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Home/Compounds/CAS 872511-34-7
Formula C26H31Cl2N7O3MW 560.5Research-use catalog entryCOA/SDS by request

Infigratinib

CAS Number: 872511-34-7

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Loading RDKit molecule structure...
InChIKey: QADPYRIHXKWUSV-UHFFFAOYSA-NC26H31Cl2N7O3 | MW 560.5

Chemical Absolute Identifiers

CAS Number

872511-34-7

PubChem CID

53235510

Molecular Formula

C26H31Cl2N7O3

Molecular Weight

560.5 g/mol

Exact Mass

559.186543

InChIKey

QADPYRIHXKWUSV-UHFFFAOYSA-N

IUPAC Name

3-(2,6-dichloro-3,5-dimethoxyphenyl)-1-[6-[4-(4-ethylpiperazin-1-yl)anilino]pyrimidin-4-yl]-1-methylurea

SMILES String

CCN1CCN(c2ccc(Nc3cc(N(C)C(=O)Nc4c(Cl)c(OC)cc(OC)c4Cl)ncn3)cc2)CC1

Physical Properties

No physical property values available.

Properties are provided as catalog reference data and may be confirmed through supplier documentation when required.

Catalog Facts

Structural features

Infigratinib (CAS 872511-34-7) is listed in the Pharmaceutical Intermediates portfolio, with molecular formula C26H31Cl2N7O3 and molecular weight 560. 50 g/mol.

Sourcing context

Catalog reference for RFQ preparation, supplier confirmation, and research chemical sourcing review.

Research use context

Intended for research-stage medicinal chemistry and intermediate synthesis workflows; structure-derived tags include nitrogen-containing heterocycle.

Documentation needs

COA/SDS status, availability, lead time, pack size, and shipment documentation can be confirmed during quotation.

Applications & Classification

Pharmaceutical Intermediate ResearchResearch intermediateCustom synthesis building blockPharmaceutical intermediate researchResearch chemical sourcingCustom synthesis and catalog availability reviewCOA, SDS, pricing, and fulfillment workflow
Biological target reference

ChEMBL reports experimental activity evidence for: Fibroblast growth factor receptor 2 (Homo sapiens) — 29 assays; Fibroblast growth factor receptor 1 (Homo sapiens) — 29 assays; Fibroblast growth factor receptor 3 (Homo sapiens) — 36 assays; Fibroblast growth factor receptor 4 (Homo sapiens) — 16 assays; Protein smoothened (Homo sapiens) — 3 assays. These records describe research assays and do not establish therapeutic efficacy or clinical use.

Fibroblast growth factor receptor 2

Homo sapiens · SINGLE PROTEIN · 29 qualifying assays · 11 documents · best pChEMBL 9.34

Experimental evidence source: ChEMBL

Fibroblast growth factor receptor 1

Homo sapiens · SINGLE PROTEIN · 29 qualifying assays · 16 documents · best pChEMBL 9.23

Experimental evidence source: ChEMBL

Fibroblast growth factor receptor 3

Homo sapiens · SINGLE PROTEIN · 36 qualifying assays · 12 documents · best pChEMBL 9.18

Experimental evidence source: ChEMBL

Fibroblast growth factor receptor 4

Homo sapiens · SINGLE PROTEIN · 16 qualifying assays · 12 documents · best pChEMBL 9.09

Experimental evidence source: ChEMBL

Protein smoothened

Homo sapiens · SINGLE PROTEIN · 3 qualifying assays · 1 documents · best pChEMBL 7.33

Experimental evidence source: ChEMBL

Safety & Handling

Safety and handling reference content is available through documentation requests.

For supplier-issued SDS, request documentation before handling, storage, shipment, or procurement decisions.

Preliminary Safety Reference

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Safety Reference / SDS Request

Names & Synonyms / External Identifiers

Chemical Name

Infigratinib

Names & Synonyms

BGJ 3983-(2,6-dichloro-3,5-dimethoxyphenyl)-1-(6-((4-(4-ethylpiperazin-1-yl)phenyl)amino)pyrimidin-4-yl)-1-methylurea3-(2,6-dichloro-3,5-dimethoxyphenyl)-1-(6-{[4-(4-ethylpiperazin-1-yl)phenyl]amino}pyrimidin-4-yl)-1-methylurea3-(2,6-Dichloro-3,5-dimethoxyphenyl)-1-[6-[[4-(4-ethylpiperazin-1-yl)phenyl]amino]pyrimidin-4-yl]-1-methylureaUrea, N'-(2,6-dichloro-3,5-dimethoxyphenyl)-N-(6-((4-(4-ethyl-1-piperazinyl)phenyl)amino)-4-pyrimidinyl)-N-methyl-
Show all synonyms
infigratinibum3-(2,6-dichloro-3,5-dimethoxyphenyl)-1-(6-(4-(4-ethylpiperazin-1-yl)anilino)pyrimidin-4-yl)-1-methylureaUrea, N'-(2,6-dichloro-3,5-dimethoxyphenyl)-N-[6-[[4-(4-ethyl-1-piperazinyl)phenyl]amino]-4-pyrimidinyl]-N-methyl-BGJ398 (NVP-BGJ398)Infigratinib [INN]Infigratinib free baseInfigratinib (BGJ398)Infigratinib [USAN]C26H31Cl2N7O33-(2,6-Dichloro-3,5-dimethoxyphenyl)-1-(6-{[4-(4-ethyl-1-piperazinyl)phenyl]amino}-4-pyrimidinyl)-1-methylurea3-(2,6-Dichloro-3,5-dimethoxyphenyl)-1-[6-[[4-(4-ethyl-1-piperazinyl)phenyl]amino]-4-pyrimidinyl]-1-methylurea872511-34-7 (free base)Infigratinib (USAN/INN)Infigratinib [USAN:INN]
External Identifiers
DSSTOX SUBSTANCE ID: DTXSID70236238CHEMBL ID: CHEMBL1852688CHEBI ID: CHEBI:63451UNII: A4055ME1VKDRUGBANK ID: DB11886HMDB ID: HMDB0247543KEGG ID: D11589METABOLOMICS WORKBENCH ID: 62789NCI THESAURUS CODE: C88302PHARMGKB ID: PA166252061WIKIDATA ID: Q27075200
Literature & Patent References
DOI 10.1021/acs.jmedchem.4c03205Discovery of Pyrrolopyrazine Carboxamide Derivatives as Potent and Selective FGFR2/3 Inhibitors that Overcome Mutant Resistance.DOI 10.1021/acs.jmedchem.5c00124Discovery of Novel 2,4,5-Trisubstituted Pyrimidine Derivatives as Potent and Selective FGFR Inhibitors against Gatekeeper Mutants for the Treatment of NSCLC.PMID 39885813Discovery of Pyrrolopyrazine Carboxamide Derivatives as Potent and Selective FGFR2/3 Inhibitors that Overcome Mutant Resistance.PMID 40032550Discovery of Novel 2,4,5-Trisubstituted Pyrimidine Derivatives as Potent and Selective FGFR Inhibitors against Gatekeeper Mutants for the Treatment of NSCLC.DOI 10.1021/acs.jmedchem.3c01819Discovery of KIN-3248, An Irreversible, Next Generation FGFR Inhibitor for the Treatment of Advanced Tumors Harboring FGFR2 and/or FGFR3 Gene Alterations.DOI 10.1021/acsmedchemlett.4c00431Design, Synthesis, and Biological Evaluation of 3-Amino-pyrazine-2-carboxamide Derivatives as Novel FGFR Inhibitors.DOI 10.6019/CHEMBL5444388Affinity Phenotypic Cellular Literature for EUbOPEN Chemogenomic LibraryDOI 10.6019/CHEMBL5445981Affinity On-target Cellular Literature for EUbOPEN Chemogenomic Library

Documentation & Compliance Facts

Compliance Facts

Shipment review: Required

Documentation available by request

Certificate of Analysis (COA): By request

Supplier Safety Data Sheet (SDS): By request

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Availability and lead time review: Confirmed by RFQ

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  1. 1We review the CAS identity, quantity, and documentation request.
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Text Reference Cues

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Non-public related references

N4-(4-(4-Ethyl-1-piperazinyl)phenyl)-N6-methyl-4,6-pyrimidinediamineCAS 872511-35-8
N-(2,6-dichloro-3,5-dimethoxyphenyl)acetamideCAS 943189-21-7
1-Ethyl-4-(4-nitrophenyl)piperazineCAS 115619-00-6
2,6-Dichloro-3,5-dimethoxyanilineCAS 872509-56-3

Non-public references are shown as text only and do not imply equivalence, availability, or shared use.

Catalog navigation

Related Catalog Entries

Other public CAS pages in this catalog. These links support navigation across additional intermediates and do not imply equivalence, availability, or shared use.

CAS 872511-35-8N4-(4-(4-Ethyl-1-piperazinyl)phenyl)-N6-methyl-4,6-pyrimidinediamineCAS 443913-73-3VandetanibCAS 571190-30-2PalbociclibCAS 877399-52-5CrizotinibCAS 871700-17-3TrametinibCAS 1002310-00-0Tert-butyl 1-(2-chloro-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)ethylcarbamateCAS 1005174-17-3(E)-3-(2-Propyl-6-(trifluoromethyl)pyridin-3-yl)acrylic acidCAS 1018125-49-92-(3-Cyclopropyl-6-ethyl-4-(trifluoromethyl)-1H-pyrazolo[3,4-b]pyridin-1-yl)acetic acidCAS 1018128-07-8Isopropyl 4-chloro-2-methylquinoline-6-carboxylateCAS 1018142-22-76-cyclopropyl-1-(2,2-difluoroethyl)-3-methyl-1H-pyrazolo[3,4-b]pyridine-4-carboxylic acid

RFQ questions for CAS 872511-34-7

What are the key identifiers for Infigratinib (CAS 872511-34-7)?

Infigratinib is identified by CAS 872511-34-7, with molecular formula C26H31Cl2N7O3, molecular weight 560.5, InChIKey QADPYRIHXKWUSV-UHFFFAOYSA-N.

Does CAS 872511-34-7 have reported biological target evidence?

ChEMBL contains qualifying experimental assay evidence associated with Fibroblast growth factor receptor 2, Fibroblast growth factor receptor 1, Fibroblast growth factor receptor 3, Fibroblast growth factor receptor 4, Protein smoothened. These records do not establish therapeutic efficacy or clinical use.

Can I request a COA for CAS 872511-34-7?

Yes. Submit an RFQ and specify COA requirements. Lot-specific COA depends on supplier confirmation.

Can I request supplier SDS for Infigratinib?

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Is CAS 872511-34-7 available for quotation?

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