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Home/Compounds/CAS 475207-59-1
Formula C28H24ClF3N4O6SMW 637Research-use catalog entryCOA/SDS by request

Sorafenib Tosylate

CAS Number: 475207-59-1

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Loading RDKit molecule structure...
InChIKey: IVDHYUQIDRJSTI-UHFFFAOYSA-NC28H24ClF3N4O6S | MW 637

Chemical Absolute Identifiers

CAS Number

475207-59-1

PubChem CID

406563

Molecular Formula

C28H24ClF3N4O6S

Molecular Weight

637 g/mol

Exact Mass

636.105718

InChIKey

IVDHYUQIDRJSTI-UHFFFAOYSA-N

IUPAC Name

4-[4-[[4-chloro-3-(trifluoromethyl)phenyl]carbamoylamino]phenoxy]-N-methylpyridine-2-carboxamide;4-methylbenzenesulfonic acid

SMILES String

CC1=CC=C(C=C1)S(=O)(=O)O.CNC(=O)C1=NC=CC(=C1)OC2=CC=C(C=C2)NC(=O)NC3=CC(=C(C=C3)Cl)C(F)(F)F

Physical Properties

No physical property values available.

Properties are provided as catalog reference data and may be confirmed through supplier documentation when required.

Catalog Facts

Structural features

Sorafenib Tosylate (CAS 475207-59-1) is listed in the Advanced Chemicals portfolio, with molecular formula C28H24ClF3N4O6S and molecular weight 637. 00 g/mol.

Sourcing context

Catalog reference for RFQ preparation, supplier confirmation, and research chemical sourcing review.

Research use context

Intended for research building-block and synthetic chemistry workflows; structure-derived tags include nitrogen-containing heterocycle.

Documentation needs

COA/SDS status, availability, lead time, pack size, and shipment documentation can be confirmed during quotation.

Applications & Classification

Organic Building BlocksSynthetic ChemistryResearch intermediateCustom synthesis building blockResearch chemical sourcingCustom synthesis and catalog availability reviewCOA, SDS, pricing, and fulfillment workflow
Biological target reference

ChEMBL reports experimental activity evidence for: Vascular endothelial growth factor receptor 2 (Homo sapiens) — 3 assays; Serine/threonine-protein kinase mTOR (Homo sapiens) — 2 assays; Tyrosyl-DNA phosphodiesterase 1 (Homo sapiens) — 2 assays. These records describe research assays and do not establish therapeutic efficacy or clinical use.

Vascular endothelial growth factor receptor 2

Homo sapiens · SINGLE PROTEIN · 3 qualifying assays · 3 documents · best pChEMBL 8.07

Experimental evidence source: ChEMBL

Serine/threonine-protein kinase mTOR

Homo sapiens · SINGLE PROTEIN · 2 qualifying assays · 1 documents

Experimental evidence source: ChEMBL

Tyrosyl-DNA phosphodiesterase 1

Homo sapiens · SINGLE PROTEIN · 2 qualifying assays · 1 documents

Experimental evidence source: ChEMBL

Safety & Handling

Safety and handling reference content is available through documentation requests.

For supplier-issued SDS, request documentation before handling, storage, shipment, or procurement decisions.

Preliminary Safety Reference

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Safety Reference / SDS Request

Names & Synonyms / External Identifiers

Chemical Name

Sorafenib Tosylate

Names & Synonyms

NexavarSorafenib tosilateBAY 54-9085BAY 43-9006 tosylate1-(4-Chloro-3-(trifluoromethyl)phenyl)-3-(4-((2-(methylcarbamoyl)pyridin-4-yl)oxy)phenyl)urea mono(4-methylbenzenesulfonate)
Show all synonyms
4-(4-(((4-CHLORO-3-(TRIFLUOROMETHYL)PHENYL)CARBAMOYL)AMINO)PHENOXY)-N-METHYLPYRIDINE-2-CARBOXAMIDE 4-METHYLBENZENESULFONATE1-[4-Chloro-3-(trifluoromethyl)phenyl]-3-[4-[[2-(methylcarbamoyl)pyridin-4-yl]oxy]phenyl]urea mono(4-methylbenzenesulfonate)4-[4-({[4-chloro-3-(trifluoromethyl)phenyl]carbamoyl}amino)phenoxy]-N-methylpyridine-2-carboxamide 4-methylbenzenesulfonate4-(4-(3-(4-Chloro-3-trifluoromethylphenyl)ureido)phenoxy)pyridine-2-carboxyllic Acid Methyamide-4-methylbenzenesulfonate Tosylate4-(4-(3-(4-Chloro-3-trifluoromethylphenyl)ureido)phenoxy)pyridine-2-carboxylic acid methyamide-4-methylbenzenesulfonateSorafenib tosylate [USAN]4-(4-(3-(4-Chloro-3-(trifluoromethyl)phenyl)ureido)phenoxy)-N2-methylpyridine-2-carboxamide mono (4-methylbenzenesulfonate)Sorafenib (Tosylate)Sorafenib Hemitosylates1040Sorafenib tosilate (JAN)Sorafenib (Nexavar)Sorafenib tosylate (USAN)Nexavar(R)4-(4-(3-(4-chloro-3-(trifluoromethyl)phenyl)ureido)phenoxy)-N-methylpicolinamide 4-methylbenzenesulfonate
External Identifiers
EC NUMBER: 641-758-8DSSTOX SUBSTANCE ID: DTXSID9047839CHEMBL ID: CHEMBL1200485CHEBI ID: CHEBI:50928UNII: 5T62Q3B36JKEGG ID: D06272NCI THESAURUS CODE: C2194RXCUI: 597744
Literature & Patent References
DOI 10.1016/j.bmc.2023.117561Discovery of pyrazolo[3,4-d]pyrimidines as novel mitogen-activated protein kinase kinase 3 (MKK3) inhibitors.PMID 38157838Discovery of pyrazolo[3,4-d]pyrimidines as novel mitogen-activated protein kinase kinase 3 (MKK3) inhibitors.DOI 10.1016/j.ejmech.2020.112851Discovery of VEGFR-2 inhibitors exerting significant anticancer activity against CD44+ and CD133+ cancer stem cells (CSCs): Reversal of TGF-β induced epithelial-mesenchymal transition (EMT) in hepatocellular carcinoma.DOI 10.21203/rs.3.rs-23951/v1Identification of inhibitors of SARS-CoV-2 in-vitro cellular toxicity in human (Caco-2) cells using a large scale drug repurposing collectionDOI 10.6019/CHEMBL4495564Identification of inhibitors of SARS-Cov2 M-Pro enzymatic activity using a small molecule repurposing screenDOI 10.6019/CHEMBL4495565Cytopathic SARS-Cov2 screening on VERO-E6 cells in a large repurposing effortPMID 33002846Discovery of VEGFR-2 inhibitors exerting significant anticancer activity against CD44+ and CD133+ cancer stem cells (CSCs): Reversal of TGF-β induced epithelial-mesenchymal transition (EMT) in hepatocellular carcinoma.DOI 10.1021/acs.jmedchem.7b01465Design, Synthesis, and Preclinical Evaluation of Fused Pyrimidine-Based Hydroxamates for the Treatment of Hepatocellular Carcinoma.

Documentation & Compliance Facts

Compliance Facts

Shipment review: Required

Documentation available by request

Certificate of Analysis (COA): By request

Supplier Safety Data Sheet (SDS): By request

Purity and pack size confirmation: By request

Availability and lead time review: Confirmed by RFQ

Shipment documentation review: By request

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  1. 1We review the CAS identity, quantity, and documentation request.
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  3. 3We review destination and shipment documentation needs when applicable.
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Text Reference Cues

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Non-public related references

(1R,2S)-2-fluorocyclopropan-1-amine;4-methylbenzenesulfonic acidCAS 143062-84-4
LY-2584702 (tosylate salt)CAS 1082949-68-5
Ethyl 2-amino-2-cyanoacetate 4-methylbenzenesulfonateCAS 37842-58-3
(S)-2-Hydroxyethyl 2-amino-3-methylbutanoate 4-methylbenzenesulfonateCAS 86150-61-0
Flumatinib MesylateCAS 895519-91-2

Non-public references are shown as text only and do not imply equivalence, availability, or shared use.

Catalog navigation

Related Catalog Entries

Other public CAS pages in this catalog. These links support navigation across additional intermediates and do not imply equivalence, availability, or shared use.

CAS 146535-11-76,7-Dimethoxy-3-phenylquinoxalineCAS 443913-73-3VandetanibCAS 10083-24-6PiceatannolCAS 100-21-0Terephthalic AcidCAS 100643-71-8DesloratadineCAS 1002310-00-0Tert-butyl 1-(2-chloro-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)ethylcarbamateCAS 1005174-17-3(E)-3-(2-Propyl-6-(trifluoromethyl)pyridin-3-yl)acrylic acidCAS 1018125-49-92-(3-Cyclopropyl-6-ethyl-4-(trifluoromethyl)-1H-pyrazolo[3,4-b]pyridin-1-yl)acetic acidCAS 1018128-07-8Isopropyl 4-chloro-2-methylquinoline-6-carboxylateCAS 1018142-22-76-cyclopropyl-1-(2,2-difluoroethyl)-3-methyl-1H-pyrazolo[3,4-b]pyridine-4-carboxylic acid

RFQ questions for CAS 475207-59-1

What are the key identifiers for Sorafenib Tosylate (CAS 475207-59-1)?

Sorafenib Tosylate is identified by CAS 475207-59-1, with molecular formula C28H24ClF3N4O6S, molecular weight 637, InChIKey IVDHYUQIDRJSTI-UHFFFAOYSA-N.

Does CAS 475207-59-1 have reported biological target evidence?

ChEMBL contains qualifying experimental assay evidence associated with Vascular endothelial growth factor receptor 2, Serine/threonine-protein kinase mTOR, Tyrosyl-DNA phosphodiesterase 1. These records do not establish therapeutic efficacy or clinical use.

Can I request a COA for CAS 475207-59-1?

Yes. Submit an RFQ and specify COA requirements. Lot-specific COA depends on supplier confirmation.

Can I request supplier SDS for Sorafenib Tosylate?

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Is CAS 475207-59-1 available for quotation?

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