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Home/Compounds/CAS 577778-58-6
Formula C13H8N6MW 248.24Research-use catalog entryCOA/SDS by request

Topiroxostat

CAS Number: 577778-58-6

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Loading RDKit molecule structure...
InChIKey: UBVZQGOVTLIHLH-UHFFFAOYSA-NC13H8N6 | MW 248.24

Chemical Absolute Identifiers

CAS Number

577778-58-6

PubChem CID

5288320

Molecular Formula

C13H8N6

Molecular Weight

248.24 g/mol

Exact Mass

248.081044

InChIKey

UBVZQGOVTLIHLH-UHFFFAOYSA-N

IUPAC Name

4-(5-pyridin-4-yl-1H-1,2,4-triazol-3-yl)pyridine-2-carbonitrile

SMILES String

N#Cc1cc(-c2n[nH]c(-c3ccncc3)n2)ccn1

Physical Properties

No physical property values available.

Properties are provided as catalog reference data and may be confirmed through supplier documentation when required.

Catalog Facts

Structural features

Topiroxostat (CAS 577778-58-6) is listed in the Materials Science portfolio, with molecular formula C13H8N6 and molecular weight 248. 24 g/mol.

Sourcing context

Catalog reference for RFQ preparation, supplier confirmation, and research chemical sourcing review.

Research use context

Intended for materials chemistry research and formulation screening workflows; structure-derived tags include nitrogen-containing heterocycle.

Documentation needs

COA/SDS status, availability, lead time, pack size, and shipment documentation can be confirmed during quotation.

Applications & Classification

Ligand ResearchMOF and COF MaterialsMaterials ScienceResearch intermediateCustom synthesis building blockResearch chemical sourcingCustom synthesis and catalog availability reviewCOA, SDS, pricing, and fulfillment workflow
Biological target reference

ChEMBL reports experimental activity evidence for: Xanthine dehydrogenase/oxidase (Bos taurus) — 6 assays; Xanthine dehydrogenase/oxidase (Homo sapiens) — 2 assays. These records describe research assays and do not establish therapeutic efficacy or clinical use.

Xanthine dehydrogenase/oxidase

Bos taurus · SINGLE PROTEIN · 6 qualifying assays · 6 documents · best pChEMBL 8.32

Experimental evidence source: ChEMBL

Xanthine dehydrogenase/oxidase

Homo sapiens · SINGLE PROTEIN · 2 qualifying assays · 2 documents · best pChEMBL 8.24

Experimental evidence source: ChEMBL

Safety & Handling

Safety and handling reference content is available through documentation requests.

For supplier-issued SDS, request documentation before handling, storage, shipment, or procurement decisions.

Preliminary Safety Reference

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Safety Reference / SDS Request

Names & Synonyms / External Identifiers

Chemical Name

Topiroxostat

Names & Synonyms

uriadec4-(5-(Pyridin-4-yl)-1h-1,2,4-triazol-3-yl)pyridine-2-carbonitrile4-[5-(pyridin-4-yl)-1H-1,2,4-triazol-3-yl]pyridine-2-carbonitrile4-(5-pyridin-4-yl-1H-(1,2,4) triazol-3-yl)pyridine-2-carbonitriletopiroxostatum
Show all synonyms
FYX 051topiloricTopiroxostat [INN]4-(3-(Pyridin-4-yl)-1H-1,2,4-triazol-5-yl)picolinonitrile4-(5-(pyridin-4-yl)-1H-1,2,4-triazol-3-yl)picolinonitrile5-(2-cyano-4-pyridyl)-3-(4-pyridyl)-1,2,4-triazole4-[5-(4-Pyridyl)-1H-1,2,4-triazol-3-yl]pyridine-2-carbonitrile2-Pyridinecarbonitrile, 4-[5-(4-pyridinyl)-1H-1,2,4-triazol-3-yl]-Uriadec (TN)Topiroxostat (Standard)Topiroxostat (JAN/INN)TOPIROXOSTAT [MI]TOPIROXOSTAT [JAN]Topiroxostat(FYX-051)?
External Identifiers
DSSTOX SUBSTANCE ID: DTXSID80206462CHEMBL ID: CHEMBL1078685UNII: 0J877412JVDRUGBANK ID: DB01685KEGG ID: D09786METABOLOMICS WORKBENCH ID: 146324NCI THESAURUS CODE: C96311WIKIDATA ID: Q15725832
Experimental Spectrum References
13C NMR SpectraATR-IR Spectra — Forensic Spectral ResearchFTIR Spectra — Forensic Spectral ResearchRaman Spectra — Forensic Spectral Research
Literature & Patent References
DOI 10.1021/acs.jmedchem.4c01260Recent Progress and Future Perspectives on Anti-Hyperuricemic Agents.PMID 39513478Recent Progress and Future Perspectives on Anti-Hyperuricemic Agents.DOI 10.1016/j.ejmech.2022.114346Targeting breast cancer resistance protein (BCRP/ABCG2): Functional inhibitors and expression modulators.PMID 35483322Targeting breast cancer resistance protein (BCRP/ABCG2): Functional inhibitors and expression modulators.DOI 10.6019/CHEMBL4808148HDAC6 screening dataset using tau-based substrate in an enzymatic assay yields selective inhibitors and activatorsDOI 10.1101/2020.04.21.054387Identification of potential treatments for COVID-19 through artificial intelligence-enabled phenomic analysis of human cells infected with SARS-CoV-2DOI 10.21203/rs.3.rs-23951/v1Identification of inhibitors of SARS-CoV-2 in-vitro cellular toxicity in human (Caco-2) cells using a large scale drug repurposing collectionDOI 10.6019/CHEMBL4495564Identification of inhibitors of SARS-Cov2 M-Pro enzymatic activity using a small molecule repurposing screen

Documentation & Compliance Facts

Compliance Facts

Shipment review: Required

Documentation available by request

Certificate of Analysis (COA): By request

Supplier Safety Data Sheet (SDS): By request

Purity and pack size confirmation: By request

Availability and lead time review: Confirmed by RFQ

Shipment documentation review: By request

For supplier-issued documentation by request, use the RFQ actions on this page.Review preliminary safety reference

What happens after RFQ

  1. 1We review the CAS identity, quantity, and documentation request.
  2. 2We check sourcing options, supplier availability, COA/SDS, purity, pack size, and lead time.
  3. 3We review destination and shipment documentation needs when applicable.
  4. 4We follow up with a quotation or clarification request.

Text Reference Cues

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Non-public related references

4,4'-(1H-1,2,4-Triazole-3,5-diyl)bis(pyridine)CAS 4329-78-6
[4,4'-Bipyridine]-2-carbonitrileCAS 137787-08-7
[4,4'-Bipyridine]-2,2'-dicarbonitrileCAS 53829-09-7
2-Chloro-[4,4'-bipyridine]-3-carbonitrileCAS 1268104-62-6
4-(1H-Imidazol-2-yl)-pyridineCAS 21202-42-6

Non-public references are shown as text only and do not imply equivalence, availability, or shared use.

Catalog navigation

Related Catalog Entries

Other public CAS pages in this catalog. These links support navigation across additional intermediates and do not imply equivalence, availability, or shared use.

CAS 4329-78-64,4'-(1H-1,2,4-Triazole-3,5-diyl)bis(pyridine)CAS 137787-08-7[4,4'-Bipyridine]-2-carbonitrileCAS 53829-09-7[4,4'-Bipyridine]-2,2'-dicarbonitrileCAS 7677-24-9Trimethylsilyl cyanideCAS 520-36-5ApigeninCAS 171228-49-2PosaconazoleCAS 1002310-00-0Tert-butyl 1-(2-chloro-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)ethylcarbamateCAS 1005174-17-3(E)-3-(2-Propyl-6-(trifluoromethyl)pyridin-3-yl)acrylic acidCAS 1018125-49-92-(3-Cyclopropyl-6-ethyl-4-(trifluoromethyl)-1H-pyrazolo[3,4-b]pyridin-1-yl)acetic acidCAS 1018128-07-8Isopropyl 4-chloro-2-methylquinoline-6-carboxylate

RFQ questions for CAS 577778-58-6

What are the key identifiers for Topiroxostat (CAS 577778-58-6)?

Topiroxostat is identified by CAS 577778-58-6, with molecular formula C13H8N6, molecular weight 248.24, InChIKey UBVZQGOVTLIHLH-UHFFFAOYSA-N.

Does CAS 577778-58-6 have reported biological target evidence?

ChEMBL contains qualifying experimental assay evidence associated with Xanthine dehydrogenase/oxidase, Xanthine dehydrogenase/oxidase. These records do not establish therapeutic efficacy or clinical use.

Can I request a COA for CAS 577778-58-6?

Yes. Submit an RFQ and specify COA requirements. Lot-specific COA depends on supplier confirmation.

Can I request supplier SDS for Topiroxostat?

Yes. Supplier SDS can be requested through the RFQ workflow before handling, storage, shipment, or procurement decisions.

Is CAS 577778-58-6 available for quotation?

Availability, pack size, lead time, and pricing are confirmed through RFQ.

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