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Home/Compounds/CAS 657-24-9
Formula C4H11N5MW 129.16Research-use catalog entryCOA/SDS by request

Metformin

CAS Number: 657-24-9

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Loading RDKit molecule structure...
InChIKey: XZWYZXLIPXDOLR-UHFFFAOYSA-NC4H11N5 | MW 129.16

Chemical Absolute Identifiers

CAS Number

657-24-9

PubChem CID

4091

Molecular Formula

C4H11N5

Molecular Weight

129.16 g/mol

Exact Mass

129.101445

InChIKey

XZWYZXLIPXDOLR-UHFFFAOYSA-N

IUPAC Name

3-(diaminomethylidene)-1,1-dimethylguanidine

SMILES String

CN(C)C(=N)N=C(N)N

Physical Properties

Melting Point

223–226 °C

pKa

12.4

Properties are provided as catalog reference data and may be confirmed through supplier documentation when required.

Catalog Facts

Structural features

Metformin (CAS 657-24-9) is listed in the Advanced Chemicals portfolio, with molecular formula C4H11N5 and molecular weight 129. 16 g/mol.

Sourcing context

Catalog reference for RFQ preparation, supplier confirmation, and research chemical sourcing review.

Research use context

Intended for research building-block and synthetic chemistry workflows.

Documentation needs

COA/SDS status, availability, lead time, pack size, and shipment documentation can be confirmed during quotation.

Applications & Classification

Organic Building BlocksSynthetic ChemistryResearch intermediateCustom synthesis building blockResearch chemical sourcingCustom synthesis and catalog availability reviewCOA, SDS, pricing, and fulfillment workflow
Biological target reference

ChEMBL reports experimental activity evidence for: Alpha-1A adrenergic receptor (Homo sapiens) — 6 assays; Dipeptidyl peptidase 4 (Homo sapiens) — 3 assays; 5-hydroxytryptamine receptor 1A (Homo sapiens) — 5 assays; Alpha-2A adrenergic receptor (Homo sapiens) — 5 assays; Muscarinic acetylcholine receptor M2 (Homo sapiens) — 5 assays. These records describe research assays and do not establish therapeutic efficacy or clinical use.

Alpha-1A adrenergic receptor

Homo sapiens · SINGLE PROTEIN · 6 qualifying assays · 1 documents · best pChEMBL 5.25

Experimental evidence source: ChEMBL

Dipeptidyl peptidase 4

Homo sapiens · SINGLE PROTEIN · 3 qualifying assays · 1 documents · best pChEMBL 4.54

Experimental evidence source: ChEMBL

5-hydroxytryptamine receptor 1A

Homo sapiens · SINGLE PROTEIN · 5 qualifying assays · 1 documents

Experimental evidence source: ChEMBL

Alpha-2A adrenergic receptor

Homo sapiens · SINGLE PROTEIN · 5 qualifying assays · 1 documents

Experimental evidence source: ChEMBL

Muscarinic acetylcholine receptor M2

Homo sapiens · SINGLE PROTEIN · 5 qualifying assays · 1 documents

Experimental evidence source: ChEMBL

Safety & Handling

PPE

Respiratory protection if needed

First Aid

  • Do not give anything to an unconscious person.
  • Rinse mouth with water.

Stability / Reactivity

  • Reactivity.

Disposal

  • Dispose of remaining and non-recyclable solutions to a licensed company.
  • Contact a professional agency with a waste disposal license to handle this substance.
Show additional safety reference fields

Accidental Release

  • Use personal protective equipment.
  • Avoid dust generation.

For supplier-issued SDS, request documentation before handling, storage, shipment, or procurement decisions.

Preliminary Safety Reference

For supplier-issued SDS or COA, submit a documentation request.

Safety Reference / SDS Request

Names & Synonyms / External Identifiers

Chemical Name

Metformin

Names & Synonyms

1,1-DimethylbiguanideN,N-dimethylimidodicarbonimidic diamideMetiguanideDimethylbiguanideMetformine
Show all synonyms
N,N-DimethylbiguanideMetforminaN1,N1-DimethylbiguanideN,N-DimethyldiguanideDiaforminDimethylbiguanidMetformin extended releaseBIGUANIDE, 1,1-DIMETHYL-MeguanNovo-MetforminDimethylguanylguanidineLA 60232-carbamimidoyl-1,1-dimethylguanidine1-((diaminomethylidene)amino)-N,N-dimethylmethanimidamide
External Identifiers
EC NUMBER: 211-517-8CHEMBL ID: CHEMBL1431CHEBI ID: CHEBI:6801UNII: 9100L32L2NDRUGBANK ID: DB00331HMDB ID: HMDB0001921KEGG ID: C07151KEGG ID: D04966METABOLOMICS WORKBENCH ID: 73614NCI THESAURUS CODE: C61612PHARMGKB ID: PA450395RXCUI: 6809
Experimental Spectrum References
1H NMR SpectraATR-IR Spectra — Forensic Spectral Research
Literature & Patent References
DOI 10.1016/j.ejmech.2024.117035Rational design and synthesis of novel N-benzylindole-based epalrestat analogs as selective aldose reductase inhibitors: An unexpected discovery of a new glucose-lowering agent (AK-4) acting as a mitochondrial uncoupler.DOI 10.1016/j.ejmech.2024.117053Allosteric inhibition of PTP1B by bromocatechol-chalcone derivatives.DOI 10.1016/j.ejmech.2024.117141Small molecule inhibitors targeting PD-L1, CTLA4, VISTA, TIM-3, and LAG3 for cancer immunotherapy (2020-2024).DOI 10.1016/j.ejmech.2024.117184Corosolic acid and its derivatives targeting MCCC1 against insulin resistance and their hypoglycemic effect on type 2 diabetic mice.DOI 10.1016/j.ejmech.2025.117366Design, synthesis, and biological evaluation of quinazolinone-dihydropyrimidinone as a potential anti-diabetic agent via GLUT4 translocation stimulation.DOI 10.1021/acs.jmedchem.4c02615Development of Novel Phthalazinone-Triazole Hybrids as Potential Antidiabetic Agents Targeting GLUT4 Translocation in Skeletal Muscle.DOI 10.1021/acs.jmedchem.4c02655Discovery of 1,4-Disubstituted Cyclohexene Analogues as Selective GPR119 Agonists for the Treatment of Type 2 Diabetes.PMID 39536493Rational design and synthesis of novel N-benzylindole-based epalrestat analogs as selective aldose reductase inhibitors: An unexpected discovery of a new glucose-lowering agent (AK-4) acting as a mitochondrial uncoupler.

Documentation & Compliance Facts

Compliance Facts

Shipment review: Required

Documentation available by request

Certificate of Analysis (COA): By request

Supplier Safety Data Sheet (SDS): By request

Purity and pack size confirmation: By request

Availability and lead time review: Confirmed by RFQ

Shipment documentation review: By request

For supplier-issued documentation by request, use the RFQ actions on this page.Review preliminary safety reference

What happens after RFQ

  1. 1We review the CAS identity, quantity, and documentation request.
  2. 2We check sourcing options, supplier availability, COA/SDS, purity, pack size, and lead time.
  3. 3We review destination and shipment documentation needs when applicable.
  4. 4We follow up with a quotation or clarification request.

Text Reference Cues

Show non-linked catalog cues

Non-public related references

Imidodicarbonimidic diamide, hydrochloride (1:1)CAS 4761-93-7
N,N-DimethylguanidineCAS 598-65-2
N,N-DimethylguanidineCAS 6145-42-2
1,1,3,3-TetramethylguanidineCAS 80-70-6
N-(Aminoiminomethyl)acetamideCAS 5699-40-1

Non-public references are shown as text only and do not imply equivalence, availability, or shared use.

Catalog navigation

Related Catalog Entries

Other public CAS pages in this catalog. These links support navigation across additional intermediates and do not imply equivalence, availability, or shared use.

CAS 4761-93-7Imidodicarbonimidic diamide, hydrochloride (1:1)CAS 60142-96-3GabapentinCAS 100643-71-8DesloratadineCAS 111974-69-7QuetiapineCAS 23593-75-1ClotrimazoleCAS 135062-02-1RepaglinideCAS 1002310-00-0Tert-butyl 1-(2-chloro-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)ethylcarbamateCAS 1005174-17-3(E)-3-(2-Propyl-6-(trifluoromethyl)pyridin-3-yl)acrylic acidCAS 1018125-49-92-(3-Cyclopropyl-6-ethyl-4-(trifluoromethyl)-1H-pyrazolo[3,4-b]pyridin-1-yl)acetic acidCAS 1018128-07-8Isopropyl 4-chloro-2-methylquinoline-6-carboxylate

RFQ questions for CAS 657-24-9

What are the key identifiers for Metformin (CAS 657-24-9)?

Metformin is identified by CAS 657-24-9, with molecular formula C4H11N5, molecular weight 129.16, InChIKey XZWYZXLIPXDOLR-UHFFFAOYSA-N.

Does CAS 657-24-9 have reported biological target evidence?

ChEMBL contains qualifying experimental assay evidence associated with Alpha-1A adrenergic receptor, Dipeptidyl peptidase 4, 5-hydroxytryptamine receptor 1A, Alpha-2A adrenergic receptor, Muscarinic acetylcholine receptor M2. These records do not establish therapeutic efficacy or clinical use.

Can I request a COA for CAS 657-24-9?

Yes. Submit an RFQ and specify COA requirements. Lot-specific COA depends on supplier confirmation.

Can I request supplier SDS for Metformin?

Yes. Supplier SDS can be requested through the RFQ workflow before handling, storage, shipment, or procurement decisions.

Is CAS 657-24-9 available for quotation?

Availability, pack size, lead time, and pricing are confirmed through RFQ.

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