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Home/Compounds/CAS 34783-48-7
Formula C9H10N2O2MW 178.19Research-use catalog entryCOA/SDS by request

PF-04859989

CAS Number: 34783-48-7

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Loading RDKit molecule structure...
InChIKey: HYTRYTZFJVVZAF-ZETCQYMHSA-NC9H10N2O2 | MW 178.19

Chemical Absolute Identifiers

CAS Number

34783-48-7

PubChem CID

22868923

Molecular Formula

C9H10N2O2

Molecular Weight

178.19 g/mol

Exact Mass

178.074228

InChIKey

HYTRYTZFJVVZAF-ZETCQYMHSA-N

IUPAC Name

(3S)-3-amino-1-hydroxy-3,4-dihydroquinolin-2-one

SMILES String

N[C@H]1Cc2ccccc2N(O)C1=O

Physical Properties

No physical property values available.

Properties are provided as catalog reference data and may be confirmed through supplier documentation when required.

Catalog Facts

Structural features

PF-04859989 (CAS 34783-48-7) is listed in the Advanced Chemicals portfolio, with molecular formula C9H10N2O2 and molecular weight 178. 19 g/mol.

Sourcing context

Catalog reference for RFQ preparation, supplier confirmation, and research chemical sourcing review.

Research use context

Intended for research building-block and synthetic chemistry workflows; structure-derived tags include nitrogen-containing heterocycle.

Documentation needs

COA/SDS status, availability, lead time, pack size, and shipment documentation can be confirmed during quotation.

Applications & Classification

Organic Building BlocksSynthetic ChemistryResearch intermediateCustom synthesis building blockResearch chemical sourcingCustom synthesis and catalog availability reviewCOA, SDS, pricing, and fulfillment workflow
Biological target reference

ChEMBL reports experimental activity evidence for: Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial (Homo sapiens) — 10 assays; Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial (Rattus norvegicus) — 2 assays; Kynurenine--oxoglutarate transaminase 3 (Homo sapiens) — 2 assays; Kynurenine--oxoglutarate transaminase 1 (Homo sapiens) — 2 assays. These records describe research assays and do not establish therapeutic efficacy or clinical use.

Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial

Homo sapiens · SINGLE PROTEIN · 10 qualifying assays · 5 documents · best pChEMBL 7.85

Experimental evidence source: ChEMBL

Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial

Rattus norvegicus · SINGLE PROTEIN · 2 qualifying assays · 1 documents · best pChEMBL 6.58

Experimental evidence source: ChEMBL

Kynurenine--oxoglutarate transaminase 3

Homo sapiens · SINGLE PROTEIN · 2 qualifying assays · 2 documents · best pChEMBL 5.04

Experimental evidence source: ChEMBL

Kynurenine--oxoglutarate transaminase 1

Homo sapiens · SINGLE PROTEIN · 2 qualifying assays · 2 documents · best pChEMBL 4.66

Experimental evidence source: ChEMBL

Safety & Handling

Safety and handling reference content is available through documentation requests.

For supplier-issued SDS, request documentation before handling, storage, shipment, or procurement decisions.

Preliminary Safety Reference

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Safety Reference / SDS Request

Names & Synonyms / External Identifiers

Chemical Name

PF-04859989

Names & Synonyms

(3S)-3-amino-1-hydroxy-1,2,3,4-tetrahydroquinolin-2-one(S)-3-Amino-1-hydroxy-3,4-dihydroquinolin-2(1H)-onePF 04859989compound 1 [PMID: 23466229]L-3-Amino-3,4-dihydro-1-hydroxycarbstyril
Show all synonyms
(3s)-3-amino-1-hydroxy-3,4-dihydroquinolin-2(1h)-one(3S)-3-Amino-3,4-dihydro-1-hydroxy-2(1H)-quinolinone
External Identifiers
EC NUMBER: 808-880-5DSSTOX SUBSTANCE ID: DTXSID501356976CHEMBL ID: CHEMBL2047851WIKIDATA ID: Q27088318
Literature & Patent References
DOI 10.1016/j.ejmech.2023.115258Therapeutic potential of targeting kynurenine pathway in neurodegenerative diseases.PMID 36917881Therapeutic potential of targeting kynurenine pathway in neurodegenerative diseases.DOI 10.6019/CHEMBL4495564Identification of inhibitors of SARS-Cov2 M-Pro enzymatic activity using a small molecule repurposing screenDOI 10.6019/CHEMBL4495565Cytopathic SARS-Cov2 screening on VERO-E6 cells in a large repurposing effortDOI 10.1016/j.bmcl.2013.02.039PF-04859989 as a template for structure-based drug design: identification of new pyrazole series of irreversible KAT II inhibitors with improved lipophilic efficiency.DOI 10.1021/ml300237vStructure-Based Design of Irreversible Human KAT II Inhibitors: Discovery of New Potency-Enhancing Interactions.DOI 10.1039/C2MD20166FDiscovery of hydroxamate bioisosteres as KAT II inhibitors with improved oral bioavailability and pharmacokineticsPMID 23466229PF-04859989 as a template for structure-based drug design: identification of new pyrazole series of irreversible KAT II inhibitors with improved lipophilic efficiency.

Documentation & Compliance Facts

Compliance Facts

Shipment review: Required

Documentation available by request

Certificate of Analysis (COA): By request

Supplier Safety Data Sheet (SDS): By request

Purity and pack size confirmation: By request

Availability and lead time review: Confirmed by RFQ

Shipment documentation review: By request

For supplier-issued documentation by request, use the RFQ actions on this page.Review preliminary safety reference

What happens after RFQ

  1. 1We review the CAS identity, quantity, and documentation request.
  2. 2We check sourcing options, supplier availability, COA/SDS, purity, pack size, and lead time.
  3. 3We review destination and shipment documentation needs when applicable.
  4. 4We follow up with a quotation or clarification request.

Text Reference Cues

Show non-linked catalog cues

Non-public related references

(S)-3-Amino-1-hydroxy-3,4-dihydroquinolin-2(1H)-one hydrochlorideCAS 177943-33-8
1-Hydroxy-3-amino-2-pyrrolidoneCAS 1003-51-6
N-Hydroxymaleimide adduct of furanCAS 5596-17-8
N-HydroxynaphthalimideCAS 7797-81-1
6-Hydroxy-5H-pyrrolo[3,4-b]pyridine-5,7(6H)-dioneCAS 23439-87-4

Non-public references are shown as text only and do not imply equivalence, availability, or shared use.

Catalog navigation

Related Catalog Entries

Other public CAS pages in this catalog. These links support navigation across additional intermediates and do not imply equivalence, availability, or shared use.

CAS 177943-33-8(S)-3-Amino-1-hydroxy-3,4-dihydroquinolin-2(1H)-one hydrochlorideCAS 1002310-00-0Tert-butyl 1-(2-chloro-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)ethylcarbamateCAS 1005174-17-3(E)-3-(2-Propyl-6-(trifluoromethyl)pyridin-3-yl)acrylic acidCAS 1018125-49-92-(3-Cyclopropyl-6-ethyl-4-(trifluoromethyl)-1H-pyrazolo[3,4-b]pyridin-1-yl)acetic acidCAS 1018128-07-8Isopropyl 4-chloro-2-methylquinoline-6-carboxylateCAS 1018142-22-76-cyclopropyl-1-(2,2-difluoroethyl)-3-methyl-1H-pyrazolo[3,4-b]pyridine-4-carboxylic acidCAS 1018144-00-72-(3-Cyclopropyl-6-isopropyl-4-(trifluoromethyl)-1H-pyrazolo[3,4-b]pyridin-1-yl)acetic acid

RFQ questions for CAS 34783-48-7

What are the key identifiers for PF-04859989 (CAS 34783-48-7)?

PF-04859989 is identified by CAS 34783-48-7, with molecular formula C9H10N2O2, molecular weight 178.19, InChIKey HYTRYTZFJVVZAF-ZETCQYMHSA-N.

Does CAS 34783-48-7 have reported biological target evidence?

ChEMBL contains qualifying experimental assay evidence associated with Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial, Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial, Kynurenine--oxoglutarate transaminase 3, Kynurenine--oxoglutarate transaminase 1. These records do not establish therapeutic efficacy or clinical use.

Can I request a COA for CAS 34783-48-7?

Yes. Submit an RFQ and specify COA requirements. Lot-specific COA depends on supplier confirmation.

Can I request supplier SDS for PF-04859989?

Yes. Supplier SDS can be requested through the RFQ workflow before handling, storage, shipment, or procurement decisions.

Is CAS 34783-48-7 available for quotation?

Availability, pack size, lead time, and pricing are confirmed through RFQ.

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