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Home/Compounds/CAS 763113-22-0
Formula C24H23FN4O3MW 434.5Research-use catalog entryCOA/SDS by request

Olaparib

CAS Number: 763113-22-0

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Loading RDKit molecule structure...
InChIKey: FDLYAMZZIXQODN-UHFFFAOYSA-NC24H23FN4O3 | MW 434.5

Chemical Absolute Identifiers

CAS Number

763113-22-0

PubChem CID

23725625

Molecular Formula

C24H23FN4O3

Molecular Weight

434.5 g/mol

Exact Mass

434.175419

InChIKey

FDLYAMZZIXQODN-UHFFFAOYSA-N

IUPAC Name

4-[[3-[4-(cyclopropanecarbonyl)piperazine-1-carbonyl]-4-fluorophenyl]methyl]-2H-phthalazin-1-one

SMILES String

O=C(c1cc(Cc2n[nH]c(=O)c3ccccc23)ccc1F)N1CCN(C(=O)C2CC2)CC1

Physical Properties

No physical property values available.

Properties are provided as catalog reference data and may be confirmed through supplier documentation when required.

Catalog Facts

Structural features

Olaparib (CAS 763113-22-0) is listed in the Pharmaceutical Intermediates portfolio, with molecular formula C24H23FN4O3 and molecular weight 434. 50 g/mol.

Sourcing context

Catalog reference for RFQ preparation, supplier confirmation, and research chemical sourcing review.

Research use context

Intended for research-stage medicinal chemistry and intermediate synthesis workflows; structure-derived tags include nitrogen-containing heterocycle.

Documentation needs

COA/SDS status, availability, lead time, pack size, and shipment documentation can be confirmed during quotation.

Applications & Classification

Pharmaceutical Intermediate ResearchResearch intermediateCustom synthesis building blockPharmaceutical intermediate researchResearch chemical sourcingCustom synthesis and catalog availability reviewCOA, SDS, pricing, and fulfillment workflow
Biological target reference

ChEMBL reports experimental activity evidence for: Poly [ADP-ribose] polymerase 1 (Homo sapiens) — 138 assays; Poly [ADP-ribose] polymerase 2 (Homo sapiens) — 47 assays; Protein mono-ADP-ribosyltransferase PARP3 (Homo sapiens) — 10 assays; Poly [ADP-ribose] polymerase tankyrase-2 (Homo sapiens) — 8 assays; Poly [ADP-ribose] polymerase tankyrase-1 (Homo sapiens) — 12 assays. These records describe research assays and do not establish therapeutic efficacy or clinical use.

Poly [ADP-ribose] polymerase 1

Homo sapiens · SINGLE PROTEIN · 138 qualifying assays · 99 documents · best pChEMBL 10

Experimental evidence source: ChEMBL

Poly [ADP-ribose] polymerase 2

Homo sapiens · SINGLE PROTEIN · 47 qualifying assays · 39 documents · best pChEMBL 10

Experimental evidence source: ChEMBL

Protein mono-ADP-ribosyltransferase PARP3

Homo sapiens · SINGLE PROTEIN · 10 qualifying assays · 10 documents · best pChEMBL 8.36

Experimental evidence source: ChEMBL

Poly [ADP-ribose] polymerase tankyrase-2

Homo sapiens · SINGLE PROTEIN · 8 qualifying assays · 8 documents · best pChEMBL 8.28

Experimental evidence source: ChEMBL

Poly [ADP-ribose] polymerase tankyrase-1

Homo sapiens · SINGLE PROTEIN · 12 qualifying assays · 12 documents · best pChEMBL 7.98

Experimental evidence source: ChEMBL

Safety & Handling

Safety and handling reference content is available through documentation requests.

For supplier-issued SDS, request documentation before handling, storage, shipment, or procurement decisions.

Preliminary Safety Reference

For supplier-issued SDS or COA, submit a documentation request.

Safety Reference / SDS Request

Names & Synonyms / External Identifiers

Chemical Name

Olaparib

Names & Synonyms

LynparzaAZD 2281Olaparibum4-(3-{[4-(Cyclopropylcarbonyl)piperazin-1-Yl]carbonyl}-4-Fluorobenzyl)phthalazin-1(2h)-OneKEYLYNK-010 COMPONENT OLAPARIB
Show all synonyms
4-{[3-(4-cyclopropanecarbonylpiperazine-1-carbonyl)-4-fluorophenyl]methyl}-1,2-dihydrophthalazin-1-one4-[(3-{[4-(Cyclopropylcarbonyl)piperazin-1-yl]carbonyl}-4-fluorophenyl)methyl]phthalazin-1(2H)-one4-(3-((4-(cyclopropylcarbonyl)piperazin-1-yl)carbonyl)-4-fluorobenzyl)phthalazin-1(2H)-one4-((3-((4-(CYCLOPROPYLCARBONYL)PIPERAZIN-1-YL)CARBONYL)-4-FLUOROPHENYL)METHYL)PHTHALAZIN-1(2H)-ONE4-((3-(4-(cyclopropanecarbonyl)piperazine-1-carbonyl)-4-fluorophenyl)methyl)-2H-phthalazin-1-one4-((3-(4-cyclopropanecarbonylpiperazine-1-carbonyl)-4-fluorophenyl)methyl)-1,2-dihydrophthalazin-1-one4-((3-{(4-(cyclopropylcarbonyl)piperazin-1-yl)carbonyl}-4-fluorophenyl)methyl)phthalazin-1(2H)-onePARP inhibitor AZD22811-(Cyclopropylcarbonyl)-4-[5-[(3,4-dihydro-4-oxo-1-phthalazinyl)methyl]-2-fluorobenzoyl]piperazine4-(3-(4-(Cyclopropanecarbonyl)piperazine-1-carbonyl)-4-fluorobenzyl)phthalazin-1(2H)-oneOlaparib (AZD2281, Ku-0059436)Olaparib (AZD2281)OLAPARIB cpdOlaparib (AZD-2281)
External Identifiers
EC NUMBER: 642-941-5DSSTOX SUBSTANCE ID: DTXSID60917988CHEMBL ID: CHEMBL521686CHEBI ID: CHEBI:83766UNII: WOH1JD9AR8DRUGBANK ID: DB09074HMDB ID: HMDB0255929KEGG ID: D09730METABOLOMICS WORKBENCH ID: 152129NCI THESAURUS CODE: C71721PHARMGKB ID: PA164920420RXCUI: 1597582WIKIDATA ID: Q7083106
Literature & Patent References
DOI 10.1016/j.bmcl.2025.130117Discovery of dual PARP/NAMPT inhibitors for the treatment of BRCA wild-type triple-negative breast cancer.DOI 10.1016/j.ejmech.2025.117367Design, synthesis and biological evaluation of dual CDK9/PARP inhibitors for the treatment of cancer.DOI 10.1016/j.ejmech.2025.117465Combination therapy and dual-target inhibitors based on cyclin-dependent kinases (CDKs): Emerging strategies for cancer therapy.DOI 10.1016/j.ejmech.2025.117601Design, synthesis and bioevaluation of novel hydrazide derivatives as enhancers of immunotherapy and DNA-damage response in antitumor therapy.DOI 10.1021/acs.jmedchem.4c02445Discovery of Highly Potent and Orally Bioavailable Histone Deacetylase 3 Inhibitors as Immunomodulators and Enhancers of DNA-Damage Response in Cancer Therapy.DOI 10.1021/acs.jmedchem.4c02642The Potential of PARP Inhibitors as Antitumor Drugs and the Perspective of Molecular Design.DOI 10.1021/acs.jmedchem.5c01058Design and Synthesis of PARP/CDK6 Dual-Target Inhibitors Modulating of Wnt/β-Catenin Signaling Pathway for the Treatment of BRCA Wild-Type TNBC.PMID 39723587The Potential of PARP Inhibitors as Antitumor Drugs and the Perspective of Molecular Design.

Documentation & Compliance Facts

Compliance Facts

Shipment review: Required

Documentation available by request

Certificate of Analysis (COA): By request

Supplier Safety Data Sheet (SDS): By request

Purity and pack size confirmation: By request

Availability and lead time review: Confirmed by RFQ

Shipment documentation review: By request

For supplier-issued documentation by request, use the RFQ actions on this page.Review preliminary safety reference

What happens after RFQ

  1. 1We review the CAS identity, quantity, and documentation request.
  2. 2We check sourcing options, supplier availability, COA/SDS, purity, pack size, and lead time.
  3. 3We review destination and shipment documentation needs when applicable.
  4. 4We follow up with a quotation or clarification request.

Text Reference Cues

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Non-public related references

1-(Cyclopropylcarbonyl)piperazine HydrochlorideCAS 1021298-67-8

Non-public references are shown as text only and do not imply equivalence, availability, or shared use.

Catalog navigation

Related Catalog Entries

Other public CAS pages in this catalog. These links support navigation across additional intermediates and do not imply equivalence, availability, or shared use.

CAS 284028-89-32-[4-(trifluoromethyl)phenyl]-1,5,7,8-tetrahydrothiopyrano[4,3-d]pyrimidin-4-oneCAS 100643-71-8DesloratadineCAS 104-31-4BenzonatateCAS 1207454-56-5TalazoparibCAS 1002310-00-0Tert-butyl 1-(2-chloro-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)ethylcarbamateCAS 1005174-17-3(E)-3-(2-Propyl-6-(trifluoromethyl)pyridin-3-yl)acrylic acidCAS 1018125-49-92-(3-Cyclopropyl-6-ethyl-4-(trifluoromethyl)-1H-pyrazolo[3,4-b]pyridin-1-yl)acetic acidCAS 1018128-07-8Isopropyl 4-chloro-2-methylquinoline-6-carboxylateCAS 1018142-22-76-cyclopropyl-1-(2,2-difluoroethyl)-3-methyl-1H-pyrazolo[3,4-b]pyridine-4-carboxylic acidCAS 1018144-00-72-(3-Cyclopropyl-6-isopropyl-4-(trifluoromethyl)-1H-pyrazolo[3,4-b]pyridin-1-yl)acetic acid

RFQ questions for CAS 763113-22-0

What are the key identifiers for Olaparib (CAS 763113-22-0)?

Olaparib is identified by CAS 763113-22-0, with molecular formula C24H23FN4O3, molecular weight 434.5, InChIKey FDLYAMZZIXQODN-UHFFFAOYSA-N.

Does CAS 763113-22-0 have reported biological target evidence?

ChEMBL contains qualifying experimental assay evidence associated with Poly [ADP-ribose] polymerase 1, Poly [ADP-ribose] polymerase 2, Protein mono-ADP-ribosyltransferase PARP3, Poly [ADP-ribose] polymerase tankyrase-2, Poly [ADP-ribose] polymerase tankyrase-1. These records do not establish therapeutic efficacy or clinical use.

Can I request a COA for CAS 763113-22-0?

Yes. Submit an RFQ and specify COA requirements. Lot-specific COA depends on supplier confirmation.

Can I request supplier SDS for Olaparib?

Yes. Supplier SDS can be requested through the RFQ workflow before handling, storage, shipment, or procurement decisions.

Is CAS 763113-22-0 available for quotation?

Availability, pack size, lead time, and pricing are confirmed through RFQ.

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