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Home/Compounds/CAS 948557-43-5
Formula C26H21N3O2SMW 439.5Research-use catalog entryCOA/SDS by request

4-(6-methoxy-2-naphthyl)-2-(4-methylsulfinylphenyl)-5-(4-pyridyl)-1H-imidazole

CAS Number: 948557-43-5

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Loading RDKit molecule structure...
InChIKey: SINQIEAULQKUPD-UHFFFAOYSA-NC26H21N3O2S | MW 439.5

Chemical Absolute Identifiers

CAS Number

948557-43-5

PubChem CID

23625762

Molecular Formula

C26H21N3O2S

Molecular Weight

439.5 g/mol

Exact Mass

439.135448

InChIKey

SINQIEAULQKUPD-UHFFFAOYSA-N

IUPAC Name

4-[4-(6-methoxynaphthalen-2-yl)-2-(4-methylsulfinylphenyl)-1H-imidazol-5-yl]pyridine

SMILES String

COc1ccc2cc(-c3[nH]c(-c4ccc(S(C)=O)cc4)nc3-c3ccncc3)ccc2c1

Physical Properties

No physical property values available.

Properties are provided as catalog reference data and may be confirmed through supplier documentation when required.

Catalog Facts

Structural features

4-(6-methoxy-2-naphthyl)-2-(4-methylsulfinylphenyl)-5-(4-pyridyl)-1H-imidazole (CAS 948557-43-5) is listed in the Advanced Chemicals portfolio, with molecular formula C26H21N3O2S and molecular weight 439. 50 g/mol.

Sourcing context

Catalog reference for RFQ preparation, supplier confirmation, and research chemical sourcing review.

Research use context

Intended for research building-block and synthetic chemistry workflows; structure-derived tags include nitrogen-containing heterocycle.

Documentation needs

COA/SDS status, availability, lead time, pack size, and shipment documentation can be confirmed during quotation.

Applications & Classification

Organic Building BlocksSynthetic ChemistryResearch intermediateCustom synthesis building blockResearch chemical sourcingCustom synthesis and catalog availability reviewCOA, SDS, pricing, and fulfillment workflow
Biological target reference

ChEMBL reports experimental activity evidence for: Angiopoietin-1 receptor (Homo sapiens) — 2 assays; Protein deacetylase HDAC6 (Homo sapiens) — 2 assays. These records describe research assays and do not establish therapeutic efficacy or clinical use.

Angiopoietin-1 receptor

Homo sapiens · SINGLE PROTEIN · 2 qualifying assays · 2 documents · best pChEMBL 6.6

Experimental evidence source: ChEMBL

Protein deacetylase HDAC6

Homo sapiens · SINGLE PROTEIN · 2 qualifying assays · 1 documents

Experimental evidence source: ChEMBL

Safety & Handling

Safety and handling reference content is available through documentation requests.

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Preliminary Safety Reference

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Names & Synonyms / External Identifiers

Chemical Name

4-(6-methoxy-2-naphthyl)-2-(4-methylsulfinylphenyl)-5-(4-pyridyl)-1H-imidazole

Names & Synonyms

Tie2 kinase inhibitorTie2 kinase inhibitor 1Tie2 kinase-IN-1Tie2-IN-54-(4-(6-methoxynaphthalen-2-yl)-2-(4-(methylsulfinyl)phenyl)-1H-imidazol-5-yl)pyridine
Show all synonyms
4-[4-(6-Methoxy-2-naphthalenyl)-2-[4-(methylsulfinyl)phenyl]-1H-imidazol-5-yl]pyridine4-[4-(6-methoxy-2-naphthalenyl)-2-(4-methylsulfinylphenyl)-1H-imidazol-5-yl]pyridineTie2kinase-IN-1Tie-2 kinase InhibitorTie2 kinase inhibitor 5compound 5 [PMID: 17618114]SDCCGSBI-0647621.P0024-[2-(4-methanesulfinylphenyl)-5-(6-methoxynaphthalen-2-yl)-1H-imidazol-4-yl]pyridineS15774-[4-(6-methoxy-2-naphthyl)-2-(4-methylsulfinylphenyl)-1H-imidazol-5-yl]pyridine4-{2-[4-(Methanesulfinyl)phenyl]-4-(6-methoxynaphthalen-2-yl)-1H-imidazol-5-yl}pyridine
External Identifiers
DSSTOX SUBSTANCE ID: DTXSID60635231CHEMBL ID: CHEMBL237352CHEBI ID: CHEBI:91442WIKIDATA ID: Q27163288
Literature & Patent References
DOI 10.1016/j.bmc.2023.117561Discovery of pyrazolo[3,4-d]pyrimidines as novel mitogen-activated protein kinase kinase 3 (MKK3) inhibitors.PMID 38157838Discovery of pyrazolo[3,4-d]pyrimidines as novel mitogen-activated protein kinase kinase 3 (MKK3) inhibitors.DOI 10.6019/CHEMBL4808148HDAC6 screening dataset using tau-based substrate in an enzymatic assay yields selective inhibitors and activatorsDOI 10.21203/rs.3.rs-23951/v1Identification of inhibitors of SARS-CoV-2 in-vitro cellular toxicity in human (Caco-2) cells using a large scale drug repurposing collectionDOI 10.6019/CHEMBL4495564Identification of inhibitors of SARS-Cov2 M-Pro enzymatic activity using a small molecule repurposing screenDOI 10.6019/CHEMBL4495565Cytopathic SARS-Cov2 screening on VERO-E6 cells in a large repurposing effortDOI 10.1016/j.bmcl.2007.06.068Pyridinylimidazole inhibitors of Tie2 kinase.DOI 10.1016/j.bmcl.2007.08.052Optimization of triarylimidazoles for Tie2: influence of conformation on potency.

Documentation & Compliance Facts

Compliance Facts

Shipment review: Required

Documentation available by request

Certificate of Analysis (COA): By request

Supplier Safety Data Sheet (SDS): By request

Purity and pack size confirmation: By request

Availability and lead time review: Confirmed by RFQ

Shipment documentation review: By request

For supplier-issued documentation by request, use the RFQ actions on this page.Review preliminary safety reference

What happens after RFQ

  1. 1We review the CAS identity, quantity, and documentation request.
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  3. 3We review destination and shipment documentation needs when applicable.
  4. 4We follow up with a quotation or clarification request.

Text Reference Cues

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Non-public related references

1-(Methylsulfinyl)-4-methoxybenzeneCAS 3517-99-5
Bis(4-methoxyphenyl) sulfoxideCAS 1774-36-3
H-180/29CAS 110374-16-8
4-Desmethoxy-4-chloroomeprazoleCAS 863029-89-4
5-Methoxy-2-[[(4-methoxy-3,5-dimethyl-2-pyridyl)methyl]sulfinyl]-1H-benzimidazole sodium saltCAS 161796-77-6

Non-public references are shown as text only and do not imply equivalence, availability, or shared use.

Catalog navigation

Related Catalog Entries

Other public CAS pages in this catalog. These links support navigation across additional intermediates and do not imply equivalence, availability, or shared use.

CAS 3517-99-51-(Methylsulfinyl)-4-methoxybenzeneCAS 146535-11-76,7-Dimethoxy-3-phenylquinoxalineCAS 211555-04-3Whi-P154CAS 319460-85-0AxitinibCAS 1002310-00-0Tert-butyl 1-(2-chloro-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)ethylcarbamateCAS 1005174-17-3(E)-3-(2-Propyl-6-(trifluoromethyl)pyridin-3-yl)acrylic acidCAS 1018125-49-92-(3-Cyclopropyl-6-ethyl-4-(trifluoromethyl)-1H-pyrazolo[3,4-b]pyridin-1-yl)acetic acidCAS 1018128-07-8Isopropyl 4-chloro-2-methylquinoline-6-carboxylateCAS 1018142-22-76-cyclopropyl-1-(2,2-difluoroethyl)-3-methyl-1H-pyrazolo[3,4-b]pyridine-4-carboxylic acidCAS 1018144-00-72-(3-Cyclopropyl-6-isopropyl-4-(trifluoromethyl)-1H-pyrazolo[3,4-b]pyridin-1-yl)acetic acid

RFQ questions for CAS 948557-43-5

What are the key identifiers for 4-(6-methoxy-2-naphthyl)-2-(4-methylsulfinylphenyl)-5-(4-pyridyl)-1H-imidazole (CAS 948557-43-5)?

4-(6-methoxy-2-naphthyl)-2-(4-methylsulfinylphenyl)-5-(4-pyridyl)-1H-imidazole is identified by CAS 948557-43-5, with molecular formula C26H21N3O2S, molecular weight 439.5, InChIKey SINQIEAULQKUPD-UHFFFAOYSA-N.

Does CAS 948557-43-5 have reported biological target evidence?

ChEMBL contains qualifying experimental assay evidence associated with Angiopoietin-1 receptor, Protein deacetylase HDAC6. These records do not establish therapeutic efficacy or clinical use.

Can I request a COA for CAS 948557-43-5?

Yes. Submit an RFQ and specify COA requirements. Lot-specific COA depends on supplier confirmation.

Can I request supplier SDS for 4-(6-methoxy-2-naphthyl)-2-(4-methylsulfinylphenyl)-5-(4-pyridyl)-1H-imidazole?

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