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Home/Compounds/CAS 503612-47-3
Formula C25H25N5O4MW 459.5Research-use catalog entryCOA/SDS by request

Apixaban

CAS Number: 503612-47-3

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Loading RDKit molecule structure...
InChIKey: QNZCBYKSOIHPEH-UHFFFAOYSA-NC25H25N5O4 | MW 459.5

Chemical Absolute Identifiers

CAS Number

503612-47-3

PubChem CID

10182969

Molecular Formula

C25H25N5O4

Molecular Weight

459.5 g/mol

Exact Mass

459.190654

InChIKey

QNZCBYKSOIHPEH-UHFFFAOYSA-N

IUPAC Name

1-(4-methoxyphenyl)-7-oxo-6-[4-(2-oxopiperidin-1-yl)phenyl]-4,5-dihydropyrazolo[5,4-c]pyridine-3-carboxamide

SMILES String

COc1ccc(-n2nc(C(N)=O)c3c2C(=O)N(c2ccc(N4CCCCC4=O)cc2)CC3)cc1

Physical Properties

No physical property values available.

Properties are provided as catalog reference data and may be confirmed through supplier documentation when required.

Catalog Facts

Structural features

Apixaban (CAS 503612-47-3) is listed in the Pharmaceutical Intermediates portfolio, with molecular formula C25H25N5O4 and molecular weight 459. 50 g/mol.

Sourcing context

Catalog reference for RFQ preparation, supplier confirmation, and research chemical sourcing review.

Research use context

Intended for research-stage medicinal chemistry and intermediate synthesis workflows; structure-derived tags include nitrogen-containing heterocycle.

Documentation needs

COA/SDS status, availability, lead time, pack size, and shipment documentation can be confirmed during quotation.

Applications & Classification

Pharmaceutical Intermediate ResearchResearch intermediateCustom synthesis building blockPharmaceutical intermediate researchResearch chemical sourcingCustom synthesis and catalog availability reviewCOA, SDS, pricing, and fulfillment workflow
Biological target reference

ChEMBL reports experimental activity evidence for: Coagulation factor X (Homo sapiens) — 16 assays; Coagulation factor X (Rattus norvegicus) — 2 assays; Prothrombin (Homo sapiens) — 2 assays; 5-hydroxytryptamine receptor 2B (Homo sapiens) — 2 assays; Alpha-1A adrenergic receptor (Homo sapiens) — 2 assays. These records describe research assays and do not establish therapeutic efficacy or clinical use.

Coagulation factor X

Homo sapiens · SINGLE PROTEIN · 16 qualifying assays · 13 documents · best pChEMBL 10.1

Experimental evidence source: ChEMBL

Coagulation factor X

Rattus norvegicus · SINGLE PROTEIN · 2 qualifying assays · 2 documents · best pChEMBL 8.89

Experimental evidence source: ChEMBL

Prothrombin

Homo sapiens · SINGLE PROTEIN · 2 qualifying assays · 2 documents · best pChEMBL 5.51

Experimental evidence source: ChEMBL

5-hydroxytryptamine receptor 2B

Homo sapiens · SINGLE PROTEIN · 2 qualifying assays · 1 documents

Experimental evidence source: ChEMBL

Alpha-1A adrenergic receptor

Homo sapiens · SINGLE PROTEIN · 2 qualifying assays · 1 documents

Experimental evidence source: ChEMBL

Safety & Handling

Safety and handling reference content is available through documentation requests.

For supplier-issued SDS, request documentation before handling, storage, shipment, or procurement decisions.

Preliminary Safety Reference

For supplier-issued SDS or COA, submit a documentation request.

Safety Reference / SDS Request

Names & Synonyms / External Identifiers

Chemical Name

Apixaban

Names & Synonyms

Eliquis1-(4-Methoxyphenyl)-7-oxo-6-[4-(2-oxopiperidin-1-yl)phenyl]-4,5,6,7-tetrahydro-1H-pyrazolo[3,4-c]pyridine-3-carboxamideBMS 562247-011-(4-methoxyphenyl)-7-oxo-6-(4-(2-oxopiperidin-1-yl)phenyl)-4,5,6,7-tetrahydro-1H-pyrazolo[3,4-c]pyridine-3-carboxamideapixabanum
Show all synonyms
1H-Pyrazolo[3,4-c]pyridine-3-carboxamide, 4,5,6,7-tetrahydro-1-(4-methoxyphenyl)-7-oxo-6-[4-(2-oxo-1-piperidinyl)phenyl]-1H-Pyrazolo(3,4-c)pyridine-3-carboxamide,4,5,6,7-tetrahydro-1-(4-methoxyphenyl)-7-oxo-6-(4-(2-oxo-1-piperidinyl)phenyl)-1-(4-methoxyphenyl)-7-oxo-6-(4-(2-oxopiperidin-1-yl)phenyl)-4,5,6,7-tetrahydro-1H-pyrazolo(3,4-c)pyridine-3-carboxamide1H-Pyrazolo(3,4-c)pyridine-3-carboxamide, 4,5,6,7-tetrahydro-1-(4-methoxyphenyl)-7-oxo-6-(4-(2-oxo-1-piperidinyl)phenyl)-ELIQUIS 30-Day Starter Pack1-(4-methoxyphenyl)-7-oxo-6-[4-(2-oxopiperidin-1-yl)phenyl]-4,5-dihydropyrazolo[3,4-c]pyridine-3-carboxamideApixaban 13CD31-(4-methoxyphenyl)-7-oxo-6-[4-(2-oxopiperidin-1-yl)phenyl]-1H,4H,5H,6H,7H-pyrazolo[3,4-c]pyridine-3-carboxamideApixaban [USAN]GG2Eliquis (TN)Apixaban (JAN/USAN/INN)Apixaban [USAN:INN:JAN]HSDB 8223Apixaban (Standard)
External Identifiers
EC NUMBER: 639-684-6DSSTOX SUBSTANCE ID: DTXSID80436500CHEMBL ID: CHEMBL231779CHEBI ID: CHEBI:72296UNII: 3Z9Y7UWC1JDRUGBANK ID: DB06605HMDB ID: HMDB0248515KEGG ID: D03213METABOLOMICS WORKBENCH ID: 65917NCI THESAURUS CODE: C61308PHARMGKB ID: PA166163740RXCUI: 1364430WIKIDATA ID: Q414462
Literature & Patent References
DOI 10.1016/j.ejmech.2024.117067Discovery of potent and selective factor XIa inhibitors incorporating triazole-based benzoic acid as novel P2' fragments: Molecular dynamics simulations and anticoagulant activity.PMID 39580913Discovery of potent and selective factor XIa inhibitors incorporating triazole-based benzoic acid as novel P2' fragments: Molecular dynamics simulations and anticoagulant activity.DOI 10.1016/j.ejmech.2024.116593The U.S. FDA approved cardiovascular drugs from 2011 to 2023: A medicinal chemistry perspective.PMID 38889609The U.S. FDA approved cardiovascular drugs from 2011 to 2023: A medicinal chemistry perspective.DOI 10.1016/j.bmcl.2023.129127Synthesis of pyrrolo[3,2-d]pyrimidineone derivatives as novel FXa inhibitors.DOI 10.1016/j.ejmech.2022.114855Discovery of novel N-acylpyrazoles as potent and selective thrombin inhibitors.DOI 10.1038/s41467-023-40064-9A preclinical secondary pharmacology resource illuminates target-adverse drug reaction associations of marketed drugs.PMID 36462436Discovery of novel N-acylpyrazoles as potent and selective thrombin inhibitors.

Documentation & Compliance Facts

Compliance Facts

Shipment review: Required

Documentation available by request

Certificate of Analysis (COA): By request

Supplier Safety Data Sheet (SDS): By request

Purity and pack size confirmation: By request

Availability and lead time review: Confirmed by RFQ

Shipment documentation review: By request

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What happens after RFQ

  1. 1We review the CAS identity, quantity, and documentation request.
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  3. 3We review destination and shipment documentation needs when applicable.
  4. 4We follow up with a quotation or clarification request.

Text Reference Cues

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Non-public related references

1-(4-Methoxyphenyl)-7-oxo-6-(4-(2-oxopiperidin-1-yl)phenyl)-4,5,6,7-tetrahydro-1H-pyrazolo(3,4-c)pyridine-3-carboxylic acidCAS 503614-92-4
6-(4-aminophenyl)-1-(4-methoxyphenyl)-7-oxo-4,5,6,7-tetrahydro-1H-pyrazolo[3,4-c]pyridine-3-carboxamideCAS 1423803-24-0
ethyl 1-(4-methoxyphenyl)-7-oxo-6-(4-(2-oxo-1-piperidinyl)phenyl)-4,5,6,7-tetrahydro-1H-pyrazolo[3,4-c]pyridine-3-carboxylateCAS 503614-91-3
Ethyl 6-(4-aminophenyl)-1-(4-methoxyphenyl)-7-oxo-4,5-dihydropyrazolo(3,4-c)pyridine-3-carboxylateCAS 503615-07-4
Ethyl 6-(4-iodophenyl)-1-(4-methoxyphenyl)-7-oxo-4,5-dihydropyrazolo[3,4-c]pyridine-3-carboxylateCAS 473927-64-9

Non-public references are shown as text only and do not imply equivalence, availability, or shared use.

Catalog navigation

Related Catalog Entries

Other public CAS pages in this catalog. These links support navigation across additional intermediates and do not imply equivalence, availability, or shared use.

CAS 503614-92-41-(4-Methoxyphenyl)-7-oxo-6-(4-(2-oxopiperidin-1-yl)phenyl)-4,5,6,7-tetrahydro-1H-pyrazolo(3,4-c)pyridine-3-carboxylic acidCAS 1423803-24-06-(4-aminophenyl)-1-(4-methoxyphenyl)-7-oxo-4,5,6,7-tetrahydro-1H-pyrazolo[3,4-c]pyridine-3-carboxamideCAS 503614-91-3ethyl 1-(4-methoxyphenyl)-7-oxo-6-(4-(2-oxo-1-piperidinyl)phenyl)-4,5,6,7-tetrahydro-1H-pyrazolo[3,4-c]pyridine-3-carboxylateCAS 503615-07-4Ethyl 6-(4-aminophenyl)-1-(4-methoxyphenyl)-7-oxo-4,5-dihydropyrazolo(3,4-c)pyridine-3-carboxylateCAS 473927-64-9Ethyl 6-(4-iodophenyl)-1-(4-methoxyphenyl)-7-oxo-4,5-dihydropyrazolo[3,4-c]pyridine-3-carboxylateCAS 107724-20-9EplerenoneCAS 139481-59-7CandesartanCAS 55142-85-3TiclopidineCAS 366789-02-8RivaroxabanCAS 274693-27-5Ticagrelor

RFQ questions for CAS 503612-47-3

What are the key identifiers for Apixaban (CAS 503612-47-3)?

Apixaban is identified by CAS 503612-47-3, with molecular formula C25H25N5O4, molecular weight 459.5, InChIKey QNZCBYKSOIHPEH-UHFFFAOYSA-N.

Does CAS 503612-47-3 have reported biological target evidence?

ChEMBL contains qualifying experimental assay evidence associated with Coagulation factor X, Coagulation factor X, Prothrombin, 5-hydroxytryptamine receptor 2B, Alpha-1A adrenergic receptor. These records do not establish therapeutic efficacy or clinical use.

Can I request a COA for CAS 503612-47-3?

Yes. Submit an RFQ and specify COA requirements. Lot-specific COA depends on supplier confirmation.

Can I request supplier SDS for Apixaban?

Yes. Supplier SDS can be requested through the RFQ workflow before handling, storage, shipment, or procurement decisions.

Is CAS 503612-47-3 available for quotation?

Availability, pack size, lead time, and pricing are confirmed through RFQ.

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