2-Fluoro-5-(trifluoromethyl)pyridin-3-ylboronic acid

2-Fluoro-5-(trifluoromethyl)pyridin-3-ylboronic acid, identified by CAS 1253569-51-5, is a highly functionalized boronic acid. Its structure incorporates a pyridine core substituted with a fluorine atom at position 2 and a trifluoromethyl group at position 5, with the boronic acid moiety at position 3. This combination of functional groups makes it a valuable intermediate in the synthesis of pharmaceuticals, agrochemicals, and advanced materials. The boronic acid group is highly reactive in palladium-catalyzed cross-coupling reactions, while the fluorine and trifluoromethyl groups can impart specific electronic and steric properties to the final compounds, influencing their biological activity or material properties. It is typically supplied as a research-use-only chemical.

• Handle with appropriate personal protective equipment, including gloves, eye protection, and a lab coat. Use in a well-ventilated area or fume hood to avoid inhalation. Avoid contact with skin and eyes. In case of contact, rinse immediately with plenty of water. Store in a cool, dry place, away from incompatible materials. Refer to the Safety Data Sheet (SDS) for comprehensive safety information. This product is for research use only and not for human or animal therapeutic or diagnostic use.