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Home/Compounds/CAS 864070-44-0
Formula C23H27ClO7MW 450.9Research-use catalog entryCOA/SDS by request

Empagliflozin

CAS Number: 864070-44-0

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Loading RDKit molecule structure...
InChIKey: OBWASQILIWPZMG-QZMOQZSNSA-NC23H27ClO7 | MW 450.9

Chemical Absolute Identifiers

CAS Number

864070-44-0

PubChem CID

11949646

Molecular Formula

C23H27ClO7

Molecular Weight

450.9 g/mol

Exact Mass

450.144531

InChIKey

OBWASQILIWPZMG-QZMOQZSNSA-N

IUPAC Name

(2S,3R,4R,5S,6R)-2-[4-chloro-3-[[4-[(3S)-oxolan-3-yl]oxyphenyl]methyl]phenyl]-6-(hydroxymethyl)oxane-3,4,5-triol

SMILES String

OC[C@H]1O[C@@H](c2ccc(Cl)c(Cc3ccc(O[C@H]4CCOC4)cc3)c2)[C@H](O)[C@@H](O)[C@@H]1O

Physical Properties

Water Solubility

0.28 mol/L

Properties are provided as catalog reference data and may be confirmed through supplier documentation when required.

Catalog Facts

Structural features

Empagliflozin (CAS 864070-44-0) is listed in the Pharmaceutical Intermediates portfolio, with molecular formula C23H27ClO7 and molecular weight 450. 90 g/mol.

Sourcing context

Catalog reference for RFQ preparation, supplier confirmation, and research chemical sourcing review.

Research use context

Intended for research-stage medicinal chemistry and intermediate synthesis workflows.

Documentation needs

COA/SDS status, availability, lead time, pack size, and shipment documentation can be confirmed during quotation.

Applications & Classification

Pharmaceutical Intermediate ResearchResearch intermediateCustom synthesis building blockPharmaceutical intermediate researchResearch chemical sourcingCustom synthesis and catalog availability reviewCOA, SDS, pricing, and fulfillment workflow
Biological target reference

ChEMBL reports experimental activity evidence for: Sodium/glucose cotransporter 2 (Homo sapiens) — 9 assays; Sodium/glucose cotransporter 1 (Homo sapiens) — 4 assays; Alpha-1A adrenergic receptor (Homo sapiens) — 2 assays; Muscarinic acetylcholine receptor M1 (Homo sapiens) — 2 assays; Prostaglandin G/H synthase 1 (Homo sapiens) — 2 assays. These records describe research assays and do not establish therapeutic efficacy or clinical use.

Sodium/glucose cotransporter 2

Homo sapiens · SINGLE PROTEIN · 9 qualifying assays · 8 documents · best pChEMBL 8.52

Experimental evidence source: ChEMBL

Sodium/glucose cotransporter 1

Homo sapiens · SINGLE PROTEIN · 4 qualifying assays · 3 documents · best pChEMBL 5.49

Experimental evidence source: ChEMBL

Alpha-1A adrenergic receptor

Homo sapiens · SINGLE PROTEIN · 2 qualifying assays · 1 documents

Experimental evidence source: ChEMBL

Muscarinic acetylcholine receptor M1

Homo sapiens · SINGLE PROTEIN · 2 qualifying assays · 1 documents

Experimental evidence source: ChEMBL

Prostaglandin G/H synthase 1

Homo sapiens · SINGLE PROTEIN · 2 qualifying assays · 1 documents

Experimental evidence source: ChEMBL

Safety & Handling

Safety and handling reference content is available through documentation requests.

For supplier-issued SDS, request documentation before handling, storage, shipment, or procurement decisions.

Preliminary Safety Reference

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Safety Reference / SDS Request

Names & Synonyms / External Identifiers

Chemical Name

Empagliflozin

Names & Synonyms

JARDIANCEBI 10773EmpagliflozinaEmpagliflozine1-chloro-4-(glucopyranos-1-yl)-2-(4-(tetrahydrofuran-3-yloxy)benzyl)benzene
Show all synonyms
GLYXAMBI COMPONENT EMPAGLIFLOZIN(2S,3R,4R,5S,6R)-2-[4-chloro-3-({4-[(3S)-oxolan-3-yloxy]phenyl}methyl)phenyl]-6-(hydroxymethyl)oxane-3,4,5-triolTRIJARDY XR COMPONENT EMPAGLIFLOZIN(1S)-1,5-anhydro-1-(4-chloro-3-{4-[(3S)-tetrahydrofuran-3-yloxy]benzyl}phenyl)-D-glucitol(1S)-1,5-anhydro-1-C-{4-chloro-3-((4-{((3S)-oxolan-3-yl)oxy}phenyl)methyl)phenyl}-D-glucitolD-Glucitol, 1,5-anhydro-1-C-(4-chloro-3-((4-(((3S)-tetrahydro-3-furanyl)oxy)phenyl)methyl)phenyl)-, (1S)-Empagliflozinum(1S)-1,5-anhydro-1-(4-chloro-3-(4-((3S)-tetrahydrofuran-3-yloxy)benzyl)phenyl)-D-glucitol(1S)-1,5-Anhydro-1-C-(4-chloro-3-((4-(((3S)-oxolan-3-yl)oxy)phenyl)methyl)phenyl)-D-glucitol(2S,3R,4R,5S,6R)-2-(4-chloro-3-((4-((3S)-oxolan-3-yloxy)phenyl)methyl)phenyl)-6-(hydroxymethyl)oxane-3,4,5-triolD-Glucitol, 1,5-anhydro-1-C-[4-chloro-3-[[4-[[(3S)-tetrahydro-3-furanyl]oxy]phenyl]methyl]phenyl]-, (1S)-Empagliflozin (BI 10773)(2S,3R,4R,5S,6R)-2-(4-chloro-3-(4-(((S)-tetrahydrofuran-3-yl)oxy)benzyl)phenyl)-6-(hydroxymethyl)tetrahydro-2H-pyran-3,4,5-triol(1S)-1,5-Anhydro-1-C-[4-chloro-3-[[4-[[(3S)-tetrahydro-3-furanyl]oxy]phenyl]methyl]phenyl]-D-glucitol
External Identifiers
EC NUMBER: 620-176-8DSSTOX SUBSTANCE ID: DTXSID601026093CHEMBL ID: CHEMBL2107830CHEBI ID: CHEBI:82720UNII: HDC1R2M35UDRUGBANK ID: DB09038KEGG ID: C22194KEGG ID: D10459METABOLOMICS WORKBENCH ID: 152102NCI THESAURUS CODE: C158136PHARMGKB ID: PA166163327RXCUI: 1545653WIKIDATA ID: Q5373824
Literature & Patent References
DOI 10.1016/j.ejmech.2023.116117Targeting autophagy drug discovery: Targets, indications and development trends.DOI 10.1016/j.ejmech.2024.116273The mechanism of UNC-51-like kinase 1 and the applications of small molecule modulators in cancer treatment.DOI 10.1016/j.ejmech.2024.116343Synthetic approaches and clinical application of small-molecule inhibitors of sodium-dependent glucose transporters 2 for the treatment of type 2 diabetes mellitus.DOI 10.6019/CHEMBL5724796Tm Shift (DSF) assay results for EUbOPEN Chemogenomics LibraryPMID 38295689Targeting autophagy drug discovery: Targets, indications and development trends.PMID 38432059The mechanism of UNC-51-like kinase 1 and the applications of small molecule modulators in cancer treatment.PMID 38513341Synthetic approaches and clinical application of small-molecule inhibitors of sodium-dependent glucose transporters 2 for the treatment of type 2 diabetes mellitus.DOI 10.1021/acs.jmedchem.3c01138Design, Synthesis, and Biological Evaluation of Thioglucoside Analogues of Gliflozin as Potent New Gliflozin Drugs.

Documentation & Compliance Facts

Compliance Facts

Shipment review: Required

Documentation available by request

Certificate of Analysis (COA): By request

Supplier Safety Data Sheet (SDS): By request

Purity and pack size confirmation: By request

Availability and lead time review: Confirmed by RFQ

Shipment documentation review: By request

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What happens after RFQ

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Text Reference Cues

Show non-linked catalog cues

Non-public related references

Bms-511926CAS 864070-37-1
(2S,3R,4S,5S,6R)-2-(4-Chloro-3-(4-(((S)-tetrahydrofuran-3-YL)oxy)benzyl)phenyl)-6-(hydroxymethyl)-2-methoxytetrahydro-2H-pyran-3,4,5-triolCAS 1279691-36-9
(S)-3-[4-(2-Chlor-5-iod-benzyl)-phenoxy]-tetrahydro-furanCAS 915095-94-2
(2-Chloro-5-iodophenyl)(4-(((3S)-tetrahydro-3-furanyl)oxy)phenyl)methanoneCAS 915095-87-3
4-Bromo-1-chloro-2-(4-methoxybenzyl)benzeneCAS 333361-51-6

Non-public references are shown as text only and do not imply equivalence, availability, or shared use.

Catalog navigation

Related Catalog Entries

Other public CAS pages in this catalog. These links support navigation across additional intermediates and do not imply equivalence, availability, or shared use.

CAS 864070-37-1Bms-511926CAS 1279691-36-9(2S,3R,4S,5S,6R)-2-(4-Chloro-3-(4-(((S)-tetrahydrofuran-3-YL)oxy)benzyl)phenyl)-6-(hydroxymethyl)-2-methoxytetrahydro-2H-pyran-3,4,5-triolCAS 915095-94-2(S)-3-[4-(2-Chlor-5-iod-benzyl)-phenoxy]-tetrahydro-furanCAS 915095-87-3(2-Chloro-5-iodophenyl)(4-(((3S)-tetrahydro-3-furanyl)oxy)phenyl)methanoneCAS 100643-71-8DesloratadineCAS 102767-28-2LevetiracetamCAS 106635-80-7TafenoquineCAS 107724-20-9EplerenoneCAS 1187594-09-7BaricitinibCAS 1002310-00-0Tert-butyl 1-(2-chloro-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)ethylcarbamate

RFQ questions for CAS 864070-44-0

What are the key identifiers for Empagliflozin (CAS 864070-44-0)?

Empagliflozin is identified by CAS 864070-44-0, with molecular formula C23H27ClO7, molecular weight 450.9, InChIKey OBWASQILIWPZMG-QZMOQZSNSA-N.

Does CAS 864070-44-0 have reported biological target evidence?

ChEMBL contains qualifying experimental assay evidence associated with Sodium/glucose cotransporter 2, Sodium/glucose cotransporter 1, Alpha-1A adrenergic receptor, Muscarinic acetylcholine receptor M1, Prostaglandin G/H synthase 1. These records do not establish therapeutic efficacy or clinical use.

Can I request a COA for CAS 864070-44-0?

Yes. Submit an RFQ and specify COA requirements. Lot-specific COA depends on supplier confirmation.

Can I request supplier SDS for Empagliflozin?

Yes. Supplier SDS can be requested through the RFQ workflow before handling, storage, shipment, or procurement decisions.

Is CAS 864070-44-0 available for quotation?

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