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Home/Compounds/CAS 516-21-2
Formula C11H14ClN5MW 251.71Research-use catalog entryCOA/SDS by request

Cycloguanil

CAS Number: 516-21-2

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Loading RDKit molecule structure...
InChIKey: QMNFFXRFOJIOKZ-UHFFFAOYSA-NC11H14ClN5 | MW 251.71

Chemical Absolute Identifiers

CAS Number

516-21-2

PubChem CID

9049

Molecular Formula

C11H14ClN5

Molecular Weight

251.71 g/mol

Exact Mass

251.093773

InChIKey

QMNFFXRFOJIOKZ-UHFFFAOYSA-N

IUPAC Name

1-(4-chlorophenyl)-6,6-dimethyl-1,3,5-triazine-2,4-diamine

SMILES String

CC1(N=C(N=C(N1C2=CC=C(C=C2)Cl)N)N)C

Physical Properties

No physical property values available.

Properties are provided as catalog reference data and may be confirmed through supplier documentation when required.

Catalog Facts

Structural features

Cycloguanil (CAS 516-21-2) is listed in the Advanced Chemicals portfolio, with molecular formula C11H14ClN5 and molecular weight 251. 71 g/mol.

Sourcing context

Catalog reference for RFQ preparation, supplier confirmation, and research chemical sourcing review.

Research use context

Intended for research building-block and synthetic chemistry workflows; structure-derived tags include nitrogen-containing heterocycle.

Documentation needs

COA/SDS status, availability, lead time, pack size, and shipment documentation can be confirmed during quotation.

Applications & Classification

Heterocyclic Building BlocksSynthetic ChemistryResearch intermediateCustom synthesis building blockResearch chemical sourcingCustom synthesis and catalog availability reviewCOA, SDS, pricing, and fulfillment workflow
Biological target reference

ChEMBL reports experimental activity evidence for: Bifunctional dihydrofolate reductase-thymidylate synthase (Plasmodium falciparum K1) — 22 assays; Dihydrofolate reductase (Pneumocystis carinii) — 3 assays; Dihydrofolate reductase (Homo sapiens) — 3 assays; Dihydrofolate reductase (Escherichia coli) — 4 assays. These records describe research assays and do not establish therapeutic efficacy or clinical use.

Bifunctional dihydrofolate reductase-thymidylate synthase

Plasmodium falciparum K1 · SINGLE PROTEIN · 22 qualifying assays · 5 documents · best pChEMBL 8.96

Experimental evidence source: ChEMBL

Dihydrofolate reductase

Pneumocystis carinii · SINGLE PROTEIN · 3 qualifying assays · 2 documents · best pChEMBL 7.63

Experimental evidence source: ChEMBL

Dihydrofolate reductase

Homo sapiens · SINGLE PROTEIN · 3 qualifying assays · 2 documents · best pChEMBL 7.25

Experimental evidence source: ChEMBL

Dihydrofolate reductase

Escherichia coli · SINGLE PROTEIN · 4 qualifying assays · 1 documents · best pChEMBL 5.99

Experimental evidence source: ChEMBL

Safety & Handling

Handling & Storage

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  • Store in a well-ventilated place.
  • Avoid contact with skin and eyes.

PPE

Respiratory protection if needed

First Aid

  • Do not give anything to an unconscious person.
  • Rinse mouth with water.

Stability / Reactivity

  • Reactivity and reaction.
  • Carbon monoxide, carbon dioxide, hydrogen chloride, nitrogen oxides.

Disposal

  • Waste product: Dispose of remaining and non-recyclable solutions to a licensed company.
  • Contact a professional institution with a waste disposal license to handle this substance.
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Fire Fighting

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Accidental Release

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  • Sweep and shovel up.

For supplier-issued SDS, request documentation before handling, storage, shipment, or procurement decisions.

Preliminary Safety Reference

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Safety Reference / SDS Request

Names & Synonyms / External Identifiers

Chemical Name

Cycloguanil

Names & Synonyms

CycloguanylChlorguanide triazine1-(4-chlorophenyl)-6,6-dimethyl-1,6-dihydro-1,3,5-triazine-2,4-diamineWR 54731-(p-Chlorophenyl)-4,6-diamino-2,2-dimethyl-1,2-dihydro-s-triazine
Show all synonyms
cycloquanil1-(4-chlorophenyl)-1,6-dihydro-6,6-dimethyl-1,2,5-triazine-2,4-diamineChlorcycloguanils-Triazine, 1,2-dihydro-1-(p-chlorophenyl)-4,6-diamino-2,2-dimethyl-1-(4-Chlorophenyl)-1,6-dihydro-6,6-dimethyl-1,3,5-triazine-2,4-diamineCGTCycloguanilum1CYCYCLOGUANIL [MI]1-p-Chlorophenyl-1,2-dihydro-2,2-dimethyl-4,6-diamino-s-triazineMaybridge1_0043164-Amino-6-p-chloroanilino-1,2-dwuhydro-2,2-dwumethylo-1,3,5-trojazyna [Polish]CYCLOGUANIL [WHO-DD]4-26-00-01176 (Beilstein Handbook Reference)
External Identifiers
DSSTOX SUBSTANCE ID: DTXSID9022867CHEMBL ID: CHEMBL747CHEMBL ID: CHEMBL92583CHEBI ID: CHEBI:135029UNII: 26RM326WVNDRUGBANK ID: DB14763HMDB ID: HMDB0060974METABOLOMICS WORKBENCH ID: 155080NCI THESAURUS CODE: C81015PHARMGKB ID: PA165107357WIKIDATA ID: Q5198706
Literature & Patent References
DOI 10.1021/acs.jmedchem.5c00056Substrate Specificity of the Organic Cation Transporters MATE1 and MATE2K and Functional Overlap with OCT1 and OCT2.PMID 40512599Substrate Specificity of the Organic Cation Transporters MATE1 and MATE2K and Functional Overlap with OCT1 and OCT2.DOI 10.6019/CHEMBL4651402Screening of ~5500 FDA-approved drugs and clinical candidates for anti-SARS-CoV-2 activityDOI 10.1016/j.ejmech.2020.112263Flexible diaminodihydrotriazine inhibitors of Plasmodium falciparum dihydrofolate reductase: Binding strengths, modes of binding and their antimalarial activities.PMID 32294614Flexible diaminodihydrotriazine inhibitors of Plasmodium falciparum dihydrofolate reductase: Binding strengths, modes of binding and their antimalarial activities.DOI 10.1021/acs.jnatprod.7b00876Isolation, Derivative Synthesis, and Structure-Activity Relationships of Antiparasitic Bromopyrrole Alkaloids from the Marine Sponge Tedania brasiliensis.DOI 10.1126/science.aat9446Open-source discovery of chemical leads for next-generation chemoprotective antimalarials.PMID 29297684Isolation, Derivative Synthesis, and Structure-Activity Relationships of Antiparasitic Bromopyrrole Alkaloids from the Marine Sponge Tedania brasiliensis.

Documentation & Compliance Facts

Compliance Facts

Shipment review: Required

Documentation available by request

Certificate of Analysis (COA): By request

Supplier Safety Data Sheet (SDS): By request

Purity and pack size confirmation: By request

Availability and lead time review: Confirmed by RFQ

Shipment documentation review: By request

For supplier-issued documentation by request, use the RFQ actions on this page.Review preliminary safety reference

What happens after RFQ

  1. 1We review the CAS identity, quantity, and documentation request.
  2. 2We check sourcing options, supplier availability, COA/SDS, purity, pack size, and lead time.
  3. 3We review destination and shipment documentation needs when applicable.
  4. 4We follow up with a quotation or clarification request.

Text Reference Cues

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Non-public related references

Cycloguanil hydrochlorideCAS 152-53-4
IrsogladineCAS 57381-26-7
2-(4'-Chloro-[1,1'-biphenyl]-4-yl)-4,6-diphenyl-1,3,5-triazineCAS 1443049-86-2

Non-public references are shown as text only and do not imply equivalence, availability, or shared use.

Catalog navigation

Related Catalog Entries

Other public CAS pages in this catalog. These links support navigation across additional intermediates and do not imply equivalence, availability, or shared use.

CAS 152-53-4Cycloguanil hydrochlorideCAS 58-14-0PyrimethamineCAS 5355-16-8DiaveridineCAS 1002310-00-0Tert-butyl 1-(2-chloro-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)ethylcarbamateCAS 1005174-17-3(E)-3-(2-Propyl-6-(trifluoromethyl)pyridin-3-yl)acrylic acidCAS 1018125-49-92-(3-Cyclopropyl-6-ethyl-4-(trifluoromethyl)-1H-pyrazolo[3,4-b]pyridin-1-yl)acetic acidCAS 1018128-07-8Isopropyl 4-chloro-2-methylquinoline-6-carboxylateCAS 1018142-22-76-cyclopropyl-1-(2,2-difluoroethyl)-3-methyl-1H-pyrazolo[3,4-b]pyridine-4-carboxylic acidCAS 1018144-00-72-(3-Cyclopropyl-6-isopropyl-4-(trifluoromethyl)-1H-pyrazolo[3,4-b]pyridin-1-yl)acetic acid

RFQ questions for CAS 516-21-2

What are the key identifiers for Cycloguanil (CAS 516-21-2)?

Cycloguanil is identified by CAS 516-21-2, with molecular formula C11H14ClN5, molecular weight 251.71, InChIKey QMNFFXRFOJIOKZ-UHFFFAOYSA-N.

Does CAS 516-21-2 have reported biological target evidence?

ChEMBL contains qualifying experimental assay evidence associated with Bifunctional dihydrofolate reductase-thymidylate synthase, Dihydrofolate reductase, Dihydrofolate reductase, Dihydrofolate reductase. These records do not establish therapeutic efficacy or clinical use.

Can I request a COA for CAS 516-21-2?

Yes. Submit an RFQ and specify COA requirements. Lot-specific COA depends on supplier confirmation.

Can I request supplier SDS for Cycloguanil?

Yes. Supplier SDS can be requested through the RFQ workflow before handling, storage, shipment, or procurement decisions.

Is CAS 516-21-2 available for quotation?

Availability, pack size, lead time, and pricing are confirmed through RFQ.

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