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CAS Number: 475108-18-0
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CAS Number
475108-18-0
PubChem CID
9911830
Molecular Formula
C22H19ClN4O5
Molecular Weight
454.9 g/mol
Exact Mass
454.104397
InChIKey
SPMVMDHWKHCIDT-UHFFFAOYSA-N
IUPAC Name
1-[2-chloro-4-(6,7-dimethoxyquinolin-4-yl)oxyphenyl]-3-(5-methyl-1,2-oxazol-3-yl)urea
SMILES String
COc1cc2nccc(Oc3ccc(NC(=O)Nc4cc(C)on4)c(Cl)c3)c2cc1OC
Water Solubility
1 mol/L
pKa
11.74
Properties are provided as catalog reference data and may be confirmed through supplier documentation when required.
Structural features
Tivozanib (CAS 475108-18-0) is listed in the Pharmaceutical Intermediates portfolio, with molecular formula C22H19ClN4O5 and molecular weight 454. 90 g/mol.
Sourcing context
Catalog reference for RFQ preparation, supplier confirmation, and research chemical sourcing review.
Research use context
Intended for research-stage medicinal chemistry and intermediate synthesis workflows; structure-derived tags include nitrogen-containing heterocycle.
Documentation needs
COA/SDS status, availability, lead time, pack size, and shipment documentation can be confirmed during quotation.
ChEMBL reports experimental activity evidence for: Mitogen-activated protein kinase 3 (Homo sapiens) — 4 assays; Vascular endothelial growth factor receptor 2 (Homo sapiens) — 10 assays; Mitogen-activated protein kinase 1 (Homo sapiens) — 4 assays; Vascular endothelial growth factor receptor 1 (Homo sapiens) — 5 assays; Vascular endothelial growth factor receptor 3 (Homo sapiens) — 6 assays. These records describe research assays and do not establish therapeutic efficacy or clinical use.
Mitogen-activated protein kinase 3
Homo sapiens · SINGLE PROTEIN · 4 qualifying assays · 3 documents · best pChEMBL 9.89
Experimental evidence source: ChEMBL
Vascular endothelial growth factor receptor 2
Homo sapiens · SINGLE PROTEIN · 10 qualifying assays · 8 documents · best pChEMBL 9.8
Experimental evidence source: ChEMBL
Mitogen-activated protein kinase 1
Homo sapiens · SINGLE PROTEIN · 4 qualifying assays · 3 documents · best pChEMBL 9.74
Experimental evidence source: ChEMBL
Vascular endothelial growth factor receptor 1
Homo sapiens · SINGLE PROTEIN · 5 qualifying assays · 4 documents · best pChEMBL 9.68
Experimental evidence source: ChEMBL
Vascular endothelial growth factor receptor 3
Homo sapiens · SINGLE PROTEIN · 6 qualifying assays · 4 documents · best pChEMBL 9.62
Experimental evidence source: ChEMBL
Safety and handling reference content is available through documentation requests.
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Preliminary Safety Reference
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Safety Reference / SDS RequestCatalog navigation
Other public CAS pages in this catalog. These links support navigation across additional intermediates and do not imply equivalence, availability, or shared use.
Tivozanib is identified by CAS 475108-18-0, with molecular formula C22H19ClN4O5, molecular weight 454.9, InChIKey SPMVMDHWKHCIDT-UHFFFAOYSA-N.
ChEMBL contains qualifying experimental assay evidence associated with Mitogen-activated protein kinase 3, Vascular endothelial growth factor receptor 2, Mitogen-activated protein kinase 1, Vascular endothelial growth factor receptor 1, Vascular endothelial growth factor receptor 3. These records do not establish therapeutic efficacy or clinical use.
Yes. Submit an RFQ and specify COA requirements. Lot-specific COA depends on supplier confirmation.
Yes. Supplier SDS can be requested through the RFQ workflow before handling, storage, shipment, or procurement decisions.
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