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Home/Compounds/CAS 500565-15-1
Formula C26H27ClN4O2MW 463Research-use catalog entryCOA/SDS by request

4-((6-Chloro-2-methoxyacridin-9-yl)amino)-2-((4-methylpiperazin-1-yl)methyl)phenol

CAS Number: 500565-15-1

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Available Options

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10 mg
Purity
97%
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Purity
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Purity
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Loading RDKit molecule structure...
InChIKey: SUSDGTMJKOGWSZ-UHFFFAOYSA-NC26H27ClN4O2 | MW 463

Chemical Absolute Identifiers

CAS Number

500565-15-1

PubChem CID

421105

Molecular Formula

C26H27ClN4O2

Molecular Weight

463 g/mol

Exact Mass

462.182254

InChIKey

SUSDGTMJKOGWSZ-UHFFFAOYSA-N

IUPAC Name

4-[(6-chloro-2-methoxyacridin-9-yl)amino]-2-[(4-methylpiperazin-1-yl)methyl]phenol

SMILES String

COc1ccc2nc3cc(Cl)ccc3c(Nc3ccc(O)c(CN4CCN(C)CC4)c3)c2c1

Physical Properties

No physical property values available.

Properties are provided as catalog reference data and may be confirmed through supplier documentation when required.

Catalog Facts

Structural features

4-((6-Chloro-2-methoxyacridin-9-yl)amino)-2-((4-methylpiperazin-1-yl)methyl)phenol (CAS 500565-15-1) is listed in the Advanced Chemicals portfolio, with molecular formula C26H27ClN4O2 and molecular weight 463. 00 g/mol.

Sourcing context

Catalog reference for RFQ preparation, supplier confirmation, and research chemical sourcing review.

Research use context

Intended for research building-block and synthetic chemistry workflows; structure-derived tags include nitrogen-containing heterocycle.

Documentation needs

COA/SDS status, availability, lead time, pack size, and shipment documentation can be confirmed during quotation.

Applications & Classification

Heterocyclic Building BlocksSynthetic ChemistryResearch intermediateCustom synthesis building blockResearch chemical sourcingCustom synthesis and catalog availability reviewCOA, SDS, pricing, and fulfillment workflow
Biological target reference

ChEMBL reports experimental activity evidence for: DNA excision repair protein ERCC-1/DNA repair endonuclease XPF (Homo sapiens) — 3 assays; Cytochrome P450 2D6 (Homo sapiens) — 3 assays; Cytochrome P450 2C19 (Homo sapiens) — 3 assays; Thyrotropin receptor (Homo sapiens) — 2 assays; Cytochrome P450 1A2 (Homo sapiens) — 2 assays. These records describe research assays and do not establish therapeutic efficacy or clinical use.

DNA excision repair protein ERCC-1/DNA repair endonuclease XPF

Homo sapiens · PROTEIN COMPLEX · 3 qualifying assays · 2 documents · best pChEMBL 6.85

Experimental evidence source: ChEMBL

Cytochrome P450 2D6

Homo sapiens · SINGLE PROTEIN · 3 qualifying assays · 2 documents · best pChEMBL 6

Experimental evidence source: ChEMBL

Cytochrome P450 2C19

Homo sapiens · SINGLE PROTEIN · 3 qualifying assays · 2 documents · best pChEMBL 5.6

Experimental evidence source: ChEMBL

Thyrotropin receptor

Homo sapiens · SINGLE PROTEIN · 2 qualifying assays · 1 documents · best pChEMBL 5.6

Experimental evidence source: ChEMBL

Cytochrome P450 1A2

Homo sapiens · SINGLE PROTEIN · 2 qualifying assays · 2 documents · best pChEMBL 5.4

Experimental evidence source: ChEMBL

Safety & Handling

Safety and handling reference content is available through documentation requests.

For supplier-issued SDS, request documentation before handling, storage, shipment, or procurement decisions.

Preliminary Safety Reference

For supplier-issued SDS or COA, submit a documentation request.

Safety Reference / SDS Request

Names & Synonyms / External Identifiers

Chemical Name

4-((6-Chloro-2-methoxyacridin-9-yl)amino)-2-((4-methylpiperazin-1-yl)methyl)phenol

Names & Synonyms

HM034-(6-chloro-2-methoxyacridin-9-ylamino)-2-((4-methylpiperazin-1-yl)methyl)phenol4-((6-chloro-2-methoxy-9-acridinyl)amino)-2-((4-methyl-1-piperazinyl)methyl)phenol4-[(6-chloro-2-methoxy-9-acridinyl)amino]-2-[(4-methyl-1-piperazinyl)methyl]phenolNCIStruc1_000031
Show all synonyms
NCIStruc2_001891cid_421105HM03?4-[(6-chloranyl-2-methoxy-acridin-9-yl)amino]-2-[(4-methylpiperazin-1-yl)methyl]phenol4-[(6-chloro-2-methoxy-acridin-9-yl)amino]-2-[(4-methylpiperazin-1-yl)methyl]phenol4-[(6-chloro-2-methoxy-acridin-9-yl)amino]-2-[(4-methylpiperazino)methyl]phenol
External Identifiers
CHEMBL ID: CHEMBL463783
Literature & Patent References
DOI 10.1016/j.ejmech.2020.112658Design, synthesis and in vitro cell-free/cell-based biological evaluations of novel ERCC1-XPF inhibitors targeting DNA repair pathway.PMID 32738410Design, synthesis and in vitro cell-free/cell-based biological evaluations of novel ERCC1-XPF inhibitors targeting DNA repair pathway.DOI 10.1021/acs.jmedchem.9b00326Targeting DNA Repair in Tumor Cells via Inhibition of ERCC1-XPF.PMID 31369707Targeting DNA Repair in Tumor Cells via Inhibition of ERCC1-XPF.DOI 10.1016/j.bmcl.2013.03.035Structure-based design of HSPA5 inhibitors: from peptide to small molecule inhibitors.PMID 23562057Structure-based design of HSPA5 inhibitors: from peptide to small molecule inhibitors.DOI 10.1016/j.bmc.2011.07.020Ellipticines and 9-acridinylamines as inhibitors of D-alanine:D-alanine ligase.PMID 21831641Ellipticines and 9-acridinylamines as inhibitors of D-alanine:D-alanine ligase.

Documentation & Compliance Facts

Compliance Facts

Shipment review: Required

Documentation available by request

Certificate of Analysis (COA): By request

Supplier Safety Data Sheet (SDS): By request

Purity and pack size confirmation: By request

Availability and lead time review: Confirmed by RFQ

Shipment documentation review: By request

For supplier-issued documentation by request, use the RFQ actions on this page.Review preliminary safety reference

What happens after RFQ

  1. 1We review the CAS identity, quantity, and documentation request.
  2. 2We check sourcing options, supplier availability, COA/SDS, purity, pack size, and lead time.
  3. 3We review destination and shipment documentation needs when applicable.
  4. 4We follow up with a quotation or clarification request.

Text Reference Cues

Show non-linked catalog cues

Non-public related references

3,9-Dichloro-7-methoxyacridineCAS 86-38-4
6-Chloro-2-methoxy-9-acridinamineCAS 3548-09-2
Quinacrine DihydrochlorideCAS 69-05-6
6,9-Dichloro-2-ethoxyacridineCAS 92428-57-4
9-Chloro-2,7-dimethoxyacridineCAS 6526-92-7

Non-public references are shown as text only and do not imply equivalence, availability, or shared use.

Catalog navigation

Related Catalog Entries

Other public CAS pages in this catalog. These links support navigation across additional intermediates and do not imply equivalence, availability, or shared use.

CAS 86-38-43,9-Dichloro-7-methoxyacridineCAS 3548-09-26-Chloro-2-methoxy-9-acridinamineCAS 69-05-6Quinacrine DihydrochlorideCAS 2543-94-4PhellopterinCAS 321-64-2TacrineCAS 50-65-7NiclosamideCAS 1002310-00-0Tert-butyl 1-(2-chloro-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)ethylcarbamateCAS 1005174-17-3(E)-3-(2-Propyl-6-(trifluoromethyl)pyridin-3-yl)acrylic acidCAS 1018125-49-92-(3-Cyclopropyl-6-ethyl-4-(trifluoromethyl)-1H-pyrazolo[3,4-b]pyridin-1-yl)acetic acidCAS 1018128-07-8Isopropyl 4-chloro-2-methylquinoline-6-carboxylate

RFQ questions for CAS 500565-15-1

What are the key identifiers for 4-((6-Chloro-2-methoxyacridin-9-yl)amino)-2-((4-methylpiperazin-1-yl)methyl)phenol (CAS 500565-15-1)?

4-((6-Chloro-2-methoxyacridin-9-yl)amino)-2-((4-methylpiperazin-1-yl)methyl)phenol is identified by CAS 500565-15-1, with molecular formula C26H27ClN4O2, molecular weight 463, InChIKey SUSDGTMJKOGWSZ-UHFFFAOYSA-N.

Does CAS 500565-15-1 have reported biological target evidence?

ChEMBL contains qualifying experimental assay evidence associated with DNA excision repair protein ERCC-1/DNA repair endonuclease XPF, Cytochrome P450 2D6, Cytochrome P450 2C19, Thyrotropin receptor, Cytochrome P450 1A2. These records do not establish therapeutic efficacy or clinical use.

Can I request a COA for CAS 500565-15-1?

Yes. Submit an RFQ and specify COA requirements. Lot-specific COA depends on supplier confirmation.

Can I request supplier SDS for 4-((6-Chloro-2-methoxyacridin-9-yl)amino)-2-((4-methylpiperazin-1-yl)methyl)phenol?

Yes. Supplier SDS can be requested through the RFQ workflow before handling, storage, shipment, or procurement decisions.

Is CAS 500565-15-1 available for quotation?

Availability, pack size, lead time, and pricing are confirmed through RFQ.

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