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Home/Compounds/CAS 622-78-6
Formula C8H7NSMW 149.21Research-use catalog entryCOA/SDS by request

Benzyl Isothiocyanate

CAS Number: 622-78-6

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Loading RDKit molecule structure...
InChIKey: MDKCFLQDBWCQCV-UHFFFAOYSA-NC8H7NS | MW 149.21

Chemical Absolute Identifiers

CAS Number

622-78-6

PubChem CID

2346

Molecular Formula

C8H7NS

Molecular Weight

149.21 g/mol

Exact Mass

149.02992

InChIKey

MDKCFLQDBWCQCV-UHFFFAOYSA-N

IUPAC Name

isothiocyanatomethylbenzene

SMILES String

C1=CC=C(C=C1)CN=C=S

Physical Properties

Melting Point

41.0 °C

Boiling Point

242–243 °C

Density

1.12 g/cm³

Water Solubility

0.109 mol/L

Show more physical data

Refractive Index

1.6

Properties are provided as catalog reference data and may be confirmed through supplier documentation when required.

Catalog Facts

Structural features

Benzyl Isothiocyanate (CAS 622-78-6) is listed in the Advanced Chemicals portfolio, with molecular formula C8H7NS and molecular weight 149. 21 g/mol.

Sourcing context

Catalog reference for RFQ preparation, supplier confirmation, and research chemical sourcing review.

Research use context

Intended for research building-block and synthetic chemistry workflows; structure-derived tags include nitrogen-containing heterocycle.

Documentation needs

COA/SDS status, availability, lead time, pack size, and shipment documentation can be confirmed during quotation.

Applications & Classification

Organic Building BlocksSynthetic ChemistryResearch intermediateCustom synthesis building blockResearch chemical sourcingCustom synthesis and catalog availability reviewCOA, SDS, pricing, and fulfillment workflow
Biological target reference

ChEMBL reports experimental activity evidence for: Transient receptor potential cation channel subfamily A member 1 (Homo sapiens) — 7 assays; Macrophage migration inhibitory factor (Homo sapiens) — 5 assays; Nuclear receptor ROR-gamma (Mus musculus) — 2 assays; Cytochrome P450 3A4 (Homo sapiens) — 2 assays; Glutathione S-transferase kappa 1 (Homo sapiens) — 6 assays. These records describe research assays and do not establish therapeutic efficacy or clinical use.

Transient receptor potential cation channel subfamily A member 1

Homo sapiens · SINGLE PROTEIN · 7 qualifying assays · 3 documents · best pChEMBL 6.6

Experimental evidence source: ChEMBL

Macrophage migration inhibitory factor

Homo sapiens · SINGLE PROTEIN · 5 qualifying assays · 3 documents · best pChEMBL 6.28

Experimental evidence source: ChEMBL

Nuclear receptor ROR-gamma

Mus musculus · SINGLE PROTEIN · 2 qualifying assays · 1 documents · best pChEMBL 5.25

Experimental evidence source: ChEMBL

Cytochrome P450 3A4

Homo sapiens · SINGLE PROTEIN · 2 qualifying assays · 1 documents · best pChEMBL 4.6

Experimental evidence source: ChEMBL

Glutathione S-transferase kappa 1

Homo sapiens · SINGLE PROTEIN · 6 qualifying assays · 1 documents

Experimental evidence source: ChEMBL

Safety & Handling

Safety and handling reference content is available through documentation requests.

For supplier-issued SDS, request documentation before handling, storage, shipment, or procurement decisions.

Preliminary Safety Reference

For supplier-issued SDS or COA, submit a documentation request.

Safety Reference / SDS Request

Names & Synonyms / External Identifiers

Chemical Name

Benzyl Isothiocyanate

Names & Synonyms

Benzylisothiocyanate(Isothiocyanatomethyl)benzeneBenzylsenfoelTromacapsTromalyt
Show all synonyms
UrogranBenzene, (isothiocyanatomethyl)-Isothiocyanic acid, benzyl esterBITCphenylmethyl isothiocyanatePMITC cpdFEMA NO. 4428Benzyl-isothiocyanateIsothiocyanic Acid Benzyl EsterBenzylsenfoel [German]AB 2 (VAN)alpha-isothiocyanatotoluene(isothiocyanatomethyl)-benzene1-(isothiocyanatomethyl)benzene
External Identifiers
EC NUMBER: 210-753-9DSSTOX SUBSTANCE ID: DTXSID0020155CHEMBL ID: CHEMBL55285CHEBI ID: CHEBI:17484UNII: 871J6YOR8QDRUGBANK ID: DB16860HMDB ID: HMDB0033969KEGG ID: C03098METABOLOMICS WORKBENCH ID: 46316NCI THESAURUS CODE: C68537WIKIDATA ID: Q18341725
Experimental Spectrum References
13C NMR Spectra1H NMR SpectraATR-IR SpectraFTIR SpectraRaman SpectraVapor Phase IR Spectra
Literature & Patent References
DOI 10.1016/j.ejmech.2025.117586Discovery of non-electrophilic TRPA1 channel agonists with anti-nociceptive effects via rapid current desensitization.PMID 40209420Discovery of non-electrophilic TRPA1 channel agonists with anti-nociceptive effects via rapid current desensitization.DOI 10.1021/acs.jmedchem.4c01558Discovery of a Covalent Inhibitor of Pro-Caspase-1 Zymogen Blocking NLRP3 Inflammasome Activation and Pyroptosis.PMID 39159426Discovery of a Covalent Inhibitor of Pro-Caspase-1 Zymogen Blocking NLRP3 Inflammasome Activation and Pyroptosis.DOI 10.6019/EOS300041ECBD screening data for assay EOS300041DOI 10.6019/EOS300044ECBD screening data for assay EOS300044DOI 10.1016/j.bmc.2019.115185Synthesis, in-vitro antiprotozoal activity and molecular docking study of isothiocyanate derivatives.DOI 10.1021/acs.jmedchem.0c011607-Hydroxycoumarins Are Affinity-Based Fluorescent Probes for Competitive Binding Studies of Macrophage Migration Inhibitory Factor.

Documentation & Compliance Facts

Compliance Facts

Shipment review: Required

Documentation available by request

Certificate of Analysis (COA): By request

Supplier Safety Data Sheet (SDS): By request

Purity and pack size confirmation: By request

Availability and lead time review: Confirmed by RFQ

Shipment documentation review: By request

For supplier-issued documentation by request, use the RFQ actions on this page.Review preliminary safety reference

What happens after RFQ

  1. 1We review the CAS identity, quantity, and documentation request.
  2. 2We check sourcing options, supplier availability, COA/SDS, purity, pack size, and lead time.
  3. 3We review destination and shipment documentation needs when applicable.
  4. 4We follow up with a quotation or clarification request.

Text Reference Cues

Show non-linked catalog cues

Non-public related references

p-Fluorobenzyl isothiocyanateCAS 2740-88-7
3-Fluorobenzyl isothiocyanateCAS 63351-94-0
4-Methoxybenzyl isothiocyanateCAS 3694-57-3
1-(Isothiocyanatomethyl)-3-(trifluoromethyl)benzeneCAS 2740-85-4
3,4-Dichlorobenzyl isothiocyanateCAS 18967-42-5

Non-public references are shown as text only and do not imply equivalence, availability, or shared use.

Catalog navigation

Related Catalog Entries

Other public CAS pages in this catalog. These links support navigation across additional intermediates and do not imply equivalence, availability, or shared use.

CAS 2740-88-7p-Fluorobenzyl isothiocyanateCAS 63351-94-03-Fluorobenzyl isothiocyanateCAS 3694-57-34-Methoxybenzyl isothiocyanateCAS 2740-85-41-(Isothiocyanatomethyl)-3-(trifluoromethyl)benzeneCAS 18967-42-53,4-Dichlorobenzyl isothiocyanateCAS 118-75-2ChloranilCAS 60940-34-3EbselenCAS 118090-09-81,3-benzothiazole-2-thiolCAS 114-07-8ErythromycinCAS 1002310-00-0Tert-butyl 1-(2-chloro-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)ethylcarbamate

RFQ questions for CAS 622-78-6

What are the key identifiers for Benzyl Isothiocyanate (CAS 622-78-6)?

Benzyl Isothiocyanate is identified by CAS 622-78-6, with molecular formula C8H7NS, molecular weight 149.21, InChIKey MDKCFLQDBWCQCV-UHFFFAOYSA-N.

Does CAS 622-78-6 have reported biological target evidence?

ChEMBL contains qualifying experimental assay evidence associated with Transient receptor potential cation channel subfamily A member 1, Macrophage migration inhibitory factor, Nuclear receptor ROR-gamma, Cytochrome P450 3A4, Glutathione S-transferase kappa 1. These records do not establish therapeutic efficacy or clinical use.

Can I request a COA for CAS 622-78-6?

Yes. Submit an RFQ and specify COA requirements. Lot-specific COA depends on supplier confirmation.

Can I request supplier SDS for Benzyl Isothiocyanate?

Yes. Supplier SDS can be requested through the RFQ workflow before handling, storage, shipment, or procurement decisions.

Is CAS 622-78-6 available for quotation?

Availability, pack size, lead time, and pricing are confirmed through RFQ.

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