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- 1 g
- Purity
- 98%
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CAS Number: 877399-52-5
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CAS Number
877399-52-5
PubChem CID
11626560
Molecular Formula
C21H22Cl2FN5O
Molecular Weight
450.3 g/mol
Exact Mass
449.118544
InChIKey
KTEIFNKAUNYNJU-GFCCVEGCSA-N
IUPAC Name
3-[(1R)-1-(2,6-dichloro-3-fluorophenyl)ethoxy]-5-(1-piperidin-4-ylpyrazol-4-yl)pyridin-2-amine
SMILES String
C[C@@H](Oc1cc(-c2cnn(C3CCNCC3)c2)cnc1N)c1c(Cl)ccc(F)c1Cl
pKa
9.4
Properties are provided as catalog reference data and may be confirmed through supplier documentation when required.
Structural features
Crizotinib (CAS 877399-52-5) is listed in the Pharmaceutical Intermediates portfolio, with molecular formula C21H22Cl2FN5O and molecular weight 450. 30 g/mol.
Sourcing context
Catalog reference for RFQ preparation, supplier confirmation, and research chemical sourcing review.
Research use context
Intended for research-stage medicinal chemistry and intermediate synthesis workflows; structure-derived tags include nitrogen-containing heterocycle.
Documentation needs
COA/SDS status, availability, lead time, pack size, and shipment documentation can be confirmed during quotation.
ChEMBL reports experimental activity evidence for: Hepatocyte growth factor receptor (Homo sapiens) — 83 assays; ALK tyrosine kinase receptor (Homo sapiens) — 145 assays; Proto-oncogene tyrosine-protein kinase ROS (Homo sapiens) — 24 assays; Leukocyte tyrosine kinase receptor (Homo sapiens) — 5 assays; BDNF/NT-3 growth factors receptor (Homo sapiens) — 8 assays. These records describe research assays and do not establish therapeutic efficacy or clinical use.
Hepatocyte growth factor receptor
Homo sapiens · SINGLE PROTEIN · 83 qualifying assays · 46 documents · best pChEMBL 9.7
Experimental evidence source: ChEMBL
ALK tyrosine kinase receptor
Homo sapiens · SINGLE PROTEIN · 145 qualifying assays · 59 documents · best pChEMBL 9.33
Experimental evidence source: ChEMBL
Proto-oncogene tyrosine-protein kinase ROS
Homo sapiens · SINGLE PROTEIN · 24 qualifying assays · 16 documents · best pChEMBL 9.22
Experimental evidence source: ChEMBL
Leukocyte tyrosine kinase receptor
Homo sapiens · SINGLE PROTEIN · 5 qualifying assays · 3 documents · best pChEMBL 8.74
Experimental evidence source: ChEMBL
BDNF/NT-3 growth factors receptor
Homo sapiens · SINGLE PROTEIN · 8 qualifying assays · 5 documents · best pChEMBL 8.7
Experimental evidence source: ChEMBL
Safety and handling reference content is available through documentation requests.
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Preliminary Safety Reference
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Safety Reference / SDS RequestCatalog navigation
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Crizotinib is identified by CAS 877399-52-5, with molecular formula C21H22Cl2FN5O, molecular weight 450.3, InChIKey KTEIFNKAUNYNJU-GFCCVEGCSA-N.
ChEMBL contains qualifying experimental assay evidence associated with Hepatocyte growth factor receptor, ALK tyrosine kinase receptor, Proto-oncogene tyrosine-protein kinase ROS, Leukocyte tyrosine kinase receptor, BDNF/NT-3 growth factors receptor. These records do not establish therapeutic efficacy or clinical use.
Yes. Submit an RFQ and specify COA requirements. Lot-specific COA depends on supplier confirmation.
Yes. Supplier SDS can be requested through the RFQ workflow before handling, storage, shipment, or procurement decisions.
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