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- Purity
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CAS Number: 443913-73-3
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CAS Number
443913-73-3
PubChem CID
3081361
Molecular Formula
C22H24BrFN4O2
Molecular Weight
475.4 g/mol
Exact Mass
474.10667
InChIKey
UHTHHESEBZOYNR-UHFFFAOYSA-N
IUPAC Name
N-(4-bromo-2-fluorophenyl)-6-methoxy-7-[(1-methylpiperidin-4-yl)methoxy]quinazolin-4-amine
SMILES String
COc1cc2c(Nc3ccc(Br)cc3F)ncnc2cc1OCC1CCN(C)CC1
No physical property values available.
Properties are provided as catalog reference data and may be confirmed through supplier documentation when required.
Structural features
Vandetanib (CAS 443913-73-3) is listed in the Pharmaceutical Intermediates portfolio, with molecular formula C22H24BrFN4O2 and molecular weight 475. 40 g/mol.
Sourcing context
Catalog reference for RFQ preparation, supplier confirmation, and research chemical sourcing review.
Research use context
Intended for research-stage medicinal chemistry and intermediate synthesis workflows; structure-derived tags include nitrogen-containing heterocycle.
Documentation needs
COA/SDS status, availability, lead time, pack size, and shipment documentation can be confirmed during quotation.
ChEMBL reports experimental activity evidence for: Vascular endothelial growth factor receptor 3 (Homo sapiens) — 5 assays; Proto-oncogene tyrosine-protein kinase receptor Ret (Homo sapiens) — 39 assays; Proto-oncogene tyrosine-protein kinase Src (Homo sapiens) — 7 assays; Vascular endothelial growth factor receptor 2 (Homo sapiens) — 58 assays; Receptor-interacting serine/threonine-protein kinase 2 (Homo sapiens) — 4 assays. These records describe research assays and do not establish therapeutic efficacy or clinical use.
Vascular endothelial growth factor receptor 3
Homo sapiens · SINGLE PROTEIN · 5 qualifying assays · 5 documents · best pChEMBL 9.96
Experimental evidence source: ChEMBL
Proto-oncogene tyrosine-protein kinase receptor Ret
Homo sapiens · SINGLE PROTEIN · 39 qualifying assays · 20 documents · best pChEMBL 9.89
Experimental evidence source: ChEMBL
Proto-oncogene tyrosine-protein kinase Src
Homo sapiens · SINGLE PROTEIN · 7 qualifying assays · 7 documents · best pChEMBL 9.1
Experimental evidence source: ChEMBL
Vascular endothelial growth factor receptor 2
Homo sapiens · SINGLE PROTEIN · 58 qualifying assays · 43 documents · best pChEMBL 8.4
Experimental evidence source: ChEMBL
Receptor-interacting serine/threonine-protein kinase 2
Homo sapiens · SINGLE PROTEIN · 4 qualifying assays · 4 documents · best pChEMBL 8.34
Experimental evidence source: ChEMBL
Safety and handling reference content is available through documentation requests.
For supplier-issued SDS, request documentation before handling, storage, shipment, or procurement decisions.
Preliminary Safety Reference
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Safety Reference / SDS RequestCatalog navigation
Other public CAS pages in this catalog. These links support navigation across additional intermediates and do not imply equivalence, availability, or shared use.
Vandetanib is identified by CAS 443913-73-3, with molecular formula C22H24BrFN4O2, molecular weight 475.4, InChIKey UHTHHESEBZOYNR-UHFFFAOYSA-N.
ChEMBL contains qualifying experimental assay evidence associated with Vascular endothelial growth factor receptor 3, Proto-oncogene tyrosine-protein kinase receptor Ret, Proto-oncogene tyrosine-protein kinase Src, Vascular endothelial growth factor receptor 2, Receptor-interacting serine/threonine-protein kinase 2. These records do not establish therapeutic efficacy or clinical use.
Yes. Submit an RFQ and specify COA requirements. Lot-specific COA depends on supplier confirmation.
Yes. Supplier SDS can be requested through the RFQ workflow before handling, storage, shipment, or procurement decisions.
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