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Home/Compounds/CAS 4008-48-4
Formula C9H6N2O3MW 190.16Research-use catalog entryCOA/SDS by request

Nitroxoline

CAS Number: 4008-48-4

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Loading RDKit molecule structure...
InChIKey: RJIWZDNTCBHXAL-UHFFFAOYSA-NC9H6N2O3 | MW 190.16

Chemical Absolute Identifiers

CAS Number

4008-48-4

PubChem CID

19910

Molecular Formula

C9H6N2O3

Molecular Weight

190.16 g/mol

Exact Mass

190.037842

InChIKey

RJIWZDNTCBHXAL-UHFFFAOYSA-N

IUPAC Name

5-nitroquinolin-8-ol

SMILES String

C1=CC2=C(C=CC(=C2N=C1)O)[N+](=O)[O-]

Physical Properties

Melting Point

18.0 °C

Properties are provided as catalog reference data and may be confirmed through supplier documentation when required.

Catalog Facts

Structural features

Nitroxoline (CAS 4008-48-4) is listed in the Pharmaceutical Intermediates portfolio, with molecular formula C9H6N2O3 and molecular weight 190. 16 g/mol.

Sourcing context

Catalog reference for RFQ preparation, supplier confirmation, and research chemical sourcing review.

Research use context

Intended for research-stage medicinal chemistry and intermediate synthesis workflows; structure-derived tags include nitrogen-containing heterocycle.

Documentation needs

COA/SDS status, availability, lead time, pack size, and shipment documentation can be confirmed during quotation.

Applications & Classification

Pharmaceutical Intermediate ResearchResearch intermediateCustom synthesis building blockPharmaceutical intermediate researchResearch chemical sourcingCustom synthesis and catalog availability reviewCOA, SDS, pricing, and fulfillment workflow
Biological target reference

ChEMBL reports experimental activity evidence for: Methionine aminopeptidase 2 (Homo sapiens) — 2 assays; Nuclear receptor ROR-gamma (Mus musculus) — 2 assays; Tyrosyl-DNA phosphodiesterase 1 (Homo sapiens) — 3 assays; Bromodomain-containing protein 4 (Homo sapiens) — 4 assays; Prostaglandin G/H synthase 2 (Homo sapiens) — 2 assays. These records describe research assays and do not establish therapeutic efficacy or clinical use.

Methionine aminopeptidase 2

Homo sapiens · SINGLE PROTEIN · 2 qualifying assays · 2 documents · best pChEMBL 7.26

Experimental evidence source: ChEMBL

Nuclear receptor ROR-gamma

Mus musculus · SINGLE PROTEIN · 2 qualifying assays · 1 documents · best pChEMBL 6.55

Experimental evidence source: ChEMBL

Tyrosyl-DNA phosphodiesterase 1

Homo sapiens · SINGLE PROTEIN · 3 qualifying assays · 1 documents · best pChEMBL 6.4

Experimental evidence source: ChEMBL

Bromodomain-containing protein 4

Homo sapiens · SINGLE PROTEIN · 4 qualifying assays · 2 documents · best pChEMBL 6.01

Experimental evidence source: ChEMBL

Prostaglandin G/H synthase 2

Homo sapiens · SINGLE PROTEIN · 2 qualifying assays · 1 documents · best pChEMBL 6

Experimental evidence source: ChEMBL

Safety & Handling

Handling & Storage

  • Keep container tightly closed and dry.
  • Store in a well-ventilated place.

PPE

Respiratory protection if needed

First Aid

  • Do not give anything to an unconscious person.
  • Rinse mouth with water.

Stability / Reactivity

  • Reactivity.
  • Carbon monoxide, carbon dioxide, nitrogen oxides.

Disposal

  • Waste product.
  • Dispose of remaining and non-recyclable solutions to a licensed company.
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Fire Fighting

  • If necessary, wear a self-contained breathing apparatus for firefighting.

Accidental Release

  • Do not generate dust when collecting and disposing.
  • Sweep and shovel up.

For supplier-issued SDS, request documentation before handling, storage, shipment, or procurement decisions.

Preliminary Safety Reference

For supplier-issued SDS or COA, submit a documentation request.

Safety Reference / SDS Request

Names & Synonyms / External Identifiers

Chemical Name

Nitroxoline

Names & Synonyms

8-Hydroxy-5-nitroquinoline5-Nitro-8-quinolinol5-Nitro-8-hydroxyquinoline5-Nitrox5-NOK
Show all synonyms
5-Nitro-8-oxyquinolineNitroxolina5NOKNitroxolinumNiceneNitroxolinNoxibiolNibiolNoxin8-Quinolinol, 5-nitro-5-Nitroxine5-Nitroks5-Nitro-8-oxychinolineNitroxolinum [INN-Latin]
External Identifiers
EC NUMBER: 223-662-4DSSTOX SUBSTANCE ID: DTXSID4046284CHEMBL ID: CHEMBL1454910CHEBI ID: CHEBI:67121UNII: A8M33244M6DRUGBANK ID: DB01422HMDB ID: HMDB0015491KEGG ID: D07245METABOLOMICS WORKBENCH ID: 43551NCI THESAURUS CODE: C72634PHARMGKB ID: PA164754993WIKIDATA ID: Q304570
Experimental Spectrum References
13C NMR Spectra1D NMR Spectra1H NMR SpectraATR-IR Spectra — Forensic Spectral ResearchFTIR SpectraRaman Spectra — Bio-Rad LaboratoriesVapor Phase IR Spectra
Literature & Patent References
DOI 10.1016/j.ejmech.2024.116158Novel small molecule inhibitors targeting renal cell carcinoma: Status, challenges, future directions.PMID 38278080Novel small molecule inhibitors targeting renal cell carcinoma: Status, challenges, future directions.DOI 10.1038/s41467-023-40064-9A preclinical secondary pharmacology resource illuminates target-adverse drug reaction associations of marketed drugs.DOI 10.6019/EOS300108ECBD screening data for assay EOS300108PMID 37468498A preclinical secondary pharmacology resource illuminates target-adverse drug reaction associations of marketed drugs.DOI 10.1016/j.ejmech.2021.113975Nitroxoline and its derivatives are potent inhibitors of metallo-β-lactamases.DOI 10.1016/j.ejmech.2021.114053A review on the treatment of multiple myeloma with small molecular agents in the past five years.DOI 10.1016/j.ejmech.2022.114550Membrane acting Povarov-Doebner derived compounds potently disperse preformed multidrug resistant Gram-positive bacterial biofilms.

Documentation & Compliance Facts

Compliance Facts

Shipment review: Required

Documentation available by request

Certificate of Analysis (COA): By request

Supplier Safety Data Sheet (SDS): By request

Purity and pack size confirmation: By request

Availability and lead time review: Confirmed by RFQ

Shipment documentation review: By request

For supplier-issued documentation by request, use the RFQ actions on this page.Review preliminary safety reference

What happens after RFQ

  1. 1We review the CAS identity, quantity, and documentation request.
  2. 2We check sourcing options, supplier availability, COA/SDS, purity, pack size, and lead time.
  3. 3We review destination and shipment documentation needs when applicable.
  4. 4We follow up with a quotation or clarification request.

Text Reference Cues

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Non-public related references

5-Chloro-8-hydroxyquinolineCAS 130-16-5
ChloroxineCAS 773-76-2
TizoxanideCAS 173903-47-4
OrnidazoleCAS 16773-42-5
TinidazoleCAS 19387-91-8

Non-public references are shown as text only and do not imply equivalence, availability, or shared use.

Catalog navigation

Related Catalog Entries

Other public CAS pages in this catalog. These links support navigation across additional intermediates and do not imply equivalence, availability, or shared use.

CAS 130-16-55-Chloro-8-hydroxyquinolineCAS 21829-25-4NifedipineCAS 100643-71-8DesloratadineCAS 181695-72-7ValdecoxibCAS 169590-42-5CelecoxibCAS 112574-44-4NitrofurazoneCAS 1002310-00-0Tert-butyl 1-(2-chloro-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)ethylcarbamateCAS 1005174-17-3(E)-3-(2-Propyl-6-(trifluoromethyl)pyridin-3-yl)acrylic acidCAS 1018125-49-92-(3-Cyclopropyl-6-ethyl-4-(trifluoromethyl)-1H-pyrazolo[3,4-b]pyridin-1-yl)acetic acidCAS 1018128-07-8Isopropyl 4-chloro-2-methylquinoline-6-carboxylate

RFQ questions for CAS 4008-48-4

What are the key identifiers for Nitroxoline (CAS 4008-48-4)?

Nitroxoline is identified by CAS 4008-48-4, with molecular formula C9H6N2O3, molecular weight 190.16, InChIKey RJIWZDNTCBHXAL-UHFFFAOYSA-N.

Does CAS 4008-48-4 have reported biological target evidence?

ChEMBL contains qualifying experimental assay evidence associated with Methionine aminopeptidase 2, Nuclear receptor ROR-gamma, Tyrosyl-DNA phosphodiesterase 1, Bromodomain-containing protein 4, Prostaglandin G/H synthase 2. These records do not establish therapeutic efficacy or clinical use.

Can I request a COA for CAS 4008-48-4?

Yes. Submit an RFQ and specify COA requirements. Lot-specific COA depends on supplier confirmation.

Can I request supplier SDS for Nitroxoline?

Yes. Supplier SDS can be requested through the RFQ workflow before handling, storage, shipment, or procurement decisions.

Is CAS 4008-48-4 available for quotation?

Availability, pack size, lead time, and pricing are confirmed through RFQ.

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