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Home/Compounds/CAS 868540-17-4
Formula C40H57N5O7MW 719.9Research-use catalog entryCOA/SDS by request

Carfilzomib

CAS Number: 868540-17-4

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Loading RDKit molecule structure...
InChIKey: BLMPQMFVWMYDKT-NZTKNTHTSA-NC40H57N5O7 | MW 719.9

Chemical Absolute Identifiers

CAS Number

868540-17-4

PubChem CID

11556711

Molecular Formula

C40H57N5O7

Molecular Weight

719.9 g/mol

Exact Mass

719.425799

InChIKey

BLMPQMFVWMYDKT-NZTKNTHTSA-N

IUPAC Name

(2S)-4-methyl-N-[(2S)-1-[[(2S)-4-methyl-1-[(2R)-2-methyloxiran-2-yl]-1-oxopentan-2-yl]amino]-1-oxo-3-phenylpropan-2-yl]-2-[[(2S)-2-[(2-morpholin-4-ylacetyl)amino]-4-phenylbutanoyl]amino]pentanamide

SMILES String

CC(C)C[C@H](NC(=O)[C@H](CCc1ccccc1)NC(=O)CN1CCOCC1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CC(C)C)C(=O)[C@@]1(C)CO1

Physical Properties

pKa

3.5

Properties are provided as catalog reference data and may be confirmed through supplier documentation when required.

Catalog Facts

Structural features

Carfilzomib (CAS 868540-17-4) is listed in the Pharmaceutical Intermediates portfolio, with molecular formula C40H57N5O7 and molecular weight 719. 90 g/mol.

Sourcing context

Catalog reference for RFQ preparation, supplier confirmation, and research chemical sourcing review.

Research use context

Intended for research-stage medicinal chemistry and intermediate synthesis workflows; structure-derived tags include nitrogen-containing heterocycle.

Documentation needs

COA/SDS status, availability, lead time, pack size, and shipment documentation can be confirmed during quotation.

Applications & Classification

Pharmaceutical Intermediate ResearchResearch intermediateCustom synthesis building blockPharmaceutical intermediate researchResearch chemical sourcingCustom synthesis and catalog availability reviewCOA, SDS, pricing, and fulfillment workflow
Biological target reference

ChEMBL reports experimental activity evidence for: Proteasome Macropain subunit MB1 (Homo sapiens) — 15 assays; Proteasome subunit beta type-8 (Homo sapiens) — 6 assays; Proteasome subunit beta type-10 (Homo sapiens) — 2 assays; Proteasome subunit beta type-9 (Homo sapiens) — 3 assays; Proteasome Macropain subunit (Homo sapiens) — 6 assays. These records describe research assays and do not establish therapeutic efficacy or clinical use.

Proteasome Macropain subunit MB1

Homo sapiens · SINGLE PROTEIN · 15 qualifying assays · 15 documents · best pChEMBL 8.68

Experimental evidence source: ChEMBL

Proteasome subunit beta type-8

Homo sapiens · SINGLE PROTEIN · 6 qualifying assays · 6 documents · best pChEMBL 8.49

Experimental evidence source: ChEMBL

Proteasome subunit beta type-10

Homo sapiens · SINGLE PROTEIN · 2 qualifying assays · 2 documents · best pChEMBL 7.89

Experimental evidence source: ChEMBL

Proteasome subunit beta type-9

Homo sapiens · SINGLE PROTEIN · 3 qualifying assays · 3 documents · best pChEMBL 7.16

Experimental evidence source: ChEMBL

Proteasome Macropain subunit

Homo sapiens · SINGLE PROTEIN · 6 qualifying assays · 6 documents · best pChEMBL 6.69

Experimental evidence source: ChEMBL

Safety & Handling

Safety and handling reference content is available through documentation requests.

For supplier-issued SDS, request documentation before handling, storage, shipment, or procurement decisions.

Preliminary Safety Reference

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Safety Reference / SDS Request

Names & Synonyms / External Identifiers

Chemical Name

Carfilzomib

Names & Synonyms

KyprolisN-{(2S)-2-[(morpholin-4-ylacetyl)amino]-4-phenylbutanoyl}-L-leucyl-N-{(2S)-4-methyl-1-[(2R)-2-methyloxiran-2-yl]-1-oxopentan-2-yl}-L-phenylalaninamideL-Phenylalaninamide, (alphaS)-alpha-((4-morpholinylacetyl)amino)benzenebutanoyl-L-leucyl-N-((1S)-3-methyl-1-(((2R)-2-methyloxiranyl)carbonyl)butyl)-carfilzomibumPR171
Show all synonyms
N-((2S)-2-((morpholin-4-ylacetyl)amino)-4-phenylbutanoyl)-L-leucyl-N-((2S)-4-methyl-1-((2R)-2-methyloxiran-2-yl)-1-oxopentan-2-yl)-L-phenylalaninamideCarfilzomib (PR-171)Carfilzomib (PR171)(S)-4-methyl-N-((S)-1-(((S)-4-methyl-1-((R)-2-methyloxiran-2-yl)-1-oxopentan-2-yl)amino)-1-oxo-3-phenylpropan-2-yl)-2-((S)-2-(2-morpholinoacetamido)-4-phenylbutanamido)pentanamideCarfilzomib [USAN](alphaS)-alpha-[[2-(4-Morpholinyl)acetyl]amino]benzenebutanoyl-L-leucyl-N-[(1S)-3-methyl-1-[[(2R)-2-methyl-2-oxiranyl]carbonyl]butyl]-L-phenylalaninamideCarfilzomib [USAN:INN]Kyprolis (TN)Carfilzomib (Standard)CARFILZOMIB [MI]CARFILZOMIB [INN]CARFILZOMIB [JAN]CARFILZOMIB [VANDF]Carfilzomib (PR-171)?CARFILZOMIB [WHO-DD]
External Identifiers
EC NUMBER: 692-054-2DSSTOX SUBSTANCE ID: DTXSID4048690CHEMBL ID: CHEMBL451887CHEBI ID: CHEBI:65347UNII: 72X6E3J5ARDRUGBANK ID: DB08889KEGG ID: D08880METABOLOMICS WORKBENCH ID: 63800NCI THESAURUS CODE: C52196PHARMGKB ID: PA166165203RXCUI: 1302966WIKIDATA ID: Q15366934
Literature & Patent References
DOI 10.1016/j.bmc.2024.117980Ringing medicinal chemistry: The importance of 3-membered rings in drug discovery.DOI 10.1016/j.ejmech.2024.116918Design and development of a series of 4-(piperazin-1-yl)pyrimidines as irreversible menin inhibitors.DOI 10.1021/acs.jmedchem.3c02133Combination Therapy and Dual-Target Inhibitors Based on LSD1: New Emerging Tools in Cancer Therapy.DOI 10.1021/acs.jmedchem.3c02488Brain-Permeable Immunoproteasome-Targeting Macrocyclic Peptide Epoxyketones for Alzheimer's Disease.DOI 10.1021/acsmedchemlett.4c00017Macrocyclic Oxindole Peptide Epoxyketones-A Comparative Study of Macrocyclic Inhibitors of the 20S Proteasome.PMID 38214982Combination Therapy and Dual-Target Inhibitors Based on LSD1: New Emerging Tools in Cancer Therapy.PMID 38628795Macrocyclic Oxindole Peptide Epoxyketones-A Comparative Study of Macrocyclic Inhibitors of the 20S Proteasome.PMID 38636481Brain-Permeable Immunoproteasome-Targeting Macrocyclic Peptide Epoxyketones for Alzheimer's Disease.

Documentation & Compliance Facts

Compliance Facts

Shipment review: Required

Documentation available by request

Certificate of Analysis (COA): By request

Supplier Safety Data Sheet (SDS): By request

Purity and pack size confirmation: By request

Availability and lead time review: Confirmed by RFQ

Shipment documentation review: By request

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  1. 1We review the CAS identity, quantity, and documentation request.
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Text Reference Cues

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Non-public related references

L-Phenylalanine, (alphaS)-alpha-((2-(4-morpholinyl)acetyl)amino)benzenebutanoyl-L-leucyl-CAS 868540-16-3
(S)-Methyl 2-((S)-4-Methyl-2-((S)-2-(2-MorpholinoacetaMido)-4-phenylbutanaMido)pentanaMido)-3-phenylpropanoateCAS 1140908-89-9
(6S,9S,12S)-Methyl 12-benzyl-9-isobutyl-2,2-dimethyl-4,7,10-trioxo-6-phenethyl-3-oxa-5,8,11-triazatridecan-13-oateCAS 868539-96-2
L-phenylalanine,(alphaS)-alpha-(((1,1-dimethylethoxy)carbonyl)amino)benzenebutanoyl-L-leucyl-,phenylmethylesterCAS 868540-15-2
(S)-benzyl 2-((S)-2-((S)-2-amino-4-phenylbutanamido)-4-methylpentanamido)-3-phenylpropanoate 2,2,2-trifluoroacetateCAS 875309-83-4

Non-public references are shown as text only and do not imply equivalence, availability, or shared use.

Catalog navigation

Related Catalog Entries

Other public CAS pages in this catalog. These links support navigation across additional intermediates and do not imply equivalence, availability, or shared use.

CAS 868540-16-3L-Phenylalanine, (alphaS)-alpha-((2-(4-morpholinyl)acetyl)amino)benzenebutanoyl-L-leucyl-CAS 1140908-89-9(S)-Methyl 2-((S)-4-Methyl-2-((S)-2-(2-MorpholinoacetaMido)-4-phenylbutanaMido)pentanaMido)-3-phenylpropanoateCAS 868539-96-2(6S,9S,12S)-Methyl 12-benzyl-9-isobutyl-2,2-dimethyl-4,7,10-trioxo-6-phenethyl-3-oxa-5,8,11-triazatridecan-13-oateCAS 868540-15-2L-phenylalanine,(alphaS)-alpha-(((1,1-dimethylethoxy)carbonyl)amino)benzenebutanoyl-L-leucyl-,phenylmethylesterCAS 875309-83-4(S)-benzyl 2-((S)-2-((S)-2-amino-4-phenylbutanamido)-4-methylpentanamido)-3-phenylpropanoate 2,2,2-trifluoroacetateCAS 179324-69-7BortezomibCAS 149647-78-9VorinostatCAS 520-36-5ApigeninCAS 1072833-77-2IxazomibCAS 1002310-00-0Tert-butyl 1-(2-chloro-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)ethylcarbamate

RFQ questions for CAS 868540-17-4

What are the key identifiers for Carfilzomib (CAS 868540-17-4)?

Carfilzomib is identified by CAS 868540-17-4, with molecular formula C40H57N5O7, molecular weight 719.9, InChIKey BLMPQMFVWMYDKT-NZTKNTHTSA-N.

Does CAS 868540-17-4 have reported biological target evidence?

ChEMBL contains qualifying experimental assay evidence associated with Proteasome Macropain subunit MB1, Proteasome subunit beta type-8, Proteasome subunit beta type-10, Proteasome subunit beta type-9, Proteasome Macropain subunit. These records do not establish therapeutic efficacy or clinical use.

Can I request a COA for CAS 868540-17-4?

Yes. Submit an RFQ and specify COA requirements. Lot-specific COA depends on supplier confirmation.

Can I request supplier SDS for Carfilzomib?

Yes. Supplier SDS can be requested through the RFQ workflow before handling, storage, shipment, or procurement decisions.

Is CAS 868540-17-4 available for quotation?

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