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- 1 g
- Purity
- 98%
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CAS Number: 58-14-0
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CAS Number
58-14-0
PubChem CID
4993
Molecular Formula
C12H13ClN4
Molecular Weight
248.71 g/mol
Exact Mass
248.082874
InChIKey
WKSAUQYGYAYLPV-UHFFFAOYSA-N
IUPAC Name
5-(4-chlorophenyl)-6-ethylpyrimidine-2,4-diamine
SMILES String
CCC1=C(C(=NC(=N1)N)N)C2=CC=C(C=C2)Cl
Appearance
White scored tablets contains 25 mg pyrimethamine /Daraprim/
Melting Point
232.78–234 °C
pKa
7.34
Properties are provided as catalog reference data and may be confirmed through supplier documentation when required.
Structural features
Pyrimethamine (CAS 58-14-0) is listed in the Pharmaceutical Intermediates portfolio, with molecular formula C12H13ClN4 and molecular weight 248. 71 g/mol.
Sourcing context
Catalog reference for RFQ preparation, supplier confirmation, and research chemical sourcing review.
Research use context
Intended for research-stage medicinal chemistry and intermediate synthesis workflows; structure-derived tags include nitrogen-containing heterocycle.
Documentation needs
COA/SDS status, availability, lead time, pack size, and shipment documentation can be confirmed during quotation.
ChEMBL reports experimental activity evidence for: Bifunctional dihydrofolate reductase-thymidylate synthase (Plasmodium falciparum K1) — 27 assays; Bifunctional dihydrofolate reductase-thymidylate synthase (Plasmodium falciparum (isolate 3D7)) — 2 assays; Dihydrofolate reductase (Escherichia coli) — 15 assays; Dihydrofolate reductase (Homo sapiens) — 20 assays; Dihydrofolate reductase (Pneumocystis carinii) — 9 assays. These records describe research assays and do not establish therapeutic efficacy or clinical use.
Bifunctional dihydrofolate reductase-thymidylate synthase
Plasmodium falciparum K1 · SINGLE PROTEIN · 27 qualifying assays · 9 documents · best pChEMBL 9.72
Experimental evidence source: ChEMBL
Bifunctional dihydrofolate reductase-thymidylate synthase
Plasmodium falciparum (isolate 3D7) · SINGLE PROTEIN · 2 qualifying assays · 1 documents · best pChEMBL 9.07
Experimental evidence source: ChEMBL
Dihydrofolate reductase
Escherichia coli · SINGLE PROTEIN · 15 qualifying assays · 4 documents · best pChEMBL 8.92
Experimental evidence source: ChEMBL
Dihydrofolate reductase
Homo sapiens · SINGLE PROTEIN · 20 qualifying assays · 14 documents · best pChEMBL 8.1
Experimental evidence source: ChEMBL
Dihydrofolate reductase
Pneumocystis carinii · SINGLE PROTEIN · 9 qualifying assays · 8 documents · best pChEMBL 8.01
Experimental evidence source: ChEMBL
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Preliminary Safety Reference
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Safety Reference / SDS RequestCatalog navigation
Other public CAS pages in this catalog. These links support navigation across additional intermediates and do not imply equivalence, availability, or shared use.
Pyrimethamine is identified by CAS 58-14-0, with molecular formula C12H13ClN4, molecular weight 248.71, InChIKey WKSAUQYGYAYLPV-UHFFFAOYSA-N.
ChEMBL contains qualifying experimental assay evidence associated with Bifunctional dihydrofolate reductase-thymidylate synthase, Bifunctional dihydrofolate reductase-thymidylate synthase, Dihydrofolate reductase, Dihydrofolate reductase, Dihydrofolate reductase. These records do not establish therapeutic efficacy or clinical use.
Yes. Submit an RFQ and specify COA requirements. Lot-specific COA depends on supplier confirmation.
Yes. Supplier SDS can be requested through the RFQ workflow before handling, storage, shipment, or procurement decisions.
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