.114301Development of inhibitors targeting glycogen synthase kinase-3β for human diseases: Strategies to improve selectivity.DOI 10.1021/acs.jmedchem.1c02102Structure-Guided Discovery of the Novel Covalent Allosteric Site and Covalent Inhibitors of Fructose-1,6-Bisphosphate Aldolase to Overcome the Azole Resistance of <i>Candidiasis</i>.

Documentation & Compliance Facts

Compliance Facts

Shipment review: Required

Documentation available by request

Certificate of Analysis (COA): By request

Supplier Safety Data Sheet (SDS): By request

Purity and pack size confirmation: By request

Availability and lead time review: Confirmed by RFQ

Shipment documentation review: By request

For supplier-issued documentation by request, use the RFQ actions on this page.Review preliminary safety reference

What happens after RFQ

  1. 1We review the CAS identity, quantity, and documentation request.
  2. 2We check sourcing options, supplier availability, COA/SDS, purity, pack size, and lead time.
  3. 3We review destination and shipment documentation needs when applicable.
  4. 4We follow up with a quotation or clarification request.

Text Reference Cues

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Non-public related references

Alagebrium ChlorideCAS 341028-37-3

Non-public references are shown as text only and do not imply equivalence, availability, or shared use.

Catalog navigation

Related Catalog Entries

Other public CAS pages in this catalog. These links support navigation across additional intermediates and do not imply equivalence, availability, or shared use.

CAS 120685-11-2MidostaurinCAS 146535-11-76,7-Dimethoxy-3-phenylquinoxalineCAS 189232-42-6BohemineCAS 118-75-2ChloranilCAS 120-78-5Accelerator DMCAS 1002310-00-0Tert-butyl 1-(2-chloro-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)ethylcarbamateCAS 1005174-17-3(E)-3-(2-Propyl-6-(trifluoromethyl)pyridin-3-yl)acrylic acidCAS 1018125-49-92-(3-Cyclopropyl-6-ethyl-4-(trifluoromethyl)-1H-pyrazolo[3,4-b]pyridin-1-yl)acetic acidCAS 1018128-07-8Isopropyl 4-chloro-2-methylquinoline-6-carboxylateCAS 1018142-22-76-cyclopropyl-1-(2,2-difluoroethyl)-3-methyl-1H-pyrazolo[3,4-b]pyridine-4-carboxylic acid

RFQ questions for CAS 327036-89-5

What are the key identifiers for Tdzd-8 (CAS 327036-89-5)?

Tdzd-8 is identified by CAS 327036-89-5, with molecular formula C10H10N2O2S, molecular weight 222.27, InChIKey JDSJDASOXWCHPN-UHFFFAOYSA-N.

Does CAS 327036-89-5 have reported biological target evidence?

ChEMBL contains qualifying experimental assay evidence associated with Replicase polyprotein 1ab, Glycogen synthase kinase-3 beta, Nuclear receptor ROR-gamma, Insulin receptor, Tyrosine-protein kinase Lck. These records do not establish therapeutic efficacy or clinical use.

Can I request a COA for CAS 327036-89-5?

Yes. Submit an RFQ and specify COA requirements. Lot-specific COA depends on supplier confirmation.

Can I request supplier SDS for Tdzd-8?

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Is CAS 327036-89-5 available for quotation?

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