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Home/Compounds/CAS 870281-82-6
Formula C22H18FN7OMW 415.4Research-use catalog entryCOA/SDS by request

Idelalisib

CAS Number: 870281-82-6

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Loading RDKit molecule structure...
InChIKey: IFSDAJWBUCMOAH-HNNXBMFYSA-NC22H18FN7O | MW 415.4

Chemical Absolute Identifiers

CAS Number

870281-82-6

PubChem CID

11625818

Molecular Formula

C22H18FN7O

Molecular Weight

415.4 g/mol

Exact Mass

415.155686

InChIKey

IFSDAJWBUCMOAH-HNNXBMFYSA-N

IUPAC Name

5-fluoro-3-phenyl-2-[(1S)-1-(7H-purin-6-ylamino)propyl]quinazolin-4-one

SMILES String

CC[C@@H](C1=NC2=C(C(=CC=C2)F)C(=O)N1C3=CC=CC=C3)NC4=NC=NC5=C4NC=N5

Physical Properties

Water Solubility

0.1 mol/L

Properties are provided as catalog reference data and may be confirmed through supplier documentation when required.

Catalog Facts

Structural features

Idelalisib (CAS 870281-82-6) is listed in the Pharmaceutical Intermediates portfolio, with molecular formula C22H18FN7O and molecular weight 415. 40 g/mol.

Sourcing context

Catalog reference for RFQ preparation, supplier confirmation, and research chemical sourcing review.

Research use context

Intended for research-stage medicinal chemistry and intermediate synthesis workflows; structure-derived tags include nitrogen-containing heterocycle.

Documentation needs

COA/SDS status, availability, lead time, pack size, and shipment documentation can be confirmed during quotation.

Applications & Classification

Pharmaceutical Intermediate ResearchResearch intermediateCustom synthesis building blockPharmaceutical intermediate researchResearch chemical sourcingCustom synthesis and catalog availability reviewCOA, SDS, pricing, and fulfillment workflow
Biological target reference

ChEMBL reports experimental activity evidence for: Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform (Homo sapiens) — 56 assays; PI3-kinase p110-delta/p85-alpha (Homo sapiens) — 11 assays; Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform (Homo sapiens) — 36 assays; Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform (Homo sapiens) — 28 assays; Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform (Homo sapiens) — 25 assays. These records describe research assays and do not establish therapeutic efficacy or clinical use.

Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform

Homo sapiens · SINGLE PROTEIN · 56 qualifying assays · 45 documents · best pChEMBL 9

Experimental evidence source: ChEMBL

PI3-kinase p110-delta/p85-alpha

Homo sapiens · PROTEIN COMPLEX · 11 qualifying assays · 9 documents · best pChEMBL 8.97

Experimental evidence source: ChEMBL

Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform

Homo sapiens · SINGLE PROTEIN · 36 qualifying assays · 33 documents · best pChEMBL 7.6

Experimental evidence source: ChEMBL

Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform

Homo sapiens · SINGLE PROTEIN · 28 qualifying assays · 26 documents · best pChEMBL 7.2

Experimental evidence source: ChEMBL

Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform

Homo sapiens · SINGLE PROTEIN · 25 qualifying assays · 23 documents · best pChEMBL 6.87

Experimental evidence source: ChEMBL

Safety & Handling

Safety and handling reference content is available through documentation requests.

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Preliminary Safety Reference

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Names & Synonyms / External Identifiers

Chemical Name

Idelalisib

Names & Synonyms

ZydeligGS 11015-Fluoro-3-phenyl-2-((S)-1-(9H-purin-6-ylamino)-propyl)-3H-quinazolin-4-one5-fluoro-3-phenyl-2-[(1S)-1-(3H-purin-6-ylamino)propyl]quinazolin-4(3H)-one5-fluoro-3-phenyl-2-[(1S)-1-[(9H-purin-6-yl)amino]propyl]-3,4-dihydroquinazolin-4-one
Show all synonyms
idelalisibum5-fluoro-3-phenyl-2-((1S)-1-(7H-purin-6-ylamino)propyl)quinazolin-4-one5-fluoro-3-phenyl-2-((1S)-1-((9H-purin-6-yl)amino)propyl)-3,4-dihydroquinazolin-4-one5-fluoro-3-phenyl-2-((1S)-1-(3H-purin-6-ylamino)propyl)quinazolin-4(3H)-onePhosphoinositide-3 Kinase Delta Inhibitor CAL-101CAL 101(S)-2-(1-((9H-Purin-6-yl)amino)propyl)-5-fluoro-3-phenylquinazolin-4(3H)-oneIdelalisib (CAL-101)CAL-101 (Idelalisib, GS-1101)5-FLUORO-3-PHENYL-2-[(1S)-1-(9H-PURIN-6-YLAMINO)PROPYL]-4(3H)-QUINAZOLINONE4(3H)-Quinazolinone,5-fluoro-3-phenyl-2-[(1S)-1-(1H-purin-6-ylamino)propyl]-CAL-101 (GS-1101)(S)-2-(1-(9H-purin-6-ylamino)propyl)-5-fluoro-3-phenylquinazolin-4(3H)-one4(3H)-Quinazolinone, 5-fluoro-3-phenyl-2-[(1S)-1-(9H-purin-6-ylamino)propyl]-
External Identifiers
EC NUMBER: 807-438-9EC NUMBER: 945-925-9DSSTOX SUBSTANCE ID: DTXSID701007266CHEMBL ID: CHEMBL2216870CHEBI ID: CHEBI:82701UNII: YG57I8T5M0DRUGBANK ID: DB09054KEGG ID: D10560METABOLOMICS WORKBENCH ID: 152112NCI THESAURUS CODE: C78825RXCUI: 1544460WIKIDATA ID: Q5908266
Literature & Patent References
DOI 10.1021/acs.jmedchem.4c02062Discovery of CHF-6523, an Inhaled Selective PI3Kδ Inhibitor for the Treatment of Chronic Obstructive Pulmonary Disease.DOI 10.1021/acs.jmedchem.5c00408Lysine-Targeted Covalent Strategy Leading to the Discovery of Novel Potent PROTAC-Based PI3Kδ Degraders.PMID 39635891Discovery of CHF-6523, an Inhaled Selective PI3Kδ Inhibitor for the Treatment of Chronic Obstructive Pulmonary Disease.PMID 40448714Lysine-Targeted Covalent Strategy Leading to the Discovery of Novel Potent PROTAC-Based PI3Kδ Degraders.DOI 10.1016/j.bmc.2023.117561Discovery of pyrazolo[3,4-d]pyrimidines as novel mitogen-activated protein kinase kinase 3 (MKK3) inhibitors.DOI 10.1016/j.ejmech.2023.116109Advancements in dual-target inhibitors of PI3K for tumor therapy: Clinical progress, development strategies, prospects.DOI 10.1016/j.ejmech.2024.116226Discovery of novel pyrrolo[2,3-d]pyrimidines as potent menin-mixed lineage leukemia interaction inhibitors.DOI 10.1021/acs.jmedchem.4c00094Discovery of Potent and Selective PI3Kδ Inhibitors for the Treatment of Acute Myeloid Leukemia.

Documentation & Compliance Facts

Compliance Facts

Shipment review: Required

Documentation available by request

Certificate of Analysis (COA): By request

Supplier Safety Data Sheet (SDS): By request

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Text Reference Cues

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Non-public related references

2-[(1S)-1-Aminopropyl]-5-fluoro-3-phenyl-4(3H)-quinazolinoneCAS 870281-86-0
tert-butyl N-[(1S)-1-(5-fluoro-4-oxo-3-phenylquinazolin-2-yl)propyl]carbamateCAS 870281-85-9

Non-public references are shown as text only and do not imply equivalence, availability, or shared use.

Catalog navigation

Related Catalog Entries

Other public CAS pages in this catalog. These links support navigation across additional intermediates and do not imply equivalence, availability, or shared use.

CAS 571190-30-2PalbociclibCAS 120685-11-2MidostaurinCAS 62996-74-1StaurosporineCAS 870281-86-02-[(1S)-1-Aminopropyl]-5-fluoro-3-phenyl-4(3H)-quinazolinoneCAS 870281-85-9tert-butyl N-[(1S)-1-(5-fluoro-4-oxo-3-phenylquinazolin-2-yl)propyl]carbamateCAS 936563-96-1IbrutinibCAS 443913-73-3VandetanibCAS 1002310-00-0Tert-butyl 1-(2-chloro-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)ethylcarbamateCAS 1005174-17-3(E)-3-(2-Propyl-6-(trifluoromethyl)pyridin-3-yl)acrylic acidCAS 1018125-49-92-(3-Cyclopropyl-6-ethyl-4-(trifluoromethyl)-1H-pyrazolo[3,4-b]pyridin-1-yl)acetic acid

RFQ questions for CAS 870281-82-6

What are the key identifiers for Idelalisib (CAS 870281-82-6)?

Idelalisib is identified by CAS 870281-82-6, with molecular formula C22H18FN7O, molecular weight 415.4, InChIKey IFSDAJWBUCMOAH-HNNXBMFYSA-N.

Does CAS 870281-82-6 have reported biological target evidence?

ChEMBL contains qualifying experimental assay evidence associated with Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform, PI3-kinase p110-delta/p85-alpha, Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform, Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform, Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform. These records do not establish therapeutic efficacy or clinical use.

Can I request a COA for CAS 870281-82-6?

Yes. Submit an RFQ and specify COA requirements. Lot-specific COA depends on supplier confirmation.

Can I request supplier SDS for Idelalisib?

Yes. Supplier SDS can be requested through the RFQ workflow before handling, storage, shipment, or procurement decisions.

Is CAS 870281-82-6 available for quotation?

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