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Home/Compounds/CAS 604769-01-9
Formula C19H19N5O4SMW 413.5Research-use catalog entryCOA/SDS by request

R-306465

CAS Number: 604769-01-9

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Loading RDKit molecule structure...
InChIKey: MUTBJZVSRNUIHA-UHFFFAOYSA-NC19H19N5O4S | MW 413.5

Chemical Absolute Identifiers

CAS Number

604769-01-9

PubChem CID

10309899

Molecular Formula

C19H19N5O4S

Molecular Weight

413.5 g/mol

Exact Mass

413.115775

InChIKey

MUTBJZVSRNUIHA-UHFFFAOYSA-N

IUPAC Name

N-hydroxy-2-(4-naphthalen-2-ylsulfonylpiperazin-1-yl)pyrimidine-5-carboxamide

SMILES String

O=C(NO)c1cnc(N2CCN(S(=O)(=O)c3ccc4ccccc4c3)CC2)nc1

Physical Properties

No physical property values available.

Properties are provided as catalog reference data and may be confirmed through supplier documentation when required.

Catalog Facts

Structural features

R-306465 (CAS 604769-01-9) is listed in the Advanced Chemicals portfolio, with molecular formula C19H19N5O4S and molecular weight 413. 50 g/mol.

Sourcing context

Catalog reference for RFQ preparation, supplier confirmation, and research chemical sourcing review.

Research use context

Intended for research building-block and synthetic chemistry workflows; structure-derived tags include nitrogen-containing heterocycle.

Documentation needs

COA/SDS status, availability, lead time, pack size, and shipment documentation can be confirmed during quotation.

Applications & Classification

Organic Building BlocksSynthetic ChemistryResearch intermediateCustom synthesis building blockResearch chemical sourcingCustom synthesis and catalog availability reviewCOA, SDS, pricing, and fulfillment workflow
Biological target reference

ChEMBL reports experimental activity evidence for: Histone deacetylase 8 (Homo sapiens) — 2 assays; Protein deacetylase HDAC6 (Homo sapiens) — 5 assays. These records describe research assays and do not establish therapeutic efficacy or clinical use.

Histone deacetylase 8

Homo sapiens · SINGLE PROTEIN · 2 qualifying assays · 2 documents · best pChEMBL 7.64

Experimental evidence source: ChEMBL

Protein deacetylase HDAC6

Homo sapiens · SINGLE PROTEIN · 5 qualifying assays · 2 documents · best pChEMBL 7.18

Experimental evidence source: ChEMBL

Safety & Handling

Safety and handling reference content is available through documentation requests.

For supplier-issued SDS, request documentation before handling, storage, shipment, or procurement decisions.

Preliminary Safety Reference

For supplier-issued SDS or COA, submit a documentation request.

Safety Reference / SDS Request

Names & Synonyms / External Identifiers

Chemical Name

R-306465

Names & Synonyms

5-Pyrimidinecarboxamide, N-hydroxy-2-(4-(2-naphthalenylsulfonyl)-1-piperazinyl)-N-hydroxy-2-(4-(naphthalene-2-sulfonyl)piperazin-1-yl)pyrimidine-5-carboxamideN-HYDROXY-2-[4-(NAPHTHALENE-2-SULFONYL)PIPERAZIN-1-YL]PYRIMIDINE-5-CARBOXAMIDER 306465N-hydroxy-2-(4-(naphthalen-2-ylsulfonyl)piperazin-1-yl)pyrimidine-5-carboxamide
Show all synonyms
N-Hydroxy-2-(4-(naphthalen-2-ylsulfonyl)-piperazin-1-yl)pyrimidine-5-carboxamide5-Pyrimidinecarboxamide, N-hydroxy-2-[4-(2-naphthalenylsulfonyl)-1-piperazinyl]- (9CI)N-Hydroxy-2-[4-(2-naphthalenylsulfonyl)-1-piperazinyl]-5-pyrimidinecarboxamideR306465(JNJ-16241199)R306465(JNJ-16241199)?2-[4-(2-naphthylsulfonyl)piperazin-1-yl]pyrimidine-5-carbohydroxamic acid
External Identifiers
DSSTOX SUBSTANCE ID: DTXSID00209218CHEMBL ID: CHEMBL609583UNII: 5WD7KK1IIQDRUGBANK ID: DB12382METABOLOMICS WORKBENCH ID: 153377WIKIDATA ID: Q27262965
Literature & Patent References
DOI 10.6019/CHEMBL4808148HDAC6 screening dataset using tau-based substrate in an enzymatic assay yields selective inhibitors and activatorsDOI 10.21203/rs.3.rs-23951/v1Identification of inhibitors of SARS-CoV-2 in-vitro cellular toxicity in human (Caco-2) cells using a large scale drug repurposing collectionDOI 10.6019/CHEMBL4495564Identification of inhibitors of SARS-Cov2 M-Pro enzymatic activity using a small molecule repurposing screenDOI 10.6019/CHEMBL4495565Cytopathic SARS-Cov2 screening on VERO-E6 cells in a large repurposing effortDOI 10.1016/j.ejmech.2018.12.039Histone deacetylase 8 (HDAC8) and its inhibitors with selectivity to other isoforms: An overview.PMID 30594678Histone deacetylase 8 (HDAC8) and its inhibitors with selectivity to other isoforms: An overview.DOI 10.1016/j.bmcl.2009.10.118Identification of a series of substituted 2-piperazinyl-5-pyrimidylhydroxamic acids as potent histone deacetylase inhibitors.PMID 19906529Identification of a series of substituted 2-piperazinyl-5-pyrimidylhydroxamic acids as potent histone deacetylase inhibitors.

Documentation & Compliance Facts

Compliance Facts

Shipment review: Required

Documentation available by request

Certificate of Analysis (COA): By request

Supplier Safety Data Sheet (SDS): By request

Purity and pack size confirmation: By request

Availability and lead time review: Confirmed by RFQ

Shipment documentation review: By request

For supplier-issued documentation by request, use the RFQ actions on this page.Review preliminary safety reference

What happens after RFQ

  1. 1We review the CAS identity, quantity, and documentation request.
  2. 2We check sourcing options, supplier availability, COA/SDS, purity, pack size, and lead time.
  3. 3We review destination and shipment documentation needs when applicable.
  4. 4We follow up with a quotation or clarification request.

Text Reference Cues

Show non-linked catalog cues

Non-public related references

Benzohydroxamic acidCAS 495-18-1
1-Naphthohydroxamic AcidCAS 6953-61-3
Isonicotinohydroxamic acidCAS 4427-22-9
N,3,4-TrihydroxybenzamideCAS 69839-83-4
N-hydroxy-2-(1-methyl-1H-pyrrole-2-carbonyl)-1,2,3,4-tetrahydroisoquinoline-6-carboxamideCAS 1259296-46-2

Non-public references are shown as text only and do not imply equivalence, availability, or shared use.

Catalog navigation

Related Catalog Entries

Other public CAS pages in this catalog. These links support navigation across additional intermediates and do not imply equivalence, availability, or shared use.

CAS 1259296-46-2N-hydroxy-2-(1-methyl-1H-pyrrole-2-carbonyl)-1,2,3,4-tetrahydroisoquinoline-6-carboxamideCAS 128517-07-7RomidepsinCAS 149647-78-9VorinostatCAS 414864-00-9BelinostatCAS 100-88-9CyclamateCAS 1002310-00-0Tert-butyl 1-(2-chloro-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)ethylcarbamateCAS 1005174-17-3(E)-3-(2-Propyl-6-(trifluoromethyl)pyridin-3-yl)acrylic acidCAS 1018125-49-92-(3-Cyclopropyl-6-ethyl-4-(trifluoromethyl)-1H-pyrazolo[3,4-b]pyridin-1-yl)acetic acidCAS 1018128-07-8Isopropyl 4-chloro-2-methylquinoline-6-carboxylateCAS 1018142-22-76-cyclopropyl-1-(2,2-difluoroethyl)-3-methyl-1H-pyrazolo[3,4-b]pyridine-4-carboxylic acid

RFQ questions for CAS 604769-01-9

What are the key identifiers for R-306465 (CAS 604769-01-9)?

R-306465 is identified by CAS 604769-01-9, with molecular formula C19H19N5O4S, molecular weight 413.5, InChIKey MUTBJZVSRNUIHA-UHFFFAOYSA-N.

Does CAS 604769-01-9 have reported biological target evidence?

ChEMBL contains qualifying experimental assay evidence associated with Histone deacetylase 8, Protein deacetylase HDAC6. These records do not establish therapeutic efficacy or clinical use.

Can I request a COA for CAS 604769-01-9?

Yes. Submit an RFQ and specify COA requirements. Lot-specific COA depends on supplier confirmation.

Can I request supplier SDS for R-306465?

Yes. Supplier SDS can be requested through the RFQ workflow before handling, storage, shipment, or procurement decisions.

Is CAS 604769-01-9 available for quotation?

Availability, pack size, lead time, and pricing are confirmed through RFQ.

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