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Home/Compounds/CAS 57808-65-8
Formula C22H14Cl2I2N2O2MW 663.1Research-use catalog entryCOA/SDS by request

Closantel

CAS Number: 57808-65-8

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Loading RDKit molecule structure...
InChIKey: JMPFSEBWVLAJKM-UHFFFAOYSA-NC22H14Cl2I2N2O2 | MW 663.1

Chemical Absolute Identifiers

CAS Number

57808-65-8

PubChem CID

42574

Molecular Formula

C22H14Cl2I2N2O2

Molecular Weight

663.1 g/mol

Exact Mass

661.85218

InChIKey

JMPFSEBWVLAJKM-UHFFFAOYSA-N

IUPAC Name

N-[5-chloro-4-[(4-chlorophenyl)-cyanomethyl]-2-methylphenyl]-2-hydroxy-3,5-diiodobenzamide

SMILES String

CC1=CC(=C(C=C1NC(=O)C2=C(C(=CC(=C2)I)I)O)Cl)C(C#N)C3=CC=C(C=C3)Cl

Physical Properties

No physical property values available.

Properties are provided as catalog reference data and may be confirmed through supplier documentation when required.

Catalog Facts

Structural features

Closantel (CAS 57808-65-8) is listed in the Pharmaceutical Intermediates portfolio, with molecular formula C22H14Cl2I2N2O2 and molecular weight 663. 10 g/mol.

Sourcing context

Catalog reference for RFQ preparation, supplier confirmation, and research chemical sourcing review.

Research use context

Intended for research-stage medicinal chemistry and intermediate synthesis workflows; structure-derived tags include nitrogen-containing heterocycle.

Documentation needs

COA/SDS status, availability, lead time, pack size, and shipment documentation can be confirmed during quotation.

Applications & Classification

Pharmaceutical Intermediate ResearchResearch intermediateCustom synthesis building blockPharmaceutical intermediate researchResearch chemical sourcingCustom synthesis and catalog availability reviewCOA, SDS, pricing, and fulfillment workflow
Biological target reference

ChEMBL reports experimental activity evidence for: Chitinase (Onchocerca volvulus) — 3 assays; GroEL/GroES (Escherichia coli) — 6 assays; HSP60/HSP10 (Homo sapiens) — 2 assays; Long-chain-fatty-acid--AMP ligase FadD32 (Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)) — 2 assays; Tyrosyl-DNA phosphodiesterase 1 (Homo sapiens) — 3 assays. These records describe research assays and do not establish therapeutic efficacy or clinical use.

Chitinase

Onchocerca volvulus · SINGLE PROTEIN · 3 qualifying assays · 2 documents · best pChEMBL 6.33

Experimental evidence source: ChEMBL

GroEL/GroES

Escherichia coli · PROTEIN COMPLEX · 6 qualifying assays · 2 documents · best pChEMBL 5.82

Experimental evidence source: ChEMBL

HSP60/HSP10

Homo sapiens · PROTEIN COMPLEX · 2 qualifying assays · 2 documents · best pChEMBL 5.6

Experimental evidence source: ChEMBL

Long-chain-fatty-acid--AMP ligase FadD32

Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv) · SINGLE PROTEIN · 2 qualifying assays · 1 documents · best pChEMBL 5.11

Experimental evidence source: ChEMBL

Tyrosyl-DNA phosphodiesterase 1

Homo sapiens · SINGLE PROTEIN · 3 qualifying assays · 1 documents · best pChEMBL 4.75

Experimental evidence source: ChEMBL

Safety & Handling

Handling & Storage

  • Keep container tightly closed and dry.
  • Store in a well-ventilated place.

PPE

Respiratory protection if needed

First Aid

  • Do not give anything to an unconscious person.
  • Rinse mouth with water.

Stability / Reactivity

  • Reactivity and reaction.
  • Carbon monoxide, carbon dioxide, hydrogen chloride, hydrogen iodide, nitrogen oxides.

Disposal

  • Dispose of remaining and non-recyclable solutions to a licensed company.
  • Contact a professional institution with a waste disposal license to handle this substance.
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Fire Fighting

  • If necessary, wear a self-contained breathing apparatus during firefighting.

Accidental Release

  • Do not generate dust when collecting and disposing.
  • Use personal protective equipment and emergency procedures.

For supplier-issued SDS, request documentation before handling, storage, shipment, or procurement decisions.

Preliminary Safety Reference

For supplier-issued SDS or COA, submit a documentation request.

Safety Reference / SDS Request

Names & Synonyms / External Identifiers

Chemical Name

Closantel

Names & Synonyms

ClosantelumR 31,520Benzamide, N-(5-chloro-4-((4-chlorophenyl)cyanomethyl)-2-methylphenyl)-2-hydroxy-3,5-diiodo-R 31520N-(5-Chloro-4-((4-chlorophenyl)cyanomethyl)-2-methylphenyl)-2-hydroxy-3,5-diiodobenzamide
Show all synonyms
Benzamide, N-[5-chloro-4-[(4-chlorophenyl)cyanomethyl]-2-methylphenyl]-2-hydroxy-3,5-diiodo-N-(5-chloro-4((4-chlorophenyl)cyanomethyl)-2-methylphenyl)-2-hydroxy-3,5-diiodobenzamideN-(5-chloro-4-((4-chlorophenyl)(cyano)methyl)-2-methylphenyl)-2-hydroxy-3,5-diiodobenzamideC22H14Cl2I2N2O2N-{5-chloro-4-[(4-chlorophenyl)(cyano)methyl]-2-methylphenyl}-2-hydroxy-3,5-diiodobenzamideN-[5-chloro-4-[(4-chlorophenyl)-cyano-methyl]-2-methyl-phenyl]-2-hydroxy-3,5-diiodo-benzamideClosantelum [INN-Latin]Closantel [USAN:INN:BAN]CCRIS 934557808-65-8 (free acid)Closantel (Standard)CLOSANTEL [INN]CLOSANTEL [MI]Closantel (USAN/INN)
External Identifiers
EC NUMBER: 260-967-1DSSTOX SUBSTANCE ID: DTXSID6040662CHEMBL ID: CHEMBL12131CHEBI ID: CHEBI:77054UNII: EUL532EI54HMDB ID: HMDB0250369KEGG ID: D03567NCI THESAURUS CODE: C79920WIKIDATA ID: Q2560163
Literature & Patent References
DOI 10.1016/j.isci.2024.108907Identification and evaluation of small-molecule inhibitors against the dNTPase SAMHD1 via a comprehensive screening funnelDOI 10.6019/CHEMBL5724801EUbOPEN Chemogenomics Library - MultiplexPMID 38318365Identification and evaluation of small-molecule inhibitors against the dNTPase SAMHD1 via a comprehensive screening funnelDOI 10.1021/acs.jmedchem.2c01731Screening through Lead Optimization of High Affinity, Allosteric Cyclin-Dependent Kinase 2 (CDK2) Inhibitors as Male Contraceptives That Reduce Sperm Counts in Mice.DOI 10.6019/CHEMBL5303304EUbOPEN Chemogenomics Library - IncuCytePMID 36701569Screening through Lead Optimization of High Affinity, Allosteric Cyclin-Dependent Kinase 2 (CDK2) Inhibitors as Male Contraceptives That Reduce Sperm Counts in Mice.DOI 10.1016/j.bmc.2022.116938Drug screening approach against mycobacterial fatty acyl-AMP ligase FAAL32 renews the interest of the salicylanilide pharmacophore in the fight against tuberculosis.PMID 35933838Drug screening approach against mycobacterial fatty acyl-AMP ligase FAAL32 renews the interest of the salicylanilide pharmacophore in the fight against tuberculosis.

Documentation & Compliance Facts

Compliance Facts

Shipment review: Required

Documentation available by request

Certificate of Analysis (COA): By request

Supplier Safety Data Sheet (SDS): By request

Purity and pack size confirmation: By request

Availability and lead time review: Confirmed by RFQ

Shipment documentation review: By request

For supplier-issued documentation by request, use the RFQ actions on this page.Review preliminary safety reference

What happens after RFQ

  1. 1We review the CAS identity, quantity, and documentation request.
  2. 2We check sourcing options, supplier availability, COA/SDS, purity, pack size, and lead time.
  3. 3We review destination and shipment documentation needs when applicable.
  4. 4We follow up with a quotation or clarification request.

Text Reference Cues

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Non-public related references

Closantel sodiumCAS 61438-64-0
NiclosamideCAS 50-65-7

Non-public references are shown as text only and do not imply equivalence, availability, or shared use.

Catalog navigation

Related Catalog Entries

Other public CAS pages in this catalog. These links support navigation across additional intermediates and do not imply equivalence, availability, or shared use.

CAS 61438-64-0Closantel sodiumCAS 1239-45-8Ethidium BromideCAS 26049-94-5(3S)-3-Benzyloxycarbonylamino-1-chloro-4-phenyl-2-butanoneCAS 65646-68-6FenretinideCAS 139481-59-7CandesartanCAS 23593-75-1ClotrimazoleCAS 1002310-00-0Tert-butyl 1-(2-chloro-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)ethylcarbamateCAS 1005174-17-3(E)-3-(2-Propyl-6-(trifluoromethyl)pyridin-3-yl)acrylic acidCAS 1018125-49-92-(3-Cyclopropyl-6-ethyl-4-(trifluoromethyl)-1H-pyrazolo[3,4-b]pyridin-1-yl)acetic acidCAS 1018128-07-8Isopropyl 4-chloro-2-methylquinoline-6-carboxylate

RFQ questions for CAS 57808-65-8

What are the key identifiers for Closantel (CAS 57808-65-8)?

Closantel is identified by CAS 57808-65-8, with molecular formula C22H14Cl2I2N2O2, molecular weight 663.1, InChIKey JMPFSEBWVLAJKM-UHFFFAOYSA-N.

Does CAS 57808-65-8 have reported biological target evidence?

ChEMBL contains qualifying experimental assay evidence associated with Chitinase, GroEL/GroES, HSP60/HSP10, Long-chain-fatty-acid--AMP ligase FadD32, Tyrosyl-DNA phosphodiesterase 1. These records do not establish therapeutic efficacy or clinical use.

Can I request a COA for CAS 57808-65-8?

Yes. Submit an RFQ and specify COA requirements. Lot-specific COA depends on supplier confirmation.

Can I request supplier SDS for Closantel?

Yes. Supplier SDS can be requested through the RFQ workflow before handling, storage, shipment, or procurement decisions.

Is CAS 57808-65-8 available for quotation?

Availability, pack size, lead time, and pricing are confirmed through RFQ.

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