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- Purity
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CAS Number: 500287-72-9
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CAS Number
500287-72-9
PubChem CID
6451164
Molecular Formula
C22H18N6
Molecular Weight
366.4 g/mol
Exact Mass
366.159295
InChIKey
YIBOMRUWOWDFLG-ONEGZZNKSA-N
IUPAC Name
4-[[4-[4-[(E)-2-cyanoethenyl]-2,6-dimethylanilino]pyrimidin-2-yl]amino]benzonitrile
SMILES String
Cc1cc(/C=C/C#N)cc(C)c1Nc1ccnc(Nc2ccc(C#N)cc2)n1
Melting Point
241–243 °C
pKa
5.6
Properties are provided as catalog reference data and may be confirmed through supplier documentation when required.
Structural features
Rilpivirine (CAS 500287-72-9) is listed in the Pharmaceutical Intermediates portfolio, with molecular formula C22H18N6 and molecular weight 366. 40 g/mol.
Sourcing context
Catalog reference for RFQ preparation, supplier confirmation, and research chemical sourcing review.
Research use context
Intended for research-stage medicinal chemistry and intermediate synthesis workflows; structure-derived tags include nitrogen-containing heterocycle.
Documentation needs
COA/SDS status, availability, lead time, pack size, and shipment documentation can be confirmed during quotation.
ChEMBL reports experimental activity evidence for: Human immunodeficiency virus type 1 reverse transcriptase (Human immunodeficiency virus 1) — 37 assays; Cytochrome P450 2C19 (Homo sapiens) — 11 assays; Cytochrome P450 2C9 (Homo sapiens) — 11 assays; Voltage-gated inwardly rectifying potassium channel KCNH2 (Homo sapiens) — 10 assays; Cytochrome P450 3A4 (Homo sapiens) — 11 assays. These records describe research assays and do not establish therapeutic efficacy or clinical use.
Human immunodeficiency virus type 1 reverse transcriptase
Human immunodeficiency virus 1 · SINGLE PROTEIN · 37 qualifying assays · 23 documents · best pChEMBL 9.7
Experimental evidence source: ChEMBL
Cytochrome P450 2C19
Homo sapiens · SINGLE PROTEIN · 11 qualifying assays · 11 documents · best pChEMBL 6.47
Experimental evidence source: ChEMBL
Cytochrome P450 2C9
Homo sapiens · SINGLE PROTEIN · 11 qualifying assays · 11 documents · best pChEMBL 6.46
Experimental evidence source: ChEMBL
Voltage-gated inwardly rectifying potassium channel KCNH2
Homo sapiens · SINGLE PROTEIN · 10 qualifying assays · 10 documents · best pChEMBL 6.3
Experimental evidence source: ChEMBL
Cytochrome P450 3A4
Homo sapiens · SINGLE PROTEIN · 11 qualifying assays · 11 documents · best pChEMBL 5.66
Experimental evidence source: ChEMBL
Safety and handling reference content is available through documentation requests.
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Preliminary Safety Reference
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Safety Reference / SDS RequestCatalog navigation
Other public CAS pages in this catalog. These links support navigation across additional intermediates and do not imply equivalence, availability, or shared use.
Rilpivirine is identified by CAS 500287-72-9, with molecular formula C22H18N6, molecular weight 366.4, InChIKey YIBOMRUWOWDFLG-ONEGZZNKSA-N.
ChEMBL contains qualifying experimental assay evidence associated with Human immunodeficiency virus type 1 reverse transcriptase, Cytochrome P450 2C19, Cytochrome P450 2C9, Voltage-gated inwardly rectifying potassium channel KCNH2, Cytochrome P450 3A4. These records do not establish therapeutic efficacy or clinical use.
Yes. Submit an RFQ and specify COA requirements. Lot-specific COA depends on supplier confirmation.
Yes. Supplier SDS can be requested through the RFQ workflow before handling, storage, shipment, or procurement decisions.
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