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- Purity
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CAS Number: 850140-73-7
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CAS Number
850140-73-7
PubChem CID
15606394
Molecular Formula
C32H33ClFN5O11
Molecular Weight
718.1 g/mol
Exact Mass
717.184913
InChIKey
USNRYVNRPYXCSP-JUGPPOIOSA-N
IUPAC Name
bis((Z)-but-2-enedioic acid);(E)-N-[4-(3-chloro-4-fluoroanilino)-7-[(3S)-oxolan-3-yl]oxyquinazolin-6-yl]-4-(dimethylamino)but-2-enamide
SMILES String
CN(C)C/C=C/C(=O)Nc1cc2c(Nc3ccc(F)c(Cl)c3)ncnc2cc1O[C@H]1CCOC1.O=C(O)/C=C\C(=O)O.O=C(O)/C=C\C(=O)O
No physical property values available.
Properties are provided as catalog reference data and may be confirmed through supplier documentation when required.
Structural features
Afatinib Dimaleate (CAS 850140-73-7) is listed in the Pharmaceutical Intermediates portfolio, with molecular formula C32H33ClFN5O11 and molecular weight 718. 10 g/mol.
Sourcing context
Catalog reference for RFQ preparation, supplier confirmation, and research chemical sourcing review.
Research use context
Intended for research-stage medicinal chemistry and intermediate synthesis workflows; structure-derived tags include nitrogen-containing heterocycle.
Documentation needs
COA/SDS status, availability, lead time, pack size, and shipment documentation can be confirmed during quotation.
ChEMBL reports experimental activity evidence for: Epidermal growth factor receptor (Homo sapiens) — 6 assays; Receptor tyrosine-protein kinase erbB-2 (Homo sapiens) — 3 assays; Receptor tyrosine-protein kinase erbB-4 (Homo sapiens) — 3 assays; Tyrosine-protein kinase ABL1 (Homo sapiens) — 11 assays; Tyrosine-protein kinase Lck (Homo sapiens) — 2 assays. These records describe research assays and do not establish therapeutic efficacy or clinical use.
Epidermal growth factor receptor
Homo sapiens · SINGLE PROTEIN · 6 qualifying assays · 4 documents · best pChEMBL 9.52
Experimental evidence source: ChEMBL
Receptor tyrosine-protein kinase erbB-2
Homo sapiens · SINGLE PROTEIN · 3 qualifying assays · 3 documents · best pChEMBL 8.3
Experimental evidence source: ChEMBL
Receptor tyrosine-protein kinase erbB-4
Homo sapiens · SINGLE PROTEIN · 3 qualifying assays · 3 documents · best pChEMBL 8.2
Experimental evidence source: ChEMBL
Tyrosine-protein kinase ABL1
Homo sapiens · SINGLE PROTEIN · 11 qualifying assays · 1 documents · best pChEMBL 6.64
Experimental evidence source: ChEMBL
Tyrosine-protein kinase Lck
Homo sapiens · SINGLE PROTEIN · 2 qualifying assays · 1 documents · best pChEMBL 6.24
Experimental evidence source: ChEMBL
Safety and handling reference content is available through documentation requests.
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Preliminary Safety Reference
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Safety Reference / SDS RequestCatalog navigation
Other public CAS pages in this catalog. These links support navigation across additional intermediates and do not imply equivalence, availability, or shared use.
Afatinib Dimaleate is identified by CAS 850140-73-7, with molecular formula C32H33ClFN5O11, molecular weight 718.1, InChIKey USNRYVNRPYXCSP-JUGPPOIOSA-N.
ChEMBL contains qualifying experimental assay evidence associated with Epidermal growth factor receptor, Receptor tyrosine-protein kinase erbB-2, Receptor tyrosine-protein kinase erbB-4, Tyrosine-protein kinase ABL1, Tyrosine-protein kinase Lck. These records do not establish therapeutic efficacy or clinical use.
Yes. Submit an RFQ and specify COA requirements. Lot-specific COA depends on supplier confirmation.
Yes. Supplier SDS can be requested through the RFQ workflow before handling, storage, shipment, or procurement decisions.
Availability, pack size, lead time, and pricing are confirmed through RFQ.
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