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Home/Compounds/CAS 624733-88-6
Formula C24H34F3N3O3MW 469.5Research-use catalog entryCOA/SDS by request

MK-0812

CAS Number: 624733-88-6

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Available Options

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10 mg
Purity
98%
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5 mg
Purity
98%
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Loading RDKit molecule structure...
InChIKey: MTMDXAIUENDNDL-RJSMDTJLSA-NC24H34F3N3O3 | MW 469.5

Chemical Absolute Identifiers

CAS Number

624733-88-6

PubChem CID

11180808

Molecular Formula

C24H34F3N3O3

Molecular Weight

469.5 g/mol

Exact Mass

469.255226

InChIKey

MTMDXAIUENDNDL-RJSMDTJLSA-N

IUPAC Name

[(1S,3R)-3-[[(3S,4S)-3-methoxyoxan-4-yl]amino]-1-propan-2-ylcyclopentyl]-[3-(trifluoromethyl)-7,8-dihydro-5H-1,6-naphthyridin-6-yl]methanone

SMILES String

CO[C@@H]1COCC[C@@H]1N[C@@H]1CC[C@@](C(=O)N2CCc3ncc(C(F)(F)F)cc3C2)(C(C)C)C1

Physical Properties

No physical property values available.

Properties are provided as catalog reference data and may be confirmed through supplier documentation when required.

Catalog Facts

Structural features

MK-0812 (CAS 624733-88-6) is listed in the Pharmaceutical Intermediates portfolio, with molecular formula C24H34F3N3O3 and molecular weight 469. 50 g/mol.

Sourcing context

Catalog reference for RFQ preparation, supplier confirmation, and research chemical sourcing review.

Research use context

Intended for research-stage medicinal chemistry and intermediate synthesis workflows; structure-derived tags include nitrogen-containing heterocycle.

Documentation needs

COA/SDS status, availability, lead time, pack size, and shipment documentation can be confirmed during quotation.

Applications & Classification

Pharmaceutical Intermediate ResearchResearch intermediateCustom synthesis building blockPharmaceutical intermediate researchResearch chemical sourcingCustom synthesis and catalog availability reviewCOA, SDS, pricing, and fulfillment workflow
Biological target reference

ChEMBL reports experimental activity evidence for: C-C chemokine receptor type 2 (Homo sapiens) — 2 assays; Sigma non-opioid intracellular receptor 1 (Homo sapiens) — 2 assays; Sigma intracellular receptor 2 (Homo sapiens) — 2 assays; Beta-2 adrenergic receptor (Homo sapiens) — 4 assays; Adhesion G-protein coupled receptor F1 (Homo sapiens) — 3 assays. These records describe research assays and do not establish therapeutic efficacy or clinical use.

C-C chemokine receptor type 2

Homo sapiens · SINGLE PROTEIN · 2 qualifying assays · 1 documents · best pChEMBL 9.32

Experimental evidence source: ChEMBL

Sigma non-opioid intracellular receptor 1

Homo sapiens · SINGLE PROTEIN · 2 qualifying assays · 2 documents · best pChEMBL 6.08

Experimental evidence source: ChEMBL

Sigma intracellular receptor 2

Homo sapiens · SINGLE PROTEIN · 2 qualifying assays · 2 documents · best pChEMBL 5.73

Experimental evidence source: ChEMBL

Beta-2 adrenergic receptor

Homo sapiens · SINGLE PROTEIN · 4 qualifying assays · 2 documents

Experimental evidence source: ChEMBL

Adhesion G-protein coupled receptor F1

Homo sapiens · SINGLE PROTEIN · 3 qualifying assays · 1 documents

Experimental evidence source: ChEMBL

Safety & Handling

Safety and handling reference content is available through documentation requests.

For supplier-issued SDS, request documentation before handling, storage, shipment, or procurement decisions.

Preliminary Safety Reference

For supplier-issued SDS or COA, submit a documentation request.

Safety Reference / SDS Request

Names & Synonyms / External Identifiers

Chemical Name

MK-0812

Names & Synonyms

((1S,3R)-1-isopropyl-3-(((3S,4S)-3-methoxytetrahydro-2H-pyran-4-yl)amino)cyclopentyl)(3-(trifluoromethyl)-7,8-dihydro-1,6-naphthyridin-6(5H)-yl)methanoneMK 08121,5-Anhydro-2,3-dideoxy-3-[[(1R,3S)-3-[[7,8-dihydro-3-(trifluoromethyl)-1,6-naphthyridin-6(5H)-yl]carbonyl]-3-(1-methylethyl)cyclopentyl]amino]-4-O-methyl-D-erythro-pentitol(3S,4S)-N-[(1R,3S)-3-isopropyl-3-{[3-(trifluoromethyl)-7,8-dihydro-5H-1,6-naphthyridin-6-yl]carbonyl}cyclopentyl]-3-methoxyoxan-4-amine[(1S,3R)-1-isopropyl-3-[[(3S,4S)-3-methoxytetrahydropyran-4-yl]amino]cyclopentyl]-[3-(trifluoromethyl)-7,8-dihydro-5H-1,6-naphthyridin-6-yl]methanone
External Identifiers
CHEMBL ID: CHEMBL3305901UNII: P3LKY4ZL5ODRUGBANK ID: DB11990METABOLOMICS WORKBENCH ID: 153057WIKIDATA ID: Q27086701
Literature & Patent References
DOI 10.6019/CHEMBL5442175EUbOPEN Chemogenomics Library - PDSP Secondary BindingDOI 10.6019/CHEMBL5442219EUbOPEN Chemogenomics Library - PDSP Primary BindingDOI 10.6019/CHEMBL5209801GPCR results for EUbOPEN Chemogenomics Library 3DOI 10.6019/CHEMBL4689842EUbOPEN Chemogenomics Library wave 1DOI 10.6019/CHEMBL4808148HDAC6 screening dataset using tau-based substrate in an enzymatic assay yields selective inhibitors and activatorsDOI 10.1016/j.ejmech.2015.01.063When structure-affinity relationships meet structure-kinetics relationships: 3-((Inden-1-yl)amino)-1-isopropyl-cyclopentane-1-carboxamides as CCR2 antagonists.PMID 25666912When structure-affinity relationships meet structure-kinetics relationships: 3-((Inden-1-yl)amino)-1-isopropyl-cyclopentane-1-carboxamides as CCR2 antagonists.

Documentation & Compliance Facts

Compliance Facts

Shipment review: Required

Documentation available by request

Certificate of Analysis (COA): By request

Supplier Safety Data Sheet (SDS): By request

Purity and pack size confirmation: By request

Availability and lead time review: Confirmed by RFQ

Shipment documentation review: By request

For supplier-issued documentation by request, use the RFQ actions on this page.Review preliminary safety reference

What happens after RFQ

  1. 1We review the CAS identity, quantity, and documentation request.
  2. 2We check sourcing options, supplier availability, COA/SDS, purity, pack size, and lead time.
  3. 3We review destination and shipment documentation needs when applicable.
  4. 4We follow up with a quotation or clarification request.

Text Reference Cues

Show non-linked catalog cues

Non-public related references

N-[2-[(3S)-3-[[4-hydroxy-4-(5-pyrimidin-2-ylpyridin-2-yl)cyclohexyl]amino]pyrrolidin-1-yl]-2-oxoethyl]-3-(trifluoromethyl)benzamideCAS 1341224-83-6
Benzamide, N-(2-(((3R)-1-(trans-4-hydroxy-4-(6-methoxy-3-pyridinyl)cyclohexyl)-3-pyrrolidinyl)amino)-2-oxoethyl)-3-(trifluoromethyl)-CAS 887401-92-5
N-(2-(((3S,4S)-1-(4-(Benzo[d][1,3]dioxol-5-yl)-4-hydroxycyclohexyl)-4-ethoxypyrrolidin-3-yl)amino)-2-oxoethyl)-3-(trifluoromethyl)benzamideCAS 1262238-11-8
Vicriviroc MaleateCAS 599179-03-0

Non-public references are shown as text only and do not imply equivalence, availability, or shared use.

Catalog navigation

Related Catalog Entries

Other public CAS pages in this catalog. These links support navigation across additional intermediates and do not imply equivalence, availability, or shared use.

CAS 79307-93-0Azelastine HydrochlorideCAS 274693-27-5TicagrelorCAS 138402-11-6IrbesartanCAS 160970-54-7SilodosinCAS 1002310-00-0Tert-butyl 1-(2-chloro-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)ethylcarbamateCAS 1005174-17-3(E)-3-(2-Propyl-6-(trifluoromethyl)pyridin-3-yl)acrylic acidCAS 1018125-49-92-(3-Cyclopropyl-6-ethyl-4-(trifluoromethyl)-1H-pyrazolo[3,4-b]pyridin-1-yl)acetic acidCAS 1018128-07-8Isopropyl 4-chloro-2-methylquinoline-6-carboxylateCAS 1018142-22-76-cyclopropyl-1-(2,2-difluoroethyl)-3-methyl-1H-pyrazolo[3,4-b]pyridine-4-carboxylic acidCAS 1018144-00-72-(3-Cyclopropyl-6-isopropyl-4-(trifluoromethyl)-1H-pyrazolo[3,4-b]pyridin-1-yl)acetic acid

RFQ questions for CAS 624733-88-6

What are the key identifiers for MK-0812 (CAS 624733-88-6)?

MK-0812 is identified by CAS 624733-88-6, with molecular formula C24H34F3N3O3, molecular weight 469.5, InChIKey MTMDXAIUENDNDL-RJSMDTJLSA-N.

Does CAS 624733-88-6 have reported biological target evidence?

ChEMBL contains qualifying experimental assay evidence associated with C-C chemokine receptor type 2, Sigma non-opioid intracellular receptor 1, Sigma intracellular receptor 2, Beta-2 adrenergic receptor, Adhesion G-protein coupled receptor F1. These records do not establish therapeutic efficacy or clinical use.

Can I request a COA for CAS 624733-88-6?

Yes. Submit an RFQ and specify COA requirements. Lot-specific COA depends on supplier confirmation.

Can I request supplier SDS for MK-0812?

Yes. Supplier SDS can be requested through the RFQ workflow before handling, storage, shipment, or procurement decisions.

Is CAS 624733-88-6 available for quotation?

Availability, pack size, lead time, and pricing are confirmed through RFQ.

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