Research chemical
CAS Number: 571190-30-2
Product details
For laboratory research and professional procurement workflows.
PubChem CID
5330286
Exact Mass
447.238273
InChIKey
AHJRHEGDXFFMBM-UHFFFAOYSA-N
IUPAC Name
6-acetyl-8-cyclopentyl-5-methyl-2-[(5-piperazin-1-yl-2-pyridinyl)amino]pyrido[2,3-d]pyrimidin-7-one
SMILES String
CC(=O)c1c(C)c2cnc(Nc3ccc(N4CCNCC4)cn3)nc2n(C2CCCC2)c1=O
Melting Point
263–266 °C
Boiling Point
711.5 °C
Water Solubility
10 mol/L
pKa
7.4
XLogP
1.8
Properties are provided as catalog reference data and may be confirmed through supplier documentation when required.
Heavy atom count
33
H-bond acceptors
9
H-bond donors
2
Rotatable bonds
5
Ring count
5
Aromatic rings
3
Topological polar surface area
105.04 Ų
Computed LogP
2.97
Structural features
Palbociclib (CAS 571190-30-2) is listed in the Pharmaceutical Intermediates portfolio, with molecular formula C24H29N7O2 and molecular weight 447. 50 g/mol.
Sourcing context
Catalog reference for RFQ preparation, supplier confirmation, and research chemical sourcing review.
Research use context
Intended for research-stage medicinal chemistry and intermediate synthesis workflows; structure-derived tags include nitrogen-containing heterocycle.
Documentation needs
SDS signal word: Danger; hazard codes: H302, H319, H372, H410; For research use only.
ChEMBL reports experimental activity evidence for: CDK6/cyclin D1 (Homo sapiens) — 14 assays; CDK4/Cyclin D3 (Homo sapiens) — 11 assays; Cyclin-dependent kinase 4/cyclin D1 (Homo sapiens) — 31 assays; CDK9/cyclin T1 (Homo sapiens) — 8 assays; CDK6/cyclin D3 (Homo sapiens) — 13 assays. These records describe research assays and do not establish therapeutic efficacy or clinical use.
CDK6/cyclin D1
Catalog navigation
Other public CAS pages in this catalog. These links support navigation across additional intermediates and do not imply equivalence, availability, or shared use.
Procurement notes
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Use the quote panel for visible public options. Additional quantities or specifications can be reviewed by RFQ.
Purity, lot identity, and batch-specific documentation are confirmed before procurement decisions.
Supplier-issued COA and SDS can be requested before handling, storage, shipment, or procurement decisions.
Final quote depends on quantity, lead time, destination, and supplier confirmation.
Palbociclib is listed as in-stock / available for research-use sourcing review. Final availability, lot specification, and lead time are confirmed by RFQ.
The page shows a public reference price in the quote panel. Submit an RFQ to confirm current price, quantity breaks, lead time, and destination-specific shipping requirements.
Yes. Supplier-issued COA and SDS can be requested during the RFQ workflow. Lot-specific documents depend on supplier and batch confirmation.
Fragment-like structure rule
No
Lead-like structure rule
No
Drug-like structure rule
Yes
Structure family
n heterocycle ligand
Precious metal motif
No
Transition metal motif
No
Phosphine ligand motif
No
N-heterocycle motif
Yes
Boronic acid motif
No
Computed structure descriptors generated from molecular structure. These are not experimental physical property values, supplier specifications, SDS data, or bioactivity claims.
Homo sapiens · PROTEIN COMPLEX · 14 qualifying assays · 9 documents · best pChEMBL 9.7
Experimental evidence source: ChEMBL
CDK4/Cyclin D3
Homo sapiens · PROTEIN COMPLEX · 11 qualifying assays · 6 documents · best pChEMBL 9.59
Experimental evidence source: ChEMBL
Cyclin-dependent kinase 4/cyclin D1
Homo sapiens · PROTEIN COMPLEX · 31 qualifying assays · 18 documents · best pChEMBL 9.1
Experimental evidence source: ChEMBL
CDK9/cyclin T1
Homo sapiens · PROTEIN COMPLEX · 8 qualifying assays · 6 documents · best pChEMBL 9
Experimental evidence source: ChEMBL
CDK6/cyclin D3
Homo sapiens · PROTEIN COMPLEX · 13 qualifying assays · 10 documents · best pChEMBL 8.4
Experimental evidence source: ChEMBL
For supplier-issued SDS, request documentation before handling, storage, shipment, or procurement decisions.
Preliminary Safety Reference
For supplier-issued SDS or COA, submit a documentation request.
Safety Reference / SDS RequestSignal word: Danger
Supplier SDS reference cue; confirm supplier documentation before use.
Hazard statements: H302, H319, H372, H410
Supplier SDS hazard code reference; confirm full text in supplier documentation.
Precautionary statements: P501, P273, P260, P270, P264, P280, P391, P314, P337+P313, P305+P351+P338, P301+P312+P330
Supplier SDS precautionary code reference; confirm full text in supplier documentation.
Shipment review: Required
Certificate of Analysis (COA): By request
Supplier Safety Data Sheet (SDS): By request
Purity and pack size confirmation: By request
Availability and lead time review: Confirmed by RFQ
Shipment documentation review: By request
For supplier-issued documentation by request, use the RFQ actions on this page.Review preliminary safety reference
Additional text reference cues are not available for this catalog entry.
Non-public references are shown as text only and do not imply equivalence, availability, or shared use.