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Home/Compounds/CAS 6199-67-3
Formula C32H46O8MW 558.7Research-use catalog entryCOA/SDS by request

(+)-Cucurbitacin B

CAS Number: 6199-67-3

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Loading RDKit molecule structure...
InChIKey: IXQKXEUSCPEQRD-DKRGWESNSA-NC32H46O8 | MW 558.7

Chemical Absolute Identifiers

CAS Number

6199-67-3

PubChem CID

5281316

Molecular Formula

C32H46O8

Molecular Weight

558.7 g/mol

Exact Mass

558.319268

InChIKey

IXQKXEUSCPEQRD-DKRGWESNSA-N

IUPAC Name

[(E,6R)-6-[(2S,8S,9R,10R,13R,14S,16R,17R)-2,16-dihydroxy-4,4,9,13,14-pentamethyl-3,11-dioxo-2,7,8,10,12,15,16,17-octahydro-1H-cyclopenta[a]phenanthren-17-yl]-6-hydroxy-2-methyl-5-oxohept-3-en-2-yl] acetate

SMILES String

CC(=O)OC(C)(C)/C=C/C(=O)[C@](C)(O)[C@H]1[C@H](O)C[C@@]2(C)[C@@H]3CC=C4[C@@H](C[C@H](O)C(=O)C4(C)C)[C@]3(C)C(=O)C[C@]12C

Physical Properties

Melting Point

184–186 °C

Properties are provided as catalog reference data and may be confirmed through supplier documentation when required.

Catalog Facts

Structural features

(+)-Cucurbitacin B (CAS 6199-67-3) is listed in the Advanced Chemicals portfolio, with molecular formula C32H46O8 and molecular weight 558. 70 g/mol.

Sourcing context

Catalog reference for RFQ preparation, supplier confirmation, and research chemical sourcing review.

Research use context

Intended for research building-block and synthetic chemistry workflows.

Documentation needs

COA/SDS status, availability, lead time, pack size, and shipment documentation can be confirmed during quotation.

Applications & Classification

Organic Building BlocksSynthetic ChemistryResearch intermediateCustom synthesis building blockResearch chemical sourcingCustom synthesis and catalog availability reviewCOA, SDS, pricing, and fulfillment workflow
Biological target reference

ChEMBL reports experimental activity evidence for: Insulin-like growth factor 2 mRNA-binding protein 1 (Homo sapiens) — 2 assays. These records describe research assays and do not establish therapeutic efficacy or clinical use.

Insulin-like growth factor 2 mRNA-binding protein 1

Homo sapiens · SINGLE PROTEIN · 2 qualifying assays · 2 documents · best pChEMBL 7.18

Experimental evidence source: ChEMBL

Safety & Handling

Safety and handling reference content is available through documentation requests.

For supplier-issued SDS, request documentation before handling, storage, shipment, or procurement decisions.

Preliminary Safety Reference

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Safety Reference / SDS Request

Names & Synonyms / External Identifiers

Chemical Name

(+)-Cucurbitacin B

Names & Synonyms

Cucurbitacin BAmarineDatisca principle BCucurbitacine BDatiscn Principle B
Show all synonyms
1,2-Dihydro-alpha-elaterin19-Nor-9beta,10alpha-lanosta-5,23-diene-3,11,22-trione, 2beta,16alpha,20,25-tetrahydroxy-9-methyl-, 25-acetate25-(Acetyloxy)-2,16,20-trihydroxy-9-methyl-19-norlanosta-5,23-diene-3,11,22-trione19-Norlanosta-5,23-diene-3,11,22-trione, 25-(acetyloxy)-2,16,20-trihydroxy-9-methyl-, (2beta,9beta,10alpha,16alpha,23E)-DATISCACINCUCURBITACIN R - DATISCA PRINCIPLE BCucurbitacine (B)Cucurbitacin-Bcucurbitacin B?HSDB 347619-nor-9.beta.,23-diene-3,11,22-trione, 9-methyl-2.beta.,16.alpha.,20,25-tetrahydroxy-, 25-acetate19-Norlanosta-5,11,22-trione, 25-(acetyloxy)-2,16,20-trihydroxy-9-methyl-, (2.beta.,9.beta.,10.alpha.,16.alpha.,23E)-CUCURBITACINBCucurbitacin B (Standard)CUCURBITACIN B [MI]
External Identifiers
EC NUMBER: 683-121-7DSSTOX SUBSTANCE ID: DTXSID501316196CHEMBL ID: CHEMBL507237CHEMBL ID: CHEMBL508185CHEBI ID: CHEBI:3941UNII: 0115W5MABFKEGG ID: C08794METABOLOMICS WORKBENCH ID: 34409RXCUI: 2688460WIKIDATA ID: Q27106259
Literature & Patent References
DOI 10.1016/j.ejmech.2024.116241Targeting insulin-like growth factor 2 mRNA-binding proteins (IGF2BPs) for the treatment of cancer.PMID 38382391Targeting insulin-like growth factor 2 mRNA-binding proteins (IGF2BPs) for the treatment of cancer.DOI 10.1021/acs.jmedchem.3c00179Opportunities and Challenges for Inhibitors Targeting Citrate Transport and Metabolism in Drug Discovery.DOI 10.1021/acs.jmedchem.3c00872Discovery of Triazolyl Derivatives of Cucurbitacin B Targeting IGF2BP1 against Non-Small Cell Lung Cancer.PMID 37428122Opportunities and Challenges for Inhibitors Targeting Citrate Transport and Metabolism in Drug Discovery.PMID 37681508Discovery of Triazolyl Derivatives of Cucurbitacin B Targeting IGF2BP1 against Non-Small Cell Lung Cancer.DOI 10.1021/acs.jnatprod.0c00364Lipid-Lowering Activities of Cucurbitacins Isolated from Trichosanthes cucumeroides and Their Synthetic Derivatives.PMID 33269591Lipid-Lowering Activities of Cucurbitacins Isolated from Trichosanthes cucumeroides and Their Synthetic Derivatives.

Documentation & Compliance Facts

Compliance Facts

Shipment review: Required

Documentation available by request

Certificate of Analysis (COA): By request

Supplier Safety Data Sheet (SDS): By request

Purity and pack size confirmation: By request

Availability and lead time review: Confirmed by RFQ

Shipment documentation review: By request

For supplier-issued documentation by request, use the RFQ actions on this page.Review preliminary safety reference

What happens after RFQ

  1. 1We review the CAS identity, quantity, and documentation request.
  2. 2We check sourcing options, supplier availability, COA/SDS, purity, pack size, and lead time.
  3. 3We review destination and shipment documentation needs when applicable.
  4. 4We follow up with a quotation or clarification request.

Text Reference Cues

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Non-public related references

Cucurbitacin ECAS 18444-66-1

Non-public references are shown as text only and do not imply equivalence, availability, or shared use.

Catalog navigation

Related Catalog Entries

Other public CAS pages in this catalog. These links support navigation across additional intermediates and do not imply equivalence, availability, or shared use.

CAS 18444-66-1Cucurbitacin ECAS 1002310-00-0Tert-butyl 1-(2-chloro-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)ethylcarbamateCAS 1005174-17-3(E)-3-(2-Propyl-6-(trifluoromethyl)pyridin-3-yl)acrylic acidCAS 1018125-49-92-(3-Cyclopropyl-6-ethyl-4-(trifluoromethyl)-1H-pyrazolo[3,4-b]pyridin-1-yl)acetic acidCAS 1018128-07-8Isopropyl 4-chloro-2-methylquinoline-6-carboxylateCAS 1018142-22-76-cyclopropyl-1-(2,2-difluoroethyl)-3-methyl-1H-pyrazolo[3,4-b]pyridine-4-carboxylic acidCAS 1018144-00-72-(3-Cyclopropyl-6-isopropyl-4-(trifluoromethyl)-1H-pyrazolo[3,4-b]pyridin-1-yl)acetic acid

RFQ questions for CAS 6199-67-3

What are the key identifiers for (+)-Cucurbitacin B (CAS 6199-67-3)?

(+)-Cucurbitacin B is identified by CAS 6199-67-3, with molecular formula C32H46O8, molecular weight 558.7, InChIKey IXQKXEUSCPEQRD-DKRGWESNSA-N.

Does CAS 6199-67-3 have reported biological target evidence?

ChEMBL contains qualifying experimental assay evidence associated with Insulin-like growth factor 2 mRNA-binding protein 1. These records do not establish therapeutic efficacy or clinical use.

Can I request a COA for CAS 6199-67-3?

Yes. Submit an RFQ and specify COA requirements. Lot-specific COA depends on supplier confirmation.

Can I request supplier SDS for (+)-Cucurbitacin B?

Yes. Supplier SDS can be requested through the RFQ workflow before handling, storage, shipment, or procurement decisions.

Is CAS 6199-67-3 available for quotation?

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