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Home/Compounds/CAS 491-78-1
Formula C15H10O3MW 238.24Research-use catalog entryCOA/SDS by request

5-Hydroxyflavone

CAS Number: 491-78-1

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98%
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Loading RDKit molecule structure...
InChIKey: IYBLVRRCNVHZQJ-UHFFFAOYSA-NC15H10O3 | MW 238.24

Chemical Absolute Identifiers

CAS Number

491-78-1

PubChem CID

68112

Molecular Formula

C15H10O3

Molecular Weight

238.24 g/mol

Exact Mass

238.062994

InChIKey

IYBLVRRCNVHZQJ-UHFFFAOYSA-N

IUPAC Name

5-hydroxy-2-phenylchromen-4-one

SMILES String

C1=CC=C(C=C1)C2=CC(=O)C3=C(C=CC=C3O2)O

Physical Properties

No physical property values available.

Properties are provided as catalog reference data and may be confirmed through supplier documentation when required.

Catalog Facts

Structural features

5-Hydroxyflavone (CAS 491-78-1) is listed in the Advanced Chemicals portfolio, with molecular formula C15H10O3 and molecular weight 238. 24 g/mol.

Sourcing context

Catalog reference for RFQ preparation, supplier confirmation, and research chemical sourcing review.

Research use context

Intended for research building-block and synthetic chemistry workflows.

Documentation needs

COA/SDS status, availability, lead time, pack size, and shipment documentation can be confirmed during quotation.

Applications & Classification

Heterocyclic Building BlocksSynthetic ChemistryResearch intermediateCustom synthesis building blockResearch chemical sourcingCustom synthesis and catalog availability reviewCOA, SDS, pricing, and fulfillment workflow
Biological target reference

ChEMBL reports experimental activity evidence for: Androgen receptor (Homo sapiens) — 3 assays; Pyruvate kinase PKM (Homo sapiens) — 2 assays; Cytochrome P450 3A4 (Homo sapiens) — 2 assays; Alpha-ketoglutarate-dependent dioxygenase FTO (Homo sapiens) — 2 assays. These records describe research assays and do not establish therapeutic efficacy or clinical use.

Androgen receptor

Homo sapiens · SINGLE PROTEIN · 3 qualifying assays · 2 documents · best pChEMBL 6.52

Experimental evidence source: ChEMBL

Pyruvate kinase PKM

Homo sapiens · SINGLE PROTEIN · 2 qualifying assays · 1 documents · best pChEMBL 5.86

Experimental evidence source: ChEMBL

Cytochrome P450 3A4

Homo sapiens · SINGLE PROTEIN · 2 qualifying assays · 1 documents · best pChEMBL 5.2

Experimental evidence source: ChEMBL

Alpha-ketoglutarate-dependent dioxygenase FTO

Homo sapiens · SINGLE PROTEIN · 2 qualifying assays · 1 documents · best pChEMBL 4.72

Experimental evidence source: ChEMBL

Safety & Handling

Handling & Storage

  • Keep container tightly closed and dry.
  • Store in a well-ventilated place.
  • Avoid contact with skin and eyes.

PPE

Respiratory protection if needed

First Aid

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  • Rinse mouth with water.

Stability / Reactivity

  • Reactivity and reaction.
  • Carbon monoxide, carbon dioxide.

Disposal

  • Waste product.
  • Dispose of remaining and non-recyclable solutions to a licensed company.
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Fire Fighting

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Accidental Release

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  • Sweep and shovel up.

For supplier-issued SDS, request documentation before handling, storage, shipment, or procurement decisions.

Preliminary Safety Reference

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Safety Reference / SDS Request

Names & Synonyms / External Identifiers

Chemical Name

5-Hydroxyflavone

Names & Synonyms

Primuletin5-Hydroxy-2-phenyl-4-benzopyrone5-hydroxy-2-phenyl-4H-chromen-4-one5-Hydroxy-2-phenyl-chromen-4-one5-Hydroxy-2-phenylchromone
Show all synonyms
5-HYDROXY-2-PHENYL-4H-1-BENZOPYRAN-4-ONE4H-1-Benzopyran-4-one, 5-hydroxy-2-phenyl-5-hydroxy-flavoneHYDROXYFLAVONE, 5-Oprea1_6885415-Hydroxyflavone, >=97%FLAVONE, 5-HYDROXY-BIDD:ER0489MEGxp0_001696ACon1_0019585-Hydroxy-2-phenyl chromen-4-oneH1238InChI=1/C15H10O3/c16-11-7-4-8-13-15(11)12(17)9-14(18-13)10-5-2-1-3-6-10/h1-9,16H
External Identifiers
EC NUMBER: 207-743-1DSSTOX SUBSTANCE ID: DTXSID90197690CHEMBL ID: CHEMBL16807CHEBI ID: CHEBI:172638UNII: 378AE9MHL3METABOLOMICS WORKBENCH ID: 23184WIKIDATA ID: Q63408974
Experimental Spectrum References
13C NMR Spectra1D NMR SpectraATR-IR Spectra — Forensic Spectral ResearchRaman Spectra — Forensic Spectral Research
Literature & Patent References
DOI 10.1021/acs.jmedchem.4c03124Discovery of the 2,3-Dihydrobenzopyrane-4-one as a Potent FTO Inhibitor against Obesity-Related Metabolic Diseases.PMID 40152179Discovery of the 2,3-Dihydrobenzopyrane-4-one as a Potent FTO Inhibitor against Obesity-Related Metabolic Diseases.DOI 10.1021/acs.jmedchem.1c00981A Perspective on Medicinal Chemistry Approaches for Targeting Pyruvate Kinase M2.PMID 34726055A Perspective on Medicinal Chemistry Approaches for Targeting Pyruvate Kinase M2.DOI 10.6019/CHEMBL4651402Screening of ~5500 FDA-approved drugs and clinical candidates for anti-SARS-CoV-2 activityDOI 10.1021/acs.jnatprod.0c00014Structural Specificity of Flavonoids in the Inhibition of Human Fructose 1,6-Bisphosphatase.PMID 32364726Structural Specificity of Flavonoids in the Inhibition of Human Fructose 1,6-Bisphosphatase.DOI 10.1016/j.ejmech.2017.04.042Inhibitors of cytochrome P450 (CYP) 1B1.

Documentation & Compliance Facts

Compliance Facts

Shipment review: Required

Documentation available by request

Certificate of Analysis (COA): By request

Supplier Safety Data Sheet (SDS): By request

Purity and pack size confirmation: By request

Availability and lead time review: Confirmed by RFQ

Shipment documentation review: By request

For supplier-issued documentation by request, use the RFQ actions on this page.Review preliminary safety reference

What happens after RFQ

  1. 1We review the CAS identity, quantity, and documentation request.
  2. 2We check sourcing options, supplier availability, COA/SDS, purity, pack size, and lead time.
  3. 3We review destination and shipment documentation needs when applicable.
  4. 4We follow up with a quotation or clarification request.

Text Reference Cues

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Non-public related references

TectochrysinCAS 520-28-5
NegleteinCAS 29550-13-8
5-Hydroxy-7,4'-dimethoxyflavoneCAS 5128-44-9
6-HydroxyluteolinCAS 18003-33-3
PectolinarigeninCAS 520-12-7

Non-public references are shown as text only and do not imply equivalence, availability, or shared use.

Catalog navigation

Related Catalog Entries

Other public CAS pages in this catalog. These links support navigation across additional intermediates and do not imply equivalence, availability, or shared use.

CAS 520-28-5TectochrysinCAS 29550-13-8NegleteinCAS 5128-44-95-Hydroxy-7,4'-dimethoxyflavoneCAS 18003-33-36-HydroxyluteolinCAS 520-12-7PectolinarigeninCAS 520-36-5ApigeninCAS 528-48-3FisetinCAS 101-18-83-Hydroxy-N-phenylanilineCAS 548-83-4GalanginCAS 1002310-00-0Tert-butyl 1-(2-chloro-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)ethylcarbamate

RFQ questions for CAS 491-78-1

What are the key identifiers for 5-Hydroxyflavone (CAS 491-78-1)?

5-Hydroxyflavone is identified by CAS 491-78-1, with molecular formula C15H10O3, molecular weight 238.24, InChIKey IYBLVRRCNVHZQJ-UHFFFAOYSA-N.

Does CAS 491-78-1 have reported biological target evidence?

ChEMBL contains qualifying experimental assay evidence associated with Androgen receptor, Pyruvate kinase PKM, Cytochrome P450 3A4, Alpha-ketoglutarate-dependent dioxygenase FTO. These records do not establish therapeutic efficacy or clinical use.

Can I request a COA for CAS 491-78-1?

Yes. Submit an RFQ and specify COA requirements. Lot-specific COA depends on supplier confirmation.

Can I request supplier SDS for 5-Hydroxyflavone?

Yes. Supplier SDS can be requested through the RFQ workflow before handling, storage, shipment, or procurement decisions.

Is CAS 491-78-1 available for quotation?

Availability, pack size, lead time, and pricing are confirmed through RFQ.

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