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Home/Compounds/CAS 99011-02-6
Formula C14H16N4MW 240.3Research-use catalog entryCOA/SDS by request

Imiquimod

CAS Number: 99011-02-6

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Loading RDKit molecule structure...
InChIKey: DOUYETYNHWVLEO-UHFFFAOYSA-NC14H16N4 | MW 240.3

Chemical Absolute Identifiers

CAS Number

99011-02-6

PubChem CID

57469

Molecular Formula

C14H16N4

Molecular Weight

240.3 g/mol

Exact Mass

240.137497

InChIKey

DOUYETYNHWVLEO-UHFFFAOYSA-N

IUPAC Name

1-(2-methylpropyl)imidazo[4,5-c]quinolin-4-amine

SMILES String

CC(C)CN1C=NC2=C1C3=CC=CC=C3N=C2N

Physical Properties

Melting Point

292–294 °C

Water Solubility

0.247 g/L

Properties are provided as catalog reference data and may be confirmed through supplier documentation when required.

Catalog Facts

Structural features

Imiquimod (CAS 99011-02-6) is listed in the Pharmaceutical Intermediates portfolio, with molecular formula C14H16N4 and molecular weight 240. 30 g/mol.

Sourcing context

Catalog reference for RFQ preparation, supplier confirmation, and research chemical sourcing review.

Research use context

Intended for research-stage medicinal chemistry and intermediate synthesis workflows; structure-derived tags include nitrogen-containing heterocycle.

Documentation needs

COA/SDS status, availability, lead time, pack size, and shipment documentation can be confirmed during quotation.

Applications & Classification

Pharmaceutical Intermediate ResearchResearch intermediateCustom synthesis building blockPharmaceutical intermediate researchResearch chemical sourcingCustom synthesis and catalog availability reviewCOA, SDS, pricing, and fulfillment workflow
Biological target reference

ChEMBL reports experimental activity evidence for: Toll-like receptor 7 (Homo sapiens) — 10 assays; Histamine H2 receptor (Homo sapiens) — 2 assays; Adenosine receptor A2a (Homo sapiens) — 2 assays; 5-hydroxytryptamine receptor 2A (Homo sapiens) — 3 assays; 5-hydroxytryptamine receptor 2B (Homo sapiens) — 2 assays. These records describe research assays and do not establish therapeutic efficacy or clinical use.

Toll-like receptor 7

Homo sapiens · SINGLE PROTEIN · 10 qualifying assays · 10 documents · best pChEMBL 6.7

Experimental evidence source: ChEMBL

Histamine H2 receptor

Homo sapiens · SINGLE PROTEIN · 2 qualifying assays · 2 documents · best pChEMBL 5.83

Experimental evidence source: ChEMBL

Adenosine receptor A2a

Homo sapiens · SINGLE PROTEIN · 2 qualifying assays · 2 documents · best pChEMBL 5.53

Experimental evidence source: ChEMBL

5-hydroxytryptamine receptor 2A

Homo sapiens · SINGLE PROTEIN · 3 qualifying assays · 1 documents · best pChEMBL 5.25

Experimental evidence source: ChEMBL

5-hydroxytryptamine receptor 2B

Homo sapiens · SINGLE PROTEIN · 2 qualifying assays · 1 documents · best pChEMBL 4.86

Experimental evidence source: ChEMBL

Safety & Handling

Safety and handling reference content is available through documentation requests.

For supplier-issued SDS, request documentation before handling, storage, shipment, or procurement decisions.

Preliminary Safety Reference

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Safety Reference / SDS Request

Names & Synonyms / External Identifiers

Chemical Name

Imiquimod

Names & Synonyms

Aldara1-(2-methylpropyl)-1H-imidazo[4,5-c]quinolin-4-amineZyclara1-isobutyl-1H-imidazo[4,5-c]quinolin-4-amine4-Amino-1-isobutyl-1H-imidazo[4,5-c]quinoline
Show all synonyms
R-837R 8374-Amino-1-isobutyl-1H-imidazo(4,5-c)quinolineImiquimodumS 26308TMX 1011H-Imidazo(4,5-c)quinolin-4-amine, 1-(2-methylpropyl)-R8371H-Imidazo[4,5-c]quinolin-4-amine, 1-(2-methylpropyl)-1-isobutyl-1H-imidazo(4,5-c)quinolin-4-amine1-(2-methylpropyl)-1H-imidazo(4,5-c)quinolin-4-amineBeselna(Hydroxypropyl)methyl cellulose phthalate1-(2-Methylpropyl)-1H-imidazole[4,5-c]quinoline-4-amine
External Identifiers
EC NUMBER: 618-567-3EC NUMBER: 619-387-8DSSTOX SUBSTANCE ID: DTXSID7041047CHEMBL ID: CHEMBL1282CHEBI ID: CHEBI:36704UNII: P1QW714R7MDRUGBANK ID: DB00724HMDB ID: HMDB0014862KEGG ID: D02500METABOLOMICS WORKBENCH ID: 43030NCI THESAURUS CODE: C1431PHARMGKB ID: PA449972RXCUI: 59943WIKIDATA ID: Q423417WIKIDATA ID: Q72481498
Experimental Spectrum References
ATR-IR Spectra — Forensic Spectral ResearchFTIR Spectra — Forensic Spectral ResearchRaman Spectra — Forensic Spectral Research
Literature & Patent References
DOI 10.1016/j.isci.2024.108907Identification and evaluation of small-molecule inhibitors against the dNTPase SAMHD1 via a comprehensive screening funnelDOI 10.1021/acs.jmedchem.4c00464Structure-Activity Relationships toward the Identification of a High-Potency Selective Human Toll-like Receptor-7 Agonist.DOI 10.1021/acs.jmedchem.4c00489Design, Synthesis, and Biological Evaluation of New 2,6,7-Substituted Purine Derivatives as Toll-like Receptor 7 Agonists for Intranasal Vaccine Adjuvants.PMID 38318365Identification and evaluation of small-molecule inhibitors against the dNTPase SAMHD1 via a comprehensive screening funnelPMID 38741265Structure-Activity Relationships toward the Identification of a High-Potency Selective Human Toll-like Receptor-7 Agonist.PMID 38787938Design, Synthesis, and Biological Evaluation of New 2,6,7-Substituted Purine Derivatives as Toll-like Receptor 7 Agonists for Intranasal Vaccine Adjuvants.DOI 10.1021/acs.jmedchem.2c01655Small-Molecule Modulators Targeting Toll-like Receptors for Potential Anticancer Therapeutics.DOI 10.1038/s41467-023-40064-9A preclinical secondary pharmacology resource illuminates target-adverse drug reaction associations of marketed drugs.

Documentation & Compliance Facts

Compliance Facts

Shipment review: Required

Documentation available by request

Certificate of Analysis (COA): By request

Supplier Safety Data Sheet (SDS): By request

Purity and pack size confirmation: By request

Availability and lead time review: Confirmed by RFQ

Shipment documentation review: By request

For supplier-issued documentation by request, use the RFQ actions on this page.Review preliminary safety reference

What happens after RFQ

  1. 1We review the CAS identity, quantity, and documentation request.
  2. 2We check sourcing options, supplier availability, COA/SDS, purity, pack size, and lead time.
  3. 3We review destination and shipment documentation needs when applicable.
  4. 4We follow up with a quotation or clarification request.

Text Reference Cues

Show non-linked catalog cues

Non-public related references

DeaminoimiquimodCAS 99010-24-9
1-isobutyl-1H-imidazo[4,5-c]quinoline-5-oxideCAS 99010-63-6
2-Chloro-N4-(2-methylpropyl)-3,4-quinolinediamineCAS 133860-76-1
N4-(2-methylpropyl)quinoline-3,4-diamineCAS 99010-09-0
2-Chloro-N-(2-methylpropyl)-3-nitro-4-quinolinamineCAS 133860-75-0

Non-public references are shown as text only and do not imply equivalence, availability, or shared use.

Catalog navigation

Related Catalog Entries

Other public CAS pages in this catalog. These links support navigation across additional intermediates and do not imply equivalence, availability, or shared use.

CAS 99010-24-9DeaminoimiquimodCAS 99010-63-61-isobutyl-1H-imidazo[4,5-c]quinoline-5-oxideCAS 21829-25-4NifedipineCAS 22916-47-8MiconazoleCAS 27220-47-9EconazoleCAS 100643-71-8DesloratadineCAS 1156-19-0TolazamideCAS 1002310-00-0Tert-butyl 1-(2-chloro-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)ethylcarbamateCAS 1005174-17-3(E)-3-(2-Propyl-6-(trifluoromethyl)pyridin-3-yl)acrylic acidCAS 1018125-49-92-(3-Cyclopropyl-6-ethyl-4-(trifluoromethyl)-1H-pyrazolo[3,4-b]pyridin-1-yl)acetic acid

RFQ questions for CAS 99011-02-6

What are the key identifiers for Imiquimod (CAS 99011-02-6)?

Imiquimod is identified by CAS 99011-02-6, with molecular formula C14H16N4, molecular weight 240.3, InChIKey DOUYETYNHWVLEO-UHFFFAOYSA-N.

Does CAS 99011-02-6 have reported biological target evidence?

ChEMBL contains qualifying experimental assay evidence associated with Toll-like receptor 7, Histamine H2 receptor, Adenosine receptor A2a, 5-hydroxytryptamine receptor 2A, 5-hydroxytryptamine receptor 2B. These records do not establish therapeutic efficacy or clinical use.

Can I request a COA for CAS 99011-02-6?

Yes. Submit an RFQ and specify COA requirements. Lot-specific COA depends on supplier confirmation.

Can I request supplier SDS for Imiquimod?

Yes. Supplier SDS can be requested through the RFQ workflow before handling, storage, shipment, or procurement decisions.

Is CAS 99011-02-6 available for quotation?

Availability, pack size, lead time, and pricing are confirmed through RFQ.

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