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Home/Compounds/CAS 78755-81-4
Formula C15H14FN3O3MW 303.29Research-use catalog entryCOA/SDS by request

Flumazenil

CAS Number: 78755-81-4

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Loading RDKit molecule structure...
InChIKey: OFBIFZUFASYYRE-UHFFFAOYSA-NC15H14FN3O3 | MW 303.29

Chemical Absolute Identifiers

CAS Number

78755-81-4

PubChem CID

3373

Molecular Formula

C15H14FN3O3

Molecular Weight

303.29 g/mol

Exact Mass

303.101919

InChIKey

OFBIFZUFASYYRE-UHFFFAOYSA-N

IUPAC Name

ethyl 8-fluoro-5-methyl-6-oxo-4H-imidazo[1,5-a][1,4]benzodiazepine-3-carboxylate

SMILES String

CCOC(=O)C1=C2CN(C(=O)C3=C(N2C=N1)C=CC(=C3)F)C

Physical Properties

Melting Point

201–203 °C

Properties are provided as catalog reference data and may be confirmed through supplier documentation when required.

Catalog Facts

Structural features

Flumazenil (CAS 78755-81-4) is listed in the Advanced Chemicals portfolio, with molecular formula C15H14FN3O3 and molecular weight 303. 29 g/mol.

Sourcing context

Catalog reference for RFQ preparation, supplier confirmation, and research chemical sourcing review.

Research use context

Intended for research building-block and synthetic chemistry workflows; structure-derived tags include nitrogen-containing heterocycle.

Documentation needs

COA/SDS status, availability, lead time, pack size, and shipment documentation can be confirmed during quotation.

Applications & Classification

Organic Building BlocksSynthetic ChemistryResearch intermediateCustom synthesis building blockResearch chemical sourcingCustom synthesis and catalog availability reviewCOA, SDS, pricing, and fulfillment workflow
Biological target reference

ChEMBL reports experimental activity evidence for: GABA-A receptor; alpha-3/beta-3/gamma-2 (Homo sapiens) — 3 assays; GABA-A receptor; alpha-1/beta-2/gamma-2 (Rattus norvegicus) — 2 assays; Gamma-aminobutyric acid receptor subunit alpha-5 (Homo sapiens) — 2 assays; Gamma-aminobutyric acid receptor subunit alpha-1 (Homo sapiens) — 4 assays; GABA-A receptor; alpha-1/beta-3/gamma-2 (Homo sapiens) — 2 assays. These records describe research assays and do not establish therapeutic efficacy or clinical use.

GABA-A receptor; alpha-3/beta-3/gamma-2

Homo sapiens · PROTEIN COMPLEX · 3 qualifying assays · 3 documents · best pChEMBL 9.35

Experimental evidence source: ChEMBL

GABA-A receptor; alpha-1/beta-2/gamma-2

Rattus norvegicus · PROTEIN COMPLEX · 2 qualifying assays · 1 documents · best pChEMBL 9.3

Experimental evidence source: ChEMBL

Gamma-aminobutyric acid receptor subunit alpha-5

Homo sapiens · SINGLE PROTEIN · 2 qualifying assays · 2 documents · best pChEMBL 9.3

Experimental evidence source: ChEMBL

Gamma-aminobutyric acid receptor subunit alpha-1

Homo sapiens · SINGLE PROTEIN · 4 qualifying assays · 4 documents · best pChEMBL 9.1

Experimental evidence source: ChEMBL

GABA-A receptor; alpha-1/beta-3/gamma-2

Homo sapiens · PROTEIN COMPLEX · 2 qualifying assays · 2 documents · best pChEMBL 9.1

Experimental evidence source: ChEMBL

Safety & Handling

Handling & Storage

  • Keep container tightly closed and dry.
  • Store in a well-ventilated place.

PPE

Respiratory protection if needed

First Aid

  • Do not give anything to an unconscious person.
  • Rinse mouth with water.

Stability / Reactivity

  • Reactivity and reaction stability.
  • Carbon monoxide, carbon dioxide, hydrogen fluoride, nitrogen oxides.

Disposal

  • Dispose of the product by handing over the remaining and non-recyclable solutions to a licensed company.
  • Contact a professional agency with a waste disposal license to handle this substance.
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Fire Fighting

  • If necessary, wear a self-contained breathing apparatus for firefighting.

Accidental Release

  • Do not generate dust when collecting and disposing.
  • Use personal protective equipment and emergency procedures.

For supplier-issued SDS, request documentation before handling, storage, shipment, or procurement decisions.

Preliminary Safety Reference

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Names & Synonyms / External Identifiers

Chemical Name

Flumazenil

Names & Synonyms

AnexateFlumazepilRomaziconLanexatMazicon
Show all synonyms
FlumazenilumFlumazeniloRo 151788Ro 15-1788/000Ro-15-1788/0004H-Imidazo(1,5-a)(1,4)benzodiazepine-3-carboxylic acid, 8-fluoro-5,6-dihydro-5-methyl-6-oxo-, ethyl esterethyl 12-fluoro-8-methyl-9-oxo-2,4,8-triazatricyclo[8.4.0.0^{2,6}]tetradeca-1(10),3,5,11,13-pentaene-5-carboxylateethyl 12-fluoro-8-methyl-9-oxo-2,4,8-triazatricyclo(8.4.0.0^(2,6))tetradeca-1(10),3,5,11,13-pentaene-5-carboxylateRo 15 1788Ro 15-1788Flumazenil (Ro 15-1788)fumazenilFlumazenilum [Latin]
External Identifiers
EC NUMBER: 616-650-9DSSTOX SUBSTANCE ID: DTXSID2023064CHEMBL ID: CHEMBL407CHEBI ID: CHEBI:5103UNII: 40P7XK9392DRUGBANK ID: DB01205HMDB ID: HMDB0015336KEGG ID: C07825KEGG ID: D00697METABOLOMICS WORKBENCH ID: 43419NCI THESAURUS CODE: C47534PHARMGKB ID: PA449659RXCUI: 4457WIKIDATA ID: Q421920Ro-15-1788Ro-151788000
Experimental Spectrum References
ATR-IR Spectra — Forensic Spectral ResearchFTIR Spectra — Forensic Spectral ResearchRaman Spectra — Forensic Spectral Research
Literature & Patent References
DOI 10.1016/j.bmc.2024.118006Use of imidazo[1,5-a]quinoline scaffold as the pharmacophore in the design of bivalent ligands of central benzodiazepine receptors.PMID 39577296Use of imidazo[1,5-a]quinoline scaffold as the pharmacophore in the design of bivalent ligands of central benzodiazepine receptors.DOI 10.1016/j.isci.2024.108907Identification and evaluation of small-molecule inhibitors against the dNTPase SAMHD1 via a comprehensive screening funnelDOI 10.6019/CHEMBL5665443Enzyme Inhibitor Single Concentration assay results for EUbOPEN Chemogenomics LibraryPMID 38318365Identification and evaluation of small-molecule inhibitors against the dNTPase SAMHD1 via a comprehensive screening funnelDOI 10.1038/s41467-023-40064-9A preclinical secondary pharmacology resource illuminates target-adverse drug reaction associations of marketed drugs.DOI 10.6019/CHEMBL5209801GPCR results for EUbOPEN Chemogenomics Library 3PMID 37468498A preclinical secondary pharmacology resource illuminates target-adverse drug reaction associations of marketed drugs.

Documentation & Compliance Facts

Compliance Facts

Shipment review: Required

Documentation available by request

Certificate of Analysis (COA): By request

Supplier Safety Data Sheet (SDS): By request

Purity and pack size confirmation: By request

Availability and lead time review: Confirmed by RFQ

Shipment documentation review: By request

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  1. 1We review the CAS identity, quantity, and documentation request.
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Text Reference Cues

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Non-public related references

Ethyl 2-chloro-4,4,4-trifluoro-3-oxobutanoateCAS 363-58-6

Non-public references are shown as text only and do not imply equivalence, availability, or shared use.

Catalog navigation

Related Catalog Entries

Other public CAS pages in this catalog. These links support navigation across additional intermediates and do not imply equivalence, availability, or shared use.

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RFQ questions for CAS 78755-81-4

What are the key identifiers for Flumazenil (CAS 78755-81-4)?

Flumazenil is identified by CAS 78755-81-4, with molecular formula C15H14FN3O3, molecular weight 303.29, InChIKey OFBIFZUFASYYRE-UHFFFAOYSA-N.

Does CAS 78755-81-4 have reported biological target evidence?

ChEMBL contains qualifying experimental assay evidence associated with GABA-A receptor; alpha-3/beta-3/gamma-2, GABA-A receptor; alpha-1/beta-2/gamma-2, Gamma-aminobutyric acid receptor subunit alpha-5, Gamma-aminobutyric acid receptor subunit alpha-1, GABA-A receptor; alpha-1/beta-3/gamma-2. These records do not establish therapeutic efficacy or clinical use.

Can I request a COA for CAS 78755-81-4?

Yes. Submit an RFQ and specify COA requirements. Lot-specific COA depends on supplier confirmation.

Can I request supplier SDS for Flumazenil?

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Is CAS 78755-81-4 available for quotation?

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